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UV radiation resistance-associated gene protein (UV-resistance associated gene)

 UVRAG_DROME             Reviewed;         696 AA.
Q9VK07;
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
27-SEP-2017, entry version 97.
RecName: Full=UV radiation resistance-associated gene protein;
AltName: Full=UV-resistance associated gene;
Name=Uvrag; ORFNames=CG6116;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley; TISSUE=Embryo;
PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214; SER-218; SER-666;
TYR-667; SER-668 AND SER-685, AND IDENTIFICATION BY MASS SPECTROMETRY.
TISSUE=Embryo;
PubMed=18327897; DOI=10.1021/pr700696a;
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
J. Proteome Res. 7:1675-1682(2008).
[5]
FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
PubMed=21729695; DOI=10.1016/j.ydbio.2011.06.024;
Lee G., Liang C., Park G., Jang C., Jung J.U., Chung J.;
"UVRAG is required for organ rotation by regulating Notch endocytosis
in Drosophila.";
Dev. Biol. 356:588-597(2011).
-!- FUNCTION: Acts as a cell growth regulator. Also has a crucial role
in controlling organ rotation by regulating membrane-localized
Notch receptor endocytosis and subsequent degradation. Regulation
of organ rotation is not by induction of autophagy.
{ECO:0000269|PubMed:21729695}.
-!- DEVELOPMENTAL STAGE: Expressed throughout development, levels
increasing from embryo to pupa, then decreasing in adults with
higher levels in adult males than females.
{ECO:0000269|PubMed:21729695}.
-!- DISRUPTION PHENOTYPE: Homozygous larval lethal. Adult viable flies
exhibit genitalia-specific organ rotation phenotypes.
{ECO:0000269|PubMed:21729695}.
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EMBL; AE014134; AAF53277.1; -; Genomic_DNA.
EMBL; AY069353; AAL39498.1; -; mRNA.
RefSeq; NP_609632.1; NM_135788.3.
UniGene; Dm.419; -.
ProteinModelPortal; Q9VK07; -.
SMR; Q9VK07; -.
BioGrid; 60773; 4.
STRING; 7227.FBpp0080039; -.
iPTMnet; Q9VK07; -.
PaxDb; Q9VK07; -.
PRIDE; Q9VK07; -.
EnsemblMetazoa; FBtr0080460; FBpp0080039; FBgn0032499.
GeneID; 34735; -.
KEGG; dme:Dmel_CG6116; -.
UCSC; CG6116-RA; d. melanogaster.
CTD; 7405; -.
FlyBase; FBgn0032499; Uvrag.
eggNOG; KOG2896; Eukaryota.
eggNOG; ENOG410YZ0H; LUCA.
GeneTree; ENSGT00390000012877; -.
InParanoid; Q9VK07; -.
KO; K21249; -.
OMA; EGYASTQ; -.
OrthoDB; EOG091G0HDH; -.
PhylomeDB; Q9VK07; -.
Reactome; R-DME-1632852; Macroautophagy.
GenomeRNAi; 34735; -.
PRO; PR:Q9VK07; -.
Proteomes; UP000000803; Chromosome 2L.
Bgee; FBgn0032499; -.
Genevisible; Q9VK07; DM.
GO; GO:0005768; C:endosome; IBA:GO_Central.
GO; GO:0000323; C:lytic vacuole; IBA:GO_Central.
GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
GO; GO:0048803; P:imaginal disc-derived male genitalia morphogenesis; IMP:FlyBase.
GO; GO:0008285; P:negative regulation of cell proliferation; IMP:FlyBase.
GO; GO:0045746; P:negative regulation of Notch signaling pathway; IGI:FlyBase.
GO; GO:0016322; P:neuron remodeling; IMP:FlyBase.
GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO; GO:0010508; P:positive regulation of autophagy; IEA:InterPro.
GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:FlyBase.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0035493; P:SNARE complex assembly; IBA:GO_Central.
InterPro; IPR018791; UV_resistance/autophagy_Atg14.
Pfam; PF10186; Atg14; 1.
1: Evidence at protein level;
Coiled coil; Complete proteome; Growth regulation;
Notch signaling pathway; Phosphoprotein; Reference proteome.
CHAIN 1 696 UV radiation resistance-associated gene
protein.
/FTId=PRO_0000065749.
COILED 251 278 {ECO:0000255}.
COILED 330 394 {ECO:0000255}.
MOD_RES 214 214 Phosphoserine.
{ECO:0000269|PubMed:18327897}.
MOD_RES 218 218 Phosphoserine.
{ECO:0000269|PubMed:18327897}.
MOD_RES 666 666 Phosphoserine.
{ECO:0000269|PubMed:18327897}.
MOD_RES 667 667 Phosphotyrosine.
{ECO:0000269|PubMed:18327897}.
MOD_RES 668 668 Phosphoserine.
{ECO:0000269|PubMed:18327897}.
MOD_RES 685 685 Phosphoserine.
{ECO:0000269|PubMed:18327897}.
SEQUENCE 696 AA; 80690 MW; 2E6FDA367CF8D0CD CRC64;
MNLRPRCRKW LPLATQQLRL RNLNRIQGFN IESWPHEKSL ELDDPDDVLL YYTLHTDKAS
EAFYTSEKLP QRHQQQKWAE ICTDDEAWRK TNAQCVCVKV WKHYSAERRD GQPPEVEQRH
KDVFGRSQLT PSRLPRPPEL LFSWGVYFSG LIPLSPLTLS QCGRNCLVFQ LNGEQFASPS
MISEQALQSQ LHLHYQKYAE EEKLEEPQDE GINSPAVSRS SSPVLRMSTM RYAQLKCQRQ
EIRRSNNLEK LLTLQRLQRL HQQKRRQMAE VCREIARLSV HCVTRNELRL KPRTTSLSGD
YSAHQYHSMG RALSVLLAEQ QQIAPLTLYN AQQLTRRIEA LSSQQRLLKA ERETFRQRNE
RTRQLLKEMR EQREAQQWEL HSQRHRLEKE RLELRTLAPQ HLEQRDQKRQ IERQVERRMS
TLVLELQEIY NIQNVGGRQF SICGIAFPHM EQYTSESRQA ANAQLLDNVS PLAVSAALGY
VAHLVQMLAI IMDRPLRNRI LYEPSKARIV DDIKELTYTT REFPLYTRSI LPSQQTKYAI
YLLRQNVSQL CFDITGQCDL RNTFGNLLEL FSTLRYIERT QRDEVDERDG TAVGAGCGEA
RLANGLTAPH LSQSHSSVDM NHVPLPTGVN AVKDALLQQL LPPGVSEALA IEGYASTQRI
CRSVGSYSDG EDEFRPRLEH NYSNSDSNIT LQTERS


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