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Vav guanine nucleotide exchange factor 3

 M3VW63_FELCA            Unreviewed;       847 AA.
M3VW63;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 2.
05-DEC-2018, entry version 53.
SubName: Full=Vav guanine nucleotide exchange factor 3 {ECO:0000313|Ensembl:ENSFCAP00000001106};
Name=VAV3 {ECO:0000313|Ensembl:ENSFCAP00000001106};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000001106, ECO:0000313|Proteomes:UP000011712};
[1] {ECO:0000313|Ensembl:ENSFCAP00000001106, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001106,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|Ensembl:ENSFCAP00000001106}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001106};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSFCAP00000001106}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001106};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
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EMBL; AANG04003279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_011283337.1; XM_011285035.2.
STRING; 9685.ENSFCAP00000001106; -.
Ensembl; ENSFCAT00000001192; ENSFCAP00000001106; ENSFCAG00000001191.
GeneID; 101087417; -.
KEGG; fca:101087417; -.
CTD; 10451; -.
eggNOG; KOG2996; Eukaryota.
eggNOG; ENOG410XPH6; LUCA.
GeneTree; ENSGT00940000155252; -.
InParanoid; M3VW63; -.
KO; K05730; -.
OrthoDB; EOG091G01O3; -.
Proteomes; UP000011712; Chromosome C1.
Bgee; ENSFCAG00000001191; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
CDD; cd00029; C1; 1.
CDD; cd00014; CH; 1.
CDD; cd01223; PH_Vav; 1.
CDD; cd00160; RhoGEF; 1.
CDD; cd10407; SH2_Vav3; 1.
CDD; cd11978; SH3_VAV3_2; 1.
Gene3D; 1.10.418.10; -; 1.
Gene3D; 1.20.900.10; -; 1.
Gene3D; 2.30.29.30; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR022613; CAMSAP_CH.
InterPro; IPR001715; CH-domain.
InterPro; IPR036872; CH_dom_sf.
InterPro; IPR035899; DBL_dom_sf.
InterPro; IPR000219; DH-domain.
InterPro; IPR001331; GDS_CDC24_CS.
InterPro; IPR002219; PE/DAG-bd.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
InterPro; IPR037832; PH_Vav.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
InterPro; IPR003096; SM22_calponin.
InterPro; IPR035881; VAV3_SH2.
InterPro; IPR035734; VAV3_SH3_2.
Pfam; PF00130; C1_1; 1.
Pfam; PF11971; CAMSAP_CH; 1.
Pfam; PF00169; PH; 1.
Pfam; PF00621; RhoGEF; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF07653; SH3_2; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
PRINTS; PR00888; SM22CALPONIN.
SMART; SM00109; C1; 1.
SMART; SM00033; CH; 1.
SMART; SM00233; PH; 1.
SMART; SM00325; RhoGEF; 1.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF47576; SSF47576; 1.
SUPFAM; SSF48065; SSF48065; 1.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50021; CH; 1.
PROSITE; PS00741; DH_1; 1.
PROSITE; PS50010; DH_2; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
PROSITE; PS00479; ZF_DAG_PE_1; 1.
PROSITE; PS50081; ZF_DAG_PE_2; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000011712};
Metal-binding {ECO:0000256|SAAS:SAAS00515414};
Reference proteome {ECO:0000313|Proteomes:UP000011712};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643}; Zinc {ECO:0000256|SAAS:SAAS00515409}.
DOMAIN 1 119 Calponin-homology (CH).
{ECO:0000259|PROSITE:PS50021}.
DOMAIN 192 371 DH. {ECO:0000259|PROSITE:PS50010}.
DOMAIN 400 502 PH. {ECO:0000259|PROSITE:PS50003}.
DOMAIN 513 562 Phorbol-ester/DAG-type.
{ECO:0000259|PROSITE:PS50081}.
DOMAIN 592 660 SH3. {ECO:0000259|PROSITE:PS50002}.
DOMAIN 672 766 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 788 847 SH3. {ECO:0000259|PROSITE:PS50002}.
COILED 292 312 {ECO:0000256|SAM:Coils}.
SEQUENCE 847 AA; 97736 MW; 496D9044DAB1B36C CRC64;
MEPWKQCAQW LIHCKVLPAN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RAHSINLKEI
NLRPQMSQFL CLKNIRTFLT ACCETFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI
ALATGIRPFP TEESVNDEDI YKGLPDLIDE THVEDEEGLY DCVYGEDEGG EVYEDLMKAE
EAHQAKCPEN DIRSCCLAEI KQTEEKYTET LESIEKYFMA PLKRFLTAAE FDSVFINIPE
LVKVHRNLMQ EIHDSIVNKN DQNLYQVFIN YKERLVIYGQ YCSGVELAIS SLDNISKTKE
DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTTDPME KANLKLALDA
MKDLAQYVNE VKRDNETLRE IKQFQLSIEN LNQPVLLFGR PQGDGEIRIT TLDKHTKQER
HIFLFDLAVI VCKRKGDNYE MKEIIDLQQY KIANNPTTDK ENKKWSYGFY LIHTQGQNGL
EFYCKTKDLK KKWLEQFEMA LSNIRPDYAD SNFHEFKMHT FSRVTSCKVC QMLLRGTFYQ
GYLCFKCGAR AHKECLGRVD NCGRVNSAEQ GTLKPPEKRT NGLRRNPRQV DPGLPKMQVI
KNYTGTPPPA LHEGPPLHIQ AGDTVELLRG DAHSLFWQGR NLASGEVGFF PSDAVKPCPC
VPKPVDYSCQ PWYAGAMERL QAETELINRV NSTYLVRHRT KESGEYAISI KYNNEAKHIK
ILTRDGFFHI AENRKFKSLM ELVEYYKHHS LKEGFRTLDT TLQFPYKEPE HSAGQRGNRA
GHSLLSPKVL GIAVARYDFC ARDMRELSLL KGDVVKIYTK MSANGWWRGE VNGRVGWFPS
TYVEEDE


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