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Uncharacterized protein

 H0W4Q8_CAVPO            Unreviewed;      1035 AA.
H0W4Q8;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
05-DEC-2018, entry version 58.
SubName: Full=Toll like receptor 8 {ECO:0000313|Ensembl:ENSCPOP00000017959};
Name=TLR8 {ECO:0000313|Ensembl:ENSCPOP00000017959};
Cavia porcellus (Guinea pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Hystricomorpha; Caviidae; Cavia.
NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000017959};
[1] {ECO:0000313|Ensembl:ENSCPOP00000017959}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017959};
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29
mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSCPOP00000017959}
IDENTIFICATION.
STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017959};
Ensembl;
Submitted (JAN-2012) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00596625}.
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EMBL; AAKN02052373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003462940.1; XM_003462892.2.
STRING; 10141.ENSCPOP00000017959; -.
Ensembl; ENSCPOT00000004812; ENSCPOP00000017959; ENSCPOG00000004761.
GeneID; 100713058; -.
CTD; 51311; -.
eggNOG; KOG4641; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00940000160879; -.
InParanoid; H0W4Q8; -.
OMA; FDCTCDI; -.
OrthoDB; EOG091G014D; -.
TreeFam; TF351113; -.
Proteomes; UP000005447; Unassembled WGS sequence.
Bgee; ENSCPOG00000004761; Expressed in 1 organ(s), highest expression level in liver.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:InterPro.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl.
GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027175; TLR8.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1.
Pfam; PF13855; LRR_8; 6.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 16.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 19.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000005447};
Immunity {ECO:0000256|SAAS:SAAS00472892};
Innate immunity {ECO:0000256|SAAS:SAAS00472892};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878};
Receptor {ECO:0000256|SAAS:SAAS00473103};
Reference proteome {ECO:0000313|Proteomes:UP000005447};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00598878};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}.
SIGNAL 1 23 {ECO:0000256|SAM:SignalP}.
CHAIN 24 1035 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003543653.
DOMAIN 872 1019 TIR. {ECO:0000259|PROSITE:PS50104}.
SEQUENCE 1035 AA; 118504 MW; B80117C0F5D0127B CRC64;
MSLQSSILTC IFLLLLGSGQ FSAEYSRSFP CDESRQNSSV IAECNNRRLQ EVPKTVGRNV
TELDLSDNLI THITNGSFQG LHKLTRLNLN HNANQQHQEE YPGIVKTGMN ITDGAFLSLK
NLKELLLEDN QLNKIPTGLP ESLTEFSLIQ NNIILVTKNN TSELRNLQKF SLSWNCYFAC
NKTFEVEDGT FENLTNLKEL SLSFNTLIHV PPKLPSSLER LYLSNAKIKA IGPEDFKGLG
NLSSLDLSGN CPRCFNAPFP CTPCEGDASL KIHPLAFQNL SNLHHLNLSS TSLQTVNSTW
FDNMPYLKEL HLEFNYLVHE IASGAFLTKL PNLKILDLSF NYVKTQYKQY IKLSPNFSKL
THLEALHLRG YVFQVLRRED FEPLMGLSHL KTINLGINFI KQIDFNIFKN FSSLKVIYLS
ENRISPLVDD TRQTSAKGFP LQNHNRKPRS TDSEFDPHSN FYHPSYPLMK PQCTRYGKAL
DLSLNSIFFI GRRQFEDFQD IVCLNLSSNG NGQVFNGSEF STVRQVKYLD LTNNRLDFDD
DNALSELHNL EVLDLSRNSH YFRIAGVTHR LGFLENLTHL KVLNLSYNSI YTLTEENELK
SASLEELNFS GNRLDLLWKP GDTRYWPIFK CLSNLSRLDL SDNRLQRIPN EAFLNLPQNL
THLYLKDNIL NFFNWTLLQH FPQLRVLDLS GNQLSSLASS LSRFTSSLQT LLLSQNRISH
LPSGFLSGAS SLMHLDLSSN LIKMINKSTL QTKTAADLSS LKLDGNPFDC TCDIGDFRRW
MDENLNVTIP RLADVICASP GDQSGKSIVT LELTTCVSDG IAAALFLCTF FLTTSVMLVA
LAHHLFYWDV WFMYQMCSAK VRGYRSLSTS QTFYDAYISY DTRDASVTDW VINELRYHLE
ESEDKNVLLC LEERDWDPGL AIIDNLMQSI NQSKKTIFVL TKKYAKSWNF KTAFYLALQR
LMDENMDVIL FILLEPVLQH SQYLRLRRRI CKSSILQWPD NPKAEGLFWQ SLKNVVLTEN
DSRYNNLYVD SIRQY


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