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Uncharacterized protein

 I3LVS7_PIG              Unreviewed;       193 AA.
11-JUL-2012, integrated into UniProtKB/TrEMBL.
11-JUL-2012, sequence version 1.
31-JAN-2018, entry version 51.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000028230};
Name=RHOA {ECO:0000313|Ensembl:ENSSSCP00000028230};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000028230, ECO:0000313|Proteomes:UP000008227};
[1] {ECO:0000313|Ensembl:ENSSSCP00000028230, ECO:0000313|Proteomes:UP000008227}
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000028230,
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSSCP00000028230}
Submitted (MAY-2012) to UniProtKB.
[3] {ECO:0000313|Ensembl:ENSSSCP00000045785}
Submitted (OCT-2017) to UniProtKB.
-!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSSSCP00000028230}.
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
EMBL; AEMK02000086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; NP_001231366.1; NM_001244437.1.
UniGene; Ssc.7096; -.
ProteinModelPortal; I3LVS7; -.
SMR; I3LVS7; -.
STRING; 9823.ENSSSCP00000028230; -.
PaxDb; I3LVS7; -.
PeptideAtlas; I3LVS7; -.
Ensembl; ENSSSCT00000022584; ENSSSCP00000028230; ENSSSCG00000022080.
Ensembl; ENSSSCT00000062870; ENSSSCP00000045785; ENSSSCG00000022080.
GeneID; 396849; -.
KEGG; ssc:396849; -.
CTD; 387; -.
eggNOG; KOG0393; Eukaryota.
eggNOG; COG1100; LUCA.
GeneTree; ENSGT00760000119020; -.
InParanoid; I3LVS7; -.
KO; K04513; -.
OrthoDB; EOG091G0QVS; -.
TreeFam; TF300837; -.
Reactome; R-SSC-114604; GPVI-mediated activation cascade.
Reactome; R-SSC-193634; Axonal growth inhibition (RHOA activation).
Reactome; R-SSC-194840; Rho GTPase cycle.
Reactome; R-SSC-198203; PI3K/AKT activation.
Reactome; R-SSC-2173791; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
Reactome; R-SSC-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-SSC-3928662; EPHB-mediated forward signaling.
Reactome; R-SSC-3928663; EPHA-mediated growth cone collapse.
Reactome; R-SSC-4086400; PCP/CE pathway.
Reactome; R-SSC-416482; G alpha (12/13) signalling events.
Reactome; R-SSC-416550; Sema4D mediated inhibition of cell attachment and migration.
Reactome; R-SSC-416572; Sema4D induced cell migration and growth-cone collapse.
Reactome; R-SSC-4420097; VEGFA-VEGFR2 Pathway.
Reactome; R-SSC-5625740; RHO GTPases activate PKNs.
Reactome; R-SSC-5625900; RHO GTPases activate CIT.
Reactome; R-SSC-5625970; RHO GTPases activate KTN1.
Reactome; R-SSC-5627117; RHO GTPases Activate ROCKs.
Reactome; R-SSC-5663220; RHO GTPases Activate Formins.
Reactome; R-SSC-5666185; RHO GTPases Activate Rhotekin and Rhophilins.
Reactome; R-SSC-5689896; Ovarian tumor domain proteases.
Reactome; R-SSC-6785631; ERBB2 Regulates Cell Motility.
Reactome; R-SSC-6798695; Neutrophil degranulation.
Reactome; R-SSC-8849471; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
Reactome; R-SSC-8985586; SLIT2:ROBO1 increases RHOA activity.
Proteomes; UP000008227; Chromosome 13.
Bgee; ENSSSCG00000022080; -.
Genevisible; I3LVS7; SS.
GO; GO:0043296; C:apical junction complex; ISS:AgBase.
GO; GO:0030424; C:axon; ISS:AgBase.
GO; GO:0005938; C:cell cortex; IDA:AgBase.
GO; GO:0071944; C:cell periphery; ISS:AgBase.
GO; GO:0032154; C:cleavage furrow; IDA:AgBase.
GO; GO:0005737; C:cytoplasm; ISS:AgBase.
GO; GO:0005829; C:cytosol; ISS:AgBase.
GO; GO:0005768; C:endosome; ISS:AgBase.
GO; GO:0070062; C:extracellular exosome; ISS:AgBase.
GO; GO:0005925; C:focal adhesion; ISS:AgBase.
GO; GO:0030027; C:lamellipodium; ISS:AgBase.
GO; GO:0072687; C:meiotic spindle; IDA:AgBase.
GO; GO:0016020; C:membrane; ISS:AgBase.
GO; GO:0005739; C:mitochondrion; ISS:AgBase.
GO; GO:0005634; C:nucleus; ISS:AgBase.
GO; GO:0005886; C:plasma membrane; ISS:AgBase.
GO; GO:0032587; C:ruffle membrane; ISS:AgBase.
GO; GO:0031982; C:vesicle; ISS:AgBase.
GO; GO:0019003; F:GDP binding; ISS:AgBase.
GO; GO:0005525; F:GTP binding; ISS:AgBase.
GO; GO:0003924; F:GTPase activity; ISS:AgBase.
GO; GO:0017022; F:myosin binding; ISS:AgBase.
GO; GO:0019904; F:protein domain specific binding; ISS:AgBase.
GO; GO:0051022; F:Rho GDP-dissociation inhibitor binding; ISS:AgBase.
GO; GO:0030036; P:actin cytoskeleton organization; ISS:AgBase.
GO; GO:0002363; P:alpha-beta T cell lineage commitment; ISS:AgBase.
GO; GO:0030521; P:androgen receptor signaling pathway; ISS:AgBase.
GO; GO:0043297; P:apical junction assembly; ISS:AgBase.
GO; GO:0038027; P:apolipoprotein A-I-mediated signaling pathway; ISS:AgBase.
GO; GO:0043366; P:beta selection; ISS:AgBase.
GO; GO:0007155; P:cell adhesion; ISS:AgBase.
GO; GO:0030154; P:cell differentiation; ISS:AgBase.
GO; GO:0000902; P:cell morphogenesis; ISS:AgBase.
GO; GO:0007160; P:cell-matrix adhesion; ISS:AgBase.
GO; GO:0021795; P:cerebral cortex cell migration; ISS:AgBase.
GO; GO:0036089; P:cleavage furrow formation; ISS:AgBase.
GO; GO:0007010; P:cytoskeleton organization; ISS:AgBase.
GO; GO:0040016; P:embryonic cleavage; IMP:AgBase.
GO; GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; IMP:AgBase.
GO; GO:0021861; P:forebrain radial glial cell differentiation; ISS:AgBase.
GO; GO:0046039; P:GTP metabolic process; ISS:AgBase.
GO; GO:0000212; P:meiotic spindle organization; IMP:AgBase.
GO; GO:0090307; P:mitotic spindle assembly; ISS:AgBase.
GO; GO:0050919; P:negative chemotaxis; ISS:AgBase.
GO; GO:0060548; P:negative regulation of cell death; ISS:AgBase.
GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; ISS:AgBase.
GO; GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; ISS:AgBase.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:AgBase.
GO; GO:0045665; P:negative regulation of neuron differentiation; ISS:AgBase.
GO; GO:0090324; P:negative regulation of oxidative phosphorylation; ISS:AgBase.
GO; GO:1903427; P:negative regulation of reactive oxygen species biosynthetic process; ISS:AgBase.
GO; GO:0043931; P:ossification involved in bone maturation; ISS:AgBase.
GO; GO:0040038; P:polar body extrusion after meiotic divisions; IMP:AgBase.
GO; GO:0030838; P:positive regulation of actin filament polymerization; ISS:AgBase.
GO; GO:0046638; P:positive regulation of alpha-beta T cell differentiation; ISS:AgBase.
GO; GO:0030307; P:positive regulation of cell growth; ISS:AgBase.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:AgBase.
GO; GO:0032467; P:positive regulation of cytokinesis; IMP:AgBase.
GO; GO:0060193; P:positive regulation of lipase activity; ISS:AgBase.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:AgBase.
GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:AgBase.
GO; GO:0071803; P:positive regulation of podosome assembly; ISS:AgBase.
GO; GO:0045987; P:positive regulation of smooth muscle contraction; ISS:AgBase.
GO; GO:0051496; P:positive regulation of stress fiber assembly; ISS:AgBase.
GO; GO:0032956; P:regulation of actin cytoskeleton organization; ISS:AgBase.
GO; GO:0051924; P:regulation of calcium ion transport; ISS:AgBase.
GO; GO:0030334; P:regulation of cell migration; ISS:AgBase.
GO; GO:0050773; P:regulation of dendrite development; ISS:AgBase.
GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; ISS:AgBase.
GO; GO:2000177; P:regulation of neural precursor cell proliferation; ISS:AgBase.
GO; GO:0010975; P:regulation of neuron projection development; ISS:AgBase.
GO; GO:0033688; P:regulation of osteoblast proliferation; ISS:AgBase.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:AgBase.
GO; GO:0042493; P:response to drug; ISS:AgBase.
GO; GO:0007266; P:Rho protein signal transduction; IMP:AgBase.
GO; GO:1902766; P:skeletal muscle satellite cell migration; ISS:AgBase.
GO; GO:0007519; P:skeletal muscle tissue development; ISS:AgBase.
GO; GO:0051653; P:spindle localization; IMP:AgBase.
GO; GO:0043149; P:stress fiber assembly; ISS:AgBase.
GO; GO:0031098; P:stress-activated protein kinase signaling cascade; ISS:AgBase.
GO; GO:0061383; P:trabecula morphogenesis; ISS:AgBase.
GO; GO:0044319; P:wound healing, spreading of cells; ISS:AgBase.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR001806; Small_GTPase.
InterPro; IPR003578; Small_GTPase_Rho.
Pfam; PF00071; Ras; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51420; RHO; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000008227};
GTP-binding {ECO:0000256|SAAS:SAAS00512948};
Membrane {ECO:0000256|SAAS:SAAS00512943};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00512948};
Proteomics identification {ECO:0000213|PeptideAtlas:I3LVS7};
Reference proteome {ECO:0000313|Proteomes:UP000008227}.
SEQUENCE 193 AA; 21768 MW; C4DA2DC31FF858BC CRC64;

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