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Uncharacterized protein

 Q3URY7_MOUSE            Unreviewed;       483 AA.
Q3URY7;
11-OCT-2005, integrated into UniProtKB/TrEMBL.
11-OCT-2005, sequence version 1.
07-NOV-2018, entry version 90.
SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:BAE24550.1};
Name=Nrg1 {ECO:0000313|MGI:MGI:96083};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE24550.1};
[1] {ECO:0000313|EMBL:BAE24550.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24550.1};
TISSUE=Cerebellum {ECO:0000313|EMBL:BAE24550.1};
PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
Carninci P., Hayashizaki Y.;
"High-efficiency full-length cDNA cloning.";
Methods Enzymol. 303:19-44(1999).
[2] {ECO:0000313|EMBL:BAE24550.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24550.1};
TISSUE=Cerebellum {ECO:0000313|EMBL:BAE24550.1};
PubMed=11042159; DOI=10.1101/gr.145100;
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
"Normalization and subtraction of cap-trapper-selected cDNAs to
prepare full-length cDNA libraries for rapid discovery of new genes.";
Genome Res. 10:1617-1630(2000).
[3] {ECO:0000313|EMBL:BAE24550.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24550.1};
TISSUE=Cerebellum {ECO:0000313|EMBL:BAE24550.1};
PubMed=11076861; DOI=10.1101/gr.152600;
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
"RIKEN integrated sequence analysis (RISA) system--384-format
sequencing pipeline with 384 multicapillary sequencer.";
Genome Res. 10:1757-1771(2000).
[4] {ECO:0000313|EMBL:BAE24550.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24550.1};
TISSUE=Cerebellum {ECO:0000313|EMBL:BAE24550.1};
PubMed=11217851; DOI=10.1038/35055500;
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
"Functional annotation of a full-length mouse cDNA collection.";
Nature 409:685-690(2001).
[5] {ECO:0000313|EMBL:BAE24550.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24550.1};
TISSUE=Cerebellum {ECO:0000313|EMBL:BAE24550.1};
PubMed=12466851; DOI=10.1038/nature01266;
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
"Analysis of the mouse transcriptome based on functional annotation of
60,770 full-length cDNAs.";
Nature 420:563-573(2002).
[6] {ECO:0000313|EMBL:BAE24550.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24550.1};
TISSUE=Cerebellum {ECO:0000313|EMBL:BAE24550.1};
Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
Muramatsu M., Hayashizaki Y.;
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|EMBL:BAE24550.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24550.1};
TISSUE=Cerebellum {ECO:0000313|EMBL:BAE24550.1};
The FANTOM Consortium;
Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
"The Transcriptional Landscape of the Mammalian Genome.";
Science 309:1559-1563(2005).
[8] {ECO:0000313|EMBL:BAE24550.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24550.1};
TISSUE=Cerebellum {ECO:0000313|EMBL:BAE24550.1};
PubMed=16141073; DOI=10.1126/science.1112009;
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
"Antisense Transcription in the Mammalian Transcriptome.";
Science 309:1564-1566(2005).
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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EMBL; AK141037; BAE24550.1; -; mRNA.
UniGene; Mm.153432; -.
UniGene; Mm.460675; -.
ProteinModelPortal; Q3URY7; -.
UCSC; uc009ljs.1; mouse.
MGI; MGI:96083; Nrg1.
eggNOG; ENOG410IEU9; Eukaryota.
eggNOG; ENOG4110ST7; LUCA.
HOVERGEN; HBG006531; -.
GO; GO:0030424; C:axon; IDA:MGI.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO.
GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
GO; GO:0031594; C:neuromuscular junction; IDA:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0045202; C:synapse; IDA:MGI.
GO; GO:0045499; F:chemorepellent activity; IDA:MGI.
GO; GO:0005176; F:ErbB-2 class receptor binding; IDA:MGI.
GO; GO:0030296; F:protein tyrosine kinase activator activity; IBA:GO_Central.
GO; GO:0030971; F:receptor tyrosine kinase binding; ISO:MGI.
GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
GO; GO:0003712; F:transcription coregulator activity; ISO:MGI.
GO; GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0007420; P:brain development; IMP:MGI.
GO; GO:0003161; P:cardiac conduction system development; IDA:MGI.
GO; GO:0048738; P:cardiac muscle tissue development; IDA:MGI.
GO; GO:0016477; P:cell migration; IGI:MGI.
GO; GO:0000902; P:cell morphogenesis; IDA:MGI.
GO; GO:0043624; P:cellular protein complex disassembly; ISO:MGI.
GO; GO:0021842; P:chemorepulsion involved in interneuron migration from the subpallium to the cortex; IMP:MGI.
GO; GO:0010001; P:glial cell differentiation; IMP:MGI.
GO; GO:0021781; P:glial cell fate commitment; IDA:MGI.
GO; GO:0007507; P:heart development; IMP:MGI.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0007626; P:locomotory behavior; IMP:MGI.
GO; GO:0000165; P:MAPK cascade; IDA:MGI.
GO; GO:0007517; P:muscle organ development; IMP:MGI.
GO; GO:0022011; P:myelination in peripheral nervous system; IMP:MGI.
GO; GO:2001223; P:negative regulation of neuron migration; IDA:MGI.
GO; GO:0042177; P:negative regulation of protein catabolic process; IDA:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0007399; P:nervous system development; IMP:MGI.
GO; GO:0048663; P:neuron fate commitment; IMP:MGI.
GO; GO:0045213; P:neurotransmitter receptor metabolic process; IMP:MGI.
GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI.
GO; GO:0007422; P:peripheral nervous system development; IMP:MGI.
GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IGI:MGI.
GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI.
GO; GO:0045860; P:positive regulation of protein kinase activity; IDA:MGI.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:MGI.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:MGI.
GO; GO:0099527; P:postsynapse to nucleus signaling pathway; IDA:SynGO.
GO; GO:0045595; P:regulation of cell differentiation; IMP:MGI.
GO; GO:0007416; P:synapse assembly; IDA:SynGO.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR002154; Neuregulin_C.
InterPro; IPR018250; NRG1.
PANTHER; PTHR11100:SF7; PTHR11100:SF7; 1.
Pfam; PF02158; Neuregulin; 1.
PRINTS; PR01089; NEUREGULIN.
SMART; SM00181; EGF; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS50026; EGF_3; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
Membrane {ECO:0000256|SAM:Phobius};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 76 99 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 303 325 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 233 277 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DISULFID 267 276 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 483 AA; 52553 MW; EB744883CFDC850A CRC64;
MEIYPPDMSE GAGGRSSSPS TQLSADPSLD GLPAAEHMPD THTEDGRSPG LLGLAVPCCV
CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV DKIFEYDSPT HLDPGGLGQD
PVISLDPTAA SAVLVSSEAY TSPVSKAQSE AEAHVTGQGD HVAVASEPSA VPTRKNRLSA
FPPLHSTPPP FPSPARTPEV RTPKSGTQPQ TTETNLQTAP KLSTSTSTTG TSHLIKCAEK
EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RQKLHDRLRQ SLRSERNNMV NIANGPHHPN
PPPENVQLVN QYVSKNVISS EHIVEREVET SFSTSHYTYT AHHSTTVTQT PSHSWSNGHT
ESIISESHSV IMMSSVENSR HSSPAGGPRG RLHGLGGPRE CNSFLRHARE TPDSYRDSPH
SER


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