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Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme N) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)

 UBE2N_BOVIN             Reviewed;         152 AA.
Q0P5K3;
06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
19-SEP-2006, sequence version 1.
23-MAY-2018, entry version 105.
RecName: Full=Ubiquitin-conjugating enzyme E2 N;
EC=2.3.2.23;
AltName: Full=E2 ubiquitin-conjugating enzyme N;
AltName: Full=Ubiquitin carrier protein N;
AltName: Full=Ubiquitin-protein ligase N;
Name=UBE2N;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Fetal skin;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze
the synthesis of non-canonical 'Lys-63'-linked polyubiquitin
chains. This type of polyubiquitination does not lead to protein
degradation by the proteasome. Mediates transcriptional activation
of target genes. Plays a role in the control of progress through
the cell cycle and differentiation. Plays a role in the error-free
DNA repair pathway and contributes to the survival of cells after
DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in
the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic
stress, which is required for DNA repair. Appears to act together
with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of
JKAMP thereby regulating JKAMP function by decreasing its
association with components of the proteasome and ERAD. Promotes
TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N
heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked
polyubiquitin chains which activate the MAP3K7/TAK1 complex which
in turn results in the induction and expression of NF-kappa-B and
MAPK-responsive inflammatory genes.
{ECO:0000250|UniProtKB:P61088}.
-!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E1 ubiquitin-activating
enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine
= [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2
ubiquitin-conjugating enzyme]-L-cysteine. {ECO:0000255|PROSITE-
ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133}.
-!- ENZYME REGULATION: Activity is inhibited by binding to OTUB1,
which prevents 'Lys-63'-linked polyubiquitination (By similarity).
Activity is inhibited by GPS2, leading to prevent 'Lys-63'-linked
polyubiquitination (By similarity). {ECO:0000250|UniProtKB:P61088,
ECO:0000250|UniProtKB:P61089}.
-!- PATHWAY: Protein modification; protein ubiquitination.
{ECO:0000255|PROSITE-ProRule:PRU00388}.
-!- SUBUNIT: Heterodimer with UBE2V2 (By similarity). Interacts
(UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box
domain); the complex has a specific 'Lys-63'-linked
polyubiquitination activity (By similarity). Interacts with RNF8
and RNF168 (By similarity). Interacts with RNF11 (By similarity).
Interacts with the E3 ligases, HLTF and SHPRH; the interactions
promote the 'Lys-63'-linked polyubiquitination of PCNA upon
genotoxic stress and lead to DNA repair (By similarity). Interacts
with ARIH2 (via RING-type 2) (By similarity). Interacts with
OTUB1; leading to inhibit E2-conjugating activity (By similarity).
Interacts with GPS2; leading to inhibit E2-conjugating activity
(By similarity). {ECO:0000250|UniProtKB:P61088,
ECO:0000250|UniProtKB:P61089}.
-!- PTM: Conjugation to ISG15 impairs formation of the thioester bond
with ubiquitin but not interaction with UBE2V2.
{ECO:0000250|UniProtKB:P61088}.
-!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
{ECO:0000255|PROSITE-ProRule:PRU00388}.
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EMBL; BC119931; AAI19932.1; -; mRNA.
RefSeq; NP_001069726.1; NM_001076258.1.
UniGene; Bt.22061; -.
ProteinModelPortal; Q0P5K3; -.
SMR; Q0P5K3; -.
STRING; 9913.ENSBTAP00000052296; -.
PaxDb; Q0P5K3; -.
PeptideAtlas; Q0P5K3; -.
PRIDE; Q0P5K3; -.
Ensembl; ENSBTAT00000052393; ENSBTAP00000052296; ENSBTAG00000021767.
GeneID; 541130; -.
KEGG; bta:541130; -.
CTD; 7334; -.
VGNC; VGNC:36590; UBE2N.
eggNOG; KOG0417; Eukaryota.
eggNOG; COG5078; LUCA.
GeneTree; ENSGT00540000070023; -.
HOGENOM; HOG000233455; -.
HOVERGEN; HBG063308; -.
InParanoid; Q0P5K3; -.
KO; K10580; -.
OMA; IDKWSPA; -.
OrthoDB; EOG091G0VPD; -.
TreeFam; TF101126; -.
Reactome; R-BTA-1169408; ISG15 antiviral mechanism.
Reactome; R-BTA-168638; NOD1/2 Signaling Pathway.
Reactome; R-BTA-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
Reactome; R-BTA-450302; activated TAK1 mediates p38 MAPK activation.
Reactome; R-BTA-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
Reactome; R-BTA-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
Reactome; R-BTA-5693571; Nonhomologous End-Joining (NHEJ).
Reactome; R-BTA-5696395; Formation of Incision Complex in GG-NER.
Reactome; R-BTA-69473; G2/M DNA damage checkpoint.
Reactome; R-BTA-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
Reactome; R-BTA-9020702; Interleukin-1 signaling.
Reactome; R-BTA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
UniPathway; UPA00143; -.
Proteomes; UP000009136; Chromosome 5.
Bgee; ENSBTAG00000021767; -.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0035370; C:UBC13-UEV1A complex; ISS:UniProtKB.
GO; GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0061631; F:ubiquitin conjugating enzyme activity; ISS:UniProtKB.
GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
GO; GO:0006301; P:postreplication repair; IBA:GO_Central.
GO; GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.
GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
CDD; cd00195; UBCc; 1.
Gene3D; 3.10.110.10; -; 1.
InterPro; IPR000608; UBQ-conjugat_E2.
InterPro; IPR023313; UBQ-conjugating_AS.
InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
Pfam; PF00179; UQ_con; 1.
SUPFAM; SSF54495; SSF54495; 1.
PROSITE; PS00183; UBIQUITIN_CONJUGAT_1; 1.
PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1.
2: Evidence at transcript level;
Acetylation; ATP-binding; Complete proteome; DNA damage; DNA repair;
Isopeptide bond; Nucleotide-binding; Reference proteome; Transferase;
Ubl conjugation; Ubl conjugation pathway.
CHAIN 1 152 Ubiquitin-conjugating enzyme E2 N.
/FTId=PRO_0000278832.
ACT_SITE 87 87 Glycyl thioester intermediate.
MOD_RES 82 82 N6-acetyllysine.
{ECO:0000250|UniProtKB:P61088}.
CROSSLNK 92 92 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ISG15).
{ECO:0000250|UniProtKB:P61088}.
SEQUENCE 152 AA; 17138 MW; FACD84D883D77407 CRC64;
MAGLPRRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GPQDSPFEGG TFKLELFLPE
EYPMAAPKVR FMTKIYHPNV DKLGRICLDI LKDKWSPALQ IRTVLLSIQA LLSAPNPDDP
LANDVAEQWK TNEAQAIETA RAWTRLYAMN NI


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