GENTAUR Molecular Products.

 F6YDC3_HORSE            Unreviewed;      1058 AA.
 F6YDC3;
 27-JUL-2011, integrated into UniProtKB/TrEMBL.
 27-JUL-2011, sequence version 1.
 16-JAN-2019, entry version 59.
 SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000007087};
 Name=TLR8 {ECO:0000313|Ensembl:ENSECAP00000007087,
 ECO:0000313|VGNC:VGNC:52444};
 Equus caballus (Horse).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
 NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007087, ECO:0000313|Proteomes:UP000002281};
 [1] {ECO:0000313|Ensembl:ENSECAP00000007087, ECO:0000313|Proteomes:UP000002281}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007087,
 ECO:0000313|Proteomes:UP000002281};
 PubMed=19892987; DOI=10.1126/science.1178158;
 Broad Institute Genome Sequencing Platform;
 Broad Institute Whole Genome Assembly Team;
 Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
 Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
 Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
 Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
 Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
 Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
 Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
 Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
 Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
 Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
 White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
 "Genome sequence, comparative analysis, and population genetics of the
 domestic horse.";
 Science 326:865-867(2009).
 [2] {ECO:0000313|Ensembl:ENSECAP00000007087}
 IDENTIFICATION.
 STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007087};
 Ensembl;
 Submitted (JUL-2011) to UniProtKB.
 -!- SIMILARITY: Belongs to the Toll-like receptor family.
     {ECO:0000256|SAAS:SAAS00596625}.
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 ProteinModelPortal; F6YDC3; -.
 STRING; 9796.ENSECAP00000007087; -.
 PaxDb; F6YDC3; -.
 Ensembl; ENSECAT00000009327; ENSECAP00000007087; ENSECAG00000009180.
 VGNC; VGNC:52444; TLR8.
 eggNOG; KOG4641; Eukaryota.
 eggNOG; COG4886; LUCA.
 GeneTree; ENSGT00940000160879; -.
 InParanoid; F6YDC3; -.
 OMA; FDCTCDI; -.
 TreeFam; TF351113; -.
 Proteomes; UP000002281; Chromosome X.
 Bgee; ENSECAG00000009180; Expressed in 2 organ(s), highest expression level in liver.
 GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
 GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
 GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
 GO; GO:0003677; F:DNA binding; IEA:Ensembl.
 GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
 GO; GO:0008329; F:signaling pattern recognition receptor activity; IBA:GO_Central.
 GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
 GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
 GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
 GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
 GO; GO:0006955; P:immune response; IBA:GO_Central.
 GO; GO:0006954; P:inflammatory response; IEA:InterPro.
 GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
 GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl.
 GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
 GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IBA:GO_Central.
 GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IBA:GO_Central.
 GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
 GO; GO:0032755; P:positive regulation of interleukin-6 production; IBA:GO_Central.
 GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
 GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IBA:GO_Central.
 GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
 GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
 GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central.
 Gene3D; 3.40.50.10140; -; 1.
 Gene3D; 3.80.10.10; -; 1.
 InterPro; IPR000483; Cys-rich_flank_reg_C.
 InterPro; IPR001611; Leu-rich_rpt.
 InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
 InterPro; IPR032675; LRR_dom_sf.
 InterPro; IPR000157; TIR_dom.
 InterPro; IPR027175; TLR8.
 InterPro; IPR035897; Toll_tir_struct_dom_sf.
 PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1.
 Pfam; PF13855; LRR_8; 7.
 Pfam; PF01582; TIR; 1.
 SMART; SM00369; LRR_TYP; 16.
 SMART; SM00082; LRRCT; 1.
 SMART; SM00255; TIR; 1.
 SUPFAM; SSF52200; SSF52200; 1.
 PROSITE; PS51450; LRR; 20.
 PROSITE; PS50104; TIR; 1.
 3: Inferred from homology;
 Complete proteome {ECO:0000313|Proteomes:UP000002281};
 Immunity {ECO:0000256|SAAS:SAAS00472892};
 Innate immunity {ECO:0000256|SAAS:SAAS00472892};
 Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
 Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
 Receptor {ECO:0000256|SAAS:SAAS00473103};
 Reference proteome {ECO:0000313|Proteomes:UP000002281};
 Repeat {ECO:0000256|SAAS:SAAS00597472};
 Transmembrane {ECO:0000256|SAAS:SAAS00598878,
 ECO:0000256|SAM:Phobius};
 Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
 ECO:0000256|SAM:Phobius}.
 TRANSMEM    843    869       Helical. {ECO:0000256|SAM:Phobius}.
 DOMAIN      895   1042       TIR. {ECO:0000259|PROSITE:PS50104}.
 SEQUENCE   1058 AA;  122409 MW;  AE6DD5BEFE9CBD74 CRC64;
 KEASLQNHSC SLGEGCEKEN MILQPLLLTC LFLIISDSCE FFTETNYSRS YPCDEKRENV
 SVIAECNDRR LEEVPQTVGK YVTELDLSDN FIIHITNESF QGLQNLTKIN LNHNGKARSQ
 NENPDVNKNG MNITDGAFLN LQNLRELLLE DNQLDKIPTG LPGSLRELSL IQNRITSVTK
 KNTSGLMNLE YLYLGWNCYF GNICNKTFDI EDGTFERLTN LKVLSLSFNN LSHVPPKLPN
 SLRELYLSNT KIKNITQEDF KELRNLTVLD LSGNCPRCFN APFPCTPCER DSSIQIHPLA
 FQDLTELRYL NLSSTSLRKV PAIWFDNMHH LKVLHLEFNY LVQEIASGEF LTKLPSLEIL
 DLSFNYIVTK YPKYIEISPN FSNLTSLQIL HLRGYVFQEV RKEHFRPLMS LSNLKTINLG
 VNFIKQIDFT FFQHFPNLTV IYLSENRISP LVNDSLQNYT NGSAFQSHIL KRRSADFEFN
 PHSNFYHNTN PLIKPQCTAY GKALDLSLNS IFFIGQKQFK AFHDIACLNL SSNGIGQPLH
 GTEFSAVPHI KYLDLTNNRI DFDDDNALRE LPELEVLDFS YNAHYFRIAG VTHRLGFIQN
 LTQLRVLNLS HNSIYTLTEY NMNSMSLEEL VFSGNRLDLL WNAEDRRYRK IFKCLRNLTR
 LDLSFNNLQH IPDEAFLNLP QNLTELYIND NRLHFFNWTL LQHFPHLHLL DLSRNKLSSL
 TNNLSKFSPS LRTLLLSQNK ISHLPSGFFS EASGLIHLDL RFNRLKMINK TTLQTKTTIN
 LAVLELGGNP FDCTCDIGDF RRWMDENLNI AIPRLADVIC ASPGDQRGKS IVSLELTTCV
 SDAIAAILCF FTFFITVTVM LAALAHHWFY WDVWFIYHMC LAKIKGYRSL STSQTFYDAY
 VSYDTKDASV TDWVINELRF HLEESEEKNV LLCLEERDWD PGLAIIDNLM QSINQSKKTI
 FVLTKKYAKN WNFKTAFYLA LQRLMDENMD VIVFILLEPV LQHSQYLRLR QRICKSSILQ
 WPDNPKAEGL FWQSLKNVVL TENNSRYNNL YVDSIKQY

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