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Uncharacterized protein

 F1RZN4_PIG              Unreviewed;       902 AA.
F1RZN4;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
22-NOV-2017, sequence version 3.
23-MAY-2018, entry version 59.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000016745};
Name=TLR3 {ECO:0000313|Ensembl:ENSSSCP00000016745};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000016745, ECO:0000313|Proteomes:UP000008227};
[1] {ECO:0000313|Ensembl:ENSSSCP00000016745, ECO:0000313|Proteomes:UP000008227}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000016745};
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSSCP00000016745}
IDENTIFICATION.
Ensembl;
Submitted (MAY-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00598595}.
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EMBL; AEMK02000099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
PRIDE; F1RZN4; -.
Ensembl; ENSSSCT00000017206; ENSSSCP00000016745; ENSSSCG00000015801.
eggNOG; KOG4641; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00760000119006; -.
Reactome; R-SSC-1679131; Trafficking and processing of endosomal TLR.
Proteomes; UP000008227; Chromosome 15.
Bgee; ENSSSCG00000015801; -.
ExpressionAtlas; F1RZN4; baseline.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0034346; P:positive regulation of type III interferon production; IEA:Ensembl.
GO; GO:0002730; P:regulation of dendritic cell cytokine production; IEA:Ensembl.
GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
GO; GO:0034138; P:toll-like receptor 3 signaling pathway; IEA:InterPro.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027173; TLR3.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR44599; PTHR44599; 1.
Pfam; PF13855; LRR_8; 6.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 16.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 17.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000008227};
Immunity {ECO:0000256|SAAS:SAAS00472892};
Innate immunity {ECO:0000256|SAAS:SAAS00472892};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|SAAS:SAAS00473103};
Reference proteome {ECO:0000313|Proteomes:UP000008227};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 26 {ECO:0000256|SAM:SignalP}.
CHAIN 27 902 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5012971824.
TRANSMEM 703 724 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 753 856 TIR. {ECO:0000259|PROSITE:PS50104}.
SEQUENCE 902 AA; 103315 MW; D8D84C1787415343 CRC64;
MSRSLPCHIY SFWVLLPFWI LYTTSTNKCT VRHEIADCSH LKLTQIPDDL PANITVLNLT
HNQLRRLPPA NFTIYSQLTT LDGGFNTISK LEPELCQSLP LLEILNLQHN ELSQLSDKTF
IFCMNLIELH LMSNSIQKIQ NNPFKNLKNL IKLDLSHNGL SSTKLGTQLQ LENLQELLLA
NNKISALKRE ELDFLGNSSL KRLELSSNQI QEFSPGCFHA IGKLFGLSLN NVKLSPSLTE
KLCLELSNTS IENLSLSTSS CTNQQHDFLG LKQTNLSMLD LSHNSLSVIG NDSFAWLPHL
KYFFLEYNNI ERLSSRSLYG LSNVKYLNLR RSFTKQSISL ASLPKIEDFS FQWLKSLEYL
NMEDNNFPGK RNTFTGLIKL KSLSLSNSFS SLRTLTNETF ISLADSPLLI LNLTKNKISK
IESGAFSWLG HLKVLDLGLN EIGQELTGQE WRGLKNIVEV YLSYNRYLEL TTDSFALVPS
LQQLMLRRVA LRNMDCSPSP FHPLFNLTIL DLSNNNIANI NDELLKGLEK LQILDLQHNN
LARLWKHANP GGPVQFLKGL SHLHILNLES NGFDEIPADA FRDLSELKSI DLGLNNLNIL
PPSVFDNQVS LKSLSLQKNL ITSVKKTVFG PAFQKLSNLD MRFNPFDCTC ESIAWFVSWI
NSTHTNISEL SSHYLCNTPP QYHGLPVILF DTSPCKDSAP FELFFMITAS MLLIFIFIIL
LIHFEGWRIS FYWNVSVHRV LGFKEIDKQP EQFEYAAYII HAYKDRDWVW EHAPMEEKDE
TLRFCLEERD FEAGALELEA IVNSIKRSRK IIFVITQHLL KDPLCKRFKV HHAVQQAIEQ
NLDSIILIFL EEIPDYKLNH ALCLRRGMFK SHCILNWPVQ KERINAFHHK LQVALGSRNS
VH


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