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Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (CD antigen CD106)

 VCAM1_CANLF             Reviewed;         739 AA.
Q28260;
24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-NOV-2017, entry version 100.
RecName: Full=Vascular cell adhesion protein 1;
Short=V-CAM 1;
Short=VCAM-1;
AltName: CD_antigen=CD106;
Flags: Precursor;
Name=VCAM1;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Ballantyne C.M., Clubb F.J., Perrard J.L., Radovencovic B.,
Youker K.A., Smith C.W., Entman M.L., Hawkins H.K., Frazier O.H.,
Willerson J.T.;
"Increased expression of VCAM-1 and ICAM-1 in early cardiac allograft
arteriopathy in the dog.";
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Important in cell-cell recognition. Appears to function
in leukocyte-endothelial cell adhesion. Interacts with integrin
alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both
adhesion and signal transduction. The VCAM1/ITGA4/ITGB1
interaction may play a pathophysiologic role both in immune
responses and in leukocyte emigration to sites of inflammation (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
membrane protein {ECO:0000250}.
-!- DOMAIN: Either the first or the fourth Ig-like C2-type domain is
required for VLA4-dependent cell adhesion. {ECO:0000250}.
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EMBL; U32086; AAA84866.1; -; mRNA.
RefSeq; NP_001003298.1; NM_001003298.1.
UniGene; Cfa.1941; -.
ProteinModelPortal; Q28260; -.
STRING; 9615.ENSCAFP00000029643; -.
PaxDb; Q28260; -.
PRIDE; Q28260; -.
GeneID; 403982; -.
KEGG; cfa:403982; -.
CTD; 7412; -.
eggNOG; ENOG410IIKS; Eukaryota.
eggNOG; ENOG4111F4V; LUCA.
HOGENOM; HOG000004820; -.
HOVERGEN; HBG053965; -.
InParanoid; Q28260; -.
KO; K06527; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
Gene3D; 2.60.40.10; -; 6.
InterPro; IPR003987; ICAM_VCAM_N.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR008424; Ig_C2-set.
InterPro; IPR013098; Ig_I-set.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR013151; Immunoglobulin.
InterPro; IPR003989; VCAM-1.
PANTHER; PTHR44644; PTHR44644; 3.
Pfam; PF05790; C2-set; 2.
Pfam; PF07679; I-set; 2.
Pfam; PF00047; ig; 1.
PRINTS; PR01472; ICAMVCAM1.
PRINTS; PR01474; VCAM1.
SMART; SM00409; IG; 6.
SMART; SM00408; IGc2; 5.
SUPFAM; SSF48726; SSF48726; 7.
PROSITE; PS50835; IG_LIKE; 5.
2: Evidence at transcript level;
Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 739 Vascular cell adhesion protein 1.
/FTId=PRO_0000014996.
TOPO_DOM 25 698 Extracellular. {ECO:0000255}.
TRANSMEM 699 720 Helical. {ECO:0000255}.
TOPO_DOM 721 739 Cytoplasmic. {ECO:0000255}.
DOMAIN 25 105 Ig-like C2-type 1.
DOMAIN 109 212 Ig-like C2-type 2.
DOMAIN 223 309 Ig-like C2-type 3.
DOMAIN 312 399 Ig-like C2-type 4.
DOMAIN 408 506 Ig-like C2-type 5.
DOMAIN 511 595 Ig-like C2-type 6.
DOMAIN 600 684 Ig-like C2-type 7.
CARBOHYD 76 76 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 77 77 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 273 273 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 531 531 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 47 95 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 52 99 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 137 195 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 246 291 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 335 383 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 534 579 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 739 AA; 81412 MW; BB5DA3853739C615 CRC64;
MPRKMVVIFG ASNILWMVFA VSQASKMEIF LEPRVAAQIG DVISLTCSTT GCETPSFSWR
TQIDSPLNGK VKNEGNNSTL TMDPVSFNNE HAYLCTATCG SKKLEKGIQV EIYSFPKDPE
IQLSGPLEVG KPVTVTCLVR DVYPFDRLEM NLLNGNDLLQ SKDFLEPMEK KSLETKSLEV
TFTPTNEDIG KGLVCRAQLH MDEIDFEPKE RETTKELQVY ISPRNTFISV TPSMRLQEGG
SVTMTCASEG LPPPQIFWSK KLDNGNLQLL SGNATLTLIA MRLEDSGTYV CEGVNEVGKD
GKEVELIVQE KPFTVEISPG PQIIAQIGDS VVLTCGVTDC ESPSFSWRTQ IDSPLSGTVK
VEGAKSTLTL SPVNLENEHS YLCTVTCGHK KLEKGIKVDL YSFPRDPEVE MSGLLVDGNP
VTVSCEVPNV YPSDRLEIEL FKGETIIESK SFLEDMDKKS LETKSLEMTF IPTTEDTGKV
LVCLAKLHID EMEFEPKQRQ STQTLYVNVA PRDTTVVVSP SSIVEEGSPV NMTCSSDGLP
APNILWSRRL SNGRLQSLSE DPILTLTSAK MEDSGIYVCE GINQAGISRK EVELIIQVAP
KDIQLIAFPS ESVKEGDTVI ISCTCGNVPK TWIILKKKAE TGDTVLKSRD GAYTIHKVQL
EDAGVYECES KNEAGLQLRS LTLDVKGREN NKDYFSPELL VLYCASSLII PAIGMIIYFA
RRANMKGSYS LVEAQKSKV


Related products :

Catalog number Product name Quantity
bs-0396P Peptides: VCAM-1_CD106(Vascular cell adhesion molecule 1 isoform b precusor; CD106 antigen) Protein Length:12-25 amino acids. 200ug lyophilized
10-663-45661 Vascular cell adhesion molecule 1 (VCAM-1) Human - V-CAM 1; CD106 antigen; INCAM-100 N_A 1 mg
10-663-45661 Vascular cell adhesion molecule 1 (VCAM-1) Human - V-CAM 1; CD106 antigen; INCAM-100 N_A 0.01 mg
10-663-45661 Vascular cell adhesion molecule 1 (VCAM-1) Human - V-CAM 1; CD106 antigen; INCAM-100 N_A 0.002 mg
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MA-4011-6 Anti-human Vascular Cell Adhesion Protein 1(VCAM-1 or CD106). IgG fraction (monoclonal) 200
C307 Recombinant Human Vascular Cell Adhesion Protein 1 per VCAM-1 per CD106 per L1CAM (C-6His) 10ug
MD-11-0003 Rat Anti-Mouse Vascular Cell Adhesion Molecule-1 (VCAM-1) _ CD106 500
P42244M CD106, VCAM-1 (Vascular Cell Adhesion Molecule) host: Mouse 0.2mg
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UB-E40115 Porcine vascular endothelial cell adhesion molecule-1 (VCAM-1 per CD106) ELISA Kit 96T
YHB0120Ca Canine Vascular endothelial cell adhesion molecule-1,VCAM-1-CD106 ELISA Kit 96T
E0021Ca Canine Vascular endothelial cell adhesion molecule-1,VCAM-1-CD106 ELISA Kit 96T
UB-S40115 Porcine Vascular Endothelial Cell Adhesion Molecule-1 (VCAM-1 CD106) ELISA Kit 96T
E0020Ca Canine Vascular endothelial cell adhesion molecule-1,VCAM-1-CD106 ELISA Kit 48T
P42244M CD106, VCAM-1 (Vascular Cell Adhesion Molecule)Mouse Purified IgG1 0.2mg
E0021Ca Canine Vascular endothelial cell adhesion molecule-1,VCAM-1 per CD106 ELISA Kit 48T
E0021Ca Canine Vascular endothelial cell adhesion molecule-1,VCAM-1 per CD106 ELISA Kit 96T
U0142m CLIA Mouse,Mus musculus,Vascular cell adhesion protein 1,V-CAM 1,Vcam1,VCAM-1,Vcam-1 96T
E0142r ELISA kit Rat,Rattus norvegicus,Vascular cell adhesion protein 1,V-CAM 1,Vcam1,VCAM-1,Vcam-1 96T
E0142m ELISA Mouse,Mus musculus,Vascular cell adhesion protein 1,V-CAM 1,Vcam1,VCAM-1,Vcam-1 96T
E0142m ELISA kit Mouse,Mus musculus,Vascular cell adhesion protein 1,V-CAM 1,Vcam1,VCAM-1,Vcam-1 96T
E0142r ELISA Rat,Rattus norvegicus,Vascular cell adhesion protein 1,V-CAM 1,Vcam1,VCAM-1,Vcam-1 96T
U0142r CLIA Rat,Rattus norvegicus,Vascular cell adhesion protein 1,V-CAM 1,Vcam1,VCAM-1,Vcam-1 96T
C307 Vascular Cell Adhesion Protein 1 VCAM-1 500


 

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