Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Uridylate kinase (UK) (EC 2.7.4.22) (Uridine monophosphate kinase) (UMP kinase) (UMPK)

 PYRH_NEIMB              Reviewed;         239 AA.
P65932; Q9JQT5;
11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
11-OCT-2004, sequence version 1.
25-OCT-2017, entry version 85.
RecName: Full=Uridylate kinase;
Short=UK;
EC=2.7.4.22;
AltName: Full=Uridine monophosphate kinase;
Short=UMP kinase;
Short=UMPK;
Name=pyrH; OrderedLocusNames=NMB2103;
Neisseria meningitidis serogroup B (strain MC58).
Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
Neisseriaceae; Neisseria.
NCBI_TaxID=122586;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MC58;
PubMed=10710307; DOI=10.1126/science.287.5459.1809;
Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C.,
Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F.,
Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D.,
Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D.,
Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E.,
Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M.,
Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M.,
Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R.,
Venter J.C.;
"Complete genome sequence of Neisseria meningitidis serogroup B strain
MC58.";
Science 287:1809-1815(2000).
[2]
FUNCTION, ENZYME REGULATION, KINETIC PARAMETERS, IDENTIFICATION BY
MASS SPECTROMETRY, AND SUBUNIT.
PubMed=17210578; DOI=10.1074/jbc.M606963200;
Evrin C., Straut M., Slavova-Azmanova N., Bucurenci N., Onu A.,
Assairi L., Ionescu M., Palibroda N., Barzu O., Gilles A.-M.;
"Regulatory mechanisms differ in UMP kinases from Gram-negative and
Gram-positive bacteria.";
J. Biol. Chem. 282:7242-7253(2007).
[3]
X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
New York structural genomics research consortium (NYSGRC);
"Crystal structure analysis of uridylate kinase from Neisseria
meningitidis.";
Submitted (FEB-2005) to the PDB data bank.
-!- FUNCTION: Catalyzes the reversible phosphorylation of UMP to UDP.
{ECO:0000269|PubMed:17210578}.
-!- CATALYTIC ACTIVITY: ATP + UMP = ADP + UDP.
-!- ENZYME REGULATION: Allosterically activated by GTP. Inhibited by
UTP. {ECO:0000269|PubMed:17210578}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=2.98 mM for ATP (in the absence of GTP)
{ECO:0000269|PubMed:17210578};
KM=0.83 mM for ATP (in the presence of GTP)
{ECO:0000269|PubMed:17210578};
KM=8.7 uM for UMP {ECO:0000269|PubMed:17210578};
Vmax=35 umol/min/mg enzyme (in the absence of GTP)
{ECO:0000269|PubMed:17210578};
Vmax=66 umol/min/mg enzyme (in the presence of GTP)
{ECO:0000269|PubMed:17210578};
-!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo
pathway; UDP from UMP (UMPK route): step 1/1.
-!- SUBUNIT: Homohexamer. {ECO:0000269|PubMed:17210578}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the UMP kinase family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AE002098; AAF42420.1; -; Genomic_DNA.
PIR; H81006; H81006.
RefSeq; NP_275091.1; NC_003112.2.
RefSeq; WP_002215090.1; NC_003112.2.
PDB; 1YBD; X-ray; 2.60 A; A/B/C=1-239.
PDBsum; 1YBD; -.
ProteinModelPortal; P65932; -.
SMR; P65932; -.
STRING; 122586.NMB2103; -.
PaxDb; P65932; -.
DNASU; 903933; -.
EnsemblBacteria; AAF42420; AAF42420; NMB2103.
GeneID; 903933; -.
KEGG; nme:NMB2103; -.
PATRIC; fig|122586.8.peg.2685; -.
eggNOG; ENOG4105C41; Bacteria.
eggNOG; COG0528; LUCA.
HOGENOM; HOG000047187; -.
KO; K09903; -.
OMA; PIIVFDM; -.
OrthoDB; POG091H02JZ; -.
BRENDA; 2.7.4.22; 3593.
SABIO-RK; P65932; -.
UniPathway; UPA00159; UER00275.
EvolutionaryTrace; P65932; -.
Proteomes; UP000000425; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0033862; F:UMP kinase activity; IEA:UniProtKB-EC.
GO; GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
Gene3D; 3.40.1160.10; -; 1.
HAMAP; MF_01220_B; PyrH_B; 1.
InterPro; IPR036393; AceGlu_kinase-like_sf.
InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
InterPro; IPR011817; Uridylate_kinase.
InterPro; IPR015963; Uridylate_kinase_bac.
Pfam; PF00696; AA_kinase; 1.
PIRSF; PIRSF005650; Uridylate_kin; 1.
SUPFAM; SSF53633; SSF53633; 1.
TIGRFAMs; TIGR02075; pyrH_bact; 1.
1: Evidence at protein level;
3D-structure; Allosteric enzyme; ATP-binding; Complete proteome;
Cytoplasm; Kinase; Nucleotide-binding; Pyrimidine biosynthesis;
Reference proteome; Transferase.
CHAIN 1 239 Uridylate kinase.
/FTId=PRO_0000143866.
NP_BIND 13 16 ATP. {ECO:0000250}.
NP_BIND 136 143 UMP. {ECO:0000250}.
BINDING 55 55 UMP; via amide nitrogen. {ECO:0000250}.
BINDING 56 56 ATP; via amide nitrogen. {ECO:0000250}.
BINDING 60 60 ATP. {ECO:0000250}.
BINDING 75 75 UMP. {ECO:0000250}.
BINDING 163 163 ATP. {ECO:0000250}.
BINDING 164 164 ATP. {ECO:0000250}.
BINDING 169 169 ATP; via amide nitrogen and carbonyl
oxygen. {ECO:0000250}.
BINDING 172 172 ATP. {ECO:0000250}.
STRAND 8 14 {ECO:0000244|PDB:1YBD}.
HELIX 16 20 {ECO:0000244|PDB:1YBD}.
STRAND 23 26 {ECO:0000244|PDB:1YBD}.
HELIX 29 44 {ECO:0000244|PDB:1YBD}.
STRAND 48 53 {ECO:0000244|PDB:1YBD}.
HELIX 56 66 {ECO:0000244|PDB:1YBD}.
HELIX 71 95 {ECO:0000244|PDB:1YBD}.
STRAND 100 106 {ECO:0000244|PDB:1YBD}.
STRAND 108 111 {ECO:0000244|PDB:1YBD}.
HELIX 117 125 {ECO:0000244|PDB:1YBD}.
STRAND 129 134 {ECO:0000244|PDB:1YBD}.
HELIX 143 153 {ECO:0000244|PDB:1YBD}.
STRAND 157 162 {ECO:0000244|PDB:1YBD}.
STRAND 164 167 {ECO:0000244|PDB:1YBD}.
STRAND 169 171 {ECO:0000244|PDB:1YBD}.
HELIX 173 175 {ECO:0000244|PDB:1YBD}.
STRAND 183 186 {ECO:0000244|PDB:1YBD}.
HELIX 187 192 {ECO:0000244|PDB:1YBD}.
HELIX 200 208 {ECO:0000244|PDB:1YBD}.
STRAND 213 216 {ECO:0000244|PDB:1YBD}.
HELIX 223 229 {ECO:0000244|PDB:1YBD}.
STRAND 234 238 {ECO:0000244|PDB:1YBD}.
SEQUENCE 239 AA; 25700 MW; CB08FD7E1AFBC5FE CRC64;
MTQQIKYKRV LLKLSGESLM GSDPFGINHD TIVQTVGEIA EVVKMGVQVG IVVGGGNIFR
GVSAQAGSMD RATADYMGMM ATVMNALALK DAFETLGIKA RVQSALSMQQ IAETYARPKA
IQYLEEGKVV IFAAGTGNPF FTTDTAAALR GAEMNCDVML KATNVDGVYT ADPKKDPSAT
RYETITFDEA LLKNLKVMDA TAFALCRERK LNIVVFGIAK EGSLKRVITG EDEGTLVHC


Related products :

Catalog number Product name Quantity
EIAAB24783 GCK family kinase MiNK,Map4k6,MAPK_ERK kinase kinase kinase 6,MEK kinase kinase 6,MEKKK 6,Mink,Mink1,Misshapen_NIK-related kinase,Misshapen-like kinase 1,Mitogen-activated protein kinase kinase kinase
EIAAB24784 GCK family kinase MiNK,Map4k6,MAPK_ERK kinase kinase kinase 6,MEK kinase kinase 6,MEKKK 6,Mink,Mink1,Misshapen_NIK-related kinase,Misshapen-like kinase 1,Mitogen-activated protein kinase kinase kinase
EIAAB25244 c-Jun N-terminal kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 7,JNK kinase 2,JNK-activating kinase 2,JNKK 2,MAP kinase kinase 7,Map2k7,MAPK_ERK kinase 7,MAPKK 7,MEK 7,Mkk7,
EIAAB25239 C-JUN N-terminal kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 4,JNK kinase 1,JNK-activating kinase 1,JNKK 1,Jnkk1,MAP kinase kinase 4,Map2k4,MAPK_ERK kinase 4,MAPKK 4,MEK 4
EIAAB25245 c-Jun N-terminal kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 7,JNK kinase 2,JNK-activating kinase 2,JNKK 2,MAP kinase kinase 7,Map2k7,MAPK_ERK kinase 7,MAPKK 7,MEK 7,Rat,R
EIAAB45174 Cytidine monophosphokinase 2,Homo sapiens,Human,Testis-specific protein TSA903,UCK 2,UCK2,UMPK,Uridine monophosphokinase 2,Uridine-cytidine kinase 2
EIAAB25246 c-Jun N-terminal kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 7,Homo sapiens,Human,JNK kinase 2,JNK-activating kinase 2,JNKK 2,JNKK2,MAP kinase kinase 7,MAP2K7,MAPK_ERK kin
EIAAB25240 c-Jun N-terminal kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 4,Homo sapiens,Human,JNK-activating kinase 1,JNKK,JNKK1,MAP kinase kinase 4,MAP2K4,MAPK_ERK kinase 4,MAPKK 4,M
EIAAB45175 Cytidine monophosphokinase 2,Mouse,Mus musculus,UCK 2,Uck2,Umpk,Uridine monophosphokinase 2,Uridine-cytidine kinase 2
EIAAB45171 Cytidine monophosphokinase 1,Mouse,Mus musculus,UCK 1,Uck1,Umpk,Uridine monophosphokinase 1,Uridine-cytidine kinase 1
E1358m ELISA kit Apoptosis signal-regulating kinase 1,Ask1,ASK-1,Map3k5,MAPK_ERK kinase kinase 5,MEK kinase 5,MEKK 5,Mekk5,Mitogen-activated protein kinase kinase kinase 5,Mouse,Mus musculus 96T
U1358m CLIA Apoptosis signal-regulating kinase 1,Ask1,ASK-1,Map3k5,MAPK_ERK kinase kinase 5,MEK kinase 5,MEKK 5,Mekk5,Mitogen-activated protein kinase kinase kinase 5,Mouse,Mus musculus 96T
E1358m ELISA Apoptosis signal-regulating kinase 1,Ask1,ASK-1,Map3k5,MAPK_ERK kinase kinase 5,MEK kinase 5,MEKK 5,Mekk5,Mitogen-activated protein kinase kinase kinase 5,Mouse,Mus musculus 96T
EIAAB24782 B55,GCK family kinase MiNK,Homo sapiens,Human,MAP4K6,MAPK_ERK kinase kinase kinase 6,MEK kinase kinase 6,MEKKK 6,MINK,MINK1,Misshapen_NIK-related kinase,Misshapen-like kinase 1,Mitogen-activated prote
E1358h ELISA kit Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
E1358h ELISA Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
U1358h CLIA Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
18-662-20092 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
18-662-20091 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
18-662-20090 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
15-288-21068 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.05 mg
15-288-21068 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 mg
18-785-210403 SEK1_MKK4 (Phospho-Thr261) - EC 2.7.12.2; MAP kinase kinase 4; JNK-activating kinase 1; c-Jun N-terminal kinase kinase 1; JNKK; SAPK_ERK kinase 1; SEK1 Polyclonal 0.1 mg
18-785-210404 SEK1_MKK4 (Phospho-Ser80) - EC 2.7.12.2; MAP kinase kinase 4; JNK-activating kinase 1; c-Jun N-terminal kinase kinase 1; JNKK; SAPK_ERK kinase 1; SEK1 Polyclonal 0.1 mg
18-785-210404 SEK1_MKK4 (Phospho-Ser80) - EC 2.7.12.2; MAP kinase kinase 4; JNK-activating kinase 1; c-Jun N-terminal kinase kinase 1; JNKK; SAPK_ERK kinase 1; SEK1 Polyclonal 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur