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Tyrosine-protein kinase (EC 2.7.10.2)

 A0A0A9YK91_LYGHE        Unreviewed;       426 AA.
A0A0A9YK91;
04-MAR-2015, integrated into UniProtKB/TrEMBL.
04-MAR-2015, sequence version 1.
22-NOV-2017, entry version 16.
RecName: Full=Tyrosine-protein kinase {ECO:0000256|RuleBase:RU362096};
EC=2.7.10.2 {ECO:0000256|RuleBase:RU362096};
Name=CSK_16 {ECO:0000313|EMBL:JAG29955.1};
Synonyms=CSK_0 {ECO:0000313|EMBL:JAG18288.1},
CSK_1 {ECO:0000313|EMBL:JAG15892.1},
CSK_10 {ECO:0000313|EMBL:JAG29953.1},
CSK_11 {ECO:0000313|EMBL:JAG01309.1},
CSK_13 {ECO:0000313|EMBL:JAG01307.1},
CSK_14 {ECO:0000313|EMBL:JAG06014.1},
CSK_15 {ECO:0000313|EMBL:JAG06031.1},
CSK_17 {ECO:0000313|EMBL:JAG29954.1},
CSK_18 {ECO:0000313|EMBL:JAG29956.1},
CSK_2 {ECO:0000313|EMBL:JAG18286.1},
CSK_20 {ECO:0000313|EMBL:JAG01308.1},
CSK_22 {ECO:0000313|EMBL:JAG18285.1},
CSK_23 {ECO:0000313|EMBL:JAG18289.1},
CSK_5 {ECO:0000313|EMBL:JAG15888.1},
CSK_7 {ECO:0000313|EMBL:JAG15893.1},
CSK_8 {ECO:0000313|EMBL:JAG15889.1},
CSK_9 {ECO:0000313|EMBL:JAG29951.1};
ORFNames=CM83_91183 {ECO:0000313|EMBL:JAG15893.1},
CM83_91184 {ECO:0000313|EMBL:JAG15892.1},
CM83_91185 {ECO:0000313|EMBL:JAG15889.1},
CM83_91186 {ECO:0000313|EMBL:JAG15888.1},
CM83_91189 {ECO:0000313|EMBL:JAG18288.1},
CM83_91191 {ECO:0000313|EMBL:JAG18286.1},
CM83_91192 {ECO:0000313|EMBL:JAG18285.1},
CM83_91193 {ECO:0000313|EMBL:JAG18289.1},
CM83_91199 {ECO:0000313|EMBL:JAG01308.1},
CM83_91200 {ECO:0000313|EMBL:JAG01309.1},
CM83_91202 {ECO:0000313|EMBL:JAG01307.1},
CM83_91203 {ECO:0000313|EMBL:JAG06014.1},
CM83_91204 {ECO:0000313|EMBL:JAG06031.1},
CM83_91205 {ECO:0000313|EMBL:JAG29955.1},
CM83_91206 {ECO:0000313|EMBL:JAG29954.1},
CM83_91207 {ECO:0000313|EMBL:JAG29956.1},
CM83_91208 {ECO:0000313|EMBL:JAG29951.1},
CM83_91209 {ECO:0000313|EMBL:JAG29953.1},
g.78476 {ECO:0000313|EMBL:JAQ05595.1},
g.78479 {ECO:0000313|EMBL:JAQ10701.1};
Lygus hesperus (Western plant bug).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Paraneoptera; Hemiptera; Heteroptera;
Panheteroptera; Cimicomorpha; Miridae; Mirini; Lygus.
NCBI_TaxID=30085 {ECO:0000313|EMBL:JAG29955.1};
[1] {ECO:0000313|EMBL:JAG29955.1}
NUCLEOTIDE SEQUENCE.
PubMed=25401762;
Hull J.J., Chaney K., Geib S.M., Fabrick J.A., Brent C.S., Walsh D.,
Lavine L.C.;
"Transcriptome-Based Identification of ABC Transporters in the Western
Tarnished Plant Bug Lygus hesperus.";
PLoS ONE 9:E113046-E113046(2014).
[2] {ECO:0000313|EMBL:JAG29955.1}
NUCLEOTIDE SEQUENCE.
Hull J.;
Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:JAG56892.1}
NUCLEOTIDE SEQUENCE.
Magalhaes I.L.F., Oliveira U., Santos F.R., Vidigal T.H.D.A.,
Brescovit A.D., Santos A.J.;
Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:JAQ05595.1}
NUCLEOTIDE SEQUENCE.
PubMed=26823975; DOI=10.1186/s13742-016-0109-6;
Tassone E.E., Geib S.M., Hall B., Fabrick J.A., Brent C.S., Hull J.J.;
"De novo construction of an expanded transcriptome assembly for the
western tarnished plant bug, Lygus hesperus.";
Gigascience 5:6-6(2016).
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00897325}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00941529}.
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EMBL; GBHO01042297; JAG01307.1; -; Transcribed_RNA.
EMBL; GBHO01042296; JAG01308.1; -; Transcribed_RNA.
EMBL; GBHO01042295; JAG01309.1; -; Transcribed_RNA.
EMBL; GBHO01037590; JAG06014.1; -; Transcribed_RNA.
EMBL; GBHO01037573; JAG06031.1; -; Transcribed_RNA.
EMBL; GBHO01027716; JAG15888.1; -; Transcribed_RNA.
EMBL; GBHO01027715; JAG15889.1; -; Transcribed_RNA.
EMBL; GBHO01027712; JAG15892.1; -; Transcribed_RNA.
EMBL; GBHO01027711; JAG15893.1; -; Transcribed_RNA.
EMBL; GBHO01025319; JAG18285.1; -; Transcribed_RNA.
EMBL; GBHO01025318; JAG18286.1; -; Transcribed_RNA.
EMBL; GBHO01025316; JAG18288.1; -; Transcribed_RNA.
EMBL; GBHO01025315; JAG18289.1; -; Transcribed_RNA.
EMBL; GBHO01013653; JAG29951.1; -; Transcribed_RNA.
EMBL; GBHO01013651; JAG29953.1; -; Transcribed_RNA.
EMBL; GBHO01013650; JAG29954.1; -; Transcribed_RNA.
EMBL; GBHO01013649; JAG29955.1; -; Transcribed_RNA.
EMBL; GBHO01013648; JAG29956.1; -; Transcribed_RNA.
EMBL; GBRD01008929; JAG56892.1; -; Transcribed_RNA.
EMBL; GBRD01008928; JAG56893.1; -; Transcribed_RNA.
EMBL; GDHC01013034; JAQ05595.1; -; Transcribed_RNA.
EMBL; GDHC01007928; JAQ10701.1; -; Transcribed_RNA.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
CDD; cd09937; SH2_csk_like; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR035026; CSK.
InterPro; IPR035027; Csk-like_SH2.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
PANTHER; PTHR24418:SF307; PTHR24418:SF307; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF00017; SH2; 1.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00109; TYRKINASE.
SMART; SM00252; SH2; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF55550; SSF55550; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS50001; SH2; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00897857};
Kinase {ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS00897698};
Nucleotide-binding {ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00897857};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
Transferase {ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00897698};
Tyrosine-protein kinase {ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00897698}.
DOMAIN 57 146 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 173 426 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
SEQUENCE 426 AA; 48712 MW; 9117EF55B5BD7F45 CRC64;
MNHTLQATLT QRYQPVAVCG PLDSKEPAWI MPVMESDKLS PTFHQAKAEV KLSAMPWFHG
KISREMAETL LNPRTDGLFL VRESTNFPGD YTLCVCFQNK VEHYRVKYKD NQLTIDDEEF
FETLAQLVEH YEEDADGLCT QLTKSLPKQG KQDFCVDTKK FIEAGWVIQE HELEYKEPIG
KGEFGDVLLA IFRGEKVAVK MLKDSSEAAQ KFLAEASLMT SLTHENLVKL LGVVFDKTHI
SLVTEYMGKG SLVDYLRSRG RQHVTKKHQI NFASDTSSGM EYLERRKVVH RDLAARNVLI
SENGVAKVAD FGLAREENFQ LDCGKLPIKW TAPEALKQAI FSNKSDMWSF GILLWEIYSF
GRVPYPRIPL ADVVKHVEKG YKMEAPEGCP PEVYEIMRQA WDLHPDKRPS FKDVKIKLMQ
LRSITI


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