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Uncharacterized protein (Fragment)
G7P401_MACFA Unreviewed; 224 AA.
G7P401;
25-JAN-2012, integrated into UniProtKB/TrEMBL.
25-JAN-2012, sequence version 1.
28-MAR-2018, entry version 30.
SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH53069.1};
Flags: Fragment;
ORFNames=EGM_13630 {ECO:0000313|EMBL:EHH53069.1};
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
[1] {ECO:0000313|EMBL:EHH53069.1, ECO:0000313|Proteomes:UP000009130}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CE-4 {ECO:0000313|EMBL:EHH53069.1};
PubMed=22002653; DOI=10.1038/nbt.1992;
Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
Wang X., Wang J.;
"Genome sequencing and comparison of two nonhuman primate animal
models, the cynomolgus and Chinese rhesus macaques.";
Nat. Biotechnol. 29:1019-1023(2011).
-!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
{ECO:0000256|RuleBase:RU003818, ECO:0000256|SAAS:SAAS00725102}.
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EMBL; CM001279; EHH53069.1; -; Genomic_DNA.
Proteomes; UP000009130; Chromosome 4.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0016020; C:membrane; IEA:InterPro.
GO; GO:0030141; C:secretory granule; ISS:UniProtKB.
GO; GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO; GO:0001968; F:fibronectin binding; ISS:UniProtKB.
GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0005161; F:platelet-derived growth factor receptor binding; ISS:UniProtKB.
GO; GO:0048018; F:receptor ligand activity; ISS:UniProtKB.
GO; GO:0043183; F:vascular endothelial growth factor receptor 1 binding; ISS:UniProtKB.
GO; GO:0043184; F:vascular endothelial growth factor receptor 2 binding; ISS:UniProtKB.
GO; GO:0005172; F:vascular endothelial growth factor receptor binding; ISS:UniProtKB.
GO; GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.
GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.
GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; ISS:UniProtKB.
GO; GO:0035767; P:endothelial cell chemotaxis; ISS:UniProtKB.
GO; GO:0030225; P:macrophage differentiation; ISS:UniProtKB.
GO; GO:0030224; P:monocyte differentiation; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISS:UniProtKB.
GO; GO:0045785; P:positive regulation of cell adhesion; ISS:UniProtKB.
GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0051272; P:positive regulation of cellular component movement; ISS:UniProtKB.
GO; GO:0032793; P:positive regulation of CREB transcription factor activity; ISS:UniProtKB.
GO; GO:0038033; P:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; ISS:BHF-UCL.
GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
GO; GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO; GO:1900086; P:positive regulation of peptidyl-tyrosine autophosphorylation; ISS:UniProtKB.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
GO; GO:0050927; P:positive regulation of positive chemotaxis; ISS:UniProtKB.
GO; GO:0031954; P:positive regulation of protein autophosphorylation; ISS:UniProtKB.
GO; GO:0090037; P:positive regulation of protein kinase C signaling; ISS:UniProtKB.
GO; GO:1903572; P:positive regulation of protein kinase D signaling; ISS:BHF-UCL.
GO; GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.
CDD; cd00135; PDGF; 1.
Gene3D; 2.10.160.10; -; 1.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR023581; PD_growth_factor_CS.
InterPro; IPR000072; PDGF/VEGF_dom.
InterPro; IPR027928; VEGF_C.
InterPro; IPR036841; VEGF_C_sf.
Pfam; PF00341; PDGF; 1.
Pfam; PF14554; VEGF_C; 1.
SMART; SM00141; PDGF; 1.
SUPFAM; SSF57501; SSF57501; 1.
SUPFAM; SSF57593; SSF57593; 1.
PROSITE; PS00249; PDGF_1; 1.
PROSITE; PS50278; PDGF_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000009130};
Growth factor {ECO:0000256|RuleBase:RU003818,
ECO:0000256|SAAS:SAAS00725099};
Reference proteome {ECO:0000313|Proteomes:UP000009130};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 18 {ECO:0000256|SAM:SignalP}.
CHAIN 19 224 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003501867.
DOMAIN 31 127 PDGF_2. {ECO:0000259|PROSITE:PS50278}.
NON_TER 1 1 {ECO:0000313|EMBL:EHH53069.1}.
NON_TER 224 224 {ECO:0000313|EMBL:EHH53069.1}.
SEQUENCE 224 AA; 26147 MW; 255CDFBE1D793333 CRC64;
HFWFTLLVYL HPDKWSQAAP MAEGGGQNHH EVVKFMDVYQ RSYCHPIETL VDIFQEYPDE
IEYIFKPSCV PLMRCGGCCN DEGLECVPTE ESNITMQIMR IKPHQGQHIG EMSFLQHNKC
ECRPKKDRAR QEKKSVRGKG KGQKRKRKKS RYKSWSVYVG ARCCLIPWSL PGPHPCGPCS
ERRKHLFVQD PQTCKCSCKN TDSRCKARQL ELNERTCRCD KPRR
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Pathways :
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining
WP1678: Nucleotide excision repair
Related Genes :
[C2orf71] Uncharacterized protein C2orf71
[C1orf94] Uncharacterized protein C1orf94
[C1orf109] Uncharacterized protein C1orf109
[SPAC17H9.02] Uncharacterized helicase C17H9.02 (EC 3.6.4.-)
[1070] Uncharacterized protein 1070
[SPBC902.06] Uncharacterized protein C902.06
[IRC20 YLR247C] Uncharacterized ATP-dependent helicase IRC20 (EC 3.6.1.-) (Increased recombination centers protein 20)
[Stg] Uncharacterized protein C6orf15 homolog (Extracellular matrix protein with prion homology) (Emprin) (Protein STG)
[C19orf57] Uncharacterized protein C19orf57 (Pre-T/NK cell-associated protein 3B3)
[T27F2.1] Uncharacterized protein T27F2.1
[yvgJ BSU33360] Lipoteichoic acid synthase-like YvgJ [Cleaved into: Uncharacterized protein YvgJ; Processed uncharacterized protein YvgJ]
[yqgS BSU24840] Lipoteichoic acid synthase-like YqgS [Cleaved into: Uncharacterized protein YqgS; Processed uncharacterized protein YqgS]
[CTDNEP1 DULLARD] CTD nuclear envelope phosphatase 1 (EC 3.1.3.16) (Serine/threonine-protein phosphatase dullard)
[CDYL CDYL1] Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-)
[CHMP3 CGI149 NEDF VPS24 CGI-149] Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Neuroendocrine differentiation factor) (Vacuolar protein sorting-associated protein 24) (hVps24)
[CHMP2A BC2 CHMP2] Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1)
[Cdyl] Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) (Putative histone acetyltransferase Cdyl) (EC 2.3.1.48)
[DCUN1D3 SCCRO3] DCN1-like protein 3 (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3)
[CYP38 At3g01480 F4P13.3] Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic (PPIase CYP38) (EC 5.2.1.8) (Rotamase CYP38) (Thylakoid lumen PPIase)
[CTDSPL C3orf8 NIF1 NIFL SCP3 YA22] CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3) (NIF-like protein) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Protein YA22) (hYA22) (RBSP3) (Small C-terminal domain phosphatase 3) (SCP3) (Small CTD phosphatase 3)
[gss gsp b2988 JW2956] Bifunctional glutathionylspermidine synthetase/amidase (GspSA) [Includes: Glutathionylspermidine amidase (Gsp amidase) (EC 3.5.1.78) (Glutathionylspermidine amidohydrolase [spermidine-forming]); Glutathionylspermidine synthetase (Gsp synthetase) (EC 6.3.1.8) (Glutathione:spermidine ligase [ADP-forming]) (Gsp synthase)]
[KCNB1] Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1)
[RABGAP1L HHL KIAA0471] Rab GTPase-activating protein 1-like
[RQC2 TAE2 YPL009C YP8132.04C] Ribosome quality control complex subunit 2 (Translation-associated element 2)
[PA0743] NAD-dependent L-serine dehydrogenase (EC 1.1.1.387) (L-serine 3-dehydrogenase (NAD(+)))
[RBG1 FUN11 YAL036C] Ribosome-interacting GTPase 1 (GTP-binding protein RBG1) (Genetically interacts with ribosomal genes protein 1)
[rsgA engC yjeQ b4161 JW4122] Small ribosomal subunit biogenesis GTPase RsgA (EC 3.6.1.-)
[Slc27a4 Acsvl4 Fatp4] Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4)
[HLA-A HLAA] HLA class I histocompatibility antigen, A-29 alpha chain (Aw-19) (MHC class I antigen A*29)
[HLA-A HLAA] HLA class I histocompatibility antigen, A-31 alpha chain (MHC class I antigen A*31)
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