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Uncharacterized protein

 F6T889_HORSE            Unreviewed;       395 AA.
F6T889;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
30-AUG-2017, entry version 48.
SubName: Full=Bone morphogenetic protein 2 {ECO:0000313|Ensembl:ENSECAP00000018745};
Name=BMP2 {ECO:0000313|Ensembl:ENSECAP00000018745};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018745, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000018745, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018745,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000018745}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018745};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSECAP00000018745}.
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RefSeq; XP_001493945.1; XM_001493895.5.
STRING; 9796.ENSECAP00000018745; -.
PaxDb; F6T889; -.
Ensembl; ENSECAT00000022668; ENSECAP00000018745; ENSECAG00000021201.
GeneID; 100051701; -.
KEGG; ecb:100051701; -.
CTD; 650; -.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00760000118883; -.
InParanoid; F6T889; -.
KO; K21283; -.
OMA; QGVSKRH; -.
OrthoDB; EOG091G0K7Z; -.
TreeFam; TF351789; -.
Proteomes; UP000002281; Chromosome 22.
Bgee; ENSECAG00000021201; -.
GO; GO:0070724; C:BMP receptor complex; IEA:Ensembl.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
GO; GO:0070700; F:BMP receptor binding; ISS:UniProtKB.
GO; GO:0039706; F:co-receptor binding; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0019211; F:phosphatase activator activity; ISS:UniProtKB.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0004745; F:retinol dehydrogenase activity; IEA:Ensembl.
GO; GO:0046332; F:SMAD binding; ISS:UniProtKB.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0003181; P:atrioventricular valve morphogenesis; IEA:Ensembl.
GO; GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.
GO; GO:0003130; P:BMP signaling pathway involved in heart induction; ISS:UniProtKB.
GO; GO:0035630; P:bone mineralization involved in bone maturation; ISS:UniProtKB.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; ISS:UniProtKB.
GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
GO; GO:0055008; P:cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:0035051; P:cardiocyte differentiation; ISS:UniProtKB.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
GO; GO:0060128; P:corticotropin hormone secreting cell differentiation; IEA:Ensembl.
GO; GO:0035054; P:embryonic heart tube anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0003203; P:endocardial cushion morphogenesis; IEA:Ensembl.
GO; GO:0001837; P:epithelial to mesenchymal transition; ISS:UniProtKB.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0048839; P:inner ear development; IEA:Ensembl.
GO; GO:0048762; P:mesenchymal cell differentiation; ISS:UniProtKB.
GO; GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEA:Ensembl.
GO; GO:0032348; P:negative regulation of aldosterone biosynthetic process; IEA:Ensembl.
GO; GO:0051042; P:negative regulation of calcium-independent cell-cell adhesion; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:2000726; P:negative regulation of cardiac muscle cell differentiation; ISS:UniProtKB.
GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
GO; GO:2000065; P:negative regulation of cortisol biosynthetic process; IEA:Ensembl.
GO; GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0003308; P:negative regulation of Wnt signaling pathway involved in heart development; ISS:UniProtKB.
GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0060039; P:pericardium development; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0048711; P:positive regulation of astrocyte differentiation; IEA:Ensembl.
GO; GO:0030501; P:positive regulation of bone mineralization; ISS:UniProtKB.
GO; GO:0061036; P:positive regulation of cartilage development; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0042482; P:positive regulation of odontogenesis; IEA:Ensembl.
GO; GO:0045778; P:positive regulation of ossification; ISS:UniProtKB.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
GO; GO:0033690; P:positive regulation of osteoblast proliferation; IEA:Ensembl.
GO; GO:1900745; P:positive regulation of p38MAPK cascade; IEA:Ensembl.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0010922; P:positive regulation of phosphatase activity; ISS:UniProtKB.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:1901522; P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; IEA:Ensembl.
GO; GO:0060804; P:positive regulation of Wnt signaling pathway by BMP signaling pathway; IEA:Ensembl.
GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
GO; GO:0006029; P:proteoglycan metabolic process; IEA:Ensembl.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0060395; P:SMAD protein signal transduction; ISS:UniProtKB.
GO; GO:0021537; P:telencephalon development; ISS:UniProtKB.
GO; GO:0021978; P:telencephalon regionalization; IEA:Ensembl.
GO; GO:0060129; P:thyroid-stimulating hormone-secreting cell differentiation; IEA:Ensembl.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
Growth factor {ECO:0000256|RuleBase:RU000354,
ECO:0000256|SAAS:SAAS00516085};
Reference proteome {ECO:0000313|Proteomes:UP000002281};
Secreted {ECO:0000256|SAAS:SAAS00516087};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 23 {ECO:0000256|SAM:SignalP}.
CHAIN 24 395 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003342257.
DOMAIN 278 395 TGF_BETA_2.
{ECO:0000259|PROSITE:PS51362}.
SEQUENCE 395 AA; 44888 MW; BA882CA367032A43 CRC64;
MVAGTHCLLA LLLPQVLLGG AAGLIPELGR RKFAASTGRS SSQPSDDVLS EFELRLLSMF
GLKQRPTPSR DAVVPPYMLD LYRRHSGQPD APAPDHRLER AASLANTVRS FHHEESLEEL
PEMSGKTTRR FFFNLTSIPT EEFITSAELQ VFREQMQDPW ENNSNFHHRI NIYEIIKPAT
ANSKFPVTRL LDTRLVNQNA SRWERFDVTP AVMRWTAQGL ANHGFVVEVA HLEENRGASK
RHVRISRSLH QDEHSWSQIR PLLVTFGHDG KGHPLHKREK RQAKHKQRKR LKSSCKRHPL
YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC
VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR


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