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U3 small nucleolar RNA-associated protein 6 (U3 snoRNA-associated protein 6) (U three protein 6)

 UTP6_YEAST              Reviewed;         440 AA.
Q02354; D6VT74; Q04115;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
15-DEC-1998, sequence version 2.
23-MAY-2018, entry version 144.
RecName: Full=U3 small nucleolar RNA-associated protein 6;
Short=U3 snoRNA-associated protein 6;
AltName: Full=U three protein 6;
Name=UTP6; OrderedLocusNames=YDR449C; ORFNames=D9461.34;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1638630; DOI=10.1016/0092-8674(92)90100-Q;
Berger S.L., Pina B., Silverman N., Marcus G.A., Agapite J.,
Regier J.L., Triezenberg S.J., Guarente L.;
"Genetic isolation of ADA2: a potential transcriptional adaptor
required for function of certain acidic activation domains.";
Cell 70:251-265(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169867;
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N.,
Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M.,
Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L.,
Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M.,
Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S.,
Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M.,
Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S.,
Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K.,
Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D.,
Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C.,
Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T.,
Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E.,
Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W.,
Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K.,
Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S.,
Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A.,
Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S.,
Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M.,
Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y.,
Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M.,
Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E.,
Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R.,
Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
Mewes H.-W., Zollner A., Zaccaria P.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
Nature 387:75-78(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
IDENTIFICATION IN PWP2 SUBCOMPLEX BY MASS SPECTROMETRY, AND
SUBCELLULAR LOCATION.
PubMed=12150911; DOI=10.1016/S1097-2765(02)00579-8;
Grandi P., Rybin V., Bassler J., Petfalski E., Strauss D.,
Marzioch M., Schaefer T., Kuster B., Tschochner H., Tollervey D.,
Gavin A.-C., Hurt E.;
"90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S
subunit processing factors but predominantly lack 60S synthesis
factors.";
Mol. Cell 10:105-115(2002).
[5]
FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU
PROCESSOME BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
PubMed=12068309; DOI=10.1038/nature00769;
Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M.,
Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E.,
Shabanowitz J., Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J.;
"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA
biogenesis.";
Nature 417:967-970(2002).
[6]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[7]
SUBUNIT.
PubMed=15590835; DOI=10.1128/EC.3.6.1619-1626.2004;
Bernstein K.A., Gallagher J.E.G., Mitchell B.M., Granneman S.,
Baserga S.J.;
"The small-subunit processome is a ribosome assembly intermediate.";
Eukaryot. Cell 3:1619-1626(2004).
[8]
IDENTIFICATION IN UTP-B SUBCOMPLEX BY MASS SPECTROMETRY.
PubMed=14759368; DOI=10.1016/S1097-2765(04)00003-6;
Krogan N.J., Peng W.-T., Cagney G., Robinson M.D., Haw R., Zhong G.,
Guo X., Zhang X., Canadien V., Richards D.P., Beattie B.K., Lalev A.,
Zhang W., Davierwala A.P., Mnaimneh S., Starostine A., Tikuisis A.P.,
Grigull J., Datta N., Bray J.E., Hughes T.R., Emili A.,
Greenblatt J.F.;
"High-definition macromolecular composition of yeast RNA-processing
complexes.";
Mol. Cell 13:225-239(2004).
[9]
SUBUNIT.
PubMed=17515605; DOI=10.1128/MCB.00380-07;
Perez-Fernandez J., Roman A., De Las Rivas J., Bustelo X.R., Dosil M.;
"The 90S preribosome is a multimodular structure that is assembled
through a hierarchical mechanism.";
Mol. Cell. Biol. 27:5414-5429(2007).
-!- FUNCTION: Component of the SSU processome, a pre-ribosomal
particle required for the maturation of the 18S rRNA from the 35S
pre-rRNA precursor. {ECO:0000269|PubMed:12068309}.
-!- SUBUNIT: Component of the ribosomal small subunit (SSU)
processome, or 90S pre-ribosomal particle, composed of the 35S
pre-rRNA precursor, the U3 snoRNA, and at least 40 protein
subunits. Component of the PWP2/UTP-B subcomplex composed of DIP2,
PWP2, UTP6, UTP13, UTP18 and UTP21. Interacts with U3 snoRNA.
Interacts with MPP10. {ECO:0000269|PubMed:12068309,
ECO:0000269|PubMed:12150911, ECO:0000269|PubMed:14759368,
ECO:0000269|PubMed:15590835, ECO:0000269|PubMed:17515605}.
-!- INTERACTION:
Self; NbExp=3; IntAct=EBI-22119, EBI-22119;
P25586:KRR1; NbExp=3; IntAct=EBI-22119, EBI-21773;
P47083:MPP10; NbExp=9; IntAct=EBI-22119, EBI-11168;
Q06512:NOC4; NbExp=4; IntAct=EBI-22119, EBI-36459;
Q12136:SAS10; NbExp=5; IntAct=EBI-22119, EBI-36084;
Q05946:UTP13; NbExp=4; IntAct=EBI-22119, EBI-34702;
P40362:UTP18; NbExp=11; IntAct=EBI-22119, EBI-4534;
Q06078:UTP21; NbExp=15; IntAct=EBI-22119, EBI-359;
P53254:UTP22; NbExp=6; IntAct=EBI-22119, EBI-1878;
-!- SUBCELLULAR LOCATION: Nucleus, nucleolus
{ECO:0000269|PubMed:12068309, ECO:0000269|PubMed:12150911}.
-!- MISCELLANEOUS: Present with 7520 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the UTP6 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M95396; AAA34394.1; -; Genomic_DNA.
EMBL; U33007; AAB64874.1; -; Genomic_DNA.
EMBL; BK006938; DAA12284.1; -; Genomic_DNA.
PIR; S69728; S69728.
RefSeq; NP_010737.1; NM_001180757.1.
PDB; 5WLC; EM; 3.80 A; LP=1-326.
PDBsum; 5WLC; -.
ProteinModelPortal; Q02354; -.
BioGrid; 32504; 219.
DIP; DIP-6479N; -.
IntAct; Q02354; 60.
MINT; Q02354; -.
STRING; 4932.YDR449C; -.
iPTMnet; Q02354; -.
MaxQB; Q02354; -.
PaxDb; Q02354; -.
PRIDE; Q02354; -.
EnsemblFungi; YDR449C; YDR449C; YDR449C.
GeneID; 852060; -.
KEGG; sce:YDR449C; -.
EuPathDB; FungiDB:YDR449C; -.
SGD; S000002857; UTP6.
GeneTree; ENSGT00390000016493; -.
HOGENOM; HOG000065928; -.
InParanoid; Q02354; -.
KO; K14557; -.
OMA; EITMIMR; -.
OrthoDB; EOG092C0Y9M; -.
BioCyc; YEAST:G3O-29980-MONOMER; -.
Reactome; R-SCE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
PRO; PR:Q02354; -.
Proteomes; UP000002311; Chromosome IV.
GO; GO:0005730; C:nucleolus; IDA:SGD.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IDA:SGD.
GO; GO:0032040; C:small-subunit processome; IDA:SGD.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0030515; F:snoRNA binding; IPI:SGD.
GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
GO; GO:0031167; P:rRNA methylation; TAS:Reactome.
Gene3D; 1.25.40.10; -; 1.
InterPro; IPR003107; HAT.
InterPro; IPR011990; TPR-like_helical_dom_sf.
InterPro; IPR013949; Utp6.
Pfam; PF08640; U3_assoc_6; 1.
SMART; SM00386; HAT; 3.
SUPFAM; SSF48452; SSF48452; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Nucleus; Reference proteome; Repeat;
Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
CHAIN 1 440 U3 small nucleolar RNA-associated protein
6.
/FTId=PRO_0000205765.
REPEAT 87 119 HAT 1.
REPEAT 124 156 HAT 2.
REPEAT 159 191 HAT 3.
CONFLICT 138 140 KLH -> SA (in Ref. 1; AAA34394).
{ECO:0000305}.
SEQUENCE 440 AA; 52418 MW; 60FD2E0E1B3B79B3 CRC64;
MSKTRYYLEQ CIPEMDDLVE KGLFTKNEVS LIMKKRTDFE HRLNSRGSSI NDYIKYINYE
SNVNKLRAKR CKRILQVKKT NSLSDWSIQQ RIGFIYQRGT NKFPQDLKFW AMYLNYMKAR
GNQTSYKKIH NIYNQLLKLH PTNVDIWISC AKYEYEVHAN FKSCRNIFQN GLRFNPDVPK
LWYEYVKFEL NFITKLINRR KVMGLINERE QELDMQNEQK NNQAPDEEKS HLQVPSTGDS
MKDKLNELPE ADISVLGNAE TNPALRGDIA LTIFDVCMKT LGKHYINKHK GYYAISDSKM
NIELNKETLN YLFSESLRYI KLFDEFLDLE RDYLINHVLQ FWKNDMYDLS LRKDLPELYL
KTVMIDITLN IRYMPVEKLD IDQLQLSVKK YFAYISKLDS ASVKSLKNEY RSYLQDNYLK
KMNAEDDPRY KILDLIISKL


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