GENTAUR Molecular Products.

 G7P401_MACFA            Unreviewed;       224 AA.
 G7P401;
 25-JAN-2012, integrated into UniProtKB/TrEMBL.
 25-JAN-2012, sequence version 1.
 28-MAR-2018, entry version 30.
 SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH53069.1};
 Flags: Fragment;
 ORFNames=EGM_13630 {ECO:0000313|EMBL:EHH53069.1};
 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
 Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
 NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
 [1] {ECO:0000313|EMBL:EHH53069.1, ECO:0000313|Proteomes:UP000009130}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=CE-4 {ECO:0000313|EMBL:EHH53069.1};
 PubMed=22002653; DOI=10.1038/nbt.1992;
 Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
 Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
 Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
 Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
 Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
 Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
 Wang X., Wang J.;
 "Genome sequencing and comparison of two nonhuman primate animal
 models, the cynomolgus and Chinese rhesus macaques.";
 Nat. Biotechnol. 29:1019-1023(2011).
 -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
     {ECO:0000256|RuleBase:RU003818, ECO:0000256|SAAS:SAAS00725102}.
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 EMBL; CM001279; EHH53069.1; -; Genomic_DNA.
 Proteomes; UP000009130; Chromosome 4.
 GO; GO:0009986; C:cell surface; ISS:UniProtKB.
 GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO; GO:0016020; C:membrane; IEA:InterPro.
 GO; GO:0030141; C:secretory granule; ISS:UniProtKB.
 GO; GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
 GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
 GO; GO:0001968; F:fibronectin binding; ISS:UniProtKB.
 GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
 GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
 GO; GO:0005161; F:platelet-derived growth factor receptor binding; ISS:UniProtKB.
 GO; GO:0048018; F:receptor ligand activity; ISS:UniProtKB.
 GO; GO:0043183; F:vascular endothelial growth factor receptor 1 binding; ISS:UniProtKB.
 GO; GO:0043184; F:vascular endothelial growth factor receptor 2 binding; ISS:UniProtKB.
 GO; GO:0005172; F:vascular endothelial growth factor receptor binding; ISS:UniProtKB.
 GO; GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.
 GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
 GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; ISS:UniProtKB.
 GO; GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.
 GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; ISS:UniProtKB.
 GO; GO:0035767; P:endothelial cell chemotaxis; ISS:UniProtKB.
 GO; GO:0030225; P:macrophage differentiation; ISS:UniProtKB.
 GO; GO:0030224; P:monocyte differentiation; ISS:UniProtKB.
 GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
 GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISS:UniProtKB.
 GO; GO:0045785; P:positive regulation of cell adhesion; ISS:UniProtKB.
 GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISS:UniProtKB.
 GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO; GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; ISS:UniProtKB.
 GO; GO:0051272; P:positive regulation of cellular component movement; ISS:UniProtKB.
 GO; GO:0032793; P:positive regulation of CREB transcription factor activity; ISS:UniProtKB.
 GO; GO:0038033; P:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; ISS:BHF-UCL.
 GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
 GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
 GO; GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
 GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
 GO; GO:1900086; P:positive regulation of peptidyl-tyrosine autophosphorylation; ISS:UniProtKB.
 GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
 GO; GO:0050927; P:positive regulation of positive chemotaxis; ISS:UniProtKB.
 GO; GO:0031954; P:positive regulation of protein autophosphorylation; ISS:UniProtKB.
 GO; GO:0090037; P:positive regulation of protein kinase C signaling; ISS:UniProtKB.
 GO; GO:1903572; P:positive regulation of protein kinase D signaling; ISS:BHF-UCL.
 GO; GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
 GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.
 GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
 GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
 GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.
 CDD; cd00135; PDGF; 1.
 Gene3D; 2.10.160.10; -; 1.
 Gene3D; 2.10.90.10; -; 1.
 InterPro; IPR029034; Cystine-knot_cytokine.
 InterPro; IPR023581; PD_growth_factor_CS.
 InterPro; IPR000072; PDGF/VEGF_dom.
 InterPro; IPR027928; VEGF_C.
 InterPro; IPR036841; VEGF_C_sf.
 Pfam; PF00341; PDGF; 1.
 Pfam; PF14554; VEGF_C; 1.
 SMART; SM00141; PDGF; 1.
 SUPFAM; SSF57501; SSF57501; 1.
 SUPFAM; SSF57593; SSF57593; 1.
 PROSITE; PS00249; PDGF_1; 1.
 PROSITE; PS50278; PDGF_2; 1.
 3: Inferred from homology;
 Complete proteome {ECO:0000313|Proteomes:UP000009130};
 Growth factor {ECO:0000256|RuleBase:RU003818,
 ECO:0000256|SAAS:SAAS00725099};
 Reference proteome {ECO:0000313|Proteomes:UP000009130};
 Signal {ECO:0000256|SAM:SignalP}.
 SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
 CHAIN        19    224       {ECO:0000256|SAM:SignalP}.
                              /FTId=PRO_5003501867.
 DOMAIN       31    127       PDGF_2. {ECO:0000259|PROSITE:PS50278}.
 NON_TER       1      1       {ECO:0000313|EMBL:EHH53069.1}.
 NON_TER     224    224       {ECO:0000313|EMBL:EHH53069.1}.
 SEQUENCE   224 AA;  26147 MW;  255CDFBE1D793333 CRC64;
 HFWFTLLVYL HPDKWSQAAP MAEGGGQNHH EVVKFMDVYQ RSYCHPIETL VDIFQEYPDE
 IEYIFKPSCV PLMRCGGCCN DEGLECVPTE ESNITMQIMR IKPHQGQHIG EMSFLQHNKC
 ECRPKKDRAR QEKKSVRGKG KGQKRKRKKS RYKSWSVYVG ARCCLIPWSL PGPHPCGPCS
 ERRKHLFVQD PQTCKCSCKN TDSRCKARQL ELNERTCRCD KPRR

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