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Uteroglobin (Clara cell phospholipid-binding protein) (CCPBP) (Clara cells 10 kDa secretory protein) (CC10) (Secretoglobin family 1A member 1) (Urinary protein 1) (UP-1) (UP1) (Urine protein 1)

 UTER_HUMAN              Reviewed;          91 AA.
P11684; B2R5F2; Q6FHH3; Q9UCM2; Q9UCM4;
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 1.
12-SEP-2018, entry version 166.
RecName: Full=Uteroglobin;
AltName: Full=Clara cell phospholipid-binding protein;
Short=CCPBP;
AltName: Full=Clara cells 10 kDa secretory protein;
Short=CC10;
AltName: Full=Secretoglobin family 1A member 1;
AltName: Full=Urinary protein 1;
Short=UP-1;
Short=UP1;
Short=Urine protein 1;
Flags: Precursor;
Name=SCGB1A1; Synonyms=CC10, CCSP, UGB;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
PubMed=3167058; DOI=10.1016/0167-4781(88)90129-7;
Singh G., Katyal S.L., Brown W.E., Phillips S., Kennedy A.L.,
Anthony J., Squeglia N.;
"Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa
protein.";
Biochim. Biophys. Acta 950:329-337(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Lung;
PubMed=7733299;
Hay J.G., Danel C., Chu C., Crystal R.G.;
"Human CC10 gene expression in airway epithelium and subchromosomal
locus suggest linkage to airway disease.";
Am. J. Physiol. 268:L565-L575(1995).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Tongue;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
PubMed=1284526; DOI=10.1093/hmg/1.6.371;
Wolf M., Klug J., Hackenberg R., Gessler M., Grzeschik K.-H.,
Beato M., Suske G.;
"Human CC10, the homologue of rabbit uteroglobin: genomic cloning,
chromosomal localization and expression in endometrial cell lines.";
Hum. Mol. Genet. 1:371-378(1992).
[8]
PROTEIN SEQUENCE OF 22-74.
TISSUE=Urine;
PubMed=1400743;
Okutani R., Itoh Y., Hirata H., Kasahara T., Mukaida N., Kawai T.;
"Simple and high-yield purification of urine protein 1 using
immunoaffinity chromatography: evidence for the identity of urine
protein 1 and human Clara cell 10-kilodalton protein.";
J. Chromatogr. A 577:25-35(1992).
[9]
PROTEIN SEQUENCE OF 22-45.
TISSUE=Urine;
PubMed=1395029; DOI=10.1016/0009-8981(92)90122-7;
Bernard A., Roels H., Lauwerys R., Witters R., Gielens C.,
Soumillion A., van Damme J., de Ley M.;
"Human urinary protein 1: evidence for identity with the Clara cell
protein and occurrence in respiratory tract and urogenital
secretions.";
Clin. Chim. Acta 207:239-249(1992).
[10]
PROTEIN SEQUENCE OF 22-33.
PubMed=11788998;
DOI=10.1002/1615-9861(200201)2:1<112::AID-PROT112>3.0.CO;2-N;
Ghafouri B., Stahlbom B., Tagesson C., Lindahl M.;
"Newly identified proteins in human nasal lavage fluid from non-
smokers and smokers using two-dimensional gel electrophoresis and
peptide mass fingerprinting.";
Proteomics 2:112-120(2002).
[11]
X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
PubMed=7664082; DOI=10.1038/nsb0894-538;
Umland T.C., Swaminathan S., Singh G., Warty V., Furey W.,
Pletcher J., Sax M.;
"Structure of a human Clara cell phospholipid-binding protein-ligand
complex at 1.9-A resolution.";
Nat. Struct. Biol. 1:538-545(1994).
-!- FUNCTION: Binds phosphatidylcholine, phosphatidylinositol,
polychlorinated biphenyls (PCB) and weakly progesterone, potent
inhibitor of phospholipase A2.
-!- SUBUNIT: Homodimer; antiparallel disulfide-linked.
-!- INTERACTION:
P02751:FN1; NbExp=3; IntAct=EBI-7797649, EBI-1220319;
Q13049:TRIM32; NbExp=6; IntAct=EBI-7797649, EBI-742790;
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Clara cells (nonciliated cells of the surface
epithelium of the pulmonary airways).
-!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
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EMBL; X13197; CAA31584.1; -; mRNA.
EMBL; U01101; AAA81885.1; -; mRNA.
EMBL; U01102; AAA18297.1; -; Genomic_DNA.
EMBL; CR541780; CAG46579.1; -; mRNA.
EMBL; AK312165; BAG35099.1; -; mRNA.
EMBL; CH471076; EAW74018.1; -; Genomic_DNA.
EMBL; BC004481; AAH04481.1; -; mRNA.
EMBL; X59875; CAA42532.1; -; Genomic_DNA.
CCDS; CCDS8020.1; -.
PIR; JS0036; JS0036.
PIR; S26651; S26651.
RefSeq; NP_003348.1; NM_003357.4.
UniGene; Hs.523732; -.
ProteinModelPortal; P11684; -.
SMR; P11684; -.
BioGrid; 113203; 6.
IntAct; P11684; 4.
MINT; P11684; -.
STRING; 9606.ENSP00000278282; -.
iPTMnet; P11684; -.
PhosphoSitePlus; P11684; -.
BioMuta; SCGB1A1; -.
DMDM; 112672; -.
MaxQB; P11684; -.
PaxDb; P11684; -.
PeptideAtlas; P11684; -.
PRIDE; P11684; -.
ProteomicsDB; 52798; -.
DNASU; 7356; -.
Ensembl; ENST00000278282; ENSP00000278282; ENSG00000149021.
GeneID; 7356; -.
KEGG; hsa:7356; -.
UCSC; uc001ntj.4; human.
CTD; 7356; -.
DisGeNET; 7356; -.
EuPathDB; HostDB:ENSG00000149021.6; -.
GeneCards; SCGB1A1; -.
HGNC; HGNC:12523; SCGB1A1.
HPA; CAB025686; -.
HPA; HPA031828; -.
MIM; 192020; gene.
neXtProt; NX_P11684; -.
OpenTargets; ENSG00000149021; -.
PharmGKB; PA34989; -.
eggNOG; ENOG410J459; Eukaryota.
eggNOG; ENOG4111966; LUCA.
GeneTree; ENSGT00530000064300; -.
HOGENOM; HOG000220914; -.
HOVERGEN; HBG018062; -.
InParanoid; P11684; -.
OMA; ASAEICP; -.
OrthoDB; EOG091G15B2; -.
PhylomeDB; P11684; -.
TreeFam; TF338407; -.
ChiTaRS; SCGB1A1; human.
GeneWiki; Uteroglobin; -.
GenomeRNAi; 7356; -.
PRO; PR:P11684; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000149021; Expressed in 91 organ(s), highest expression level in bronchial epithelial cell.
CleanEx; HS_SCGB1A1; -.
ExpressionAtlas; P11684; baseline and differential.
Genevisible; P11684; HS.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
GO; GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO; GO:0030141; C:secretory granule; IEA:Ensembl.
GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
GO; GO:0097160; F:polychlorinated biphenyl binding; IEA:Ensembl.
GO; GO:0007566; P:embryo implantation; TAS:ProtInc.
GO; GO:0007565; P:female pregnancy; NAS:ProtInc.
GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl.
GO; GO:0032696; P:negative regulation of interleukin-13 production; IEA:Ensembl.
GO; GO:0032713; P:negative regulation of interleukin-4 production; IEA:Ensembl.
GO; GO:0032714; P:negative regulation of interleukin-5 production; IEA:Ensembl.
GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
GO; GO:0043488; P:regulation of mRNA stability; IEA:Ensembl.
GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
GO; GO:0071774; P:response to fibroblast growth factor; IEA:Ensembl.
GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0010193; P:response to ozone; IEA:Ensembl.
GO; GO:0034021; P:response to silicon dioxide; IEA:Ensembl.
GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; NAS:ProtInc.
CDD; cd00633; Secretoglobin; 1.
InterPro; IPR016126; Secretoglobin.
InterPro; IPR035960; Secretoglobin_sf.
InterPro; IPR000329; Uteroglobin.
Pfam; PF01099; Uteroglobin; 1.
PRINTS; PR00486; UTEROGLOBIN.
SUPFAM; SSF48201; SSF48201; 1.
PROSITE; PS51311; SCGB; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond;
Phospholipase A2 inhibitor; Polymorphism; Reference proteome;
Secreted; Signal.
SIGNAL 1 21 {ECO:0000269|PubMed:11788998,
ECO:0000269|PubMed:1395029,
ECO:0000269|PubMed:1400743}.
CHAIN 22 91 Uteroglobin.
/FTId=PRO_0000036365.
DISULFID 24 24 Interchain (with C-90).
DISULFID 90 90 Interchain (with C-24).
VARIANT 56 56 R -> G (in dbSNP:rs1802634).
/FTId=VAR_012045.
VARIANT 68 68 T -> A (in dbSNP:rs1802632).
/FTId=VAR_012046.
CONFLICT 24 24 C -> E (in Ref. 10; AA sequence).
{ECO:0000305}.
SEQUENCE 91 AA; 9994 MW; FE65ACA678F12ABD CRC64;
MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA
QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N


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