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Urocortin (Corticotensin)

 UCN1_RAT                Reviewed;         122 AA.
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
05-DEC-2018, entry version 128.
RecName: Full=Urocortin;
AltName: Full=Corticotensin;
Flags: Precursor;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
PubMed=7477349; DOI=10.1038/378287a0;
Vaughan J.M., Donaldson C.J., Bittencourt J., Perrin M.H., Lewis K.A.,
Sutton S.W., Chan R., Turnbull A., Lovejoy D., Rivier C., Rivier J.E.,
Sawchenko P., Vale W.W.;
"Urocortin, a mammalian neuropeptide related to fish urotensin I and
to corticotropin-releasing factor.";
Nature 378:287-292(1995).
Park J.H., Lee Y.J., Kim K.L.;
"Detection of rat urocortin in lymphoid tissues: implications for the
functional assessment of urocortin as a novel neuro-immunomodulatory
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
PubMed=21540451; DOI=10.1152/ajpendo.00695.2010;
Yakabi K., Noguchi M., Ohno S., Ro S., Onouchi T., Ochiai M.,
Takabayashi H., Takayama K., Harada Y., Sadakane C., Hattori T.;
"Urocortin 1 reduces food intake and ghrelin secretion via CRF(2)
Am. J. Physiol. 301:E72-82(2011).
-!- FUNCTION: Acts in vitro to stimulate the secretion of
adrenocorticotropic hormone (ACTH) (PubMed:7477349). Binds with
high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By
similarity). Plays a role in the establishment of normal hearing
thresholds (By similarity). Reduces food intake and regulates
ghrelin levels in gastric body and plasma (PubMed:21540451).
{ECO:0000250|UniProtKB:P55089, ECO:0000250|UniProtKB:P81615,
ECO:0000269|PubMed:21540451, ECO:0000269|PubMed:7477349}.
-!- SUBUNIT: Interacts with CRHR1 and CRHR2 (via their N-terminal
extracellular domain). {ECO:0000250}.
P35353:Crhr1; NbExp=3; IntAct=EBI-9030248, EBI-9030306;
-!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
factor/urotensin I family. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; U33935; AAA87566.1; -; mRNA.
EMBL; AF093623; AAF63153.1; -; Genomic_DNA.
PIR; S60262; S60262.
RefSeq; NP_062023.1; NM_019150.1.
UniGene; Rn.10190; -.
ProteinModelPortal; P55090; -.
SMR; P55090; -.
BioGrid; 247834; 4.
IntAct; P55090; 1.
STRING; 10116.ENSRNOP00000008037; -.
PaxDb; P55090; -.
PRIDE; P55090; -.
Ensembl; ENSRNOT00000008037; ENSRNOP00000008037; ENSRNOG00000006090.
GeneID; 29151; -.
KEGG; rno:29151; -.
CTD; 7349; -.
RGD; 3929; Ucn.
eggNOG; ENOG410J8KZ; Eukaryota.
eggNOG; ENOG410Y0J4; LUCA.
GeneTree; ENSGT00940000154473; -.
HOGENOM; HOG000121779; -.
HOVERGEN; HBG036241; -.
InParanoid; P55090; -.
OrthoDB; EOG091G15U8; -.
PhylomeDB; P55090; -.
TreeFam; TF332956; -.
Reactome; R-RNO-373080; Class B/2 (Secretin family receptors).
PRO; PR:P55090; -.
Proteomes; UP000002494; Chromosome 6.
Bgee; ENSRNOG00000006090; Expressed in 4 organ(s), highest expression level in skeletal muscle tissue.
Genevisible; P55090; RN.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0043679; C:axon terminus; IDA:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0043196; C:varicosity; IDA:RGD.
GO; GO:0017045; F:corticotropin-releasing hormone activity; IBA:GO_Central.
GO; GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; IPI:RGD.
GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IPI:RGD.
GO; GO:0001664; F:G protein-coupled receptor binding; IDA:RGD.
GO; GO:0046811; F:histone deacetylase inhibitor activity; IDA:RGD.
GO; GO:0034199; P:activation of protein kinase A activity; IDA:RGD.
GO; GO:0009060; P:aerobic respiration; IDA:RGD.
GO; GO:0008306; P:associative learning; IDA:RGD.
GO; GO:0042756; P:drinking behavior; IMP:RGD.
GO; GO:0007631; P:feeding behavior; IMP:RGD.
GO; GO:0007565; P:female pregnancy; IEP:RGD.
GO; GO:0035483; P:gastric emptying; IDA:RGD.
GO; GO:0006954; P:inflammatory response; IEP:RGD.
GO; GO:0007611; P:learning or memory; IDA:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
GO; GO:0032099; P:negative regulation of appetite; IDA:RGD.
GO; GO:0045776; P:negative regulation of blood pressure; IDA:RGD.
GO; GO:0060548; P:negative regulation of cell death; IMP:RGD.
GO; GO:0045792; P:negative regulation of cell size; IDA:RGD.
GO; GO:0032811; P:negative regulation of epinephrine secretion; IBA:GO_Central.
GO; GO:2000252; P:negative regulation of feeding behavior; IDA:RGD.
GO; GO:0060455; P:negative regulation of gastric acid secretion; IDA:RGD.
GO; GO:0010629; P:negative regulation of gene expression; IDA:RGD.
GO; GO:0070093; P:negative regulation of glucagon secretion; IBA:GO_Central.
GO; GO:0046888; P:negative regulation of hormone secretion; IDA:RGD.
GO; GO:0060547; P:negative regulation of necrotic cell death; IDA:RGD.
GO; GO:1901215; P:negative regulation of neuron death; IDA:RGD.
GO; GO:0031175; P:neuron projection development; IDA:RGD.
GO; GO:0007218; P:neuropeptide signaling pathway; IDA:RGD.
GO; GO:0030157; P:pancreatic juice secretion; IDA:RGD.
GO; GO:2000987; P:positive regulation of behavioral fear response; IDA:RGD.
GO; GO:0097755; P:positive regulation of blood vessel diameter; IDA:RGD.
GO; GO:0090280; P:positive regulation of calcium ion import; IDA:RGD.
GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; IDA:RGD.
GO; GO:0060452; P:positive regulation of cardiac muscle contraction; IDA:RGD.
GO; GO:0030307; P:positive regulation of cell growth; IDA:RGD.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:RGD.
GO; GO:0051461; P:positive regulation of corticotropin secretion; IDA:RGD.
GO; GO:0051464; P:positive regulation of cortisol secretion; IBA:GO_Central.
GO; GO:0045740; P:positive regulation of DNA replication; IDA:RGD.
GO; GO:0010628; P:positive regulation of gene expression; IDA:RGD.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IDA:RGD.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0045727; P:positive regulation of translation; IDA:RGD.
GO; GO:0043117; P:positive regulation of vascular permeability; IDA:RGD.
GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IDA:RGD.
GO; GO:0010996; P:response to auditory stimulus; IEA:Ensembl.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
GO; GO:0006979; P:response to oxidative stress; IDA:RGD.
GO; GO:0048265; P:response to pain; IEP:RGD.
GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
GO; GO:0035176; P:social behavior; IDA:RGD.
GO; GO:0001964; P:startle response; IEA:Ensembl.
InterPro; IPR018446; Corticotropin-releasing_fac_CS.
InterPro; IPR000187; CRF.
InterPro; IPR003620; Urocortin_CRF.
PANTHER; PTHR15035; PTHR15035; 1.
Pfam; PF00473; CRF; 1.
SMART; SM00039; CRF; 1.
PROSITE; PS00511; CRF; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hearing; Hormone; Reference proteome; Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 80
PEPTIDE 81 120 Urocortin.
MOD_RES 120 120 Valine amide. {ECO:0000250}.
SEQUENCE 122 AA; 13711 MW; 9F0AF834CBFFCE74 CRC64;

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