GENTAUR Molecular Products.

 G7NLJ0_MACMU            Unreviewed;       390 AA.
 G7NLJ0;
 25-JAN-2012, integrated into UniProtKB/TrEMBL.
 25-JAN-2012, sequence version 1.
 13-FEB-2019, entry version 31.
 RecName: Full=Transforming growth factor beta {ECO:0000256|PIRNR:PIRNR001787};
 ORFNames=EGK_10649 {ECO:0000313|EMBL:EHH30065.1};
 Macaca mulatta (Rhesus macaque).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
 Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
 NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH30065.1};
 [1] {ECO:0000313|EMBL:EHH30065.1}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=CR-5 {ECO:0000313|EMBL:EHH30065.1};
 PubMed=22002653; DOI=10.1038/nbt.1992;
 Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
 Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
 Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
 Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
 Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
 Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
 Wang X., Wang J.;
 "Genome sequencing and comparison of two nonhuman primate animal
 models, the cynomolgus and Chinese rhesus macaques.";
 Nat. Biotechnol. 29:1019-1023(2011).
 -!- SUBUNIT: Homodimer; disulfide-linked.
     {ECO:0000256|PIRNR:PIRNR001787}.
 -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001787,
     ECO:0000256|SAAS:SAAS00581915}.
 -!- SIMILARITY: Belongs to the TGF-beta family.
     {ECO:0000256|PIRNR:PIRNR001787, ECO:0000256|RuleBase:RU000354,
     ECO:0000256|SAAS:SAAS00581927}.
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 EMBL; CM001271; EHH30065.1; -; Genomic_DNA.
 GO; GO:0072562; C:blood microparticle; ISS:AgBase.
 GO; GO:0009986; C:cell surface; ISS:AgBase.
 GO; GO:0005737; C:cytoplasm; ISS:AgBase.
 GO; GO:0005615; C:extracellular space; ISS:AgBase.
 GO; GO:0005634; C:nucleus; ISS:AgBase.
 GO; GO:0003823; F:antigen binding; ISS:AgBase.
 GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
 GO; GO:0034713; F:type I transforming growth factor beta receptor binding; ISS:AgBase.
 GO; GO:0005114; F:type II transforming growth factor beta receptor binding; ISS:AgBase.
 GO; GO:0034714; F:type III transforming growth factor beta receptor binding; ISS:AgBase.
 GO; GO:0006754; P:ATP biosynthetic process; ISS:AgBase.
 GO; GO:0007050; P:cell cycle arrest; ISS:AgBase.
 GO; GO:0045216; P:cell-cell junction organization; ISS:AgBase.
 GO; GO:0071407; P:cellular response to organic cyclic compound; ISS:AgBase.
 GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISS:AgBase.
 GO; GO:0002062; P:chondrocyte differentiation; ISS:AgBase.
 GO; GO:0007182; P:common-partner SMAD protein phosphorylation; ISS:AgBase.
 GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; ISS:AgBase.
 GO; GO:0019049; P:evasion or tolerance of host defenses by virus; ISS:AgBase.
 GO; GO:0085029; P:extracellular matrix assembly; ISS:AgBase.
 GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:AgBase.
 GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:AgBase.
 GO; GO:0030214; P:hyaluronan catabolic process; ISS:AgBase.
 GO; GO:0006954; P:inflammatory response; ISS:AgBase.
 GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:AgBase.
 GO; GO:0000165; P:MAPK cascade; ISS:AgBase.
 GO; GO:0007093; P:mitotic cell cycle checkpoint; ISS:AgBase.
 GO; GO:0043537; P:negative regulation of blood vessel endothelial cell migration; ISS:AgBase.
 GO; GO:0045786; P:negative regulation of cell cycle; ISS:AgBase.
 GO; GO:0030308; P:negative regulation of cell growth; ISS:AgBase.
 GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:AgBase.
 GO; GO:0022408; P:negative regulation of cell-cell adhesion; ISS:AgBase.
 GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:AgBase.
 GO; GO:0045599; P:negative regulation of fat cell differentiation; ISS:AgBase.
 GO; GO:0010629; P:negative regulation of gene expression; ISS:BHF-UCL.
 GO; GO:0060965; P:negative regulation of gene silencing by miRNA; ISS:BHF-UCL.
 GO; GO:1900126; P:negative regulation of hyaluronan biosynthetic process; ISS:AgBase.
 GO; GO:0010936; P:negative regulation of macrophage cytokine production; ISS:AgBase.
 GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISS:AgBase.
 GO; GO:0045662; P:negative regulation of myoblast differentiation; ISS:AgBase.
 GO; GO:0001933; P:negative regulation of protein phosphorylation; ISS:AgBase.
 GO; GO:0048642; P:negative regulation of skeletal muscle tissue development; ISS:AgBase.
 GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:AgBase.
 GO; GO:0043932; P:ossification involved in bone remodeling; ISS:AgBase.
 GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; ISS:AgBase.
 GO; GO:0006796; P:phosphate-containing compound metabolic process; ISS:AgBase.
 GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISS:AgBase.
 GO; GO:0030501; P:positive regulation of bone mineralization; ISS:AgBase.
 GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-UniRule.
 GO; GO:0030335; P:positive regulation of cell migration; ISS:BHF-UCL.
 GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:AgBase.
 GO; GO:0032270; P:positive regulation of cellular protein metabolic process; ISS:AgBase.
 GO; GO:0050921; P:positive regulation of chemotaxis; ISS:AgBase.
 GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISS:AgBase.
 GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISS:AgBase.
 GO; GO:0010763; P:positive regulation of fibroblast migration; ISS:AgBase.
 GO; GO:0032740; P:positive regulation of interleukin-17 production; ISS:AgBase.
 GO; GO:0048298; P:positive regulation of isotype switching to IgA isotypes; ISS:AgBase.
 GO; GO:0043406; P:positive regulation of MAP kinase activity; ISS:AgBase.
 GO; GO:1901666; P:positive regulation of NAD+ ADP-ribosyltransferase activity; ISS:AgBase.
 GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISS:AgBase.
 GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:AgBase.
 GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; ISS:AgBase.
 GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISS:AgBase.
 GO; GO:0031334; P:positive regulation of protein complex assembly; ISS:AgBase.
 GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISS:AgBase.
 GO; GO:0042307; P:positive regulation of protein import into nucleus; ISS:AgBase.
 GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:AgBase.
 GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:AgBase.
 GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; ISS:AgBase.
 GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:AgBase.
 GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; ISS:AgBase.
 GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:AgBase.
 GO; GO:0006611; P:protein export from nucleus; ISS:AgBase.
 GO; GO:0043491; P:protein kinase B signaling; ISS:AgBase.
 GO; GO:0032801; P:receptor catabolic process; ISS:AgBase.
 GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; ISS:AgBase.
 GO; GO:0070723; P:response to cholesterol; ISS:AgBase.
 GO; GO:0032355; P:response to estradiol; ISS:AgBase.
 GO; GO:0032570; P:response to progesterone; ISS:AgBase.
 GO; GO:0009611; P:response to wounding; ISS:AgBase.
 GO; GO:0007435; P:salivary gland morphogenesis; ISS:AgBase.
 GO; GO:0007183; P:SMAD protein complex assembly; ISS:AgBase.
 GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:AgBase.
 Gene3D; 2.10.90.10; -; 1.
 InterPro; IPR029034; Cystine-knot_cytokine.
 InterPro; IPR001839; TGF-b_C.
 InterPro; IPR001111; TGF-b_propeptide.
 InterPro; IPR016319; TGF-beta.
 InterPro; IPR015615; TGF-beta-rel.
 InterPro; IPR003939; TGFb1.
 InterPro; IPR017948; TGFb_CS.
 PANTHER; PTHR11848; PTHR11848; 1.
 Pfam; PF00019; TGF_beta; 1.
 Pfam; PF00688; TGFb_propeptide; 1.
 PIRSF; PIRSF001787; TGF-beta; 1.
 PRINTS; PR01423; TGFBETA.
 PRINTS; PR01424; TGFBETA1.
 SMART; SM00204; TGFB; 1.
 SUPFAM; SSF57501; SSF57501; 1.
 PROSITE; PS00250; TGF_BETA_1; 1.
 PROSITE; PS51362; TGF_BETA_2; 1.
 3: Inferred from homology;
 Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
 Growth factor {ECO:0000256|PIRNR:PIRNR001787,
 ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00516085};
 Mitogen {ECO:0000256|PIRNR:PIRNR001787};
 Secreted {ECO:0000256|PIRNR:PIRNR001787,
 ECO:0000256|SAAS:SAAS00516087};
 Signal {ECO:0000256|PIRNR:PIRNR001787}.
 SIGNAL        1     29       {ECO:0000256|PIRNR:PIRNR001787}.
 CHAIN        30    390       Transforming growth factor beta.
                              {ECO:0000256|PIRNR:PIRNR001787}.
                              /FTId=PRO_5016196207.
 DOMAIN      275    390       TGF_BETA_2.
                              {ECO:0000259|PROSITE:PS51362}.
 SEQUENCE   390 AA;  44324 MW;  089B7F95D11043A3 CRC64;
 MPPSGLRPLP LLLPLLWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR GQILSKLRLA
 SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESAEPEPEPE ADYYAKEVTR VLMVETHNEI
 YDKFKQSTHS IYMFFNTSEL REAVPEPVLL SRAELRLLRL KLKVEQHVEL YQKYSNNSWR
 YLSNRLLAPS DSPEWLSFDV TGVVRQWLSR GGEIEGFRLS AHCSCDSKDN TLQVDINGFT
 TGRRGDLATI HGMNRPFLLL MATPLERAQH LQSSRHRRAL DTNYCFSSTE KNCCVRQLYI
 DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVR ALYNQHNPGA SAAPCCVPQA
 LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS

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