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Vav guanine nucleotide exchange factor 3

 K7FDK0_PELSI            Unreviewed;       808 AA.
K7FDK0;
09-JAN-2013, integrated into UniProtKB/TrEMBL.
09-JAN-2013, sequence version 1.
20-JUN-2018, entry version 49.
SubName: Full=Vav guanine nucleotide exchange factor 3 {ECO:0000313|Ensembl:ENSPSIP00000006110};
Name=VAV3 {ECO:0000313|Ensembl:ENSPSIP00000006110};
Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae;
Pelodiscus.
NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000006110, ECO:0000313|Proteomes:UP000007267};
[1] {ECO:0000313|Ensembl:ENSPSIP00000006110}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=17381049; DOI=10.1080/10425170600760091;
Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.;
"The complete mitochondrial genome of the Korean soft-shelled turtle
Pelodiscus sinensis (Testudines, Trionychidae).";
DNA Seq. 17:471-483(2006).
[2] {ECO:0000313|Proteomes:UP000007267}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
Soft-shell Turtle Genome Consortium;
Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSPSIP00000006110}
IDENTIFICATION.
Ensembl;
Submitted (NOV-2012) to UniProtKB.
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EMBL; AGCU01063150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGCU01063151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGCU01063152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGCU01063153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGCU01063154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGCU01063155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGCU01063156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGCU01063157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGCU01063158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGCU01063159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 13735.ENSPSIP00000006110; -.
Ensembl; ENSPSIT00000006147; ENSPSIP00000006110; ENSPSIG00000005525.
eggNOG; KOG2996; Eukaryota.
eggNOG; ENOG410XPH6; LUCA.
GeneTree; ENSGT00920000148946; -.
OMA; LGRVDNC; -.
OrthoDB; EOG091G01O3; -.
TreeFam; TF316171; -.
Proteomes; UP000007267; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IEA:Ensembl.
GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl.
GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
GO; GO:0043087; P:regulation of GTPase activity; IEA:Ensembl.
GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
GO; GO:0006906; P:vesicle fusion; IEA:Ensembl.
CDD; cd00029; C1; 1.
CDD; cd01223; PH_Vav; 1.
CDD; cd00160; RhoGEF; 1.
CDD; cd11978; SH3_VAV3_2; 1.
Gene3D; 1.10.418.10; -; 1.
Gene3D; 1.20.900.10; -; 1.
Gene3D; 2.30.29.30; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR001715; CH-domain.
InterPro; IPR036872; CH_dom_sf.
InterPro; IPR035899; DBL_dom_sf.
InterPro; IPR000219; DH-domain.
InterPro; IPR017868; Filamin/ABP280_repeat-like.
InterPro; IPR001331; GDS_CDC24_CS.
InterPro; IPR002219; PE/DAG-bd.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
InterPro; IPR037832; PH_Vav.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
InterPro; IPR035734; VAV3_SH3_2.
Pfam; PF00130; C1_1; 1.
Pfam; PF00307; CH; 1.
Pfam; PF00169; PH; 1.
Pfam; PF00621; RhoGEF; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
Pfam; PF07653; SH3_2; 1.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00109; C1; 1.
SMART; SM00233; PH; 1.
SMART; SM00325; RhoGEF; 1.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF47576; SSF47576; 1.
SUPFAM; SSF48065; SSF48065; 1.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS00741; DH_1; 1.
PROSITE; PS50010; DH_2; 1.
PROSITE; PS50194; FILAMIN_REPEAT; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
PROSITE; PS00479; ZF_DAG_PE_1; 1.
PROSITE; PS50081; ZF_DAG_PE_2; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000007267};
Metal-binding {ECO:0000256|SAAS:SAAS00515414};
Reference proteome {ECO:0000313|Proteomes:UP000007267};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643}; Zinc {ECO:0000256|SAAS:SAAS00515409}.
DOMAIN 124 303 DH. {ECO:0000259|PROSITE:PS50010}.
DOMAIN 332 434 PH. {ECO:0000259|PROSITE:PS50003}.
DOMAIN 445 494 Phorbol-ester/DAG-type.
{ECO:0000259|PROSITE:PS50081}.
DOMAIN 525 593 SH3. {ECO:0000259|PROSITE:PS50002}.
DOMAIN 605 699 SH2. {ECO:0000259|PROSITE:PS50001}.
REPEAT 616 652 Filamin. {ECO:0000256|PROSITE-
ProRule:PRU00087}.
DOMAIN 749 808 SH3. {ECO:0000259|PROSITE:PS50002}.
COILED 224 244 {ECO:0000256|SAM:Coils}.
SEQUENCE 808 AA; 93430 MW; 21B044C8CDF80CD7 CRC64;
FLCLKNIRTF LSACCEIFGM KKSELFEAFD LFDVRDFGKV IETLSKLSRT PIALVTGIRP
FPTEESVNDE DIYKGLPDLL DENGVDEDEE LYDCVYGEDE GGEVYEDLMK DEAPHQPKCI
ENDIRSCCLT EIKQTEEKYT ETLESIEKFF MVPLKRFLSA SEFDIVFINI PELVKTHRSL
MQDIHDSIVN KNDQNLYQIF ISYKERMVIY GQYCSQVETA ITCLDNISKT KEDVKLKLEE
CSKRANNGKF TLRDLLVVPM QRVLKYHLLL QELVKHTTDP AEKENLKLAL DAMKDLAQYV
NEVKRDNETL REIKQFQLSI ENVNHSLLTY GRPQGDGEIK MTTLDKRARQ DRHIFLFDLA
VIVCKRRGDN YEMKEIIDLQ KYRITNNPTT DKENKKWSYG FYLIHIQGQN GLEFYCKTKD
LKKKWLEQFE MALSNIRPDN ANTSFHEFKM YTFNRVTSCR VCQMLLRGTF YQGYLCSKCG
AGVHKECLGR LDNCGGANSG DAFDLYFCMQ KRTNGIRKSS RHPDSGLPKM QVVRNYNGVP
QPNPHDGPPL HIQTGDTIEL LKGDAHSRFW QGRNLVTGEL GYFPSDVVKP YPCVPKPVDY
SCQPWFAGAM ERLQAESELI NRGNRTYLVR YRTKESGEYA ISIKYNNEVK HIKILTKDGF
FHIAENKKFK SLMELVEYYN RHSLKEGFRS LDTTLQFPYK ESENSDGQRS NRASSNSPSL
FCGFSFVTPP DYSFVPPSST PFWSVLNPKV IGIAIARYDF CARDMRELSL VKGDVVKIYT
KMSANGWWRG EVNGRMGWFP STYVEEDE


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