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Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)

 JAK2_RAT                Reviewed;        1132 AA.
Q62689;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
22-NOV-2017, entry version 166.
RecName: Full=Tyrosine-protein kinase JAK2;
EC=2.7.10.2;
AltName: Full=Janus kinase 2;
Short=JAK-2;
Name=Jak2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=7607555; DOI=10.1016/0378-1119(95)00041-4;
Duhe R.J., Rui H., Greenwood J.D., Garvey K., Farrar W.L.;
"Cloning of the gene encoding rat JAK2, a protein tyrosine kinase.";
Gene 158:281-285(1995).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Non-receptor tyrosine kinase involved in various
processes such as cell growth, development, differentiation or
histone modifications. Mediates essential signaling events in both
innate and adaptive immunity. In the cytoplasm, plays a pivotal
role in signal transduction via its association with type I
receptors such as growth hormone (GHR), prolactin (PRLR), leptin
(LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II
receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple
interleukins. Following ligand-binding to cell surface receptors,
phosphorylates specific tyrosine residues on the cytoplasmic tails
of the receptor, creating docking sites for STATs proteins.
Subsequently, phosphorylates the STATs proteins once they are
recruited to the receptor. Phosphorylated STATs then form
homodimer or heterodimers and translocate to the nucleus to
activate gene transcription. For example, cell stimulation with
erythropoietin (EPO) during erythropoiesis leads to JAK2
autophosphorylation, activation, and its association with
erythropoietin receptor (EPOR) that becomes phosphorylated in its
cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited,
phosphorylated and activated by JAK2. Once activated, dimerized
STAT5 translocates into the nucleus and promotes the transcription
of several essential genes involved in the modulation of
erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced
ARHGEF1 phosphorylation. Plays a role in cell cycle by
phosphorylating CDKN1B. Cooperates with TEC through reciprocal
phosphorylation to mediate cytokine-driven activation of FOS
transcription. In the nucleus, plays a key role in chromatin by
specifically mediating phosphorylation of 'Tyr-41' of histone H3
(H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1
alpha) from chromatin (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-
ProRule:PRU10028}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305};
Note=Mn(2+) was used in the in vitro kinase assay but Mg(2+) is
likely to be the in vivo cofactor. {ECO:0000305};
-!- ENZYME REGULATION: Regulated by autophosphorylation, can both
activate or decrease activity. Heme regulates its activity by
enhancing the phosphorylation on Tyr-1007 and Tyr-1008 (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with IL23R, SKB1 and STAM2 (By similarity).
Interacts with EPOR. Interacts with LYN. Interacts with SIRPA.
Interacts with SH2B1. Interacts with TEC (By similarity).
Interacts with IFNGR2 (via intracellular domain) (By similarity).
Interacts with LEPR (Isoform B) (By similarity). Interacts with
HSP90AB1; promotes functional activation in a heat shock-dependent
manner (By similarity). {ECO:0000250|UniProtKB:O60674,
ECO:0000250|UniProtKB:Q62120}.
-!- INTERACTION:
P15127:Insr; NbExp=2; IntAct=EBI-8656708, EBI-7472166;
P41499:Ptpn11; NbExp=3; IntAct=EBI-8656708, EBI-7180604;
-!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250};
Peripheral membrane protein {ECO:0000250}. Cytoplasm
{ECO:0000250}. Nucleus {ECO:0000250}.
-!- TISSUE SPECIFICITY: Ubiquitously expressed throughout most
tissues. {ECO:0000269|PubMed:7607555}.
-!- DOMAIN: The N-terminal domain of JAKs mediates their interaction
with cytokine/interferon/growth hormone receptors. Possesses 2
protein kinase domains. The second one probably contains the
catalytic domain, while the presence of slight differences suggest
a different role for protein kinase 1 (By similarity).
{ECO:0000250}.
-!- PTM: Autophosphorylated, leading to regulate its activity. Leptin
promotes phosphorylation on tyrosine residues, including
phosphorylation on Tyr-813. Autophosphorylation on Tyr-119 in
response to EPO down-regulates its kinase activity.
Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to
growth hormone (GH) are required for maximal kinase activity. Also
phosphorylated by TEC. Phosphorylated on tyrosine residues in
response to interferon gamma signaling.
{ECO:0000250|UniProtKB:O60674, ECO:0000250|UniProtKB:Q62120}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. JAK subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
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EMBL; U13396; AAA79911.1; -; mRNA.
PIR; JC4127; JC4127.
RefSeq; NP_113702.1; NM_031514.1.
UniGene; Rn.18909; -.
ProteinModelPortal; Q62689; -.
SMR; Q62689; -.
BioGrid; 246670; 9.
DIP; DIP-491N; -.
IntAct; Q62689; 3.
STRING; 10116.ENSRNOP00000021218; -.
ChEMBL; CHEMBL1075225; -.
iPTMnet; Q62689; -.
PhosphoSitePlus; Q62689; -.
PaxDb; Q62689; -.
PRIDE; Q62689; -.
Ensembl; ENSRNOT00000087011; ENSRNOP00000071877; ENSRNOG00000059968.
GeneID; 24514; -.
KEGG; rno:24514; -.
UCSC; RGD:2939; rat.
CTD; 3717; -.
RGD; 2939; Jak2.
eggNOG; KOG0197; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00900000140909; -.
HOGENOM; HOG000049158; -.
HOVERGEN; HBG006195; -.
InParanoid; Q62689; -.
KO; K04447; -.
OMA; SNCHGPI; -.
OrthoDB; EOG091G01IS; -.
PhylomeDB; Q62689; -.
BRENDA; 2.7.10.2; 5301.
Reactome; R-RNO-110056; MAPK3 (ERK1) activation.
Reactome; R-RNO-112411; MAPK1 (ERK2) activation.
Reactome; R-RNO-114604; GPVI-mediated activation cascade.
Reactome; R-RNO-1170546; Prolactin receptor signaling.
Reactome; R-RNO-1433557; Signaling by SCF-KIT.
Reactome; R-RNO-2586552; Signaling by Leptin.
Reactome; R-RNO-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-RNO-447115; Interleukin-12 family signaling.
Reactome; R-RNO-512988; Interleukin-3, 5 and GM-CSF signaling.
Reactome; R-RNO-5673000; RAF activation.
Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
Reactome; R-RNO-6783589; Interleukin-6 family signaling.
Reactome; R-RNO-6785807; Interleukin-4 and 13 signaling.
Reactome; R-RNO-6788467; IL-6-type cytokine receptor ligand interactions.
Reactome; R-RNO-69231; Cyclin D associated events in G1.
Reactome; R-RNO-877300; Interferon gamma signaling.
Reactome; R-RNO-877312; Regulation of IFNG signaling.
Reactome; R-RNO-8984722; Interleukin-35 Signalling.
Reactome; R-RNO-912526; Interleukin receptor SHC signaling.
Reactome; R-RNO-982772; Growth hormone receptor signaling.
Reactome; R-RNO-983231; Factors involved in megakaryocyte development and platelet production.
PRO; PR:Q62689; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000059968; -.
Genevisible; Q62689; RN.
GO; GO:0005901; C:caveola; ISO:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; ISO:RGD.
GO; GO:0016363; C:nuclear matrix; IDA:RGD.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0033130; F:acetylcholine receptor binding; IPI:RGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005131; F:growth hormone receptor binding; IPI:BHF-UCL.
GO; GO:0020037; F:heme binding; ISS:UniProtKB.
GO; GO:0042393; F:histone binding; ISS:UniProtKB.
GO; GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0043560; F:insulin receptor substrate binding; IPI:RGD.
GO; GO:0005143; F:interleukin-12 receptor binding; ISO:RGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.
GO; GO:0051428; F:peptide hormone receptor binding; IPI:RGD.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IPI:RGD.
GO; GO:0008022; F:protein C-terminus binding; IPI:RGD.
GO; GO:0019901; F:protein kinase binding; ISO:RGD.
GO; GO:0004713; F:protein tyrosine kinase activity; IMP:RGD.
GO; GO:0005102; F:receptor binding; ISO:RGD.
GO; GO:0042169; F:SH2 domain binding; ISO:RGD.
GO; GO:0031702; F:type 1 angiotensin receptor binding; IPI:RGD.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:RGD.
GO; GO:0097296; P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; ISO:RGD.
GO; GO:0042976; P:activation of Janus kinase activity; ISS:UniProtKB.
GO; GO:0000186; P:activation of MAPKK activity; IMP:RGD.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0031103; P:axon regeneration; IMP:RGD.
GO; GO:0030154; P:cell differentiation; ISO:RGD.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; ISO:RGD.
GO; GO:0036016; P:cellular response to interleukin-3; ISO:RGD.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0007167; P:enzyme linked receptor protein signaling pathway; ISO:RGD.
GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.
GO; GO:0060396; P:growth hormone receptor signaling pathway; ISO:RGD.
GO; GO:0035409; P:histone H3-Y41 phosphorylation; ISS:UniProtKB.
GO; GO:0009755; P:hormone-mediated signaling pathway; IDA:RGD.
GO; GO:0034050; P:host programmed cell death induced by symbiont; ISO:RGD.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IDA:BHF-UCL.
GO; GO:0035722; P:interleukin-12-mediated signaling pathway; ISO:RGD.
GO; GO:0035556; P:intracellular signal transduction; ISO:RGD.
GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IMP:RGD.
GO; GO:0007259; P:JAK-STAT cascade; IDA:RGD.
GO; GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; IDA:RGD.
GO; GO:0061180; P:mammary gland epithelium development; ISO:RGD.
GO; GO:0031959; P:mineralocorticoid receptor signaling pathway; IMP:RGD.
GO; GO:0030099; P:myeloid cell differentiation; ISO:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IMP:RGD.
GO; GO:0060548; P:negative regulation of cell death; IMP:RGD.
GO; GO:0008285; P:negative regulation of cell proliferation; ISO:RGD.
GO; GO:0022408; P:negative regulation of cell-cell adhesion; IMP:RGD.
GO; GO:0043392; P:negative regulation of DNA binding; ISO:RGD.
GO; GO:0045822; P:negative regulation of heart contraction; IMP:RGD.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.
GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central.
GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; ISO:RGD.
GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; ISO:RGD.
GO; GO:0050867; P:positive regulation of cell activation; IMP:RGD.
GO; GO:0045597; P:positive regulation of cell differentiation; IMP:RGD.
GO; GO:0030335; P:positive regulation of cell migration; IMP:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
GO; GO:0010811; P:positive regulation of cell-substrate adhesion; ISO:RGD.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD.
GO; GO:0043388; P:positive regulation of DNA binding; IMP:RGD.
GO; GO:1904037; P:positive regulation of epithelial cell apoptotic process; IMP:RGD.
GO; GO:1902728; P:positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; IMP:RGD.
GO; GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; ISO:RGD.
GO; GO:0050729; P:positive regulation of inflammatory response; IMP:RGD.
GO; GO:0032024; P:positive regulation of insulin secretion; IMP:RGD.
GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IMP:RGD.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:RGD.
GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IDA:BHF-UCL.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISO:RGD.
GO; GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IMP:RGD.
GO; GO:0033160; P:positive regulation of protein import into nucleus, translocation; IMP:RGD.
GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:RGD.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:RGD.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.
GO; GO:1904707; P:positive regulation of vascular smooth muscle cell proliferation; IMP:RGD.
GO; GO:0035166; P:post-embryonic hemopoiesis; ISO:RGD.
GO; GO:0046777; P:protein autophosphorylation; IMP:RGD.
GO; GO:0050727; P:regulation of inflammatory response; ISO:RGD.
GO; GO:0046677; P:response to antibiotic; ISO:RGD.
GO; GO:0033194; P:response to hydroperoxide; IMP:RGD.
GO; GO:0070671; P:response to interleukin-12; ISO:RGD.
GO; GO:0032496; P:response to lipopolysaccharide; ISO:RGD.
GO; GO:0006979; P:response to oxidative stress; IMP:RGD.
GO; GO:0034612; P:response to tumor necrosis factor; ISO:RGD.
GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
GO; GO:0007262; P:STAT protein import into nucleus; ISO:RGD.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; ISO:RGD.
GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; IMP:RGD.
CDD; cd05078; PTK_Jak2_rpt1; 1.
CDD; cd14205; PTKc_Jak2_rpt2; 1.
CDD; cd10379; SH2_Jak2; 1.
Gene3D; 1.20.80.10; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR019749; Band_41_domain.
InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
InterPro; IPR035963; FERM_2.
InterPro; IPR000299; FERM_domain.
InterPro; IPR035860; JAK2_SH2.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR035588; PTK_Jak2_rpt1.
InterPro; IPR035589; PTKc_Jak2_rpt2.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
InterPro; IPR020693; Tyr_kinase_non-rcpt_Jak2.
Pfam; PF07714; Pkinase_Tyr; 2.
Pfam; PF00017; SH2; 1.
PIRSF; PIRSF000636; TyrPK_Jak; 1.
PRINTS; PR01823; JANUSKINASE.
PRINTS; PR01825; JANUSKINASE2.
PRINTS; PR00109; TYRKINASE.
SMART; SM00295; B41; 1.
SMART; SM00252; SH2; 1.
SMART; SM00219; TyrKc; 2.
SUPFAM; SSF47031; SSF47031; 1.
SUPFAM; SSF50729; SSF50729; 1.
SUPFAM; SSF55550; SSF55550; 2.
SUPFAM; SSF56112; SSF56112; 2.
PROSITE; PS50057; FERM_3; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS50001; SH2; 1.
1: Evidence at protein level;
Adaptive immunity; ATP-binding; Chromatin regulator;
Complete proteome; Cytoplasm; Immunity; Innate immunity; Kinase;
Magnesium; Membrane; Metal-binding; Nucleotide-binding; Nucleus;
Phosphoprotein; Reference proteome; Repeat; SH2 domain; Transferase;
Tyrosine-protein kinase.
CHAIN 1 1132 Tyrosine-protein kinase JAK2.
/FTId=PRO_0000088114.
DOMAIN 37 380 FERM. {ECO:0000255|PROSITE-
ProRule:PRU00084}.
DOMAIN 401 482 SH2; atypical. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
DOMAIN 545 809 Protein kinase 1. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
DOMAIN 849 1126 Protein kinase 2. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 855 863 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 1 239 Interaction with
cytokine/interferon/growth hormone
receptors. {ECO:0000250}.
ACT_SITE 976 976 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10028}.
BINDING 882 882 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 119 119 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:Q62120}.
MOD_RES 372 372 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q62120}.
MOD_RES 373 373 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q62120}.
MOD_RES 523 523 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 570 570 Phosphotyrosine.
{ECO:0000250|UniProtKB:O60674}.
MOD_RES 813 813 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q62120}.
MOD_RES 868 868 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:Q62120}.
MOD_RES 966 966 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:Q62120}.
MOD_RES 972 972 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:Q62120}.
MOD_RES 1007 1007 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:O60674}.
MOD_RES 1008 1008 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:Q62120}.
SEQUENCE 1132 AA; 130585 MW; C3AEDF2FECE8B95A CRC64;
MGMACLTMTE MEGTSTSPAH QNGDIPGNAN SVKQTEPVLQ VYLYHSLGQA EGDYLKFPNG
EYVAEEICVA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NILYRIRFYF
PHWYCSGSNR TYRYGVSRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG
MAVLDMMRIA KEKDQTPLAV YNSISYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIQQF
SQCKATARNL KLKYLINLET LQSAFYTEQF EVKESARGPS GEEIFATIII TGNGGIQWSR
GKHKESETLT EQDLQLYCDF PDIIDVSIKQ ANQECSTESR VVTVHKQDGK VLEIELSSLK
EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIHSNC HGPISMDFAI SKLKKAGNQT
GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENG EYNLSGTKRN FSSLKDLLNC
YQMETVRSDS IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV QLSPTLQRHN NVNQMVFHKI
RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM
MSQLSHKHLV LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINILWK LGVAKQLAWA
MHFLEEKSLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP
PECIENPKNL TLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDKH QLPAPKWTEL
ANLINTCMDY EPDFRPAFRA VIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD
PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE
ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI
CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW
YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPVE FMRMIGNDKQ GQMIVFHLIE
LLKNNGRLPR PEGCPDEIYV IMTECWNNNV NQRPSFRDLS LRVDQIRDSM AA


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FP-0041 Tyrosine-protein kinase JAK3 (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) 10ug
FP-0041 Fusion proteins: Tyrosine-protein kinase JAK3 (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) , JAK3 10ug
FP-0041 Tyrosine-protein kinase JAK3 (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) ; SH2-Domain: JAK3 10ug
32-232 Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family 0.1 mL
EIAAB33008 CCK4,CCK-4,Colon carcinoma kinase 4,Homo sapiens,Human,Inactive tyrosine-protein kinase 7,Protein-tyrosine kinase 7,Pseudo tyrosine kinase receptor 7,PTK7,Tyrosine-protein kinase-like 7
FP-0039 Tyrosine-protein kinase JAK1 (Janus kinase 1) 10ug
FP-0040 Tyrosine_protein kinase JAK2 (Janus kinase 2) 10 ug
E1915m ELISA kit Agammaglobulinaemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bpk,Bruton tyrosine kinase,Btk,Kinase EMB,Mouse,Mus musculus,Tyrosine-protein kinase BTK 96T
E1915m ELISA Agammaglobulinaemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bpk,Bruton tyrosine kinase,Btk,Kinase EMB,Mouse,Mus musculus,Tyrosine-protein kinase BTK 96T
U1915m CLIA Agammaglobulinaemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bpk,Bruton tyrosine kinase,Btk,Kinase EMB,Mouse,Mus musculus,Tyrosine-protein kinase BTK 96T
U1915m CLIA kit Agammaglobulinaemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bpk,Bruton tyrosine kinase,Btk,Kinase EMB,Mouse,Mus musculus,Tyrosine-protein kinase BTK 96T
DL-JAK2-Ra Rat Janus Kinase 2 (JAK2) ELISA Kit 96T
EIAAB33010 Inactive tyrosine-protein kinase 7,Mouse,Mus musculus,Protein chuzhoi,Protein-tyrosine kinase 7,Pseudo tyrosine kinase receptor 7,Ptk7,Tyrosine-protein kinase-like 7
JAK2-336H Protein: Recombinant Human Janus Kinase 2, GST-tagged, Active 5μg
JAK2-336H Protein Recombinant Human Janus Kinase 2, GST-tagged, Active 5μg
U1915h CLIA kit Agammaglobulinaemia tyrosine kinase,AGMX1,ATK,ATK,B-cell progenitor kinase,BPK,BPK,Bruton tyrosine kinase,BTK,Homo sapiens,Human,Tyrosine-protein kinase BTK 96T


 

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