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Urocortin 3

 Q3UFJ9_MOUSE            Unreviewed;       164 AA.
Q3UFJ9;
11-OCT-2005, integrated into UniProtKB/TrEMBL.
11-OCT-2005, sequence version 1.
25-OCT-2017, entry version 103.
SubName: Full=Urocortin 3 {ECO:0000313|EMBL:AAI19434.1};
Name=Ucn3 {ECO:0000313|EMBL:AAI19434.1, ECO:0000313|MGI:MGI:1932970};
ORFNames=mCG_1034323 {ECO:0000313|EMBL:EDL32235.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE28561.1};
[1] {ECO:0000313|EMBL:BAE28561.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE28561.1};
TISSUE=Pancreas {ECO:0000313|EMBL:BAE28561.1};
PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
Carninci P., Hayashizaki Y.;
"High-efficiency full-length cDNA cloning.";
Methods Enzymol. 303:19-44(1999).
[2] {ECO:0000313|EMBL:BAE28561.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE28561.1};
TISSUE=Pancreas {ECO:0000313|EMBL:BAE28561.1};
PubMed=11042159; DOI=10.1101/gr.145100;
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
"Normalization and subtraction of cap-trapper-selected cDNAs to
prepare full-length cDNA libraries for rapid discovery of new genes.";
Genome Res. 10:1617-1630(2000).
[3] {ECO:0000313|EMBL:BAE28561.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE28561.1};
TISSUE=Pancreas {ECO:0000313|EMBL:BAE28561.1};
PubMed=11076861; DOI=10.1101/gr.152600;
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
"RIKEN integrated sequence analysis (RISA) system--384-format
sequencing pipeline with 384 multicapillary sequencer.";
Genome Res. 10:1757-1771(2000).
[4] {ECO:0000313|EMBL:BAE28561.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE28561.1};
TISSUE=Pancreas {ECO:0000313|EMBL:BAE28561.1};
PubMed=11217851; DOI=10.1038/35055500;
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
"Functional annotation of a full-length mouse cDNA collection.";
Nature 409:685-690(2001).
[5] {ECO:0000313|EMBL:BAE28561.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE28561.1};
TISSUE=Pancreas {ECO:0000313|EMBL:BAE28561.1};
PubMed=12466851; DOI=10.1038/nature01266;
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
"Analysis of the mouse transcriptome based on functional annotation of
60,770 full-length cDNAs.";
Nature 420:563-573(2002).
[6] {ECO:0000313|EMBL:EDL32235.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL32235.1};
PubMed=12040188; DOI=10.1126/science.1069193;
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
"A comparison of whole-genome shotgun-derived mouse chromosome 16 and
the human genome.";
Science 296:1661-1671(2002).
[7] {ECO:0000313|EMBL:AAI19434.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI19434.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8] {ECO:0000313|EMBL:BAE28561.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE28561.1};
TISSUE=Pancreas {ECO:0000313|EMBL:BAE28561.1};
Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
Muramatsu M., Hayashizaki Y.;
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[9] {ECO:0000313|EMBL:BAE28561.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE28561.1};
TISSUE=Pancreas {ECO:0000313|EMBL:BAE28561.1};
The FANTOM Consortium;
Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
"The Transcriptional Landscape of the Mammalian Genome.";
Science 309:1559-1563(2005).
[10] {ECO:0000313|EMBL:BAE28561.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE28561.1};
TISSUE=Pancreas {ECO:0000313|EMBL:BAE28561.1};
PubMed=16141073; DOI=10.1126/science.1112009;
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
"Antisense Transcription in the Mammalian Transcriptome.";
Science 309:1564-1566(2005).
[11] {ECO:0000313|EMBL:EDL32235.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL32235.1};
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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EMBL; BC119433; AAI19434.1; -; mRNA.
EMBL; AK148451; BAE28561.1; -; mRNA.
EMBL; CH466588; EDL32235.1; -; Genomic_DNA.
RefSeq; NP_112540.2; NM_031250.5.
UniGene; Mm.313662; -.
GeneID; 83428; -.
KEGG; mmu:83428; -.
CTD; 114131; -.
MGI; MGI:1932970; Ucn3.
eggNOG; ENOG410IZ00; Eukaryota.
eggNOG; ENOG410YJR9; LUCA.
HOVERGEN; HBG036243; -.
KO; K05257; -.
OMA; KFYKAKP; -.
OrthoDB; EOG091G10Y0; -.
Bgee; ENSMUSG00000044988; -.
GO; GO:0043679; C:axon terminus; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0043196; C:varicosity; IEA:Ensembl.
GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IEA:InterPro.
GO; GO:0005179; F:hormone activity; IEA:InterPro.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
GO; GO:0031669; P:cellular response to nutrient levels; IEA:Ensembl.
GO; GO:0007586; P:digestion; IEA:InterPro.
GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
GO; GO:0045838; P:positive regulation of membrane potential; IEA:Ensembl.
GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
GO; GO:0035902; P:response to immobilization stress; IEA:Ensembl.
GO; GO:0042594; P:response to starvation; IEA:Ensembl.
InterPro; IPR000187; CRF.
InterPro; IPR024270; Urocortin_II/III.
PANTHER; PTHR17575; PTHR17575; 1.
Pfam; PF00473; CRF; 1.
2: Evidence at transcript level;
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 23 {ECO:0000256|SAM:SignalP}.
CHAIN 24 164 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5011098857.
DOMAIN 123 160 CRF. {ECO:0000259|Pfam:PF00473}.
SEQUENCE 164 AA; 18063 MW; 93A77CB93DA56E5C CRC64;
MLMPTYFLLP LLLLLGGPRT SLSHKFYNTG PVFSCLNTAL SEVKKNKLED VPLLSKKSFG
HLPTQDPSGE EDDNQTHLQI KRTFSGAAGG NGAGSTRYRY QSQAQHKGKL YPDKPKSDRG
TKFTLSLDVP TNIMNILFNI DKAKNLRAKA AANAQLMAQI GKKK


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