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Vacuolar cation/proton exchanger 1 (Ca(2 )/H( ) antiporter CAX1) (Ca(2 )/H( ) exchanger 1) (Protein CATION EXCHANGER 1) (Protein RARE COLD INDUCIBLE 4)

 CAX1_ARATH              Reviewed;         463 AA.
Q39253; O80442; Q56WC8;
09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
09-JAN-2007, sequence version 3.
20-JUN-2018, entry version 114.
RecName: Full=Vacuolar cation/proton exchanger 1;
AltName: Full=Ca(2+)/H(+) antiporter CAX1;
AltName: Full=Ca(2+)/H(+) exchanger 1;
AltName: Full=Protein CATION EXCHANGER 1;
AltName: Full=Protein RARE COLD INDUCIBLE 4;
Name=CAX1; Synonyms=RCI4; OrderedLocusNames=At2g38170;
ORFNames=F16M14.10;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11706183; DOI=10.1104/pp.127.3.1020;
Pittman J.K., Hirschi K.D.;
"Regulation of CAX1, an Arabidopsis Ca(2+)/H+ antiporter.
Identification of an N-terminal autoinhibitory domain.";
Plant Physiol. 127:1020-1029(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 37-463.
PubMed=8710949; DOI=10.1073/pnas.93.16.8782;
Hirschi K.D., Zhen R.-G., Cunningham K.W., Rea P.A., Fink G.R.;
"CAX1, an H+/Ca2+ antiporter from Arabidopsis.";
Proc. Natl. Acad. Sci. U.S.A. 93:8782-8786(1996).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-463.
STRAIN=cv. Columbia;
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J.,
Hayashizaki Y., Shinozaki K.;
"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[7]
INDUCTION.
PubMed=10559438; DOI=10.1105/tpc.11.11.2113;
Hirschi K.D.;
"Expression of Arabidopsis CAX1 in tobacco: altered calcium
homeostasis and increased stress sensitivity.";
Plant Cell 11:2113-2122(1999).
[8]
ENZYME REGULATION.
PubMed=11562366; DOI=10.1074/jbc.M106637200;
Shigaki T., Cheng N.-H., Pittman J.K., Hirschi K.D.;
"Structural determinants of Ca2+ transport in the Arabidopsis H+/Ca2+
antiporter CAX1.";
J. Biol. Chem. 276:43152-43159(2001).
[9]
GENE FAMILY, AND NOMENCLATURE.
PubMed=11500563; DOI=10.1104/pp.126.4.1646;
Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A.,
Guerinot M.L.;
"Phylogenetic relationships within cation transporter families of
Arabidopsis.";
Plant Physiol. 126:1646-1667(2001).
[10]
MUTAGENESIS OF THR-6; SER-10; SER-24; SER-25; ARG-29; ARG-32 AND
THR-33.
PubMed=12006570; DOI=10.1074/jbc.M202563200;
Pittman J.K., Shigaki T., Cheng N.-H., Hirschi K.D.;
"Mechanism of N-terminal autoinhibition in the Arabidopsis Ca(2+)/H(+)
antiporter CAX1.";
J. Biol. Chem. 277:26452-26459(2002).
[11]
ENZYME REGULATION, AND INTERACTION WITH GRXS14.
PubMed=12480930; DOI=10.1074/jbc.M210883200;
Cheng N.-H., Hirschi K.D.;
"Cloning and characterization of CXIP1 A novel PICOT domain-containing
Arabidopsis protein that associates with CAX1.";
J. Biol. Chem. 278:6503-6509(2003).
[12]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=12566577; DOI=10.1105/tpc.007385;
Cheng N.-H., Pittman J.K., Barkla B.J., Shigaki T., Hirschi K.D.;
"The Arabidopsis cax1 mutant exhibits impaired ion homeostasis,
development, and hormonal responses and reveals interplay among
vacuolar transporters.";
Plant Cell 15:347-364(2003).
[13]
FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
PubMed=14630965; DOI=10.1105/tpc.015248;
Catala R., Santos E., Alonso J.M., Ecker J.R., Martinez-Zapater J.M.,
Salinas J.;
"Mutations in the Ca2+/H+ transporter CAX1 increase CBF/DREB1
expression and the cold-acclimation response in Arabidopsis.";
Plant Cell 15:2940-2951(2003).
[14]
ENZYME REGULATION, AND INTERACTION WITH CXIP4.
PubMed=14960315; DOI=10.1016/S0014-5793(04)00036-5;
Cheng N.-H., Liu J.-Z., Nelson R.S., Hirschi K.D.;
"Characterization of CXIP4, a novel Arabidopsis protein that activates
the H+/Ca2+ antiporter, CAX1.";
FEBS Lett. 559:99-106(2004).
[15]
BIOTECHNOLOGY.
PubMed=15998121; DOI=10.1021/jf050531c;
Park S., Kang T.S., Kim C.K., Han J.S., Kim S., Smith R.H., Pike L.M.,
Hirschi K.D.;
"Genetic manipulation for enhancing calcium content in potato tuber.";
J. Agric. Food Chem. 53:5598-5603(2005).
[16]
BIOPHYSICOCHEMICAL PROPERTIES.
PubMed=15862304; DOI=10.1016/j.febslet.2005.03.085;
Pittman J.K., Shigaki T., Hirschi K.D.;
"Evidence of differential pH regulation of the Arabidopsis vacuolar
Ca2+/H+ antiporters CAX1 and CAX2.";
FEBS Lett. 579:2648-2656(2005).
[17]
BIOPHYSICOCHEMICAL PROPERTIES, AND MUTAGENESIS OF HIS-259; HIS-338;
HIS-412; HIS-443 AND HIS-446.
PubMed=15994298; DOI=10.1074/jbc.M503610200;
Shigaki T., Barkla B.J., Miranda-Vergara M.C., Zhao J., Pantoja O.,
Hirschi K.D.;
"Identification of a crucial histidine involved in metal transport
activity in the Arabidopsis cation/H+ exchanger CAX1.";
J. Biol. Chem. 280:30136-30142(2005).
[18]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=16055687; DOI=10.1104/pp.105.061218;
Cheng N.-H., Pittman J.K., Shigaki T., Lachmansingh J., LeClere S.,
Lahner B., Salt D.E., Hirschi K.D.;
"Functional association of Arabidopsis CAX1 and CAX3 is required for
normal growth and ion homeostasis.";
Plant Physiol. 138:2048-2060(2005).
[19]
ENZYME REGULATION, AND BIOTECHNOLOGY.
PubMed=16244156; DOI=10.1104/pp.105.066266;
Park S., Cheng N.-H., Pittman J.K., Yoo K.S., Park J., Smith R.H.,
Hirschi K.D.;
"Increased calcium levels and prolonged shelf life in tomatoes
expressing Arabidopsis H+/Ca2+ transporters.";
Plant Physiol. 139:1194-1206(2005).
[20]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22223895; DOI=10.1074/mcp.M111.015131;
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C.,
Meinnel T., Giglione C.;
"Comparative large-scale characterisation of plant vs. mammal proteins
reveals similar and idiosyncratic N-alpha acetylation features.";
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
-!- FUNCTION: Vacuolar cation/proton exchanger (CAX). Translocates
Ca(2+) and other metal ions into vacuoles using the proton
gradient formed by H(+)-ATPase and H(+)-pyrophosphatase. Involved
in ion homeostasis in association with CAX3. May play a role in
cold-acclimation response. {ECO:0000269|PubMed:12566577,
ECO:0000269|PubMed:14630965, ECO:0000269|PubMed:16055687}.
-!- ENZYME REGULATION: Activated by monothiol glutaredoxin GRXS14 and
CXIP4. Inhibited by excess of Ca(2+) and Cd(2+), Na(+) and K(+),
but not Mn(2+). {ECO:0000269|PubMed:11562366,
ECO:0000269|PubMed:12480930, ECO:0000269|PubMed:14960315,
ECO:0000269|PubMed:16244156}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=230 uM for Cd(2+) {ECO:0000269|PubMed:15862304,
ECO:0000269|PubMed:15994298};
KM=225 uM for Zn(2+) {ECO:0000269|PubMed:15862304,
ECO:0000269|PubMed:15994298};
Note=Measured in vacuolar yeast membrane vesicles with a shorter
CAX1 starting at Met-37.;
pH dependence:
Optimum pH is 7.5 for cytosolic pH.
{ECO:0000269|PubMed:15862304, ECO:0000269|PubMed:15994298};
-!- SUBUNIT: Interacts with GRXS14 and CXIP4.
{ECO:0000269|PubMed:12480930, ECO:0000269|PubMed:14960315}.
-!- INTERACTION:
Q93Z81:CAX3; NbExp=4; IntAct=EBI-2292388, EBI-2292420;
-!- SUBCELLULAR LOCATION: Vacuole membrane
{ECO:0000305|PubMed:12566577}; Multi-pass membrane protein
{ECO:0000305|PubMed:12566577}. Note=Tonoplast.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q39253-1; Sequence=Displayed;
Name=2;
IsoId=Q39253-2; Sequence=VSP_022343;
Note=Derived from EST data. May be due to intron retention. No
experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed at low levels in leaves, stems and
flowers. {ECO:0000269|PubMed:14630965}.
-!- INDUCTION: By cold in leaves. Highly induced by Ca(2+) and at low
levels by Na(+) and Ni(2+). {ECO:0000269|PubMed:10559438,
ECO:0000269|PubMed:14630965}.
-!- DISRUPTION PHENOTYPE: Plants exhibit a 50% reduction in tonoplast
Ca(2+)/H(+) exchange activity, a 40% reduction in tonoplast V-type
H(+)-translocating ATPase activity, a 36% increase in tonoplast
Ca(2+)-ATPase activity and an increased expression of CAX3 and
CAX4. These plants exhibit altered plant development, perturbed
hormone sensitivities, altered auxin signaling response, lower
sensitivity to other metal ions and increased freezing tolerance
after cold acclimation. {ECO:0000269|PubMed:16055687}.
-!- BIOTECHNOLOGY: CAX1 expression in tomato increases calcium content
and prolonges shelf life and may serve as an alternative to the
application of CaCl(2) used to extend shelf life in numerous
agricultural commodities. Expression in potato tubers increases
calcium content by 3-fold without the adverse effect of increasing
other metal ion contents. {ECO:0000269|PubMed:15998121,
ECO:0000269|PubMed:16244156}.
-!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC
2.A.19) family. Cation/proton exchanger (CAX) subfamily.
{ECO:0000305}.
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EMBL; AF461691; AAL66749.1; -; mRNA.
EMBL; AC003028; AAC27166.1; -; Genomic_DNA.
EMBL; CP002685; AEC09499.1; -; Genomic_DNA.
EMBL; CP002685; AEC09501.1; -; Genomic_DNA.
EMBL; AF372938; AAK50078.1; -; mRNA.
EMBL; U57411; AAB05913.2; -; mRNA.
EMBL; AK222114; BAD95074.1; -; mRNA.
PIR; T01249; T01249.
RefSeq; NP_181352.1; NM_129373.4. [Q39253-1]
RefSeq; NP_973630.1; NM_201901.4. [Q39253-2]
UniGene; At.12459; -.
ProteinModelPortal; Q39253; -.
BioGrid; 3739; 6.
ComplexPortal; CPX-1326; CAX1-CAX3 complex.
ComplexPortal; CPX-1428; CAX1 homodimer.
IntAct; Q39253; 1.
STRING; 3702.AT2G38170.3; -.
TCDB; 2.A.19.2.3; the ca(2+):cation antiporter (caca) family.
iPTMnet; Q39253; -.
PaxDb; Q39253; -.
EnsemblPlants; AT2G38170.1; AT2G38170.1; AT2G38170. [Q39253-1]
EnsemblPlants; AT2G38170.3; AT2G38170.3; AT2G38170. [Q39253-2]
GeneID; 818395; -.
Gramene; AT2G38170.1; AT2G38170.1; AT2G38170. [Q39253-1]
Gramene; AT2G38170.3; AT2G38170.3; AT2G38170. [Q39253-2]
KEGG; ath:AT2G38170; -.
Araport; AT2G38170; -.
TAIR; locus:2042852; AT2G38170.
eggNOG; KOG1397; Eukaryota.
eggNOG; COG0387; LUCA.
HOGENOM; HOG000083011; -.
InParanoid; Q39253; -.
KO; K07300; -.
OMA; GCLAVSI; -.
PhylomeDB; Q39253; -.
SABIO-RK; Q39253; -.
PRO; PR:Q39253; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; Q39253; baseline and differential.
Genevisible; Q39253; AT.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IDA:TAIR.
GO; GO:0009705; C:plant-type vacuole membrane; IDA:TAIR.
GO; GO:0005773; C:vacuole; IDA:TAIR.
GO; GO:0015369; F:calcium:proton antiporter activity; IDA:TAIR.
GO; GO:0006816; P:calcium ion transport; IDA:TAIR.
GO; GO:0030026; P:cellular manganese ion homeostasis; IMP:TAIR.
GO; GO:0006882; P:cellular zinc ion homeostasis; IMP:TAIR.
GO; GO:0009631; P:cold acclimation; IMP:TAIR.
GO; GO:0055062; P:phosphate ion homeostasis; IGI:TAIR.
GO; GO:0009651; P:response to salt stress; IMP:TAIR.
InterPro; IPR004713; CaH_exchang.
InterPro; IPR004798; CAX.
InterPro; IPR004837; NaCa_Exmemb.
Pfam; PF01699; Na_Ca_ex; 2.
TIGRFAMs; TIGR00846; caca2; 1.
TIGRFAMs; TIGR00378; cax; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Antiport; Calcium;
Calcium transport; Complete proteome; Glycoprotein; Ion transport;
Membrane; Reference proteome; Transmembrane; Transmembrane helix;
Transport; Vacuole.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:22223895}.
CHAIN 2 463 Vacuolar cation/proton exchanger 1.
/FTId=PRO_0000270150.
TOPO_DOM 2 68 Cytoplasmic. {ECO:0000255}.
TRANSMEM 69 89 Helical. {ECO:0000255}.
TOPO_DOM 90 96 Extracellular. {ECO:0000255}.
TRANSMEM 97 116 Helical. {ECO:0000255}.
TOPO_DOM 117 127 Cytoplasmic. {ECO:0000255}.
TRANSMEM 128 148 Helical. {ECO:0000255}.
TOPO_DOM 149 161 Extracellular. {ECO:0000255}.
TRANSMEM 162 182 Helical. {ECO:0000255}.
TOPO_DOM 183 197 Cytoplasmic. {ECO:0000255}.
TRANSMEM 198 218 Helical. {ECO:0000255}.
TOPO_DOM 219 238 Extracellular. {ECO:0000255}.
TRANSMEM 239 259 Helical. {ECO:0000255}.
TOPO_DOM 260 281 Cytoplasmic. {ECO:0000255}.
TRANSMEM 282 302 Helical. {ECO:0000255}.
TOPO_DOM 303 325 Extracellular. {ECO:0000255}.
TRANSMEM 326 346 Helical. {ECO:0000255}.
TOPO_DOM 347 360 Cytoplasmic. {ECO:0000255}.
TRANSMEM 361 381 Helical. {ECO:0000255}.
TOPO_DOM 382 384 Extracellular. {ECO:0000255}.
TRANSMEM 385 405 Helical. {ECO:0000255}.
TOPO_DOM 406 411 Cytoplasmic. {ECO:0000255}.
TRANSMEM 412 432 Helical. {ECO:0000255}.
TOPO_DOM 433 463 Extracellular. {ECO:0000255}.
REGION 25 33 Required for autoinhibitory regulation.
REGION 56 62 Required for interaction with
autoinhibitory region.
REGION 87 95 Required for Ca(2+)/H(+) exchange
activity.
REGION 137 172 Cation selection. {ECO:0000255}.
REGION 333 368 Cation selection. {ECO:0000255}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000244|PubMed:22223895}.
CARBOHYD 318 318 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 438 463 KQNAIHLGHQAMNNVVTATGGGVFSS -> SELVFKCICML
LLGKTIIEAYNTHISNGNASSNKVKTG (in isoform
2). {ECO:0000305}.
/FTId=VSP_022343.
MUTAGEN 6 6 T->A: No effect on autoinhibitory
regulation.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 10 10 S->A: No effect on autoinhibitory
regulation.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 24 24 S->A: No effect on autoinhibitory
regulation.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 25 25 S->A: No effect on autoinhibitory
regulation.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 25 25 S->D: Loss of autoinhibitory regulation.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 25 25 S->T: No effect on autoinhibitory
regulation.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 29 29 R->A: Loss of autoinhibitory regulation;
when associated with A-32.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 32 32 R->A: Loss of autoinhibitory regulation;
when associated with A-29.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 33 33 T->A: Loss of autoinhibitory regulation.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 33 33 T->D: Loss of autoinhibitory regulation.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 33 33 T->E: Loss of autoinhibitory regulation.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 33 33 T->S: Loss of autoinhibitory regulation.
{ECO:0000269|PubMed:12006570}.
MUTAGEN 259 259 H->A: No effect on transport activity.
{ECO:0000269|PubMed:15994298}.
MUTAGEN 338 338 H->A: Loss of transport activity.
{ECO:0000269|PubMed:15994298}.
MUTAGEN 338 338 H->K: Reduced transport activity.
{ECO:0000269|PubMed:15994298}.
MUTAGEN 338 338 H->N: Increased affinity for Cd(2+) and
Zn(2+) transport.
{ECO:0000269|PubMed:15994298}.
MUTAGEN 338 338 H->Q: No effect on transport activity.
{ECO:0000269|PubMed:15994298}.
MUTAGEN 412 412 H->A: No effect on transport activity.
{ECO:0000269|PubMed:15994298}.
MUTAGEN 443 443 H->A: No effect on transport activity.
{ECO:0000269|PubMed:15994298}.
MUTAGEN 446 446 H->A: No effect on transport activity.
{ECO:0000269|PubMed:15994298}.
CONFLICT 374 374 I -> T (in Ref. 5; AAB05913).
{ECO:0000305}.
CONFLICT 396 396 A -> V (in Ref. 5; AAB05913).
{ECO:0000305}.
SEQUENCE 463 AA; 50177 MW; C7502A62AA51DF0A CRC64;
MAGIVTEPWS VAENGNPSIT AKGSSRELRL GRTAHNMSSS SLRKKSDLRV IQKVPYKGLK
DFLSNLQEVI LGTKLAILFP AIPAAIICTY CGVSQPWIFG LSLLGLTPLA ERVSFLTEQL
AFYTGPTLGG LLNATCGNAT ELIIAILALT NNKVAVVKYS LLGSILSNLL LVLGTSLFCG
GIANIRREQR FDRKQADVNF FLLLLGFLCH LLPLLVGYLK NGEASAAVLS DMQLSISRGF
SIVMLISYIA YLVFQLWTHR QLFDAQEQED EYDDDVEQET AVISFWSGFA WLVGMTLVIA
LLSEYVVATI EEASDKWNLS VSFISIILLP IVGNAAEHAG AVIFAFKNKL DISLGVALGS
ATQIGLFVVP LTIIVAWILG INMDLNFGPL ETGCLAVSII ITAFTLQDGS SHYMKGLVLL
LCYFIIAICF FVDKLPQKQN AIHLGHQAMN NVVTATGGGV FSS


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EIAAB38619 Homo sapiens,Human,Mitochondrial Na(+)_H(+) exchanger NHA2,Mitochondrial sodium_hydrogen exchanger 9B2,Na(+)_H(+) exchanger-like domain-containing protein 2,NHA2,NHE domain-containing protein 2,NHEDC2
EIAAB26536 Na(+)_K(+)_Ca(2+)-exchange protein 1,Nckx1,Rat,Rattus norvegicus,Retinal rod Na-Ca+K exchanger,Slc24a1,Sodium_potassium_calcium exchanger 1
EIAAB26539 Bos taurus,Bovine,Na(+)_K(+)_Ca(2+)-exchange protein 1,NCKX1,Retinal rod Na-Ca+K exchanger,SLC24A1,Sodium_potassium_calcium exchanger 1
EIAAB26542 Na(+)_K(+)_Ca(2+)-exchange protein 2,Nckx2,Rat,Rattus norvegicus,Retinal cone Na-Ca+K exchanger,Slc24a2,Sodium_potassium_calcium exchanger 2
EIAAB38618 Mouse,Mus musculus,Na(+)_H(+) exchanger-like domain-containing protein 1,NHE domain-containing protein 1,Nhedc1,Slc9b1,Sodium_hydrogen exchanger 9B1,Sodium_hydrogen exchanger-like domain-containing pr
EIAAB26537 Homo sapiens,Human,KIAA0702,Na(+)_K(+)_Ca(2+)-exchange protein 1,NCKX1,Retinal rod Na-Ca+K exchanger,SLC24A1,Sodium_potassium_calcium exchanger 1
EIAAB38620 Mitochondrial Na(+)_H(+) exchanger NHA2,Mitochondrial sodium_hydrogen exchanger 9B2,Mouse,Mus musculus,Na(+)_H(+) exchanger-like domain-containing protein 2,Nha2,NHA-oc,NHE domain-containing protein 2
EIAAB26540 Homo sapiens,Human,Na(+)_K(+)_Ca(2+)-exchange protein 2,NCKX2,Retinal cone Na-Ca+K exchanger,SLC24A2,Sodium_potassium_calcium exchanger 2,Solute carrier family 24 member 2
EIAAB32341 DEP domain-containing protein 2,Depdc2,Mouse,Mus musculus,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein,Prex2,P-Rex2,PtdIns(3,4,5)-dependent Rac exchanger 2
EIAAB32342 DEP domain-containing protein 2,DEPDC2,Homo sapiens,Human,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein,PREX2,P-Rex2,PtdIns(3,4,5)-dependent Rac exchanger 2
EIAAB26541 Chicken,Gallus gallus,Na(+)_K(+)_Ca(2+)-exchange protein 2,NCKX2,Retinal cone Na-Ca+K exchanger,SLC24A2,Sodium_potassium_calcium exchanger 2
EIAAB32339 Kiaa1415,Mouse,Mus musculus,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Prex1,P-Rex1,PtdIns(3,4,5)-dependent Rac exchanger 1
EIAAB26538 Chicken,Gallus gallus,Na(+)_K(+)_Ca(2+)-exchange protein 1,NCKX1,Retinal rod Na-Ca+K exchanger,SLC24A1,Sodium_potassium_calcium exchanger 1
EIAAB32340 Homo sapiens,Human,KIAA1415,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,PREX1,P-Rex1,PtdIns(3,4,5)-dependent Rac exchanger 1
EIAAB27172 Bos taurus,Bovine,Na(+)_H(+) exchange regulatory cofactor NHE-RF3,Na(+)_H(+) exchanger regulatory factor 3,NHERF3,NHERF-3,PDZ domain-containing protein 1,PDZD1,PDZK1,Sodium-hydrogen exchanger regulato
EIAAB26261 HLC3,HLC-3,Homo sapiens,Human,Human lung cancer oncogene 3 protein,Kanadaptin,Kidney anion exchanger adapter protein,SLC4A1AP,Solute carrier family 4 anion exchanger member 1 adapter protein
AS09 484 NHE_1 | Na+_H+ antiporter, sodium_hydrogen exchanger 100 ul
AS09484 NHE_1 | Na+_H+ antiporter, sodium_hydrogen exchanger 100 ul
EIAAB38595 Na(+)_H(+) exchanger 1,NHE1,NHE-1,Pig,SLC9A1,Sodium_hydrogen exchanger 1,Solute carrier family 9 member 1,Sus scrofa
Y050747 Anti-NHE-9Sodium per hydrogen exchanger 9 Na+ per H+ exchanger 9 antibody 250ug


 

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