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Ubiquitin-conjugating enzyme E2 2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 2) (Ubiquitin carrier protein UBC2) (Ubiquitin-protein ligase UBC2)

 UBC2_KLULA              Reviewed;         164 AA.
Q6CUD9;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
16-AUG-2004, sequence version 1.
25-APR-2018, entry version 101.
RecName: Full=Ubiquitin-conjugating enzyme E2 2;
EC=2.3.2.23;
AltName: Full=E2 ubiquitin-conjugating enzyme 2;
AltName: Full=Ubiquitin carrier protein UBC2;
AltName: Full=Ubiquitin-protein ligase UBC2;
Name=UBC2; OrderedLocusNames=KLLA0C05632g;
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC
1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
NCBI_TaxID=284590;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
WM37;
PubMed=15229592; DOI=10.1038/nature02579;
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
-!- FUNCTION: Catalyzes the covalent attachment of ubiquitin to other
proteins. Plays a role in transcription regulation by catalyzing
the monoubiquitination of histone H2B to form H2BK123ub1.
H2BK123ub1 gives a specific tag for epigenetic transcriptional
activation and is also a prerequisite for H3K4me and H3K79me
formation. Also involved in postreplication repair of UV-damaged
DNA, in N-end rule-dependent protein degradation and in
sporulation. {ECO:0000255|PROSITE-ProRule:PRU00388}.
-!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E1 ubiquitin-activating
enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine
= [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2
ubiquitin-conjugating enzyme]-L-cysteine. {ECO:0000255|PROSITE-
ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133}.
-!- PATHWAY: Protein modification; protein ubiquitination.
{ECO:0000255|PROSITE-ProRule:PRU00388}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5VVX9}.
Nucleus {ECO:0000250|UniProtKB:Q5VVX9}.
-!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
{ECO:0000255|PROSITE-ProRule:PRU00388}.
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EMBL; CR382123; CAH01301.1; -; Genomic_DNA.
RefSeq; XP_452450.1; XM_452450.1.
ProteinModelPortal; Q6CUD9; -.
SMR; Q6CUD9; -.
STRING; 284590.XP_452450.1; -.
EnsemblFungi; CAH01301; CAH01301; KLLA0_C05632g.
GeneID; 2892656; -.
KEGG; kla:KLLA0C05632g; -.
eggNOG; KOG0419; Eukaryota.
eggNOG; COG5078; LUCA.
HOGENOM; HOG000233454; -.
InParanoid; Q6CUD9; -.
KO; K10573; -.
OMA; RENMKEY; -.
OrthoDB; EOG092C50OL; -.
UniPathway; UPA00143; -.
Proteomes; UP000000598; Chromosome C.
GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0033503; C:HULC complex; IEA:EnsemblFungi.
GO; GO:1990304; C:MUB1-RAD6-UBR2 ubiquitin ligase complex; IEA:EnsemblFungi.
GO; GO:0000790; C:nuclear chromatin; IEA:EnsemblFungi.
GO; GO:0000502; C:proteasome complex; IEA:EnsemblFungi.
GO; GO:0097505; C:Rad6-Rad18 complex; IEA:EnsemblFungi.
GO; GO:1990303; C:UBR1-RAD6 ubiquitin ligase complex; IEA:EnsemblFungi.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
GO; GO:0043142; F:single-stranded DNA-dependent ATPase activity; IEA:EnsemblFungi.
GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IEA:EnsemblFungi.
GO; GO:0071455; P:cellular response to hyperoxia; IEA:EnsemblFungi.
GO; GO:0031497; P:chromatin assembly; IEA:EnsemblFungi.
GO; GO:0006348; P:chromatin silencing at telomere; IEA:EnsemblFungi.
GO; GO:0071629; P:cytoplasm protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
GO; GO:0006353; P:DNA-templated transcription, termination; IEA:EnsemblFungi.
GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:EnsemblFungi.
GO; GO:0042275; P:error-free postreplication DNA repair; IEA:EnsemblFungi.
GO; GO:0070987; P:error-free translesion synthesis; IEA:EnsemblFungi.
GO; GO:0042276; P:error-prone translesion synthesis; IEA:EnsemblFungi.
GO; GO:0071894; P:histone H2B conserved C-terminal lysine ubiquitination; IEA:EnsemblFungi.
GO; GO:0010390; P:histone monoubiquitination; IEA:EnsemblFungi.
GO; GO:0042138; P:meiotic DNA double-strand break formation; IEA:EnsemblFungi.
GO; GO:0031571; P:mitotic G1 DNA damage checkpoint; IEA:EnsemblFungi.
GO; GO:0061186; P:negative regulation of chromatin silencing at silent mating-type cassette; IEA:EnsemblFungi.
GO; GO:0031939; P:negative regulation of chromatin silencing at telomere; IEA:EnsemblFungi.
GO; GO:2000639; P:negative regulation of SREBP signaling pathway; IEA:EnsemblFungi.
GO; GO:1990920; P:proteasome localization to nuclear periphery; IEA:EnsemblFungi.
GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:EnsemblFungi.
GO; GO:0090089; P:regulation of dipeptide transport; IEA:EnsemblFungi.
GO; GO:0051569; P:regulation of histone H3-K4 methylation; IEA:EnsemblFungi.
GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblFungi.
GO; GO:0006366; P:transcription by RNA polymerase II; IEA:EnsemblFungi.
GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:EnsemblFungi.
GO; GO:0071596; P:ubiquitin-dependent protein catabolic process via the N-end rule pathway; IEA:EnsemblFungi.
CDD; cd00195; UBCc; 1.
Gene3D; 3.10.110.10; -; 1.
InterPro; IPR000608; UBQ-conjugat_E2.
InterPro; IPR023313; UBQ-conjugating_AS.
InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
Pfam; PF00179; UQ_con; 1.
SUPFAM; SSF54495; SSF54495; 1.
PROSITE; PS00183; UBIQUITIN_CONJUGAT_1; 1.
PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1.
3: Inferred from homology;
ATP-binding; Chromatin regulator; Complete proteome; Cytoplasm;
DNA damage; DNA repair; Nucleotide-binding; Nucleus;
Reference proteome; Sporulation; Transcription;
Transcription regulation; Transferase; Ubl conjugation pathway.
CHAIN 1 164 Ubiquitin-conjugating enzyme E2 2.
/FTId=PRO_0000082533.
ACT_SITE 88 88 Glycyl thioester intermediate.
{ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}.
SEQUENCE 164 AA; 18871 MW; CE7C16806938D62A CRC64;
MSTPARRRLM RDFKRMKEDS PPGVSASPLP DNVMIWNAMI IGPADTPYED GTFRLLLEFD
EEYPNKPPHV KFLSEMFHPN VYANGEICLD ILQNRWTPTY DVASILTSIQ SLFNDPNPAS
PANVEAATLF QDHKSQYVKR VKETVEKSWE DDMEDMADED EDEE


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