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Vasopressin-neurophysin 2-copeptin (AVP-NPII) [Cleaved into: Arg-vasopressin (Arginine-vasopressin); Neurophysin 2 (Neurophysin-II); Copeptin]

 NEU2_BOVIN              Reviewed;         166 AA.
P01180; Q3SZF1;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
25-APR-2018, entry version 145.
RecName: Full=Vasopressin-neurophysin 2-copeptin;
AltName: Full=AVP-NPII;
Contains:
RecName: Full=Arg-vasopressin;
AltName: Full=Arginine-vasopressin;
Contains:
RecName: Full=Neurophysin 2;
AltName: Full=Neurophysin-II;
Contains:
RecName: Full=Copeptin;
Flags: Precursor;
Name=AVP;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=6276766; DOI=10.1038/295299a0;
Land H., Schuetz G., Schmale H., Richter D.;
"Nucleotide sequence of cloned cDNA encoding bovine arginine
vasopressin-neurophysin II precursor.";
Nature 295:299-303(1982).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6709064; DOI=10.1038/308554a0;
Ruppert S., Scherer G., Schuetz G.;
"Recent gene conversion involving bovine vasopressin and oxytocin
precursor genes suggested by nucleotide sequence.";
Nature 308:554-557(1984).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3768139;
Rehbein M., Hillers M., Mohr E., Ivell R., Morley S., Schmale H.,
Richter D.;
"The neurohypophyseal hormones vasopressin and oxytocin. Precursor
structure, synthesis and regulation.";
Biol. Chem. Hoppe-Seyler 367:695-704(1986).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Hypothalamus;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[5]
PROTEIN SEQUENCE OF 20-28, AND AMIDATION AT GLY-28.
du Vigneaud V., Lawler H.C., Popenoe E.A.;
"Enzymatic cleavage of glycinamide from vasopressin and a proposed
structure for this pressor-antidiuretic hormone of the posterior
pituitary.";
J. Am. Chem. Soc. 75:4880-4881(1953).
[6]
PROTEIN SEQUENCE OF 20-28.
PubMed=13115463; DOI=10.1016/0006-3002(53)90173-5;
Acher R., Chauvet J.;
"The structure of bovine vasopressin.";
Biochim. Biophys. Acta 12:487-488(1953).
[7]
PROTEIN SEQUENCE OF 32-126.
PubMed=3318825; DOI=10.1016/0006-291X(87)90950-8;
Burman S., Breslow E., Chait B.T., Chaudhary T.;
"Partial assignment of disulfide pairs in neurophysins.";
Biochem. Biophys. Res. Commun. 148:827-833(1987).
[8]
PROTEIN SEQUENCE OF 32-126.
Chauvet M.-T., Chauvet J., Acher R.;
"The neurohypophysial hormone-binding protein: complete amino-acid
sequence of ovine and bovine MSEL-neurophysins.";
Eur. J. Biochem. 69:475-485(1976).
[9]
PROTEIN SEQUENCE OF 32-126.
PubMed=1252249; DOI=10.1016/0006-291X(76)91192-X;
Wuu T.-C., Crumm S.E.;
"Amino acid sequence of bovine neurophysin-II: a reinvestigation.";
Biochem. Biophys. Res. Commun. 68:634-639(1976).
[10]
PRELIMINARY PROTEIN SEQUENCE (FETAL NEUROPHYSIN 2).
PubMed=1248642; DOI=10.1016/0014-5793(76)80023-3;
Chauvet M.-T., Chauvet J., Acher R.;
"Foetal bovine MSEL-neurophysin: comparison with adult homologous
neurophysin.";
FEBS Lett. 62:89-92(1976).
[11]
DISULFIDE BONDS IN NEUROPHYSIN 2.
PubMed=4564211; DOI=10.1073/pnas.69.11.3350;
Schlesinger D.H., Frangione B., Walter R.;
"Covalent structure of bovine neurophysin-II: localization of the
disulfide bonds.";
Proc. Natl. Acad. Sci. U.S.A. 69:3350-3354(1972).
[12]
PROTEIN SEQUENCE OF 128-166.
PubMed=465021; DOI=10.1016/S0006-291X(79)80007-8;
Smyth D.G., Massey D.E.;
"A new glycopeptide in pig, ox and sheep pituitary.";
Biochem. Biophys. Res. Commun. 87:1006-1010(1979).
[13]
X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF NEUROPHYSIN 2.
PubMed=2034668; DOI=10.1073/pnas.88.10.4240;
Chen L.Q., Rose J.P., Breslow E., Yang D., Chang W.-R.,
Furey W.F. Jr., Sax M., Wang B.-C.;
"Crystal structure of a bovine neurophysin II dipeptide complex at 2.8
A determined from the single-wavelength anomalous scattering signal of
an incorporated iodine atom.";
Proc. Natl. Acad. Sci. U.S.A. 88:4240-4244(1991).
[14]
X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF NEUROPHYSIN 2.
TISSUE=Pituitary;
PubMed=8564543; DOI=10.1038/nsb0296-163;
Rose J.P., Wu C.-K., Hsiao C.-D., Breslow E., Wang B.-C.;
"Crystal structure of the neurophysin-oxytocin complex.";
Nat. Struct. Biol. 3:163-169(1996).
-!- FUNCTION: Neurophysin 2 specifically binds vasopressin.
-!- FUNCTION: Vasopressin has a direct antidiuretic action on the
kidney, it also causes vasoconstriction of the peripheral vessels.
Acts by binding to vasopressin receptors (V1bR/AVPR1B,
V1aR/AVPR1A, and V2R/AVPR2) (By similarity).
{ECO:0000250|UniProtKB:P01185}.
-!- SUBUNIT: Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85
pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (By
similarity). Interacts with oxytocin receptor (OXTR) (Ki=110 nM)
(By similarity). {ECO:0000250|UniProtKB:P01185}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- MISCELLANEOUS: Fetal neurophysin is the major neurophysin present
in the neurohypophysis of 7 to 9 month fetuses and its sequence
appears to be identical with that of the adult.
-!- SIMILARITY: Belongs to the vasopressin/oxytocin family.
{ECO:0000305}.
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EMBL; V00113; CAA23447.1; -; mRNA.
EMBL; X00503; CAA25195.1; -; Genomic_DNA.
EMBL; M25645; AAA30806.1; -; mRNA.
EMBL; BC102897; AAI02898.1; -; mRNA.
PIR; S09580; NVBO2.
RefSeq; NP_789824.1; NM_176854.2.
UniGene; Bt.49210; -.
PDB; 1JK4; X-ray; 2.30 A; A=38-126, B=20-26.
PDB; 1JK6; X-ray; 2.40 A; A/C=38-126.
PDB; 1NPO; X-ray; 3.00 A; A/C=32-126.
PDB; 2BN2; X-ray; 2.80 A; A/C/E/G=32-126.
PDBsum; 1JK4; -.
PDBsum; 1JK6; -.
PDBsum; 1NPO; -.
PDBsum; 2BN2; -.
ProteinModelPortal; P01180; -.
SMR; P01180; -.
STRING; 9913.ENSBTAP00000010555; -.
PaxDb; P01180; -.
Ensembl; ENSBTAT00000010555; ENSBTAP00000010555; ENSBTAG00000008027.
GeneID; 280728; -.
KEGG; bta:280728; -.
CTD; 551; -.
VGNC; VGNC:26356; AVP.
eggNOG; ENOG410IXM5; Eukaryota.
eggNOG; ENOG4111S8B; LUCA.
GeneTree; ENSGT00390000004511; -.
HOGENOM; HOG000113768; -.
HOVERGEN; HBG004462; -.
InParanoid; P01180; -.
KO; K05242; -.
OMA; SGLCCNS; -.
OrthoDB; EOG091G0V8Z; -.
TreeFam; TF333018; -.
Reactome; R-BTA-388479; Vasopressin-like receptors.
Reactome; R-BTA-416476; G alpha (q) signalling events.
Reactome; R-BTA-418555; G alpha (s) signalling events.
Reactome; R-BTA-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
Reactome; R-BTA-879518; Transport of organic anions.
Reactome; R-BTA-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-BTA-8856828; Clathrin-mediated endocytosis.
EvolutionaryTrace; P01180; -.
Proteomes; UP000009136; Chromosome 13.
Bgee; ENSBTAG00000008027; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
GO; GO:0004871; F:signal transducer activity; IEA:Ensembl.
GO; GO:0031894; F:V1A vasopressin receptor binding; IEA:Ensembl.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO; GO:0030819; P:positive regulation of cAMP biosynthetic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0070528; P:protein kinase C signaling; IEA:Ensembl.
GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
Gene3D; 2.60.9.10; -; 1.
InterPro; IPR000981; Neurhyp_horm.
InterPro; IPR036387; Neurhyp_horm_dom_sf.
InterPro; IPR022423; Neurohypophysial_hormone_CS.
PANTHER; PTHR11681; PTHR11681; 1.
Pfam; PF00220; Hormone_4; 1.
Pfam; PF00184; Hormone_5; 1.
PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
PRINTS; PR00831; NEUROPHYSIN.
ProDom; PD001676; Neurhyp_horm; 1.
SMART; SM00003; NH; 1.
SUPFAM; SSF49606; SSF49606; 1.
PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
1: Evidence at protein level;
3D-structure; Amidation; Cleavage on pair of basic residues;
Complete proteome; Direct protein sequencing; Disulfide bond;
Glycoprotein; Hormone; Reference proteome; Secreted; Signal;
Vasoactive; Vasoconstrictor.
SIGNAL 1 19 {ECO:0000269|PubMed:13115463,
ECO:0000269|Ref.5}.
PEPTIDE 20 28 Arg-vasopressin.
/FTId=PRO_0000020509.
CHAIN 32 126 Neurophysin 2.
/FTId=PRO_0000020510.
PEPTIDE 128 166 Copeptin.
/FTId=PRO_0000020511.
SITE 28 28 Important for agonist activity on
V1aR/AVPR1A.
{ECO:0000250|UniProtKB:P01185}.
MOD_RES 28 28 Glycine amide. {ECO:0000269|Ref.5}.
CARBOHYD 133 133 N-linked (GlcNAc...) asparagine.
DISULFID 20 25 {ECO:0000269|PubMed:4564211}.
DISULFID 41 85 {ECO:0000269|PubMed:4564211}.
DISULFID 44 58 {ECO:0000269|PubMed:4564211}.
DISULFID 52 75 {ECO:0000269|PubMed:4564211}.
DISULFID 59 65 {ECO:0000269|PubMed:4564211}.
DISULFID 92 104 {ECO:0000269|PubMed:4564211}.
DISULFID 98 116 {ECO:0000269|PubMed:4564211}.
DISULFID 105 110 {ECO:0000269|PubMed:4564211}.
VARIANT 120 120 V -> I (in 30% of the molecules).
TURN 22 24 {ECO:0000244|PDB:1JK4}.
HELIX 35 37 {ECO:0000244|PDB:2BN2}.
STRAND 43 45 {ECO:0000244|PDB:1JK4}.
HELIX 46 48 {ECO:0000244|PDB:1JK4}.
STRAND 50 54 {ECO:0000244|PDB:1JK4}.
STRAND 57 60 {ECO:0000244|PDB:1JK4}.
TURN 61 63 {ECO:0000244|PDB:1JK4}.
STRAND 64 69 {ECO:0000244|PDB:1JK4}.
HELIX 70 80 {ECO:0000244|PDB:1JK4}.
STRAND 89 92 {ECO:0000244|PDB:1JK4}.
TURN 93 95 {ECO:0000244|PDB:1JK4}.
STRAND 96 100 {ECO:0000244|PDB:1JK4}.
STRAND 103 105 {ECO:0000244|PDB:1JK4}.
STRAND 110 112 {ECO:0000244|PDB:1JK4}.
HELIX 114 116 {ECO:0000244|PDB:1JK6}.
SEQUENCE 166 AA; 17325 MW; 0441DC255288D8F6 CRC64;
MPDATLPACF LSLLAFTSAC YFQNCPRGGK RAMSDLELRQ CLPCGPGGKG RCFGPSICCG
DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA AGICCNDESC VTEPECREGV
GFPRRVRAND RSNATLLDGP SGALLLRLVQ LAGAPEPAEP AQPGVY


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