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Uncharacterized protein

 F6SAM1_HORSE            Unreviewed;       380 AA.
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
25-OCT-2017, entry version 46.
SubName: Full=Presenilin 1 {ECO:0000313|Ensembl:ENSECAP00000003149};
Name=PSEN1 {ECO:0000313|Ensembl:ENSECAP00000003149};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003149, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000003149, ECO:0000313|Proteomes:UP000002281}
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003149,
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000003149}
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003149};
Submitted (JUL-2011) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSECAP00000003149}.
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
STRING; 9796.ENSECAP00000003149; -.
MEROPS; A22.001; -.
PaxDb; F6SAM1; -.
Ensembl; ENSECAT00000004545; ENSECAP00000003149; ENSECAG00000004387.
eggNOG; KOG2736; Eukaryota.
GeneTree; ENSGT00390000016593; -.
InParanoid; F6SAM1; -.
OrthoDB; EOG091G0C72; -.
TreeFam; TF315040; -.
Proteomes; UP000002281; Chromosome 24.
Bgee; ENSECAG00000004387; -.
GO; GO:0016235; C:aggresome; IEA:Ensembl.
GO; GO:0030424; C:axon; IBA:GO_Central.
GO; GO:0005938; C:cell cortex; IBA:GO_Central.
GO; GO:0030054; C:cell junction; IEA:Ensembl.
GO; GO:0009986; C:cell surface; IBA:GO_Central.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0035253; C:ciliary rootlet; IBA:GO_Central.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0043198; C:dendritic shaft; IBA:GO_Central.
GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
GO; GO:0070765; C:gamma-secretase complex; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0030426; C:growth cone; IBA:GO_Central.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0000776; C:kinetochore; IEA:Ensembl.
GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
GO; GO:0045121; C:membrane raft; IBA:GO_Central.
GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
GO; GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
GO; GO:0098793; C:presynapse; IEA:GOC.
GO; GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
GO; GO:0030018; C:Z disc; IBA:GO_Central.
GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:Ensembl.
GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
GO; GO:0004175; F:endopeptidase activity; IBA:GO_Central.
GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
GO; GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO; GO:0042987; P:amyloid precursor protein catabolic process; IBA:GO_Central.
GO; GO:0034205; P:amyloid-beta formation; IEA:Ensembl.
GO; GO:0050435; P:amyloid-beta metabolic process; IBA:GO_Central.
GO; GO:0002265; P:astrocyte activation involved in immune response; IEA:Ensembl.
GO; GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO; GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl.
GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO; GO:0015871; P:choline transport; IEA:Ensembl.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO; GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO; GO:0006509; P:membrane protein ectodomain proteolysis; IBA:GO_Central.
GO; GO:0007613; P:memory; IEA:Ensembl.
GO; GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO; GO:0090647; P:modulation of age-related behavioral decline; IEA:Ensembl.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO; GO:1904797; P:negative regulation of core promoter binding; IEA:Ensembl.
GO; GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO; GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0048666; P:neuron development; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:1990535; P:neuron projection maintenance; IEA:Ensembl.
GO; GO:0007220; P:Notch receptor processing; IBA:GO_Central.
GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO; GO:1905908; P:positive regulation of amyloid fibril formation; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO; GO:0060999; P:positive regulation of dendritic spine development; IEA:Ensembl.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
GO; GO:0015031; P:protein transport; IEA:Ensembl.
GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO; GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO; GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO; GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
GO; GO:0050808; P:synapse organization; IEA:Ensembl.
GO; GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO; GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
InterPro; IPR001108; Peptidase_A22A.
InterPro; IPR006639; Preselin/SPP.
PANTHER; PTHR10202; PTHR10202; 1.
Pfam; PF01080; Presenilin; 2.
SMART; SM00730; PSN; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000002281};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 20 38 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 50 68 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 80 96 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 102 126 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 147 175 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 321 341 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 347 366 Helical. {ECO:0000256|SAM:Phobius}.
SEQUENCE 380 AA; 43271 MW; 359FB3DFF3C9A5D0 CRC64;

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