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VIP peptides [Cleaved into: Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)] (Fragment)

 VIP_RABIT               Reviewed;          72 AA.
P32649;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
25-OCT-2017, entry version 69.
RecName: Full=VIP peptides;
Contains:
RecName: Full=Intestinal peptide PHI-27;
AltName: Full=Peptide histidine isoleucinamide 27;
Contains:
RecName: Full=Vasoactive intestinal peptide;
Short=VIP;
AltName: Full=Vasoactive intestinal polypeptide;
Flags: Precursor; Fragment;
Name=VIP;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
PROTEIN SEQUENCE OF 1-27 AND 45-72, AND AMIDATION AT ILE-27 AND
ASN-72.
TISSUE=Small intestine;
PubMed=2342988; DOI=10.1016/0196-9781(90)90120-T;
Gossen D., Buscail L., Cauvin A., Gourlet P., de Neef P., Rathe J.,
Robberecht P., Vandermeers-Piret M.C., Vandermeers A., Christophe J.;
"Amino acid sequence of VIP, PHI and secretin from the rabbit small
intestine.";
Peptides 11:123-128(1990).
-!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
stimulates myocardial contractility, increases glycogenolysis and
relaxes the smooth muscle of trachea, stomach and gall bladder.
-!- FUNCTION: PHM-27 is a potent agonist of the calcitonin receptor
CALCR, with similar efficacy as calcitonin (By similarity). PHI
also causes vasodilation. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- MISCELLANEOUS: X's at positions 28 to 44 were included by homology
with the human precursor sequence.
-!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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PIR; B60415; VRRB.
InParanoid; P32649; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0048255; P:mRNA stabilization; ISS:AgBase.
GO; GO:0070459; P:prolactin secretion; ISS:AgBase.
InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
InterPro; IPR015523; VIP.
PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
Pfam; PF00123; Hormone_2; 2.
SMART; SM00070; GLUCA; 2.
PROSITE; PS00260; GLUCAGON; 2.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Hormone; Reference proteome; Secreted.
PEPTIDE 1 27 Intestinal peptide PHI-27.
/FTId=PRO_0000011469.
PEPTIDE 45 72 Vasoactive intestinal peptide.
/FTId=PRO_0000011470.
MOD_RES 27 27 Isoleucine amide.
{ECO:0000269|PubMed:2342988}.
MOD_RES 72 72 Asparagine amide.
{ECO:0000269|PubMed:2342988}.
NON_TER 1 1
NON_TER 72 72
SEQUENCE 72 AA; 8198 MW; EF03B1F0E5C1CA3A CRC64;
HADGVFTSDF SRLLGQLSAK KYLESLIXXX XXXXXXXXXX XXXXHSDAVF TDNYTRLRKQ
MAVKKYLNSI LN


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