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 UCN1_MOUSE              Reviewed;         122 AA.
P81615; O88390; Q14A76;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
01-JAN-1999, sequence version 1.
20-JUN-2018, entry version 117.
RecName: Full=Urocortin;
Flags: Precursor;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
PubMed=9628819; DOI=10.1006/geno.1998.5292;
Zhao L., Donaldson C.J., Smith G.W., Vale W.W.;
"The structures of the mouse and human urocortin genes (Ucn and
Genomics 50:23-33(1998).
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
PubMed=10690896; DOI=10.1210/jcem.85.2.6381;
Slominski A., Roloff B., Curry J., Dahiya M., Szczesniewski A.,
Wortsman J.;
"The skin produces urocortin.";
J. Clin. Endocrinol. Metab. 85:815-823(2000).
Vetter D.E., Li C., Zhao L., Contarino A., Liberman M.C., Smith G.W.,
Marchuk Y., Koob G.F., Heinemann S.F., Vale W., Lee K.F.;
"Urocortin-deficient mice show hearing impairment and increased
anxiety-like behavior.";
Nat. Genet. 31:363-369(2002).
-!- FUNCTION: Acts in vitro to stimulate the secretion of
adrenocorticotropic hormone (ACTH) (By similarity). Binds with
high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By
similarity). Plays a role in the establishment of normal hearing
thresholds (PubMed:12091910). Reduces food intake and regulates
ghrelin levels in gastric body and plasma (By similarity).
{ECO:0000250|UniProtKB:P55089, ECO:0000250|UniProtKB:P55090,
-!- SUBUNIT: Interacts with CRHR1 and CRHR2 (via their N-terminal
extracellular domain). {ECO:0000250}.
-!- TISSUE SPECIFICITY: In the organ of Corti, detected in the inner
hair cell region (at protein level) (PubMed:12091910). Expressed
in skin (at protein level) (PubMed:10690896).
{ECO:0000269|PubMed:10690896, ECO:0000269|PubMed:12091910}.
-!- DEVELOPMENTAL STAGE: In skin, levels decrease gradually from the
telogen (resting) phase of the hair follicle with lowest levels
observed in late anagen IV phase of active growth (at protein
level). {ECO:0000269|PubMed:10690896}.
-!- DISRUPTION PHENOTYPE: Increased anxiety-like behavior, reduced
Crhr2 mRNA levels in the lateral septum, normal basal feeding
behavior, and hearing impairment at the level of the inner ear
with shorter outer hair cells, higher threshold for auditory
stimuli and higher distortion product otoacoustic emissions.
-!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
factor/urotensin I family. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AF038632; AAC24202.1; -; Genomic_DNA.
EMBL; CH466524; EDL37339.1; -; Genomic_DNA.
EMBL; BC116948; AAI16949.1; -; mRNA.
EMBL; BC116950; AAI16951.1; -; mRNA.
EMBL; BC144891; AAI44892.1; -; mRNA.
CCDS; CCDS19174.1; -.
RefSeq; NP_001332939.1; NM_001346010.1.
RefSeq; NP_067265.1; NM_021290.2.
UniGene; Mm.377116; -.
ProteinModelPortal; P81615; -.
SMR; P81615; -.
STRING; 10090.ENSMUSP00000035321; -.
PaxDb; P81615; -.
PRIDE; P81615; -.
Ensembl; ENSMUST00000043475; ENSMUSP00000035321; ENSMUSG00000038676.
Ensembl; ENSMUST00000201184; ENSMUSP00000144390; ENSMUSG00000038676.
GeneID; 22226; -.
KEGG; mmu:22226; -.
UCSC; uc008wxe.1; mouse.
CTD; 7349; -.
MGI; MGI:1276123; Ucn.
eggNOG; ENOG410J8KZ; Eukaryota.
eggNOG; ENOG410Y0J4; LUCA.
GeneTree; ENSGT00510000049284; -.
HOGENOM; HOG000121779; -.
HOVERGEN; HBG036241; -.
InParanoid; P81615; -.
OrthoDB; EOG091G15U8; -.
PhylomeDB; P81615; -.
TreeFam; TF332956; -.
Reactome; R-MMU-373080; Class B/2 (Secretin family receptors).
PRO; PR:P81615; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000038676; -.
CleanEx; MM_UCN; -.
Genevisible; P81615; MM.
GO; GO:0030424; C:axon; ISO:MGI.
GO; GO:0043679; C:axon terminus; ISO:MGI.
GO; GO:0030425; C:dendrite; ISO:MGI.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0043025; C:neuronal cell body; ISO:MGI.
GO; GO:0043204; C:perikaryon; ISO:MGI.
GO; GO:0043196; C:varicosity; ISO:MGI.
GO; GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; ISO:MGI.
GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; ISO:MGI.
GO; GO:0001664; F:G-protein coupled receptor binding; ISO:MGI.
GO; GO:0046811; F:histone deacetylase inhibitor activity; ISO:MGI.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0034199; P:activation of protein kinase A activity; ISO:MGI.
GO; GO:0009060; P:aerobic respiration; ISO:MGI.
GO; GO:0008306; P:associative learning; ISO:MGI.
GO; GO:0042756; P:drinking behavior; ISO:MGI.
GO; GO:0007631; P:feeding behavior; ISO:MGI.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0035483; P:gastric emptying; ISO:MGI.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0007611; P:learning or memory; ISO:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
GO; GO:0032099; P:negative regulation of appetite; ISO:MGI.
GO; GO:0045776; P:negative regulation of blood pressure; ISO:MGI.
GO; GO:0060548; P:negative regulation of cell death; ISO:MGI.
GO; GO:0045792; P:negative regulation of cell size; ISO:MGI.
GO; GO:2000252; P:negative regulation of feeding behavior; ISO:MGI.
GO; GO:0060455; P:negative regulation of gastric acid secretion; ISO:MGI.
GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
GO; GO:0046888; P:negative regulation of hormone secretion; ISO:MGI.
GO; GO:0060547; P:negative regulation of necrotic cell death; ISO:MGI.
GO; GO:1901215; P:negative regulation of neuron death; ISO:MGI.
GO; GO:0031175; P:neuron projection development; ISO:MGI.
GO; GO:0007218; P:neuropeptide signaling pathway; ISO:MGI.
GO; GO:0030157; P:pancreatic juice secretion; ISO:MGI.
GO; GO:2000987; P:positive regulation of behavioral fear response; ISO:MGI.
GO; GO:0097755; P:positive regulation of blood vessel diameter; ISO:MGI.
GO; GO:0090280; P:positive regulation of calcium ion import; ISO:MGI.
GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISO:MGI.
GO; GO:0060452; P:positive regulation of cardiac muscle contraction; ISO:MGI.
GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISO:MGI.
GO; GO:0051461; P:positive regulation of corticotropin secretion; ISO:MGI.
GO; GO:0045740; P:positive regulation of DNA replication; ISO:MGI.
GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:MGI.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
GO; GO:0045727; P:positive regulation of translation; ISO:MGI.
GO; GO:0043117; P:positive regulation of vascular permeability; ISO:MGI.
GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISO:MGI.
GO; GO:0010996; P:response to auditory stimulus; IMP:UniProtKB.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO; GO:0006979; P:response to oxidative stress; ISO:MGI.
GO; GO:0048265; P:response to pain; IEA:Ensembl.
GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
GO; GO:0035176; P:social behavior; ISO:MGI.
GO; GO:0001964; P:startle response; IMP:UniProtKB.
InterPro; IPR018446; Corticotropin-releasing_fac_CS.
InterPro; IPR000187; CRF.
InterPro; IPR003620; Urocortin_CRF.
PANTHER; PTHR15035; PTHR15035; 1.
Pfam; PF00473; CRF; 1.
SMART; SM00039; CRF; 1.
PROSITE; PS00511; CRF; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hearing; Hormone; Reference proteome; Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 80 {ECO:0000250}.
PEPTIDE 81 120 Urocortin.
MOD_RES 120 120 Valine amide. {ECO:0000250}.
SEQUENCE 122 AA; 13558 MW; D2969756F36F5DEA CRC64;

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