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Uricase (EC 1.7.3.3) (Urate oxidase)

 C1BR88_CALRO            Unreviewed;       300 AA.
C1BR88;
26-MAY-2009, integrated into UniProtKB/TrEMBL.
26-MAY-2009, sequence version 1.
27-SEP-2017, entry version 32.
RecName: Full=Uricase {ECO:0000256|PIRNR:PIRNR000241, ECO:0000256|RuleBase:RU004455};
EC=1.7.3.3 {ECO:0000256|PIRNR:PIRNR000241, ECO:0000256|RuleBase:RU004455};
AltName: Full=Urate oxidase {ECO:0000256|PIRNR:PIRNR000241};
Name=URIC {ECO:0000313|EMBL:ACO11541.1};
Caligus rogercresseyi (Sea louse).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Maxillopoda;
Copepoda; Siphonostomatoida; Caligidae; Caligus.
NCBI_TaxID=217165 {ECO:0000313|EMBL:ACO11541.1};
[1] {ECO:0000313|EMBL:ACO11541.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Whole tissue {ECO:0000313|EMBL:ACO11541.1};
Yasuike M., von Schalburg K., Cooper G., Leong J., Jones S.R.M.,
Koop B.F.;
"Caligus rogercresseyi ESTs and full-length cDNAs.";
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the oxidation of uric acid to 5-
hydroxyisourate, which is further processed to form (S)-allantoin.
{ECO:0000256|PIRNR:PIRNR000241, ECO:0000256|RuleBase:RU004455}.
-!- CATALYTIC ACTIVITY: Urate + O(2) + H(2)O = 5-hydroxyisourate +
H(2)O(2). {ECO:0000256|PIRNR:PIRNR000241,
ECO:0000256|RuleBase:RU004455}.
-!- PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from
urate: step 1/3. {ECO:0000256|PIRNR:PIRNR000241}.
-!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|PIRNR:PIRNR000241}.
-!- SIMILARITY: Belongs to the uricase family.
{ECO:0000256|PIRNR:PIRNR000241, ECO:0000256|RuleBase:RU004455}.
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EMBL; BT077117; ACO11541.1; -; mRNA.
UniPathway; UPA00394; UER00650.
GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
GO; GO:0004846; F:urate oxidase activity; IEA:UniProtKB-EC.
GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
InterPro; IPR002042; Uricase.
Pfam; PF01014; Uricase; 2.
PIRSF; PIRSF000241; Urate_oxidase; 1.
PRINTS; PR00093; URICASE.
TIGRFAMs; TIGR03383; urate_oxi; 1.
2: Evidence at transcript level;
Oxidoreductase {ECO:0000256|PIRNR:PIRNR000241,
ECO:0000256|RuleBase:RU004455};
Peroxisome {ECO:0000256|PIRNR:PIRNR000241};
Purine metabolism {ECO:0000256|PIRNR:PIRNR000241,
ECO:0000256|RuleBase:RU004455}.
REGION 60 61 Substrate binding.
{ECO:0000256|PIRSR:PIRSR000241-2}.
REGION 230 231 Substrate binding.
{ECO:0000256|PIRSR:PIRSR000241-2}.
ACT_SITE 15 15 Charge relay system.
{ECO:0000256|PIRSR:PIRSR000241-1}.
ACT_SITE 60 60 Charge relay system.
{ECO:0000256|PIRSR:PIRSR000241-1}.
ACT_SITE 259 259 Charge relay system.
{ECO:0000256|PIRSR:PIRSR000241-1}.
BINDING 162 162 Substrate.
{ECO:0000256|PIRSR:PIRSR000241-2}.
BINDING 179 179 Substrate.
{ECO:0000256|PIRSR:PIRSR000241-2}.
SEQUENCE 300 AA; 33944 MW; CD9E26CB6C4144D8 CRC64;
MSKESFKILE RRYGKSFVKL FHVERRGDIH TAREYEVNTF LTLAREIDYI EGNNEDVIAT
DSQKNTVYLL AKQHGVESPE SFASVIVSHF LKKYPGNVVK ATAEVEECVV WKRMQGSHAH
AFNADTSAIH FCKVTQSAGE KDQQISGGLK NYRILKTTKS SFVNFLDDEY RSLPSMDDRI
FSTVVESEWE YKSGSPMSPR QYHEVFQKII NLIDEGFSGD PKEGIASPSV QQTMYLCQCS
ILSDIPSISK ISMKMPNKHY FSINLSKFKE FVGGTSDNND VFLPVDKPSG IIECTIGRDS


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