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Uncharacterized protein

 F7BG35_HORSE            Unreviewed;       606 AA.
F7BG35;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
30-AUG-2017, entry version 42.
SubName: Full=Sirtuin 1 {ECO:0000313|Ensembl:ENSECAP00000011762};
Name=SIRT1 {ECO:0000313|Ensembl:ENSECAP00000011762};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000011762, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000011762, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011762,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000011762}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011762};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSECAP00000011762}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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STRING; 9796.ENSECAP00000011762; -.
PaxDb; F7BG35; -.
Ensembl; ENSECAT00000014702; ENSECAP00000011762; ENSECAG00000013909.
eggNOG; KOG2684; Eukaryota.
eggNOG; COG0846; LUCA.
GeneTree; ENSGT00870000136443; -.
InParanoid; F7BG35; -.
OMA; SDSGTCQ; -.
OrthoDB; EOG091G07CT; -.
TreeFam; TF105896; -.
Proteomes; UP000002281; Chromosome 1.
Bgee; ENSECAG00000013909; -.
GO; GO:0005677; C:chromatin silencing complex; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0035098; C:ESC/E(Z) complex; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0005719; C:nuclear euchromatin; IEA:Ensembl.
GO; GO:0005720; C:nuclear heterochromatin; IEA:Ensembl.
GO; GO:0005637; C:nuclear inner membrane; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0016605; C:PML body; IEA:Ensembl.
GO; GO:0033553; C:rDNA heterochromatin; IEA:Ensembl.
GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
GO; GO:0001046; F:core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0042393; F:histone binding; IEA:Ensembl.
GO; GO:0043398; F:HLH domain binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:1990254; F:keratin filament binding; IEA:Ensembl.
GO; GO:0051019; F:mitogen-activated protein kinase binding; IEA:Ensembl.
GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
GO; GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:Ensembl.
GO; GO:0035257; F:nuclear hormone receptor binding; IEA:Ensembl.
GO; GO:0002039; F:p53 binding; IEA:Ensembl.
GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
GO; GO:0042595; P:behavioral response to starvation; IEA:Ensembl.
GO; GO:0001678; P:cellular glucose homeostasis; IEA:Ensembl.
GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0035356; P:cellular triglyceride homeostasis; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0000183; P:chromatin silencing at rDNA; IEA:Ensembl.
GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
GO; GO:0000731; P:DNA synthesis involved in DNA repair; IEA:Ensembl.
GO; GO:0006343; P:establishment of chromatin silencing; IEA:Ensembl.
GO; GO:0055089; P:fatty acid homeostasis; IEA:Ensembl.
GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
GO; GO:0033210; P:leptin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0010934; P:macrophage cytokine production; IEA:Ensembl.
GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
GO; GO:0006344; P:maintenance of chromatin silencing; IEA:Ensembl.
GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; IEA:Ensembl.
GO; GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IEA:Ensembl.
GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
GO; GO:2000655; P:negative regulation of cellular response to testosterone stimulus; IEA:Ensembl.
GO; GO:2000773; P:negative regulation of cellular senescence; IEA:Ensembl.
GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0051097; P:negative regulation of helicase activity; IEA:Ensembl.
GO; GO:0071441; P:negative regulation of histone H3-K14 acetylation; IEA:Ensembl.
GO; GO:1900113; P:negative regulation of histone H3-K9 trimethylation; IEA:Ensembl.
GO; GO:2000619; P:negative regulation of histone H4-K16 acetylation; IEA:Ensembl.
GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:1902166; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0031393; P:negative regulation of prostaglandin biosynthetic process; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0032007; P:negative regulation of TOR signaling; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
GO; GO:0001542; P:ovulation from ovarian follicle; IEA:Ensembl.
GO; GO:0018394; P:peptidyl-lysine acetylation; IEA:Ensembl.
GO; GO:0034983; P:peptidyl-lysine deacetylation; IEA:Ensembl.
GO; GO:0002821; P:positive regulation of adaptive immune response; IEA:Ensembl.
GO; GO:1904179; P:positive regulation of adipose tissue development; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; IEA:Ensembl.
GO; GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
GO; GO:0010875; P:positive regulation of cholesterol efflux; IEA:Ensembl.
GO; GO:0031937; P:positive regulation of chromatin silencing; IEA:Ensembl.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
GO; GO:1902237; P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:0051574; P:positive regulation of histone H3-K9 methylation; IEA:Ensembl.
GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0016239; P:positive regulation of macroautophagy; IEA:Ensembl.
GO; GO:2000111; P:positive regulation of macrophage apoptotic process; IEA:Ensembl.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0051152; P:positive regulation of smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
GO; GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IEA:Ensembl.
GO; GO:0070857; P:regulation of bile acid biosynthetic process; IEA:Ensembl.
GO; GO:0090335; P:regulation of brown fat cell differentiation; IEA:Ensembl.
GO; GO:0032071; P:regulation of endodeoxyribonuclease activity; IEA:Ensembl.
GO; GO:0010906; P:regulation of glucose metabolic process; IEA:Ensembl.
GO; GO:0010883; P:regulation of lipid storage; IEA:Ensembl.
GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
GO; GO:0035358; P:regulation of peroxisome proliferator activated receptor signaling pathway; IEA:Ensembl.
GO; GO:0033158; P:regulation of protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:0034391; P:regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:0032868; P:response to insulin; IEA:Ensembl.
GO; GO:0000012; P:single strand break repair; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0090400; P:stress-induced premature senescence; IEA:Ensembl.
GO; GO:0006642; P:triglyceride mobilization; IEA:Ensembl.
GO; GO:0070914; P:UV-damage excision repair; IEA:Ensembl.
GO; GO:0050872; P:white fat cell differentiation; IEA:Ensembl.
Gene3D; 3.40.50.1220; -; 1.
InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
InterPro; IPR003000; Sirtuin.
InterPro; IPR026590; Ssirtuin_cat_dom.
Pfam; PF02146; SIR2; 1.
SUPFAM; SSF52467; SSF52467; 1.
PROSITE; PS50305; SIRTUIN; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Reference proteome {ECO:0000313|Proteomes:UP000002281}.
DOMAIN 101 355 Deacetylase sirtuin-type.
{ECO:0000259|PROSITE:PS50305}.
SEQUENCE 606 AA; 67803 MW; 8DF9C01CF2A39AC2 CRC64;
DDLLFGDEII TNGFHSCESD EDDRASHASS SDWTPRPRIG PYTFVQQHLM IGTDPRTILK
DLLPETIPPP ELDDMTLWQI VINILSEPPK RKKRKDINTI EDAVKLLQEC KKIIVLTGAG
VSVSCGIPDF RSRDGIYARL AVDFPDLPDP QAMFDIEYFR KDPRPFFKFA KEIYPGQFQP
SLCHKFIALS DKEGKLLRNY TQNIDTLEQV AGIQRIIQCH GSFATASCLI CKYKVDCEAV
RGDIFNQVVP RCPRCPADEP LAIMKPEIVF FGENLPEQFH RAMKYDKDEV DLLIVIGSSL
KVRPVALIPS SIPHEVPQIL INREPLPHLH FDVELLGDCD VIINELCHRL GGEYAKLCCN
PIKLSEITEK PPRTQRELAH LSELPPTPLN ISEDSSSPER TSPPDSSVIV TLLDQATKSN
VDDPDVSKSK DCMEEKSQEV QTSTRSFQSV TERLGSPYLK NVGSDTGEKN ERTSVAEAVR
KCWPARLAKE QISKRLDGNQ YLFLPPNRYI FHGAEVYSDS EEDVLSSSSC GSNSDSGTCQ
SPSLEEPMED ESEIEEFYNG LEDDADVNER AGGTGFRADG SDQEAVNETI STKQEATDIN
YSSNKS


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