GENTAUR Molecular Products.

 H0X4X8_OTOGA            Unreviewed;       295 AA.
 H0X4X8;
 22-FEB-2012, integrated into UniProtKB/TrEMBL.
 22-FEB-2012, sequence version 1.
 16-JAN-2019, entry version 51.
 SubName: Full=Cyclin D1 {ECO:0000313|Ensembl:ENSOGAP00000010293};
 Name=CCND1 {ECO:0000313|Ensembl:ENSOGAP00000010293};
 Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
 Lorisiformes; Galagidae; Otolemur.
 NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010293, ECO:0000313|Proteomes:UP000005225};
 [1] {ECO:0000313|Ensembl:ENSOGAP00000010293}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 The Broad Institute Genome Sequencing Platform;
 Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
 Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
 Walker B.J., Sharpe T., Hall G.;
 "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
 Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
 [2] {ECO:0000313|Ensembl:ENSOGAP00000010293}
 IDENTIFICATION.
 Ensembl;
 Submitted (JAN-2012) to UniProtKB.
 -!- SIMILARITY: Belongs to the cyclin family.
     {ECO:0000256|RuleBase:RU000383, ECO:0000256|SAAS:SAAS00861960}.
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 EMBL; AAQR03144580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 RefSeq; XP_003798339.1; XM_003798291.2.
 STRING; 30611.ENSOGAP00000010293; -.
 Ensembl; ENSOGAT00000011498; ENSOGAP00000010293; ENSOGAG00000011495.
 GeneID; 100958947; -.
 CTD; 595; -.
 eggNOG; KOG0656; Eukaryota.
 eggNOG; ENOG410XRKC; LUCA.
 GeneTree; ENSGT00940000157816; -.
 InParanoid; H0X4X8; -.
 OMA; YRTTHFL; -.
 OrthoDB; 1234739at2759; -.
 TreeFam; TF101004; -.
 Proteomes; UP000005225; Unassembled WGS sequence.
 GO; GO:0005923; C:bicellular tight junction; IEA:Ensembl.
 GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; ISS:UniProtKB.
 GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
 GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
 GO; GO:0005634; C:nucleus; ISS:UniProtKB.
 GO; GO:0017053; C:transcriptional repressor complex; IEA:Ensembl.
 GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:Ensembl.
 GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
 GO; GO:0070064; F:proline-rich region binding; IEA:Ensembl.
 GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
 GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
 GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
 GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
 GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
 GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
 GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
 GO; GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.
 GO; GO:0007595; P:lactation; IEA:Ensembl.
 GO; GO:0097421; P:liver regeneration; IEA:Ensembl.
 GO; GO:0060749; P:mammary gland alveolus development; IEA:Ensembl.
 GO; GO:0033598; P:mammary gland epithelial cell proliferation; IEA:Ensembl.
 GO; GO:0031571; P:mitotic G1 DNA damage checkpoint; ISS:UniProtKB.
 GO; GO:0071157; P:negative regulation of cell cycle arrest; IEA:Ensembl.
 GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Ensembl.
 GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
 GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB.
 GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
 GO; GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
 GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
 GO; GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
 GO; GO:0042493; P:response to drug; IEA:Ensembl.
 GO; GO:0044321; P:response to leptin; IEA:Ensembl.
 GO; GO:0070141; P:response to UV-A; ISS:UniProtKB.
 GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
 CDD; cd00043; CYCLIN; 1.
 InterPro; IPR039361; Cyclin.
 InterPro; IPR013763; Cyclin-like.
 InterPro; IPR036915; Cyclin-like_sf.
 InterPro; IPR004367; Cyclin_C-dom.
 InterPro; IPR015451; Cyclin_D.
 InterPro; IPR006671; Cyclin_N.
 PANTHER; PTHR10177; PTHR10177; 1.
 PANTHER; PTHR10177:SF67; PTHR10177:SF67; 1.
 Pfam; PF02984; Cyclin_C; 1.
 Pfam; PF00134; Cyclin_N; 1.
 PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
 SMART; SM00385; CYCLIN; 1.
 SMART; SM01332; Cyclin_C; 1.
 SUPFAM; SSF47954; SSF47954; 2.
 PROSITE; PS00292; CYCLINS; 1.
 3: Inferred from homology;
 Coiled coil {ECO:0000256|SAM:Coils};
 Complete proteome {ECO:0000313|Proteomes:UP000005225};
 Cyclin {ECO:0000256|RuleBase:RU000383, ECO:0000256|SAAS:SAAS00862020};
 Reference proteome {ECO:0000313|Proteomes:UP000005225}.
 DOMAIN       57     88       Cyclin N-terminal.
                              {ECO:0000259|PROSITE:PS00292}.
 COILED      259    279       {ECO:0000256|SAM:Coils}.
 SEQUENCE   295 AA;  33612 MW;  9814F880AAE14997 CRC64;
 MEHQLLCCEV ETIRRAYPDG NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EILPSMRKIV
 ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT
 AEKLCIYTDN SIRPDELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPE AEENKQIIRK
 HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLGSP NQFLSYYRLT RFLSRVIKCD
 PDCLRACQEQ IEALLESSLR QAQQNLDPKA AEEEEEEEEE VDLACTPTDV RDVDI

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