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UDP-glucuronosyltransferase 1-1 (UDPGT 1-1) (UGT1*1) (UGT1-01) (UGT1.1) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1A1) (UGTBR1)

 UD11_MOUSE              Reviewed;         535 AA.
Q63886; Q561M6; Q6XL50;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
30-AUG-2017, entry version 131.
RecName: Full=UDP-glucuronosyltransferase 1-1;
Short=UDPGT 1-1;
Short=UGT1*1;
Short=UGT1-01;
Short=UGT1.1;
EC=2.4.1.17;
AltName: Full=UDP-glucuronosyltransferase 1A1;
AltName: Full=UGTBR1;
Flags: Precursor;
Name=Ugt1a1; Synonyms=Ugt1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8464825; DOI=10.1023/A:1018965011846;
Kong A.N., Ma M., Tao D., Yang L.;
"Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol
family of UDP-glucuronosyltransferases (mUGTBr/p).";
Pharm. Res. 10:461-465(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Colon;
PubMed=14672974; DOI=10.1101/gr.1225204;
Zhang T., Haws P., Wu Q.;
"Multiple variable first exons: a mechanism for cell- and tissue-
specific gene regulation.";
Genome Res. 14:79-89(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
COMPONENT OF A CHAPERONE COMPLEX.
PubMed=12475965; DOI=10.1091/mbc.E02-05-0311;
Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M.;
"A subset of chaperones and folding enzymes form multiprotein
complexes in endoplasmic reticulum to bind nascent proteins.";
Mol. Biol. Cell 13:4456-4469(2002).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: UDPGT is of major importance in the conjugation and
subsequent elimination of potentially toxic xenobiotics and
endogenous compounds.
-!- CATALYTIC ACTIVITY: UDP-glucuronate + acceptor = UDP + acceptor
beta-D-glucuronoside.
-!- SUBUNIT: Part of a large chaperone multiprotein complex comprising
DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1,
UGT1A1 and very small amounts of ERP29, but not, or at very low
levels, CALR nor CANX.
-!- SUBCELLULAR LOCATION: Microsome. Endoplasmic reticulum membrane
{ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=1;
Comment=A number of isoforms are produced. The different
isozymes have a different N-terminal domain and a common
C-terminal domain of 245 residues.;
Name=1;
IsoId=Q63886-1; Sequence=Displayed;
-!- TISSUE SPECIFICITY: Highly expressed in liver and at lower levels
in colon, kidney, stomach and intestine.
{ECO:0000269|PubMed:14672974}.
-!- INDUCTION: By dioxin.
-!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
{ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; S64760; AAB26033.2; -; mRNA.
EMBL; AY227194; AAP48593.1; -; mRNA.
EMBL; BC093516; AAH93516.1; -; mRNA.
CCDS; CCDS15143.1; -. [Q63886-1]
RefSeq; NP_964007.2; NM_201645.2. [Q63886-1]
UniGene; Mm.300095; -.
ProteinModelPortal; Q63886; -.
IntAct; Q63886; 4.
MINT; MINT-1859173; -.
STRING; 10090.ENSMUSP00000072803; -.
CAZy; GT1; Glycosyltransferase Family 1.
iPTMnet; Q63886; -.
PhosphoSitePlus; Q63886; -.
SwissPalm; Q63886; -.
MaxQB; Q63886; -.
PaxDb; Q63886; -.
PeptideAtlas; Q63886; -.
PRIDE; Q63886; -.
Ensembl; ENSMUST00000073049; ENSMUSP00000072803; ENSMUSG00000089960. [Q63886-1]
GeneID; 394436; -.
KEGG; mmu:394436; -.
UCSC; uc007byk.1; mouse. [Q63886-1]
CTD; 54658; -.
MGI; MGI:98898; Ugt1a1.
eggNOG; KOG1192; Eukaryota.
eggNOG; COG1819; LUCA.
GeneTree; ENSGT00760000118949; -.
HOGENOM; HOG000220832; -.
HOVERGEN; HBG004033; -.
InParanoid; Q63886; -.
KO; K00699; -.
OMA; ESHFRRM; -.
OrthoDB; EOG091G06JC; -.
TreeFam; TF315472; -.
Reactome; R-MMU-156588; Glucuronidation.
Reactome; R-MMU-189483; Heme degradation.
PRO; PR:Q63886; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000089960; -.
Genevisible; Q63886; MM.
GO; GO:0070069; C:cytochrome complex; IEA:Ensembl.
GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
GO; GO:0034663; C:endoplasmic reticulum chaperone complex; IDA:ParkinsonsUK-UCL.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
GO; GO:0019899; F:enzyme binding; ISO:MGI.
GO; GO:0004857; F:enzyme inhibitor activity; ISO:MGI.
GO; GO:0015020; F:glucuronosyltransferase activity; ISO:MGI.
GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0001972; F:retinoic acid binding; ISO:MGI.
GO; GO:0005496; F:steroid binding; ISO:MGI.
GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
GO; GO:0031100; P:animal organ regeneration; IEA:Ensembl.
GO; GO:0070980; P:biphenyl catabolic process; IEA:Ensembl.
GO; GO:0052695; P:cellular glucuronidation; ISO:MGI.
GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:Ensembl.
GO; GO:0071361; P:cellular response to ethanol; IEA:Ensembl.
GO; GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
GO; GO:0051552; P:flavone metabolic process; ISO:MGI.
GO; GO:0052696; P:flavonoid glucuronidation; ISO:MGI.
GO; GO:0001889; P:liver development; IEA:Ensembl.
GO; GO:2001030; P:negative regulation of cellular glucuronidation; ISO:MGI.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
GO; GO:0042594; P:response to starvation; IEA:Ensembl.
GO; GO:0052697; P:xenobiotic glucuronidation; ISO:MGI.
InterPro; IPR002213; UDP_glucos_trans.
InterPro; IPR035595; UDP_glycos_trans_CS.
PANTHER; PTHR11926; PTHR11926; 1.
Pfam; PF00201; UDPGT; 1.
PROSITE; PS00375; UDPGT; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Endoplasmic reticulum;
Glycoprotein; Glycosyltransferase; Membrane; Microsome;
Reference proteome; Signal; Transferase; Transmembrane;
Transmembrane helix.
SIGNAL 1 29 {ECO:0000255}.
CHAIN 30 535 UDP-glucuronosyltransferase 1-1.
/FTId=PRO_0000036010.
TRANSMEM 493 509 Helical. {ECO:0000255}.
CARBOHYD 89 89 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 297 297 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 435 435 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 25 25 S -> Y (in Ref. 1; AAB26033).
{ECO:0000305}.
CONFLICT 363 363 L -> I (in Ref. 1; AAB26033).
{ECO:0000305}.
CONFLICT 378 378 H -> R (in Ref. 2; AAP48593).
{ECO:0000305}.
SEQUENCE 535 AA; 60047 MW; 8C938AFD2D6DEB1D CRC64;
MTVVCWSSRL LLLLPYLLLC VFGPSASHAG RLLVFPMDGS HWLSMLGVIQ QLQQKGHEVV
VIAPEASIHI KEGSFYTLRK FPVPFQKENV TATLVELGRT AFNQDSFLLR VVKIYMKVKR
DSSMLLAGCS HLLHNAEFMA SLEESHFDAL LTDPFLPCGS IVAQYLTVPT VYFLNKLPCS
LDSEATQCPV PLSYVPKSLS FNSDRMNFLQ RVKNVLLAVS ENFMCRVVYS PYGSLATEIL
QKEVTVQDLL SPASIWLMRS DFVKDYPRPI MPNMVFIGGI NCLQKKPLSQ EFEAYVNASG
EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN TILVKWLPQN
DLLGHPKTRA FITHSGSHGI YEGICNGVPM VMMPLFGDQM DNAKRMETRG AGVTLNVLEM
TADDLENALK TVINNKSYKE NIMRLSSLHK DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA
HDLTWYQYHS LDVIGFLLAI VLTVVFIVFK CCAYGCRKCF GGKGRVKKSH KSKTH


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