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Urocortin-2

 A1YKY4_RAT              Unreviewed;       110 AA.
A1YKY4;
06-FEB-2007, integrated into UniProtKB/TrEMBL.
06-FEB-2007, sequence version 1.
18-JUL-2018, entry version 84.
SubName: Full=Urocortin-2 {ECO:0000313|EMBL:ABM45864.1, ECO:0000313|Ensembl:ENSRNOP00000028031};
Name=Ucn2 {ECO:0000313|Ensembl:ENSRNOP00000028031,
ECO:0000313|RGD:620765};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:ABM45864.1};
[1] {ECO:0000313|Ensembl:ENSRNOP00000028031, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000028031,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[2] {ECO:0000313|EMBL:ABM45864.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Sprague-Dawley {ECO:0000313|EMBL:ABM45864.1};
TISSUE=Esophagus {ECO:0000313|EMBL:ABM45864.1};
PubMed=17218420; DOI=10.1210/en.2006-0565;
Wu S.V., Yuan P.Q., Wang L., Peng Y.L., Chen C.Y., Tache Y.;
"Identification and characterization of multiple corticotropin-
releasing factor type 2 receptor isoforms in the rat esophagus.";
Endocrinology 148:1675-1687(2007).
[3] {ECO:0000313|Ensembl:ENSRNOP00000028031}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000028031};
Ensembl;
Submitted (JUN-2015) to UniProtKB.
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EMBL; AABR07073448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; EF078966; ABM45864.1; -; mRNA.
RefSeq; NP_596876.2; NM_133385.2.
UniGene; Rn.153037; -.
Ensembl; ENSRNOT00000028031; ENSRNOP00000028031; ENSRNOG00000020655.
GeneID; 170896; -.
KEGG; rno:170896; -.
CTD; 90226; -.
RGD; 620765; Ucn2.
eggNOG; ENOG410J5CP; Eukaryota.
eggNOG; ENOG4111C21; LUCA.
GeneTree; ENSGT00390000004650; -.
HOGENOM; HOG000154768; -.
HOVERGEN; HBG036242; -.
KO; K05257; -.
OMA; QNSPQTT; -.
OrthoDB; EOG091G171N; -.
Reactome; R-RNO-373080; Class B/2 (Secretin family receptors).
Proteomes; UP000002494; Chromosome 8.
Bgee; ENSRNOG00000020655; -.
Genevisible; A1YKY4; RN.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0005622; C:intracellular; IEA:Ensembl.
GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IEA:InterPro.
GO; GO:0005179; F:hormone activity; IEA:InterPro.
GO; GO:0042562; F:hormone binding; IEA:Ensembl.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0007586; P:digestion; IEA:InterPro.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:Ensembl.
GO; GO:0006950; P:response to stress; IEA:InterPro.
InterPro; IPR000187; CRF.
InterPro; IPR024273; Urocortin_II.
InterPro; IPR024270; Urocortin_II/III.
PANTHER; PTHR17575; PTHR17575; 1.
PANTHER; PTHR17575:SF0; PTHR17575:SF0; 1.
Pfam; PF00473; CRF; 1.
ProDom; PD455741; PD455741; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 110 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5015285058.
DOMAIN 71 107 CRF. {ECO:0000259|Pfam:PF00473}.
SEQUENCE 110 AA; 12053 MW; 179D9DCC02544DCD CRC64;
MMTRWALVVF MVLMLDRVPG TPIPTFQLLP QNYPETTPSS VSSESPSDTT TGPSASWSNS
KASPYLDTRV ILSLDVPIGL LRILLEQARN KAARNQAATN AQILARVGRR


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