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Universal stress protein A

 USPA_ECOLI              Reviewed;         144 AA.
P0AED0; P28242; Q2M7F7;
06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
25-APR-2018, entry version 98.
RecName: Full=Universal stress protein A;
Name=uspA; OrderedLocusNames=b3495, JW3462;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-15.
STRAIN=K12;
PubMed=1453957; DOI=10.1111/j.1365-2958.1992.tb01774.x;
Nystroem T., Neidhardt F.C.;
"Cloning, mapping and nucleotide sequencing of a gene encoding a
universal stress protein in Escherichia coli.";
Mol. Microbiol. 6:3187-3198(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=8041620; DOI=10.1093/nar/22.13.2576;
Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
"Analysis of the Escherichia coli genome. V. DNA sequence of the
region from 76.0 to 81.5 minutes.";
Nucleic Acids Res. 22:2576-2586(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[5]
PROTEIN SEQUENCE OF 2-19.
PubMed=8506346; DOI=10.1073/pnas.90.11.5011;
Henzel W.J., Billeci T.M., Stults J.T., Wong S.C., Grimley C.,
Watanabe C.;
"Identifying proteins from two-dimensional gels by molecular mass
searching of peptide fragments in protein sequence databases.";
Proc. Natl. Acad. Sci. U.S.A. 90:5011-5015(1993).
[6]
PROTEIN SEQUENCE OF 2-13.
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
Pasquali C., Sanchez J.-C., Ravier F., Golaz O., Hughes G.J.,
Frutiger S., Paquet N., Wilkins M., Appel R.D., Bairoch A.,
Hochstrasser D.F.;
Submitted (SEP-1994) to UniProtKB.
[7]
PROTEIN SEQUENCE OF 2-13.
STRAIN=K12 / EMG2;
PubMed=9298646; DOI=10.1002/elps.1150180807;
Link A.J., Robison K., Church G.M.;
"Comparing the predicted and observed properties of proteins encoded
in the genome of Escherichia coli K-12.";
Electrophoresis 18:1259-1313(1997).
[8]
IDENTIFICATION BY 2D-GEL.
PubMed=9298644; DOI=10.1002/elps.1150180805;
VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R.,
Neidhardt F.C.;
"Escherichia coli proteome analysis using the gene-protein database.";
Electrophoresis 18:1243-1251(1997).
[9]
PHOSPHORYLATION.
PubMed=9405142; DOI=10.1006/jmbi.1997.1397;
Freestone P., Nystroem T., Trinei M., Norris V.;
"The universal stress protein, UspA, of Escherichia coli is
phosphorylated in response to stasis.";
J. Mol. Biol. 274:318-324(1997).
[10]
REGULATION BY FADR.
STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
PubMed=8932299; DOI=10.1128/jb.178.22.6443-6450.1996;
Farewell A., Diez A.A., DiRusso C.C., Nystroem T.;
"Role of the Escherichia coli FadR regulator in stasis survival and
growth phase-dependent expression of the uspA, fad, and fab genes.";
J. Bacteriol. 178:6443-6450(1996).
[11]
REGULATION BY PPGPP AND FADR.
STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
PubMed=10652104; DOI=10.1046/j.1365-2958.2000.01714.x;
Kvint K., Hosbond C., Farewell A., Nybroe O., Nystroem T.;
"Emergency derepression: stringency allows RNA polymerase to override
negative control by an active repressor.";
Mol. Microbiol. 35:435-443(2000).
[12]
REGULATION BY RECA/FTSK.
STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
PubMed=10931298; DOI=10.1046/j.1365-2958.2000.01979.x;
Diez A., Gustavsson N., Nystroem T.;
"The universal stress protein A of Escherichia coli is required for
resistance to DNA damaging agents and is regulated by a RecA/FtsK-
dependent regulatory pathway.";
Mol. Microbiol. 36:1494-1503(2000).
[13]
REGULATION BY CSPC AND CSPE.
STRAIN=K12 / ATCC 35607 / JM83;
PubMed=11157932; DOI=10.1128/JB.183.4.1205-1214.2001;
Phadtare S., Inouye M.;
"Role of CspC and CspE in regulation of expression of RpoS and UspA,
the stress response proteins in Escherichia coli.";
J. Bacteriol. 183:1205-1214(2001).
-!- FUNCTION: Required for resistance to DNA-damaging agents.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- INTERACTION:
Self; NbExp=2; IntAct=EBI-552843, EBI-552843;
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- INDUCTION: During growth inhibition caused by the exhaustion of
any of a variety of nutrients (carbon, nitrogen, phosphate,
sulfate, required amino acid) or by the presence of a variety of
toxic agents. Positively regulated by guanosine 3',5'-bisphosphate
(ppGpp) and by a RecA/FtsK-dependent regulatory pathway.
Negatively regulated by FadR. Also regulated by CspC and CspE.
-!- PTM: Phosphorylated on serine or threonine in response to stasis.
{ECO:0000269|PubMed:9405142}.
-!- SIMILARITY: Belongs to the universal stress protein A family.
{ECO:0000305}.
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EMBL; X67639; CAA47884.1; -; Genomic_DNA.
EMBL; U00039; AAB18471.1; -; Genomic_DNA.
EMBL; U00096; AAC76520.1; -; Genomic_DNA.
EMBL; AP009048; BAE77799.1; -; Genomic_DNA.
PIR; S47715; S47715.
RefSeq; NP_417952.1; NC_000913.3.
RefSeq; WP_000323571.1; NZ_LN832404.1.
ProteinModelPortal; P0AED0; -.
SMR; P0AED0; -.
BioGrid; 4262517; 6.
DIP; DIP-36230N; -.
IntAct; P0AED0; 9.
STRING; 316385.ECDH10B_3671; -.
SWISS-2DPAGE; P0AED0; -.
EPD; P0AED0; -.
PaxDb; P0AED0; -.
PRIDE; P0AED0; -.
EnsemblBacteria; AAC76520; AAC76520; b3495.
EnsemblBacteria; BAE77799; BAE77799; BAE77799.
GeneID; 948007; -.
KEGG; ecj:JW3462; -.
KEGG; eco:b3495; -.
PATRIC; fig|511145.12.peg.3597; -.
EchoBASE; EB1363; -.
EcoGene; EG11390; uspA.
eggNOG; COG0589; LUCA.
HOGENOM; HOG000238899; -.
InParanoid; P0AED0; -.
KO; K06149; -.
OMA; QVMNSIT; -.
PhylomeDB; P0AED0; -.
BioCyc; EcoCyc:EG11390-MONOMER; -.
PRO; PR:P0AED0; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0006950; P:response to stress; IEA:InterPro.
Gene3D; 3.40.50.620; -; 1.
InterPro; IPR014729; Rossmann-like_a/b/a_fold.
InterPro; IPR006015; Universal_stress_UspA.
InterPro; IPR006016; UspA.
Pfam; PF00582; Usp; 1.
PIRSF; PIRSF006276; UspA; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Direct protein sequencing;
Phosphoprotein; Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:1453957,
ECO:0000269|PubMed:8506346,
ECO:0000269|PubMed:9298646,
ECO:0000269|Ref.6}.
CHAIN 2 144 Universal stress protein A.
/FTId=PRO_0000147396.
CONFLICT 140 140 R -> A (in Ref. 1; CAA47884).
{ECO:0000305}.
SEQUENCE 144 AA; 16066 MW; EE3BF2141E44D826 CRC64;
MAYKHILIAV DLSPESKVLV EKAVSMARPY NAKVSLIHVD VNYSDLYTGL IDVNLGDMQK
RISEETHHAL TELSTNAGYP ITETLSGSGD LGQVLVDAIK KYDMDLVVCG HHQDFWSKLM
SSARQLINTV HVDMLIVPLR DEEE


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