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Tyrosine-protein phosphatase 99A

 A0A0K8W0B8_BACLA        Unreviewed;      1633 AA.
A0A0K8W0B8;
11-NOV-2015, integrated into UniProtKB/TrEMBL.
11-NOV-2015, sequence version 1.
27-SEP-2017, entry version 22.
SubName: Full=Tyrosine-protein phosphatase 99A {ECO:0000313|EMBL:JAI44534.1};
Name=Ptp99A_6 {ECO:0000313|EMBL:JAI44534.1};
Synonyms=Ptp99A_2 {ECO:0000313|EMBL:JAI19429.1};
ORFNames=c0_g3_i10 {ECO:0000313|EMBL:JAI19429.1},
c0_g3_i6 {ECO:0000313|EMBL:JAI44534.1};
Bactrocera latifrons (Malaysian fruit fly) (Chaetodacus latifrons).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Tephritoidea; Tephritidae; Bactrocera; Bactrocera.
NCBI_TaxID=174628 {ECO:0000313|EMBL:JAI44534.1};
[1] {ECO:0000313|EMBL:JAI44534.1}
NUCLEOTIDE SEQUENCE.
Hoefler B.C., Straight P.D.;
Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
-!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
tyrosine + phosphate. {ECO:0000256|SAAS:SAAS00697399}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00160}.
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EMBL; GDHF01032885; JAI19429.1; -; Transcribed_RNA.
EMBL; GDHF01007780; JAI44534.1; -; Transcribed_RNA.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
CDD; cd00063; FN3; 2.
Gene3D; 2.60.40.10; -; 2.
Gene3D; 3.90.190.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
InterPro; IPR000242; PTPase_domain.
InterPro; IPR016130; Tyr_Pase_AS.
InterPro; IPR003595; Tyr_Pase_cat.
InterPro; IPR000387; TYR_PHOSPHATASE_dom.
Pfam; PF00041; fn3; 2.
Pfam; PF00102; Y_phosphatase; 2.
PRINTS; PR00700; PRTYPHPHTASE.
SMART; SM00060; FN3; 2.
SMART; SM00194; PTPc; 2.
SMART; SM00404; PTPc_motif; 2.
SUPFAM; SSF49265; SSF49265; 1.
SUPFAM; SSF52799; SSF52799; 2.
PROSITE; PS50853; FN3; 2.
PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
4: Predicted;
Hydrolase {ECO:0000256|SAAS:SAAS00614364};
Membrane {ECO:0000256|SAAS:SAAS00747529, ECO:0000256|SAM:Phobius};
Protein phosphatase {ECO:0000256|SAAS:SAAS00614364};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00747529,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00747529,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 31 {ECO:0000256|SAM:SignalP}.
CHAIN 32 1633 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5010916563.
TRANSMEM 434 459 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 216 312 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 313 419 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 519 786 Tyrosine-protein phosphatase.
{ECO:0000259|PROSITE:PS50055}.
DOMAIN 703 777 TYR_PHOSPHATASE_2.
{ECO:0000259|PROSITE:PS50056}.
DOMAIN 809 1061 Tyrosine-protein phosphatase.
{ECO:0000259|PROSITE:PS50055}.
ACT_SITE 727 727 Phosphocysteine intermediate.
{ECO:0000256|PROSITE-ProRule:PRU00160}.
SEQUENCE 1633 AA; 180605 MW; D5CF4C23ECE9708B CRC64;
MPRPRYAPRL RLLLNLLLFT AIIAEHRGAS AAGIAIDPEL SSPSPFTIAP TAALPTATPT
SAPTTPNAVP NASVVDSKLA YDDGSTTTVS NILEVNAYAV NGVGLDAKNV LPAVADDDSE
TVETDFRLPA AAPTSPASVE QQDQPLVPPT TLSFANIAPA SGLDSDLYSG SAGGGGGGGG
SIAGFEFGDG DGKTATTSGD ATPPYAAVDE KYVPSKPLNL TVLNVTSTSI TMSWYPPKNQ
NGAIAGYHVF HIHDNQTGVE IMKNSRNSQD SLIIFELPNL KPFTDYRVIV QAFTMKNEGN
PSDQIVQRTD VAGPSPPYVV NLTCHSQDAI AIRWRRPHEF YNTIDFYIIK TRVVGQDNHR
DIRINASAKE LETAMILQNI TTHTEYEVRV AAATLSIINP KKIVLGKYSE PRKISLHPNC
EKIQSLLRQS HNDYNLAVLV GIIFSCFGIV LIVMAFFLWS RKCFHAAYYY LDDPPHHPNM
PQVDWEAPVE VAGEIRAAVP VNEFAKHVAS LHADGDIGFS REYEAIQNES IDDLPCEHSQ
HPENKRKNRY LNITAYDHSR VHLHPTPGQK KNLDYINANF IDGYQKSRAF IGTQGPLPDT
FDCFWRMIWE QRVSIIVMIT NLVERGRRKC DMYWPKDGVE TYGVIQVKMV DEEVMSTYTV
RTLQIKHLKV KQLKKKKQCN AEKIVYQYHY TNWPDHGTPD HPLPVLDFVK KSSAANPDDA
GPIVVHCSAG VGRTGTYIVL DAMLKQIQQK LVVNVFGFLR HIRIQRNFLV QTEEQYIFIH
DALVEAIASG ETNLRTEQIE ELKNCTPYLE QQYKNIIQFQ TKDIHIASAM KQVNSVKNRG
AIFPIESSRV HLTPKPGEEG SDYINASWLH GFRRLRDFIV TQHPMSHTMK DFWQMVWDHN
AQTIVLLSSL DEINFAQFWP DDTQPIESDY YRVKFLRKTN KSDYVSRDFV IQSIQDDYEL
NVKMLHCPSW PEMSNPKSIY DFIVDVHERC ADYRNGPIVV VDRYGGAQAC TFCAISSLAM
EMEYCSTASI YQYAKLYHNK RPGVWTSSED IRLIYNILSF LPRNLQLLER TALRTEFEDV
TTATPDLYSK ICSNGNINAQ QNCNNLVYHN HSSSVNHSNS ISNTNVLNEN ANACNNTTNN
LNTNYTTNTI TTTTTTATAT TPTTIDTSGG NITPPTTLTP NTSANNLQYE QQQQYQQSSQ
QQPHFASQHM QSLNSVQSPT TTTTTNNTPA SNQYTPATSN SQCATPTPLP SSSSSPNTTP
AMSTTPVAPL ASITANNHST AMFTTTTTPD LTNNMTTNSI NNTNNCNANL IGNANYNENF
ANTNTTTNAY TTATTNTKTN TTNQHNTTSY CVSPNTNPNI NTNTNNTDSV STNHFTTNTT
TPTSIAAIST NGERFSLVNN LEQQQRHHEQ QQQQTYQYEP TNLHHHHNQQ QQQPSQLTSL
TDAIAELQLY ATNGNSNLAT TTTTTNGIDC YATTMALPPP PPAFDNDPDL TLQQQQLQQQ
HEHQLDPLNS NASTLSAPCS DDTIDGLTPL LPTPPPQYPN NAYANNTCNT VDVNATTPLT
KSSSNTSLSS SNATINYNGN GYANGNGNNN QTHLHGNGNG LLNATNTNMK QMTTLTTTKA
ATVTDAQSLD IVG


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