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Urocortin-3 (Stresscopin) (Urocortin III) (Ucn III)

 UCN3_HUMAN              Reviewed;         161 AA.
Q969E3; Q496H2; Q5SR91;
10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
18-MAY-2010, sequence version 2.
25-OCT-2017, entry version 117.
RecName: Full=Urocortin-3;
AltName: Full=Stresscopin;
AltName: Full=Urocortin III;
Short=Ucn III;
Flags: Precursor;
Name=UCN3; Synonyms=SPC;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], SYNTHESIS OF UCN III, AND VARIANT
GLY-91.
PubMed=11416224; DOI=10.1073/pnas.121165198;
Lewis K., Li C., Perrin M.H., Blount A., Kunitake K., Donaldson C.,
Vaughan J., Reyes T.M., Gulyas J., Fischer W., Bilezikjian L.,
Rivier J., Sawchenko P.E., Vale W.W.;
"Identification of urocortin III, an additional member of the
corticotropin-releasing factor (CRF) family with high affinity for the
CRF2 receptor.";
Proc. Natl. Acad. Sci. U.S.A. 98:7570-7575(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLY-91.
PubMed=11329063; DOI=10.1038/87936;
Hsu S.Y., Hsueh A.J.W.;
"Human stresscopin and stresscopin-related peptide are selective
ligands for the type 2 corticotropin-releasing hormone receptor.";
Nat. Med. 7:605-611(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164054; DOI=10.1038/nature02462;
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-91.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
STRUCTURE BY NMR OF 120-157.
PubMed=18052377; DOI=10.1021/ja0760933;
Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E.,
Riek R.;
"Common and divergent structural features of a series of corticotropin
releasing factor-related peptides.";
J. Am. Chem. Soc. 129:16102-16114(2007).
[6]
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 142-157 IN COMPLEX WITH
CRHR2.
PubMed=20966082; DOI=10.1074/jbc.M110.186072;
Pal K., Swaminathan K., Xu H.E., Pioszak A.A.;
"Structural basis for hormone recognition by the Human CRFR2{alpha} G
protein-coupled receptor.";
J. Biol. Chem. 285:40351-40361(2010).
-!- FUNCTION: Suppresses food intake, delays gastric emptying and
decreases heat-induced edema. Might represent an endogenous ligand
for maintaining homeostasis after stress.
-!- SUBUNIT: Binds with high affinity to CRF receptors 2-alpha and 2-
beta. {ECO:0000269|PubMed:20966082}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
factor/urotensin I family. {ECO:0000305}.
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EMBL; AF361943; AAK67317.1; -; Genomic_DNA.
EMBL; AY026949; AAK11729.1; -; mRNA.
EMBL; AL683826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC069530; AAH69530.1; -; mRNA.
EMBL; BC100867; AAI00868.1; -; mRNA.
EMBL; BC100868; AAI00869.1; -; mRNA.
EMBL; BC100869; AAI00870.1; -; mRNA.
EMBL; BC100870; AAI00871.1; -; mRNA.
CCDS; CCDS7065.1; -.
RefSeq; NP_444277.2; NM_053049.3.
UniGene; Hs.511775; -.
UniGene; Hs.680475; -.
PDB; 2RMH; NMR; -; A=120-157.
PDB; 3N93; X-ray; 2.50 A; C=142-157.
PDBsum; 2RMH; -.
PDBsum; 3N93; -.
ProteinModelPortal; Q969E3; -.
SMR; Q969E3; -.
BioGrid; 125284; 16.
STRING; 9606.ENSP00000369798; -.
iPTMnet; Q969E3; -.
PhosphoSitePlus; Q969E3; -.
BioMuta; UCN3; -.
DMDM; 296452853; -.
PaxDb; Q969E3; -.
PeptideAtlas; Q969E3; -.
PRIDE; Q969E3; -.
DNASU; 114131; -.
Ensembl; ENST00000380433; ENSP00000369798; ENSG00000178473.
GeneID; 114131; -.
KEGG; hsa:114131; -.
UCSC; uc001ihx.2; human.
CTD; 114131; -.
DisGeNET; 114131; -.
EuPathDB; HostDB:ENSG00000178473.6; -.
GeneCards; UCN3; -.
H-InvDB; HIX0035360; -.
HGNC; HGNC:17781; UCN3.
HPA; HPA038281; -.
MIM; 605901; gene.
neXtProt; NX_Q969E3; -.
OpenTargets; ENSG00000178473; -.
PharmGKB; PA130413153; -.
eggNOG; ENOG410IZ00; Eukaryota.
eggNOG; ENOG410YJR9; LUCA.
GeneTree; ENSGT00390000001251; -.
HOGENOM; HOG000230495; -.
HOVERGEN; HBG036243; -.
InParanoid; Q969E3; -.
KO; K05257; -.
OMA; KFYKAKP; -.
OrthoDB; EOG091G10Y0; -.
PhylomeDB; Q969E3; -.
TreeFam; TF330723; -.
Reactome; R-HSA-373080; Class B/2 (Secretin family receptors).
EvolutionaryTrace; Q969E3; -.
GeneWiki; UCN3; -.
GenomeRNAi; 114131; -.
PRO; PR:Q969E3; -.
Proteomes; UP000005640; Chromosome 10.
Bgee; ENSG00000178473; -.
CleanEx; HS_UCN3; -.
Genevisible; Q969E3; HS.
GO; GO:0043679; C:axon terminus; IEA:Ensembl.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0043196; C:varicosity; IEA:Ensembl.
GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IEA:InterPro.
GO; GO:0001664; F:G-protein coupled receptor binding; IBA:GO_Central.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
GO; GO:0007586; P:digestion; IEA:InterPro.
GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
GO; GO:0045838; P:positive regulation of membrane potential; IEA:Ensembl.
GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
GO; GO:0035902; P:response to immobilization stress; IEA:Ensembl.
GO; GO:0042594; P:response to starvation; IEA:Ensembl.
InterPro; IPR000187; CRF.
InterPro; IPR024270; Urocortin_II/III.
PANTHER; PTHR17575; PTHR17575; 1.
Pfam; PF00473; CRF; 1.
1: Evidence at protein level;
3D-structure; Amidation; Complete proteome; Hormone; Polymorphism;
Reference proteome; Secreted; Signal.
SIGNAL 1 21 {ECO:0000255}.
PROPEP 22 118
/FTId=PRO_0000006245.
CHAIN 120 157 Urocortin-3.
/FTId=PRO_0000006246.
MOD_RES 157 157 Isoleucine amide. {ECO:0000255}.
VARIANT 77 77 E -> K (in dbSNP:rs12768730).
/FTId=VAR_060410.
VARIANT 91 91 R -> G (in dbSNP:rs10904481).
{ECO:0000269|PubMed:11329063,
ECO:0000269|PubMed:11416224,
ECO:0000269|PubMed:15489334}.
/FTId=VAR_060411.
HELIX 121 123 {ECO:0000244|PDB:2RMH}.
HELIX 143 156 {ECO:0000244|PDB:3N93}.
SEQUENCE 161 AA; 17961 MW; B83B3D8D30879911 CRC64;
MLMPVHFLLL LLLLLGGPRT GLPHKFYKAK PIFSCLNTAL SEAEKGQWED ASLLSKRSFH
YLRSRDASSG EEEEGKEKKT FPISGARGGA RGTRYRYVSQ AQPRGKPRQD TAKSPHRTKF
TLSLDVPTNI MNLLFNIAKA KNLRAQAAAN AHLMAQIGRK K


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