GENTAUR Molecular Products.

 VTI1A_HUMAN             Reviewed;         217 AA.
 Q96AJ9; A2A307; B4E137; Q5W0D7;
 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
 25-JAN-2012, sequence version 2.
 28-MAR-2018, entry version 133.
 RecName: Full=Vesicle transport through interaction with t-SNAREs homolog 1A;
 AltName: Full=Vesicle transport v-SNARE protein Vti1-like 2;
 AltName: Full=Vti1-rp2;
 Name=VTI1A;
 Homo sapiens (Human).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
 Catarrhini; Hominidae; Homo.
 NCBI_TaxID=9606 {ECO:0000312|EMBL:AAH17052.1};
 [1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
 TISSUE=Thymus;
 PubMed=14702039; DOI=10.1038/ng1285;
 Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
 Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
 Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
 Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
 Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
 Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
 Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
 Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
 Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
 Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
 Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
 Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
 Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
 Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
 Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
 Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
 Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
 Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
 Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
 Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
 Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
 Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
 Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
 Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
 Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
 Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
 Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
 Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
 "Complete sequencing and characterization of 21,243 full-length human
 cDNAs.";
 Nat. Genet. 36:40-45(2004).
 [2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 PubMed=15164054; DOI=10.1038/nature02462;
 Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
 Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
 Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
 Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
 Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
 Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
 Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
 Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
 Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
 Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
 Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
 Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
 Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
 Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
 Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
 Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
 Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
 Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
 Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
 Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
 Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
 Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
 Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
 Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
 Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
 Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
 "The DNA sequence and comparative analysis of human chromosome 10.";
 Nature 429:375-381(2004).
 [3] {ECO:0000312|EMBL:AAH17052.1}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
 Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
 Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
 Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
 Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
 Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
 Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
 Venter J.C.;
 Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
 [4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
 TISSUE=Lung;
 PubMed=15489334; DOI=10.1101/gr.2596504;
 The MGC Project Team;
 "The status, quality, and expansion of the NIH full-length cDNA
 project: the Mammalian Gene Collection (MGC).";
 Genome Res. 14:2121-2127(2004).
 [5]
 FUNCTION.
 PubMed=18195106; DOI=10.1083/jcb.200707136;
 Ganley I.G., Espinosa E., Pfeffer S.R.;
 "A syntaxin 10-SNARE complex distinguishes two distinct transport
 routes from endosomes to the trans-Golgi in human cells.";
 J. Cell Biol. 180:159-172(2008).
 [6]
 FUNCTION, AND SUBCELLULAR LOCATION.
 PubMed=19138172; DOI=10.1042/BJ20081736;
 Flowerdew S.E., Burgoyne R.D.;
 "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic
 route to the cell surface used by KChIP1 and Kv4 potassium channels.";
 Biochem. J. 418:529-540(2009).
 [7]
 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
 PubMed=21269460; DOI=10.1186/1752-0509-5-17;
 Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
 Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
 "Initial characterization of the human central proteome.";
 BMC Syst. Biol. 5:17-17(2011).
 [8]
 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
 PubMed=25944712; DOI=10.1002/pmic.201400617;
 Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
 Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
 "N-terminome analysis of the human mitochondrial proteome.";
 Proteomics 15:2519-2524(2015).
 -!- FUNCTION: V-SNARE that mediates vesicle transport pathways through
     interactions with t-SNAREs on the target membrane. These
     interactions are proposed to mediate aspects of the specificity of
     vesicle trafficking and to promote fusion of the lipid bilayers.
     Involved in vesicular transport from the late endosomes to the
     trans-Golgi network. Along with VAMP7, involved in an non-
     conventional RAB1-dependent traffic route to the cell surface used
     by KCNIP1 and KCND2. May be involved in increased cytokine
     secretion associated with cellular senescence.
     {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}.
 -!- SUBUNIT: Interacts with distinct SNARE complexes that contain
     either STX5 or STX6. Interacts with NAPA and, to a lesser extent,
     with NAPG. Identified in a complex containing STX6, STX12, VAMP4
     and VTI1A. {ECO:0000250}.
 -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
     {ECO:0000269|PubMed:19138172}. Golgi apparatus membrane
     {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
 -!- ALTERNATIVE PRODUCTS:
     Event=Alternative splicing; Named isoforms=2;
     Name=2;
       IsoId=Q96AJ9-2; Sequence=Displayed;
     Name=1;
       IsoId=Q96AJ9-1; Sequence=VSP_039848;
       Note=No experimental confirmation available.;
 -!- SIMILARITY: Belongs to the VTI1 family. {ECO:0000305}.
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 EMBL; AK303646; BAG64649.1; -; mRNA.
 EMBL; AL139120; CAH71781.2; -; Genomic_DNA.
 EMBL; AC022018; CAH71781.2; JOINED; Genomic_DNA.
 EMBL; AL158212; CAH71781.2; JOINED; Genomic_DNA.
 EMBL; AL139120; CAM15142.1; -; Genomic_DNA.
 EMBL; AC022018; CAM15142.1; JOINED; Genomic_DNA.
 EMBL; AL158212; CAM22437.1; -; Genomic_DNA.
 EMBL; AC022018; CAM22437.1; JOINED; Genomic_DNA.
 EMBL; AL139120; CAM22437.1; JOINED; Genomic_DNA.
 EMBL; CH471066; EAW49524.1; -; Genomic_DNA.
 EMBL; CH471066; EAW49525.1; -; Genomic_DNA.
 EMBL; BC017052; AAH17052.1; -; mRNA.
 CCDS; CCDS7575.2; -. [Q96AJ9-2]
 RefSeq; NP_001305132.1; NM_001318203.1.
 RefSeq; NP_001305134.1; NM_001318205.1.
 RefSeq; NP_660207.2; NM_145206.3. [Q96AJ9-2]
 RefSeq; XP_005269601.1; XM_005269544.4. [Q96AJ9-1]
 UniGene; Hs.194554; -.
 ProteinModelPortal; Q96AJ9; -.
 SMR; Q96AJ9; -.
 BioGrid; 126789; 14.
 CORUM; Q96AJ9; -.
 DIP; DIP-44223N; -.
 IntAct; Q96AJ9; 6.
 MINT; Q96AJ9; -.
 STRING; 9606.ENSP00000376792; -.
 iPTMnet; Q96AJ9; -.
 PhosphoSitePlus; Q96AJ9; -.
 BioMuta; VTI1A; -.
 DMDM; 374095459; -.
 EPD; Q96AJ9; -.
 PaxDb; Q96AJ9; -.
 PeptideAtlas; Q96AJ9; -.
 PRIDE; Q96AJ9; -.
 DNASU; 143187; -.
 Ensembl; ENST00000393077; ENSP00000376792; ENSG00000151532. [Q96AJ9-2]
 Ensembl; ENST00000432306; ENSP00000395017; ENSG00000151532. [Q96AJ9-1]
 GeneID; 143187; -.
 KEGG; hsa:143187; -.
 UCSC; uc001kzz.5; human. [Q96AJ9-2]
 CTD; 143187; -.
 DisGeNET; 143187; -.
 EuPathDB; HostDB:ENSG00000151532.13; -.
 GeneCards; VTI1A; -.
 H-InvDB; HIX0023094; -.
 HGNC; HGNC:17792; VTI1A.
 HPA; HPA054108; -.
 MIM; 614316; gene.
 neXtProt; NX_Q96AJ9; -.
 OpenTargets; ENSG00000151532; -.
 PharmGKB; PA134928049; -.
 eggNOG; KOG1666; Eukaryota.
 eggNOG; ENOG4111J90; LUCA.
 GeneTree; ENSGT00530000063466; -.
 HOGENOM; HOG000116573; -.
 HOVERGEN; HBG104027; -.
 InParanoid; Q96AJ9; -.
 KO; K08493; -.
 OMA; NYEQQYA; -.
 OrthoDB; EOG091G0L3Z; -.
 PhylomeDB; Q96AJ9; -.
 TreeFam; TF312874; -.
 Reactome; R-HSA-6811438; Intra-Golgi traffic.
 Reactome; R-HSA-6811440; Retrograde transport at the Trans-Golgi-Network.
 SIGNOR; Q96AJ9; -.
 ChiTaRS; VTI1A; human.
 GeneWiki; VTI1A; -.
 GenomeRNAi; 143187; -.
 PRO; PR:Q96AJ9; -.
 Proteomes; UP000005640; Chromosome 10.
 Bgee; ENSG00000151532; -.
 CleanEx; HS_VTI1A; -.
 Genevisible; Q96AJ9; HS.
 GO; GO:0005776; C:autophagosome; IDA:ParkinsonsUK-UCL.
 GO; GO:0030136; C:clathrin-coated vesicle; ISS:ParkinsonsUK-UCL.
 GO; GO:0005829; C:cytosol; IEA:GOC.
 GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
 GO; GO:0005768; C:endosome; ISS:ParkinsonsUK-UCL.
 GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
 GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
 GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
 GO; GO:0044306; C:neuron projection terminus; ISS:ParkinsonsUK-UCL.
 GO; GO:0043025; C:neuronal cell body; ISS:ParkinsonsUK-UCL.
 GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:ParkinsonsUK-UCL.
 GO; GO:0031201; C:SNARE complex; ISS:ParkinsonsUK-UCL.
 GO; GO:0008021; C:synaptic vesicle; ISS:ParkinsonsUK-UCL.
 GO; GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
 GO; GO:0005484; F:SNAP receptor activity; IDA:HGNC.
 GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
 GO; GO:0006914; P:autophagy; IMP:ParkinsonsUK-UCL.
 GO; GO:0006888; P:ER to Golgi vesicle-mediated transport; ISS:ParkinsonsUK-UCL.
 GO; GO:0090161; P:Golgi ribbon formation; IMP:UniProtKB.
 GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
 GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
 GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
 GO; GO:0042147; P:retrograde transport, endosome to Golgi; IDA:UniProtKB.
 GO; GO:0048280; P:vesicle fusion with Golgi apparatus; ISS:ParkinsonsUK-UCL.
 GO; GO:0050882; P:voluntary musculoskeletal movement; IMP:UniProtKB.
 Gene3D; 1.20.58.400; -; 1.
 InterPro; IPR027027; GOSR2/Membrin/Bos1.
 InterPro; IPR010989; SNARE.
 InterPro; IPR000727; T_SNARE_dom.
 InterPro; IPR038407; v-SNARE_N_sf.
 InterPro; IPR007705; Vesicle_trsprt_v-SNARE_N.
 Pfam; PF05008; V-SNARE; 1.
 PIRSF; PIRSF028865; Membrin-2; 1.
 SMART; SM00397; t_SNARE; 1.
 SUPFAM; SSF47661; SSF47661; 1.
 1: Evidence at protein level;
 Alternative splicing; Coiled coil; Complete proteome;
 Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport;
 Reference proteome; Transmembrane; Transmembrane helix; Transport.
 CHAIN         1    217       Vesicle transport through interaction
                              with t-SNAREs homolog 1A.
                              /FTId=PRO_0000218225.
 TOPO_DOM      1    192       Cytoplasmic. {ECO:0000255}.
 TRANSMEM    193    213       Helical. {ECO:0000255}.
 TOPO_DOM    214    217       Extracellular. {ECO:0000255}.
 COILED       31     92       {ECO:0000255}.
 COILED      112    178       {ECO:0000255}.
 VAR_SEQ     188    217       IIQNRILLVILGIIVVITILMAITFSVRRH -> GCSVKKQ
                              CNLSLAPKA (in isoform 1).
                              {ECO:0000303|PubMed:15489334}.
                              /FTId=VSP_039848.
 CONFLICT     83     83       K -> E (in Ref. 1; BAG64649).
                              {ECO:0000305}.
 SEQUENCE   217 AA;  25218 MW;  3FE5FE787B5958F0 CRC64;
 MSSDFEGYEQ DFAVLTAEIT SKIARVPRLP PDEKKQMVAN VEKQLEEAKE LLEQMDLEVR
 EIPPQSRGMY SNRMRSYKQE MGKLETDFKR SRIAYSDEVR NELLGDDGNS SENQRAHLLD
 NTERLERSSR RLEAGYQIAV ETEQIGQEML ENLSHDREKI QRARERLRET DANLGKSSRI
 LTGMLRRIIQ NRILLVILGI IVVITILMAI TFSVRRH

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