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Vacuolating cytotoxin autotransporter [Cleaved into: Vacuolating cytotoxin; Vacuolating cytotoxin translocator]

 VACA2_HELPX             Reviewed;        1287 AA.
Q48245; Q9R5K9;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-NOV-2017, entry version 83.
RecName: Full=Vacuolating cytotoxin autotransporter;
Contains:
RecName: Full=Vacuolating cytotoxin;
Contains:
RecName: Full=Vacuolating cytotoxin translocator;
Flags: Precursor;
Name=vacA;
Helicobacter pylori (Campylobacter pylori).
Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
Helicobacteraceae; Helicobacter.
NCBI_TaxID=210;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 49503 / 60190;
PubMed=8144644;
Cover T.L., Tummuru M.K., Cao P., Thompson S.A., Blaser M.J.;
"Divergence of genetic sequences for the vacuolating cytotoxin among
Helicobacter pylori strains.";
J. Biol. Chem. 269:10566-10573(1994).
[2]
PROTEIN SEQUENCE OF 34-56, AND CHARACTERIZATION.
STRAIN=ATCC 49503 / 60190;
PubMed=1587837;
Cover T.L., Blaser M.J.;
"Purification and characterization of the vacuolating toxin from
Helicobacter pylori.";
J. Biol. Chem. 267:10570-10575(1992).
-!- FUNCTION: Induces vacuolation of eukaryotic cells. Causes
ulceration and gastric lesions.
-!- SUBCELLULAR LOCATION: Vacuolating cytotoxin autotransporter:
Periplasm {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Vacuolating cytotoxin: Secreted. Cell
surface.
-!- SUBCELLULAR LOCATION: Vacuolating cytotoxin translocator: Cell
outer membrane {ECO:0000250}; Multi-pass membrane protein
{ECO:0000250}. Note=The cleaved C-terminal fragment
(autotransporter domain) is localized in the outer membrane.
{ECO:0000250}.
-!- DOMAIN: The signal peptide, cleaved at the inner membrane, guides
the autotransporter protein to the periplasmic space. Then,
insertion of the C-terminal translocator domain in the outer
membrane forms a hydrophilic pore for the translocation of the
passenger domain to the bacterial cell surface, with subsequent
cleavage (By similarity). {ECO:0000250}.
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EMBL; U05676; AAA17657.1; -; Unassigned_DNA.
PIR; B53739; B53739.
PDB; 1SEW; Model; -; A/B/C/D/E/F=39-62.
PDB; 2QV3; X-ray; 2.40 A; A=388-844.
PDBsum; 1SEW; -.
PDBsum; 2QV3; -.
ProteinModelPortal; Q48245; -.
SMR; Q48245; -.
DIP; DIP-46228N; -.
TCDB; 1.B.12.6.1; the autotransporter-1 (at-1) family.
EvolutionaryTrace; Q48245; -.
GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
InterPro; IPR005546; Autotransporte_beta.
InterPro; IPR036709; Autotransporte_beta_dom_sf.
InterPro; IPR006315; OM_autotransptr_brl.
InterPro; IPR003842; Vacuolating_cytotoxin.
Pfam; PF02691; VacA; 1.
PRINTS; PR01656; VACCYTOTOXIN.
SMART; SM00869; Autotransporter; 1.
SUPFAM; SSF103515; SSF103515; 1.
TIGRFAMs; TIGR01414; autotrans_barl; 1.
PROSITE; PS51208; AUTOTRANSPORTER; 1.
1: Evidence at protein level;
3D-structure; Cell outer membrane; Direct protein sequencing;
Membrane; Periplasm; Secreted; Signal; Toxin; Transmembrane;
Transmembrane beta strand.
SIGNAL 1 33 {ECO:0000269|PubMed:1587837}.
CHAIN 34 1287 Vacuolating cytotoxin.
/FTId=PRO_0000387588.
CHAIN 34 ? Vacuolating cytotoxin autotransporter.
/FTId=PRO_0000002716.
CHAIN ? 1287 Vacuolating cytotoxin translocator.
{ECO:0000255}.
/FTId=PRO_0000002717.
DOMAIN 1014 1287 Autotransporter. {ECO:0000255|PROSITE-
ProRule:PRU00556}.
STRAND 390 396 {ECO:0000244|PDB:2QV3}.
STRAND 411 414 {ECO:0000244|PDB:2QV3}.
STRAND 416 428 {ECO:0000244|PDB:2QV3}.
STRAND 430 435 {ECO:0000244|PDB:2QV3}.
STRAND 437 448 {ECO:0000244|PDB:2QV3}.
STRAND 452 454 {ECO:0000244|PDB:2QV3}.
STRAND 468 475 {ECO:0000244|PDB:2QV3}.
TURN 476 478 {ECO:0000244|PDB:2QV3}.
STRAND 482 485 {ECO:0000244|PDB:2QV3}.
STRAND 495 510 {ECO:0000244|PDB:2QV3}.
STRAND 515 541 {ECO:0000244|PDB:2QV3}.
STRAND 543 552 {ECO:0000244|PDB:2QV3}.
STRAND 563 568 {ECO:0000244|PDB:2QV3}.
TURN 570 572 {ECO:0000244|PDB:2QV3}.
STRAND 573 580 {ECO:0000244|PDB:2QV3}.
STRAND 592 607 {ECO:0000244|PDB:2QV3}.
STRAND 612 631 {ECO:0000244|PDB:2QV3}.
STRAND 639 648 {ECO:0000244|PDB:2QV3}.
STRAND 653 656 {ECO:0000244|PDB:2QV3}.
STRAND 660 666 {ECO:0000244|PDB:2QV3}.
STRAND 668 672 {ECO:0000244|PDB:2QV3}.
STRAND 674 678 {ECO:0000244|PDB:2QV3}.
STRAND 687 697 {ECO:0000244|PDB:2QV3}.
TURN 703 705 {ECO:0000244|PDB:2QV3}.
STRAND 706 708 {ECO:0000244|PDB:2QV3}.
STRAND 711 715 {ECO:0000244|PDB:2QV3}.
HELIX 717 719 {ECO:0000244|PDB:2QV3}.
STRAND 722 730 {ECO:0000244|PDB:2QV3}.
STRAND 732 738 {ECO:0000244|PDB:2QV3}.
STRAND 742 745 {ECO:0000244|PDB:2QV3}.
HELIX 751 756 {ECO:0000244|PDB:2QV3}.
STRAND 759 763 {ECO:0000244|PDB:2QV3}.
STRAND 769 775 {ECO:0000244|PDB:2QV3}.
HELIX 776 786 {ECO:0000244|PDB:2QV3}.
HELIX 789 793 {ECO:0000244|PDB:2QV3}.
HELIX 795 801 {ECO:0000244|PDB:2QV3}.
STRAND 804 807 {ECO:0000244|PDB:2QV3}.
STRAND 811 815 {ECO:0000244|PDB:2QV3}.
STRAND 817 824 {ECO:0000244|PDB:2QV3}.
STRAND 837 839 {ECO:0000244|PDB:2QV3}.
SEQUENCE 1287 AA; 139041 MW; 0007370062FCB71F CRC64;
MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT GTAVGTVSGL
LGWGLKQAEE ANKTPDKPDK VWRIQAGKGF NEFPNKEYDL YKSLLSSKID GGWDWGNAAT
HYWIKGGQWN KLEVDMKDAV GTYKLSGLRN FTGGDLDVNM QKATLRLGQF NGNSFTSYKD
SADRTTRVDF NAKNILIDNF LEINNRVGSG AGRKASSTVL TLQASEGITS SKNAEISLYD
GATLNLASNS VKLNGNVWMG RLQYVGAYLA PSYSTINTSK VTGEVNFNHL TVGDHNAAQA
GIIASNKTHI GTLDLWQSAG LNIIAPPEGG YKDKPNNTPS QSGAKNDKQE SSQNNSNTQV
INPPNSTQKT EVQPTQVIDG PFAGGKDTVV NIDRINTKAD GTIKVGGFKA SLTTNAAHLN
IGKGGVNLSN QASGRTLLVE NLTGNITVDG PLRVNNQVGG YALAGSSANF EFKAGVDTKN
GTATFNNDIS LGRFVNLKVD AHTANFKGID TGNGGFNTLD FSGVTNKVNI NKLITASTNV
AVKNFNINEL IVKTNGVSVG EYTHFSEDIG SQSRINTVRL ETGTRSIFSG GVKFKSGEKL
VIDEFYYSPW NYFDARNIKN VEITRKFASS TPENPWGTSK LMFNNLTLGQ NAVMDYSQFS
NLTIQGDFIN NQGTINYLVR GGKVATLNVG NAAAMMFNND IDSATGFYKP LIKINSAQDL
IKNTEHVLLK AKIIGYGNVS TGTNGISNVN LEEQFKERLA LYNNNNRMDT CVVRNTDDIK
ACGMAIGNQS MVNNPDNYKY LIGKAWKNIG ISKTANGSKI SVYYLGNSTP TENGGNTTNL
PTNTTNNARF ASYALIKNAP FAHSATPNLV AINQHDFGTI ESVFELANRS KDIDTLYANS
GAQGRDLLQT LLIDSHDAGY ARTMIDATSA NEITKQLNTA TTTLNNIASL EHKTSSLQTL
SLSNAMILNS RLVNLSRRHT NNIDSFAKRL QALKDQRFAS LESAAEVLYQ FAPKYEKPTN
VWANAIGGAS LNNGGNASLY GTSAGVDAYL NGQVEAIVGG FGSYGYSSFN NQANSLNSGA
NNTNFGVYSR IFANQHEFDF EAQGALGSDQ SSLNFKSALL RDLNQSYNYL AYSAATRASY
GYDFAFFRNA LVLKPSVGVS YNHLGSTNFK SNSTNKVALS NGSSSQHLFN ASANVEARYY
YGDTSYFYMN AGVLQEFANF GSSNAVSLNT FKVNATRNPL NTHARVMMGG ELKLAKEVFL
NLGVVYLHNL ISNIGHFASN LGMRYSF


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