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Urocortin-3 (Urocortin III) (Ucn III)

 UCN3_BOVIN              Reviewed;         166 AA.
Q1RMJ9;
26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
16-MAY-2006, sequence version 1.
25-OCT-2017, entry version 53.
RecName: Full=Urocortin-3;
AltName: Full=Urocortin III;
Short=Ucn III;
Flags: Precursor;
Name=UCN3; Synonyms=SPC;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Hypothalamus;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Suppresses food intake, delays gastric emptying and
decreases heat-induced edema. Might represent an endogenous ligand
for maintaining homeostasis after stress (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Binds with high affinity to CRF receptors 2-alpha and 2-
beta. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
factor/urotensin I family. {ECO:0000305}.
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EMBL; BC114855; AAI14856.1; -; mRNA.
RefSeq; NP_001069995.1; NM_001076527.1.
UniGene; Bt.60941; -.
ProteinModelPortal; Q1RMJ9; -.
SMR; Q1RMJ9; -.
STRING; 9913.ENSBTAP00000046927; -.
PaxDb; Q1RMJ9; -.
PRIDE; Q1RMJ9; -.
GeneID; 751573; -.
KEGG; bta:751573; -.
CTD; 114131; -.
eggNOG; ENOG410IZ00; Eukaryota.
eggNOG; ENOG410YJR9; LUCA.
HOGENOM; HOG000230495; -.
HOVERGEN; HBG036243; -.
InParanoid; Q1RMJ9; -.
KO; K05257; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IEA:InterPro.
GO; GO:0001664; F:G-protein coupled receptor binding; IBA:GO_Central.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
GO; GO:0007586; P:digestion; IEA:InterPro.
GO; GO:0006950; P:response to stress; IEA:InterPro.
InterPro; IPR000187; CRF.
InterPro; IPR024270; Urocortin_II/III.
PANTHER; PTHR17575; PTHR17575; 1.
Pfam; PF00473; CRF; 1.
2: Evidence at transcript level;
Amidation; Complete proteome; Hormone; Reference proteome; Secreted;
Signal.
SIGNAL 1 23 {ECO:0000255}.
PROPEP 24 123 {ECO:0000250}.
/FTId=PRO_0000318943.
CHAIN 125 162 Urocortin-3.
/FTId=PRO_0000318944.
COMPBIAS 88 96 Poly-Gly.
MOD_RES 162 162 Isoleucine amide. {ECO:0000255}.
SEQUENCE 166 AA; 17849 MW; 1595B7C69B7CBC2B CRC64;
MLVPAPFLLV LLLLLGAPQV GLSQRSPKAG SSPSCLHTAL REAEKSQRKD TSLLIKRTFP
ALPRGDPEDQ EGQEEEDTEK RTFPGSVGGG GGGGAGSTRY KYPSQAQFQG RPSQDKAKSD
RRTKVTLSLD VPTNIMNILF NIAKAKNLRA KAAANAHLMA QIGRKK


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