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Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase)

 CSK_CHICK               Reviewed;         450 AA.
P41239;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
22-NOV-2017, entry version 128.
RecName: Full=Tyrosine-protein kinase CSK;
EC=2.7.10.2 {ECO:0000250|UniProtKB:P41240};
AltName: Full=C-Src kinase;
Name=CSK;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=1372437; DOI=10.1073/pnas.89.6.2190;
Sabe H., Knudsen B., Okada M., Nada S., Nakagawa H., Hanafusa H.;
"Molecular cloning and expression of chicken C-terminal Src kinase:
lack of stable association with c-Src protein.";
Proc. Natl. Acad. Sci. U.S.A. 89:2190-2194(1992).
[2]
FUNCTION.
PubMed=7935444; DOI=10.1128/MCB.14.11.7306;
Hata A., Sabe H., Kurosaki T., Takata M., Hanafusa H.;
"Functional analysis of Csk in signal transduction through the B-cell
antigen receptor.";
Mol. Cell. Biol. 14:7306-7313(1994).
-!- FUNCTION: Non-receptor tyrosine-protein kinase that plays an
important role in the regulation of cell growth, differentiation,
migration and immune response. Phosphorylates tyrosine residues
located in the C-terminal tails of Src-family kinases (SFKs). Upon
tail phosphorylation, Src-family members engage in intramolecular
interactions between the phosphotyrosine tail and the SH2 domain
that result in an inactive conformation. To inhibit SFKs, CSK is
recruited to the plasma membrane via binding to transmembrane
proteins or adapter proteins located near the plasma membrane (By
similarity). {ECO:0000250, ECO:0000269|PubMed:7935444}.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000250|UniProtKB:P41240,
ECO:0000255|PROSITE-ProRule:PRU10028}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000250|UniProtKB:P41240};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000250|UniProtKB:P41240};
-!- SUBUNIT: Homodimer (via SH3-domain). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
-!- DOMAIN: The architecture of this protein is similar to that of
Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2
domain, and a C-terminal kinase domain. {ECO:0000250}.
-!- PTM: Phosphorylated at Ser-364 by PKA, leading to increased
activity. Autophosphorylated (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. CSK subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
-----------------------------------------------------------------------
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EMBL; M85039; AAA51436.1; -; mRNA.
PIR; A41973; A41973.
RefSeq; NP_990756.1; NM_205425.1.
UniGene; Gga.2691; -.
ProteinModelPortal; P41239; -.
SMR; P41239; -.
BioGrid; 676646; 1.
MINT; MINT-139440; -.
iPTMnet; P41239; -.
PRIDE; P41239; -.
GeneID; 396396; -.
KEGG; gga:396396; -.
CTD; 1445; -.
HOVERGEN; HBG008761; -.
InParanoid; P41239; -.
KO; K05728; -.
PhylomeDB; P41239; -.
BRENDA; 2.7.10.2; 1306.
PRO; PR:P41239; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0005102; F:receptor binding; IBA:GO_Central.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0034332; P:adherens junction organization; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
GO; GO:0060368; P:regulation of Fc receptor mediated stimulatory signaling pathway; IBA:GO_Central.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
CDD; cd09937; SH2_csk_like; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR035026; CSK.
InterPro; IPR035027; Csk-like_SH2.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
PANTHER; PTHR24418:SF307; PTHR24418:SF307; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00109; TYRKINASE.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF50044; SSF50044; 1.
SUPFAM; SSF55550; SSF55550; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 1.
2: Evidence at transcript level;
Adaptive immunity; ATP-binding; Complete proteome; Cytoplasm;
Immunity; Kinase; Magnesium; Manganese; Metal-binding;
Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain;
SH3 domain; Transferase; Tyrosine-protein kinase.
CHAIN 1 450 Tyrosine-protein kinase CSK.
/FTId=PRO_0000088069.
DOMAIN 9 70 SH3. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
DOMAIN 82 171 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
DOMAIN 195 450 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 201 209 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 9 70 Interaction with PTPN8. {ECO:0000250}.
ACT_SITE 314 314 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10028}.
BINDING 222 222 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 364 364 Phosphoserine; by PKA. {ECO:0000250}.
MOD_RES 416 416 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P41240}.
SEQUENCE 450 AA; 50751 MW; 5AA3C406AA4F246F CRC64;
MSGMQAVWPS GTECIAKYNF HGTAEQDLPF SKGDVLTIVA VTKDPNWYKA KNKVGREGII
PANYVQKREG VKAGIKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV
SCEGKVEHYR IIYSSSKLSI DEEVYFENLM QLVEHYTTDA DGLCSRLIKP KVMEGTVAAQ
DEFSRSGWAL NMKDLKLLQI IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM
TQLRHSNLVQ LLGVIVEEKS GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE
AMEYLEANNF VHRDLAARNV LVSEDNIAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE
KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDPPDG CPAIVYEVMK
KCWTLDPGHR PSFHQLREQL VHIKEKELYL


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