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Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (mHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)

 UBE2A_MOUSE             Reviewed;         152 AA.
Q9Z255;
04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
25-OCT-2017, entry version 143.
RecName: Full=Ubiquitin-conjugating enzyme E2 A;
EC=2.3.2.23;
AltName: Full=E2 ubiquitin-conjugating enzyme A;
AltName: Full=RAD6 homolog A;
Short=HR6A;
Short=mHR6A;
AltName: Full=Ubiquitin carrier protein A;
AltName: Full=Ubiquitin-protein ligase A;
Name=Ube2a; Synonyms=Rad6a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BCBA; TISSUE=Brain;
Roest H.P., van Klaveren J., Koken M.H.M., Vermey M.,
van Cappellen W.A., Baarends W.M., Hoogerbrugge J.W., Bootsma D.,
Hoeijmakers J.H.J., Grootegoed J.A., de Wit J.;
"Isolation of mHR6A, a gene highly homologous to the male fertility
gene mHR6B.";
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Skeletal muscle;
Kwon Y.T., Varshavsky A.;
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Lung, Pancreas, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its
covalent attachment to other proteins. In association with the E3
enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription
regulation by catalyzing the monoubiquitination of histone H2B at
'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for
epigenetic transcriptional activation, elongation by RNA
polymerase II, telomeric silencing, and is also a prerequisite for
H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well
as 'Lys-48'-linked polyubiquitination. Required for
postreplication repair of UV-damaged DNA.
{ECO:0000250|UniProtKB:P49459}.
-!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E1 ubiquitin-activating
enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine
= [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2
ubiquitin-conjugating enzyme]-L-cysteine.
{ECO:0000250|UniProtKB:P49459, ECO:0000255|PROSITE-
ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133}.
-!- PATHWAY: Protein modification; protein ubiquitination.
{ECO:0000255|PROSITE-ProRule:PRU00388}.
-!- SUBUNIT: Interacts with RAD18 and WAC.
-!- PTM: Phosphorylation at Ser-120 by CDK9 increases activity towards
histone H2B. {ECO:0000250|UniProtKB:P49459}.
-!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
{ECO:0000255|PROSITE-ProRule:PRU00388}.
-----------------------------------------------------------------------
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EMBL; AF089812; AAC64563.1; -; mRNA.
EMBL; AF383148; AAK62984.1; -; mRNA.
EMBL; BC026053; AAH26053.1; -; mRNA.
CCDS; CCDS30064.1; -.
RefSeq; NP_062642.1; NM_019668.4.
UniGene; Mm.395649; -.
ProteinModelPortal; Q9Z255; -.
SMR; Q9Z255; -.
BioGrid; 204414; 3.
STRING; 10090.ENSMUSP00000016452; -.
iPTMnet; Q9Z255; -.
PhosphoSitePlus; Q9Z255; -.
EPD; Q9Z255; -.
MaxQB; Q9Z255; -.
PaxDb; Q9Z255; -.
PRIDE; Q9Z255; -.
Ensembl; ENSMUST00000016452; ENSMUSP00000016452; ENSMUSG00000016308.
GeneID; 22209; -.
KEGG; mmu:22209; -.
UCSC; uc009sxv.1; mouse.
CTD; 7319; -.
MGI; MGI:102959; Ube2a.
eggNOG; KOG0419; Eukaryota.
eggNOG; COG5078; LUCA.
GeneTree; ENSGT00900000140930; -.
HOGENOM; HOG000233454; -.
HOVERGEN; HBG063308; -.
InParanoid; Q9Z255; -.
KO; K10573; -.
OMA; RENMKEY; -.
OrthoDB; EOG091G0UM8; -.
PhylomeDB; Q9Z255; -.
TreeFam; TF101128; -.
Reactome; R-MMU-8866652; Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
Reactome; R-MMU-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
UniPathway; UPA00143; -.
PRO; PR:Q9Z255; -.
Proteomes; UP000000589; Chromosome X.
Bgee; ENSMUSG00000016308; -.
ExpressionAtlas; Q9Z255; baseline and differential.
Genevisible; Q9Z255; MM.
GO; GO:0000785; C:chromatin; IDA:MGI.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0033503; C:HULC complex; ISS:UniProtKB.
GO; GO:0000790; C:nuclear chromatin; IDA:MGI.
GO; GO:0001741; C:XY body; IDA:MGI.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IGI:MGI.
GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
GO; GO:0031625; F:ubiquitin protein ligase binding; IDA:MGI.
GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
GO; GO:0006281; P:DNA repair; ISO:MGI.
GO; GO:0033522; P:histone H2A ubiquitination; ISO:MGI.
GO; GO:0016574; P:histone ubiquitination; IBA:GO_Central.
GO; GO:0001701; P:in utero embryonic development; IGI:MGI.
GO; GO:0060135; P:maternal process involved in female pregnancy; IMP:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; ISO:MGI.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
GO; GO:0051865; P:protein autoubiquitination; ISO:MGI.
GO; GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
GO; GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
GO; GO:0016567; P:protein ubiquitination; IDA:MGI.
GO; GO:0009411; P:response to UV; ISO:MGI.
CDD; cd00195; UBCc; 1.
Gene3D; 3.10.110.10; -; 1.
InterPro; IPR000608; UBQ-conjugat_E2.
InterPro; IPR023313; UBQ-conjugating_AS.
InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
Pfam; PF00179; UQ_con; 1.
SUPFAM; SSF54495; SSF54495; 1.
PROSITE; PS00183; UBIQUITIN_CONJUGAT_1; 1.
PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; DNA damage; DNA repair;
Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase;
Ubl conjugation pathway.
CHAIN 1 152 Ubiquitin-conjugating enzyme E2 A.
/FTId=PRO_0000082446.
ACT_SITE 88 88 Glycyl thioester intermediate.
{ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}.
MOD_RES 120 120 Phosphoserine; by CDK9.
{ECO:0000250|UniProtKB:P49459}.
SEQUENCE 152 AA; 17315 MW; 0AAEB5B7770E47E2 CRC64;
MSTPARRRLM RDFKRLQEDP PAGVSGAPSE NNIMVWNAVI FGPEGTPFED GTFKLTIEFT
EEYPNKPPTV RFVSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS
PANSQAAQLY QENKREYEKR VSAIVEQSWR DC


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