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Uncharacterized protein

 G1TWS2_RABIT            Unreviewed;       192 AA.
G1TWS2;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
25-OCT-2017, entry version 42.
SubName: Full=BCL2 associated X, apoptosis regulator {ECO:0000313|Ensembl:ENSOCUP00000021520};
Name=BAX {ECO:0000313|Ensembl:ENSOCUP00000021520};
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000021520, ECO:0000313|Proteomes:UP000001811};
[1] {ECO:0000313|Proteomes:UP000001811}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
The Genome Sequencing Platform;
The Genome Assembly Team;
Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.;
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Proteomes:UP000001811}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
The Genome Sequencing Platform;
The Assembly Computation and Development Core Team;
Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S.,
Lindblad-Toh K.;
"Version 2 of The Genome Sequence of Oryctolagus cuniculus (European
rabbit).";
Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSOCUP00000021520}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000021520};
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29
mammals.";
Nature 478:476-482(2011).
[4] {ECO:0000313|Ensembl:ENSOCUP00000021520}
IDENTIFICATION.
STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000021520};
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000021520}.
-----------------------------------------------------------------------
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ProteinModelPortal; G1TWS2; -.
STRING; 9986.ENSOCUP00000021520; -.
Ensembl; ENSOCUT00000024642; ENSOCUP00000021520; ENSOCUG00000006423.
eggNOG; ENOG410IWQJ; Eukaryota.
eggNOG; ENOG4112738; LUCA.
GeneTree; ENSGT00730000111112; -.
InParanoid; G1TWS2; -.
OMA; VINWIRE; -.
OrthoDB; EOG091G0YWR; -.
TreeFam; TF315834; -.
Proteomes; UP000001811; Unplaced.
Bgee; ENSOCUG00000006423; -.
GO; GO:0097144; C:BAX complex; IEA:Ensembl.
GO; GO:0071944; C:cell periphery; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
GO; GO:0005757; C:mitochondrial permeability transition pore complex; IEA:Ensembl.
GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
GO; GO:0051434; F:BH3 domain binding; IEA:Ensembl.
GO; GO:0015267; F:channel activity; IEA:Ensembl.
GO; GO:0051087; F:chaperone binding; IEA:Ensembl.
GO; GO:0030544; F:Hsp70 protein binding; IEA:Ensembl.
GO; GO:0008289; F:lipid binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IEA:Ensembl.
GO; GO:0097296; P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1902262; P:apoptotic process involved in blood vessel morphogenesis; IEA:Ensembl.
GO; GO:1902263; P:apoptotic process involved in embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
GO; GO:0002358; P:B cell homeostatic proliferation; IEA:Ensembl.
GO; GO:0002352; P:B cell negative selection; IEA:Ensembl.
GO; GO:1990117; P:B cell receptor apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl.
GO; GO:0071310; P:cellular response to organic substance; IEA:Ensembl.
GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO; GO:0045136; P:development of secondary sexual characteristics; IEA:Ensembl.
GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
GO; GO:0010248; P:establishment or maintenance of transmembrane electrochemical gradient; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0009566; P:fertilization; IEA:Ensembl.
GO; GO:0007281; P:germ cell development; IEA:Ensembl.
GO; GO:0006687; P:glycosphingolipid metabolic process; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO; GO:0021854; P:hypothalamus development; IEA:Ensembl.
GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IEA:Ensembl.
GO; GO:0008053; P:mitochondrial fusion; IEA:Ensembl.
GO; GO:0070584; P:mitochondrion morphogenesis; IEA:Ensembl.
GO; GO:0002262; P:myeloid cell homeostasis; IEA:Ensembl.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0032471; P:negative regulation of endoplasmic reticulum calcium ion concentration; IEA:Ensembl.
GO; GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
GO; GO:1902512; P:positive regulation of apoptotic DNA fragmentation; IEA:Ensembl.
GO; GO:0060058; P:positive regulation of apoptotic process involved in mammary gland involution; IEA:Ensembl.
GO; GO:0002904; P:positive regulation of B cell apoptotic process; IEA:Ensembl.
GO; GO:0048087; P:positive regulation of developmental pigmentation; IEA:Ensembl.
GO; GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0032461; P:positive regulation of protein oligomerization; IEA:Ensembl.
GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0048597; P:post-embryonic camera-type eye morphogenesis; IEA:Ensembl.
GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO; GO:0001844; P:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
GO; GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
GO; GO:1902445; P:regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; IEA:Ensembl.
GO; GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO; GO:0006808; P:regulation of nitrogen utilization; IEA:Ensembl.
GO; GO:0043497; P:regulation of protein heterodimerization activity; IEA:Ensembl.
GO; GO:0043496; P:regulation of protein homodimerization activity; IEA:Ensembl.
GO; GO:0001836; P:release of cytochrome c from mitochondria; IEA:Ensembl.
GO; GO:0032976; P:release of matrix enzymes from mitochondria; IEA:Ensembl.
GO; GO:0048678; P:response to axon injury; IEA:Ensembl.
GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO; GO:0009651; P:response to salt stress; IEA:Ensembl.
GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
GO; GO:0046666; P:retinal cell programmed cell death; IEA:Ensembl.
GO; GO:0060011; P:Sertoli cell proliferation; IEA:Ensembl.
GO; GO:0048515; P:spermatid differentiation; IEA:Ensembl.
GO; GO:0001777; P:T cell homeostatic proliferation; IEA:Ensembl.
GO; GO:0070242; P:thymocyte apoptotic process; IEA:Ensembl.
GO; GO:0060068; P:vagina development; IEA:Ensembl.
Gene3D; 1.10.437.10; -; 1.
InterPro; IPR026304; BAX.
InterPro; IPR002475; Bcl2-like.
InterPro; IPR020726; Bcl2_BH2_motif_CS.
InterPro; IPR020728; Bcl2_BH3_motif_CS.
InterPro; IPR036834; Blc2-like_sf.
InterPro; IPR026298; Blc2_fam.
PANTHER; PTHR11256; PTHR11256; 1.
PANTHER; PTHR11256:SF42; PTHR11256:SF42; 1.
Pfam; PF00452; Bcl-2; 1.
PRINTS; PR01862; BCL2FAMILY.
SUPFAM; SSF56854; SSF56854; 1.
PROSITE; PS50062; BCL2_FAMILY; 1.
PROSITE; PS01258; BH2; 1.
PROSITE; PS01259; BH3; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001811};
Reference proteome {ECO:0000313|Proteomes:UP000001811}.
SEQUENCE 192 AA; 21106 MW; FA80A5119512A023 CRC64;
SPGASSLLSP LGPTSSEQIM KTGALLLQGF IQDRASRMGG QTPELAVAQG PQDESTKKLS
ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF ADGNFNWGRV VALFYFATKL
VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTLTILGAGV
LTASLTIWKK MG


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