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Uncharacterized protein

 F6RND0_HORSE            Unreviewed;       398 AA.
F6RND0;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
25-OCT-2017, entry version 40.
SubName: Full=GATA binding protein 3 {ECO:0000313|Ensembl:ENSECAP00000022063};
Name=GATA3 {ECO:0000313|Ensembl:ENSECAP00000022063};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022063, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000022063, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022063,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000022063}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022063};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSECAP00000022063}.
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RefSeq; XP_014592634.1; XM_014737148.1.
STRING; 9796.ENSECAP00000022063; -.
PaxDb; F6RND0; -.
Ensembl; ENSECAT00000026448; ENSECAP00000022063; ENSECAG00000024574.
GeneID; 100069946; -.
KEGG; ecb:100069946; -.
CTD; 2625; -.
eggNOG; KOG1601; Eukaryota.
eggNOG; COG5641; LUCA.
GeneTree; ENSGT00760000119221; -.
InParanoid; F6RND0; -.
KO; K17895; -.
OMA; QRYPPTH; -.
OrthoDB; EOG091G0AUR; -.
TreeFam; TF315391; -.
Proteomes; UP000002281; Chromosome 29.
Bgee; ENSECAG00000024574; -.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005667; C:transcription factor complex; IBA:GO_Central.
GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
GO; GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0070888; F:E-box binding; IEA:Ensembl.
GO; GO:0001158; F:enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
GO; GO:0005134; F:interleukin-2 receptor binding; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IBA:GO_Central.
GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; IBA:GO_Central.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
GO; GO:0007411; P:axon guidance; IEA:Ensembl.
GO; GO:0061290; P:canonical Wnt signaling pathway involved in metanephric kidney development; IEA:Ensembl.
GO; GO:0003215; P:cardiac right ventricle morphogenesis; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0071773; P:cellular response to BMP stimulus; IEA:Ensembl.
GO; GO:0035457; P:cellular response to interferon-alpha; IEA:Ensembl.
GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
GO; GO:0048589; P:developmental growth; IEA:Ensembl.
GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
GO; GO:0072643; P:interferon-gamma secretion; IEA:Ensembl.
GO; GO:0072602; P:interleukin-4 secretion; IEA:Ensembl.
GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
GO; GO:0072676; P:lymphocyte migration; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0060374; P:mast cell differentiation; IEA:Ensembl.
GO; GO:0060231; P:mesenchymal to epithelial transition; IEA:Ensembl.
GO; GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO; GO:2000146; P:negative regulation of cell motility; IEA:Ensembl.
GO; GO:2000607; P:negative regulation of cell proliferation involved in mesonephros development; IEA:Ensembl.
GO; GO:1901536; P:negative regulation of DNA demethylation; IEA:Ensembl.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:2000703; P:negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation; IEA:Ensembl.
GO; GO:2000734; P:negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl.
GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl.
GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
GO; GO:0072179; P:nephric duct formation; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0042421; P:norepinephrine biosynthetic process; IEA:Ensembl.
GO; GO:0071599; P:otic vesicle development; IEA:Ensembl.
GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
GO; GO:0035898; P:parathyroid hormone secretion; IEA:Ensembl.
GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
GO; GO:0071442; P:positive regulation of histone H3-K14 acetylation; IEA:Ensembl.
GO; GO:2000617; P:positive regulation of histone H3-K9 acetylation; IEA:Ensembl.
GO; GO:2000667; P:positive regulation of interleukin-13 secretion; IEA:Ensembl.
GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
GO; GO:2000664; P:positive regulation of interleukin-5 secretion; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IEA:Ensembl.
GO; GO:2000611; P:positive regulation of thyroid hormone generation; IEA:Ensembl.
GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IEA:Ensembl.
GO; GO:0072107; P:positive regulation of ureteric bud formation; IEA:Ensembl.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0002572; P:pro-T cell differentiation; IEA:Ensembl.
GO; GO:0043370; P:regulation of CD4-positive, alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:2000683; P:regulation of cellular response to X-ray; IEA:Ensembl.
GO; GO:0042035; P:regulation of cytokine biosynthetic process; IEA:Ensembl.
GO; GO:2000114; P:regulation of establishment of cell polarity; IEA:Ensembl.
GO; GO:0061085; P:regulation of histone H3-K27 methylation; IEA:Ensembl.
GO; GO:0051569; P:regulation of histone H3-K4 methylation; IEA:Ensembl.
GO; GO:0072182; P:regulation of nephron tubule epithelial cell differentiation; IEA:Ensembl.
GO; GO:0043523; P:regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0009615; P:response to virus; IEA:Ensembl.
GO; GO:0048485; P:sympathetic nervous system development; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0045064; P:T-helper 2 cell differentiation; IEA:Ensembl.
GO; GO:0045061; P:thymic T cell selection; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0031929; P:TOR signaling; IEA:Ensembl.
GO; GO:0035799; P:ureter maturation; IEA:Ensembl.
GO; GO:0060676; P:ureteric bud formation; IEA:Ensembl.
GO; GO:0060065; P:uterus development; IEA:Ensembl.
GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
Gene3D; 3.30.50.10; -; 2.
InterPro; IPR029521; GATA-3.
InterPro; IPR016374; TF_GATA-2/3.
InterPro; IPR000679; Znf_GATA.
InterPro; IPR013088; Znf_NHR/GATA.
PANTHER; PTHR10071:SF106; PTHR10071:SF106; 1.
Pfam; PF00320; GATA; 2.
PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
PRINTS; PR00619; GATAZNFINGER.
SMART; SM00401; ZnF_GATA; 2.
PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00094};
Reference proteome {ECO:0000313|Proteomes:UP000002281};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00094};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00094}.
DOMAIN 212 266 GATA-type. {ECO:0000259|PROSITE:PS50114}.
DOMAIN 266 319 GATA-type. {ECO:0000259|PROSITE:PS50114}.
SEQUENCE 398 AA; 42827 MW; A7CBB17A1A400936 CRC64;
LDVLFNIDSQ GSHVSPYYGN SVRATVQRYP PTHHGSQVCR PPLLHGSLPW LDGGKALGSH
HTASPWNLSP FSKTSIHHGS PGPLSVYPPA SSSSLSAGHS SPHLFTFPPT PPKDVSPDPS
LSTPGSAGSA RQDEKECIKY QVPLPDSMKL EASHSRASMP TLGGAASTAH HPITTYPPYV
PEYSSGLFPP SSLLGGSPTG FGCKSRPKAR SSTEGRECVN CGATSTPLWR RDGTGHYLCN
ACGLYHKMNG QNRPLIKPKR RLSAARRAGT SCANCQTTTT TLWRRNANGD PVCNACGLYY
KLHNINRPLT MKKEGIQTRN RKMSSKSKKC KKVHDTLEDF PKGSSFNPAA LSRHMSSLSH
ISPFSHSSHM LTTPTPMHPP SSLSFGPHHP SSMVTAMG


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