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Ubiquitin carboxyl-terminal hydrolase 17-like protein E (USP17-E) (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 2) (Deubiquitinating protein 3) (DUB-3) (Deubiquitinating protein 6) (Ubiquitin carboxyl-terminal hydrolase 17-like protein 2) (Ubiquitin thioesterase 17-like protein 2) (Ubiquitin-specific-processing protease 17-like protein 2)

 U17PE_MOUSE             Reviewed;         540 AA.
Q7M764; D3YU85;
13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
13-JUL-2010, sequence version 2.
30-AUG-2017, entry version 80.
RecName: Full=Ubiquitin carboxyl-terminal hydrolase 17-like protein E;
Short=USP17-E;
EC=3.4.19.12;
AltName: Full=Deubiquitinating enzyme 17-like protein 2;
AltName: Full=Deubiquitinating protein 3;
Short=DUB-3;
AltName: Full=Deubiquitinating protein 6;
AltName: Full=Ubiquitin carboxyl-terminal hydrolase 17-like protein 2;
AltName: Full=Ubiquitin thioesterase 17-like protein 2;
AltName: Full=Ubiquitin-specific-processing protease 17-like protein 2;
Name=Usp17le; Synonyms=Dub3, Dub6, Usp17, Usp17l2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2]
IDENTIFICATION.
PubMed=12838346; DOI=10.1038/nrg1111;
Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C.;
"Human and mouse proteases: a comparative genomic approach.";
Nat. Rev. Genet. 4:544-558(2003).
[3]
FUNCTION.
PubMed=20228808; DOI=10.1038/ncb2041;
Pereg Y., Liu B.Y., O'Rourke K.M., Sagolla M., Dey A., Komuves L.,
French D.M., Dixit V.M.;
"Ubiquitin hydrolase Dub3 promotes oncogenic transformation by
stabilizing Cdc25A.";
Nat. Cell Biol. 12:400-406(2010).
-!- FUNCTION: Deubiquitinating enzyme that removes conjugated
ubiquitin from specific proteins to regulate different cellular
processes that may include cell proliferation, progression through
the cell cycle, apoptosis, cell migration, and the cellular
response to viral infection. {ECO:0000269|PubMed:20228808}.
-!- CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester,
thioester, amide, peptide and isopeptide bonds formed by the C-
terminal Gly of ubiquitin (a 76-residue protein attached to
proteins as an intracellular targeting signal).
-!- SUBUNIT: Interacts with SUDS3; the interaction is direct.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum
{ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase C19 family. USP17 subfamily.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAD66057.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; AC110621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BN000117; CAD66057.1; ALT_SEQ; Genomic_DNA.
CCDS; CCDS85368.1; -.
UniGene; Mm.14130; -.
ProteinModelPortal; Q7M764; -.
SMR; Q7M764; -.
STRING; 10090.ENSMUSP00000051716; -.
MEROPS; C19.082; -.
PaxDb; Q7M764; -.
PRIDE; Q7M764; -.
UCSC; uc029wnn.1; mouse.
MGI; MGI:107697; Usp17le.
eggNOG; KOG1865; Eukaryota.
eggNOG; ENOG410XQ92; LUCA.
HOGENOM; HOG000144638; -.
HOVERGEN; HBG007129; -.
InParanoid; Q7M764; -.
PhylomeDB; Q7M764; -.
PRO; PR:Q7M764; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IDA:MGI.
GO; GO:0036459; F:thiol-dependent ubiquitinyl hydrolase activity; ISS:UniProtKB.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0071586; P:CAAX-box protein processing; ISS:UniProtKB.
GO; GO:0007093; P:mitotic cell cycle checkpoint; ISS:UniProtKB.
GO; GO:0034260; P:negative regulation of GTPase activity; ISS:UniProtKB.
GO; GO:0031064; P:negative regulation of histone deacetylation; ISS:UniProtKB.
GO; GO:0010955; P:negative regulation of protein processing; ISS:UniProtKB.
GO; GO:0090315; P:negative regulation of protein targeting to membrane; ISS:UniProtKB.
GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
GO; GO:1900245; P:positive regulation of MDA-5 signaling pathway; ISS:UniProtKB.
GO; GO:1900246; P:positive regulation of RIG-I signaling pathway; ISS:UniProtKB.
GO; GO:0016579; P:protein deubiquitination; IDA:MGI.
GO; GO:0071108; P:protein K48-linked deubiquitination; ISS:UniProtKB.
GO; GO:0070536; P:protein K63-linked deubiquitination; ISS:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
GO; GO:0042127; P:regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0050691; P:regulation of defense response to virus by host; ISS:UniProtKB.
GO; GO:1900027; P:regulation of ruffle assembly; ISS:UniProtKB.
GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
InterPro; IPR001394; Peptidase_C19_UCH.
InterPro; IPR018200; USP_CS.
InterPro; IPR028889; USP_dom.
Pfam; PF00443; UCH; 1.
PROSITE; PS00972; USP_1; 1.
PROSITE; PS00973; USP_2; 1.
PROSITE; PS50235; USP_3; 1.
3: Inferred from homology;
Apoptosis; Cell cycle; Complete proteome; Endoplasmic reticulum;
Hydrolase; Nucleus; Protease; Reference proteome; Thiol protease;
Ubl conjugation pathway.
CHAIN 1 540 Ubiquitin carboxyl-terminal hydrolase 17-
like protein E.
/FTId=PRO_5000095963.
DOMAIN 85 382 USP.
ACT_SITE 94 94 Nucleophile. {ECO:0000255|PROSITE-
ProRule:PRU10092, ECO:0000255|PROSITE-
ProRule:PRU10093}.
ACT_SITE 341 341 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU10092, ECO:0000255|PROSITE-
ProRule:PRU10093}.
SEQUENCE 540 AA; 60219 MW; C71382D289659704 CRC64;
MVVSLSFPEE TGGENLPSAP LEDSSKFFEE VFGDMVFARS FPEADPALSS PDAPELHQDE
AQVVEELTTN GKHSLSWESP QGPGCGLQNT GNSCYLNAAL QCLTHTPPLA DYMLSQEHSQ
TCCSPEGCKM CAMEAHVTQS LLHSHSGDVM KPSQILTSAF HKHQQEDAHE FLMFTLETMH
ESCLQVHRQS DPTPQDTSPI HDIFGGWWRS QIKCLHCQGT SHTFDPFLDV PLDISSAQSV
NQALWDTGKS EELLGENAYY CGRCRQKMPA SKTLHVHIAP KVLLLVLKRF SAFTGNKLDR
KVSYPEFLDL KPYLSEPTGG PLPYALYAVL VHDGATSNSG HYFCCVKAGH GKWYKMDDTK
VTRCDVTSVL NENAYVLFYV QQTDLKQVSI DMPEGRVHEV LDPKYQLKKS RRKKRKKQCH
CTDDAGEACE NREKRAKKET SLGEGKVPQE VNHEKAGQKH GNTKLVPQEQ NHQRAGQNLR
NTEVELDLPV DAIVIHQPRS TANWGTDAPD KENQPWHNGD RLLTSQGLMS PGQLCSQGGR


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