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Tyrosine-protein kinase (EC 2.7.10.2)

 G7PSP1_MACFA            Unreviewed;       635 AA.
G7PSP1;
25-JAN-2012, integrated into UniProtKB/TrEMBL.
25-JAN-2012, sequence version 1.
28-MAR-2018, entry version 39.
RecName: Full=Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000604};
EC=2.7.10.2 {ECO:0000256|PIRNR:PIRNR000604};
Name=SYK {ECO:0000313|Ensembl:ENSMFAP00000020581};
ORFNames=EGM_07157 {ECO:0000313|EMBL:EHH57507.1};
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
[1] {ECO:0000313|EMBL:EHH57507.1, ECO:0000313|Proteomes:UP000009130}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CE-4 {ECO:0000313|EMBL:EHH57507.1};
PubMed=22002653; DOI=10.1038/nbt.1992;
Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
Wang X., Wang J.;
"Genome sequencing and comparison of two nonhuman primate animal
models, the cynomolgus and Chinese rhesus macaques.";
Nat. Biotechnol. 29:1019-1023(2011).
[2] {ECO:0000313|Ensembl:ENSMFAP00000020581}
NUCLEOTIDE SEQUENCE.
Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSMFAP00000020581}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000256|PIRNR:PIRNR000604,
ECO:0000256|SAAS:SAAS00897325}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. SYK/ZAP-70 subfamily.
{ECO:0000256|PIRNR:PIRNR000604}.
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EMBL; AQIA01025558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AQIA01025559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AQIA01025560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CM001290; EHH57507.1; -; Genomic_DNA.
RefSeq; XP_005582280.1; XM_005582223.2.
RefSeq; XP_005582281.1; XM_005582224.2.
RefSeq; XP_005582282.1; XM_005582225.2.
Ensembl; ENSMFAT00000035557; ENSMFAP00000020581; ENSMFAG00000033243.
GeneID; 102145713; -.
KEGG; mcf:102145713; -.
CTD; 6850; -.
GeneTree; ENSGT00760000118799; -.
KO; K05855; -.
Proteomes; UP000009130; Chromosome 15.
GO; GO:0019815; C:B cell receptor complex; IEA:Ensembl.
GO; GO:0032009; C:early phagosome; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0042101; C:T cell receptor complex; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005178; F:integrin binding; IEA:Ensembl.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
GO; GO:0004716; F:signal transducer, downstream of receptor, with protein tyrosine kinase activity; IEA:Ensembl.
GO; GO:0035325; F:Toll-like receptor binding; IEA:Ensembl.
GO; GO:0007257; P:activation of JUN kinase activity; IEA:Ensembl.
GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0043366; P:beta selection; IEA:Ensembl.
GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
GO; GO:0071226; P:cellular response to molecule of fungal origin; IEA:Ensembl.
GO; GO:0038063; P:collagen-activated tyrosine kinase receptor signaling pathway; IEA:Ensembl.
GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
GO; GO:0045087; P:innate immune response; IEA:Ensembl.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
GO; GO:0019370; P:leukotriene biosynthetic process; IEA:Ensembl.
GO; GO:0001945; P:lymph vessel development; IEA:Ensembl.
GO; GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO; GO:0002283; P:neutrophil activation involved in immune response; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0046641; P:positive regulation of alpha-beta T cell proliferation; IEA:Ensembl.
GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Ensembl.
GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
GO; GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Ensembl.
GO; GO:0045425; P:positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; IEA:Ensembl.
GO; GO:0045401; P:positive regulation of interleukin-3 biosynthetic process; IEA:Ensembl.
GO; GO:0043306; P:positive regulation of mast cell degranulation; IEA:Ensembl.
GO; GO:1900086; P:positive regulation of peptidyl-tyrosine autophosphorylation; IEA:Ensembl.
GO; GO:0002092; P:positive regulation of receptor internalization; IEA:Ensembl.
GO; GO:0032481; P:positive regulation of type I interferon production; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0090237; P:regulation of arachidonic acid secretion; IEA:Ensembl.
GO; GO:0051090; P:regulation of DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0043313; P:regulation of neutrophil degranulation; IEA:Ensembl.
GO; GO:0050764; P:regulation of phagocytosis; IEA:Ensembl.
GO; GO:0090330; P:regulation of platelet aggregation; IEA:Ensembl.
GO; GO:0032928; P:regulation of superoxide anion generation; IEA:Ensembl.
GO; GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002554; P:serotonin secretion by platelet; IEA:Ensembl.
GO; GO:0042991; P:transcription factor import into nucleus; IEA:Ensembl.
CDD; cd09938; SH2_N-SH2_Zap70_Syk_like; 1.
Gene3D; 1.10.930.10; -; 1.
Gene3D; 3.30.505.10; -; 2.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR023420; Kinase_SYK/ZAP-70_inter-SH2_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR035838; SYK/ZAP-70_N_SH2.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR012234; Tyr_kinase_non-rcpt_SYK/ZAP70.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF00017; SH2; 2.
PIRSF; PIRSF000604; TyrPK_SYK; 1.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00109; TYRKINASE.
SMART; SM00252; SH2; 2.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF55550; SSF55550; 2.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS50001; SH2; 2.
3: Inferred from homology;
ATP-binding {ECO:0000256|PIRNR:PIRNR000604,
ECO:0000256|PIRSR:PIRSR000604-2, ECO:0000256|SAAS:SAAS00990534};
Complete proteome {ECO:0000313|Proteomes:UP000009130};
Kinase {ECO:0000256|PIRNR:PIRNR000604, ECO:0000256|SAAS:SAAS00897698};
Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000604,
ECO:0000256|PIRSR:PIRSR000604-2, ECO:0000256|SAAS:SAAS00990534};
Reference proteome {ECO:0000313|Proteomes:UP000009130};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
Transferase {ECO:0000256|PIRNR:PIRNR000604,
ECO:0000256|SAAS:SAAS00897698};
Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000604,
ECO:0000256|SAAS:SAAS00897698}.
DOMAIN 15 107 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 168 259 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 371 631 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
NP_BIND 377 385 ATP. {ECO:0000256|PIRSR:PIRSR000604-2}.
ACT_SITE 494 494 Proton acceptor.
{ECO:0000256|PIRSR:PIRSR000604-1}.
BINDING 402 402 ATP. {ECO:0000256|PIRSR:PIRSR000604-2}.
SEQUENCE 635 AA; 72088 MW; 7DFEE71C1FF26BB8 CRC64;
MASSGMADNA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK
AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV CLLKKPFNRP QGVQPKTGPF
EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ
IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL
VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK
PGHRKPSPAQ GNRPESTVSF NPYEPEVAPW AAEKGPQREA LPMDTEVYES PYADPEEIRP
KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE
ANVMQQLDNP YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM
GMKYLEECNF VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA
PECINYYKFS SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE
MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN


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