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Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (mVGAT) (mVIAAT)

 VIAAT_MOUSE             Reviewed;         525 AA.
O35633;
28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
28-MAR-2003, sequence version 3.
07-JUN-2017, entry version 144.
RecName: Full=Vesicular inhibitory amino acid transporter;
AltName: Full=GABA and glycine transporter;
AltName: Full=Solute carrier family 32 member 1;
AltName: Full=Vesicular GABA transporter;
Short=mVGAT;
Short=mVIAAT;
Name=Slc32a1; Synonyms=Vgat, Viaat;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND FUNCTION.
STRAIN=BALB/cJ; TISSUE=Brain;
PubMed=9395291; DOI=10.1016/S0014-5793(97)01279-9;
Sagne C., El Mestikawy S., Isambert M.-F., Hamon M., Henry J.-P.,
Giros B.P., Gasnier B.;
"Cloning of a functional vesicular GABA and glycine transporter by
screening of genome databases.";
FEBS Lett. 417:177-183(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
PubMed=12573541; DOI=10.1016/S0169-328X(02)00648-4;
Ebihara S., Obata K., Yanagawa Y.;
"Mouse vesicular GABA transporter gene: genomic organization,
transcriptional regulation and chromosomal localization.";
Brain Res. Mol. Brain Res. 110:126-139(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
TISSUE SPECIFICITY.
PubMed=12115694; DOI=10.1002/cne.10272;
Jellali A., Stussi-Garaud C., Gasnier B., Rendon A., Sahel J.-A.,
Dreyfus H., Picaud S.;
"Cellular localization of the vesicular inhibitory amino acid
transporter in the mouse and human retina.";
J. Comp. Neurol. 449:76-87(2002).
[5]
NITRATION [LARGE SCALE ANALYSIS] AT TYR-186, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=16800626; DOI=10.1021/bi060474w;
Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H.,
Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J.,
Squier T.C., Bigelow D.J.;
"Endogenously nitrated proteins in mouse brain: links to
neurodegenerative disease.";
Biochemistry 45:8009-8022(2006).
[6]
DISRUPTION PHENOTYPE.
PubMed=16701208; DOI=10.1016/j.neuron.2006.04.016;
Wojcik S.M., Katsurabayashi S., Guillemin I., Friauf E., Rosenmund C.,
Brose N., Rhee J.S.;
"A shared vesicular carrier allows synaptic corelease of GABA and
glycine.";
Neuron 50:575-587(2006).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Involved in the uptake of GABA and glycine into the
synaptic vesicles. {ECO:0000250|UniProtKB:O35458,
ECO:0000269|PubMed:9395291}.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
{ECO:0000250|UniProtKB:O35458}; Multi-pass membrane protein
{ECO:0000255}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=b;
IsoId=O35633-1; Sequence=Displayed;
Name=2; Synonyms=a;
IsoId=O35633-2; Sequence=VSP_007063;
-!- TISSUE SPECIFICITY: Brain and retina. Localized in horizontal cell
tips at both rod and cone terminals.
{ECO:0000269|PubMed:12115694}.
-!- DISRUPTION PHENOTYPE: Deficient mice exhibit embryonic lethality
and a cleft palate and omphalocele. {ECO:0000269|PubMed:16701208}.
-!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB080232; BAC44888.1; -; Genomic_DNA.
EMBL; AB080232; BAC44889.1; -; Genomic_DNA.
EMBL; AJ001598; CAA04864.1; -; mRNA.
EMBL; BC052020; AAH52020.1; -; mRNA.
CCDS; CCDS38309.1; -. [O35633-1]
RefSeq; NP_033534.2; NM_009508.2. [O35633-1]
UniGene; Mm.143404; -.
UniGene; Mm.413854; -.
ProteinModelPortal; O35633; -.
STRING; 10090.ENSMUSP00000036299; -.
TCDB; 2.A.18.5.3; the amino acid/auxin permease (aaap) family.
iPTMnet; O35633; -.
PhosphoSitePlus; O35633; -.
SwissPalm; O35633; -.
PaxDb; O35633; -.
PeptideAtlas; O35633; -.
PRIDE; O35633; -.
Ensembl; ENSMUST00000045738; ENSMUSP00000036299; ENSMUSG00000037771. [O35633-1]
GeneID; 22348; -.
KEGG; mmu:22348; -.
UCSC; uc008nqk.1; mouse. [O35633-1]
UCSC; uc029uhu.1; mouse. [O35633-2]
CTD; 140679; -.
MGI; MGI:1194488; Slc32a1.
eggNOG; KOG4303; Eukaryota.
eggNOG; COG0814; LUCA.
GeneTree; ENSGT00490000043380; -.
HOGENOM; HOG000220837; -.
HOVERGEN; HBG061364; -.
InParanoid; O35633; -.
KO; K15015; -.
OMA; NWSHIAA; -.
OrthoDB; EOG091G05MY; -.
PhylomeDB; O35633; -.
TreeFam; TF312818; -.
Reactome; R-MMU-425393; Transport of inorganic cations/anions and amino acids/oligopeptides.
Reactome; R-MMU-888590; GABA synthesis, release, reuptake and degradation.
PRO; PR:O35633; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000037771; -.
ExpressionAtlas; O35633; baseline and differential.
Genevisible; O35633; MM.
GO; GO:0051286; C:cell tip; IDA:MGI.
GO; GO:0044316; C:cone cell pedicle; IDA:MGI.
GO; GO:0030425; C:dendrite; ISO:MGI.
GO; GO:0044292; C:dendrite terminus; IDA:MGI.
GO; GO:0060077; C:inhibitory synapse; IDA:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IC:MGI.
GO; GO:0030285; C:integral component of synaptic vesicle membrane; IEA:Ensembl.
GO; GO:0043005; C:neuron projection; IDA:MGI.
GO; GO:0044306; C:neuron projection terminus; IDA:MGI.
GO; GO:0048786; C:presynaptic active zone; IDA:MGI.
GO; GO:0045202; C:synapse; ISO:MGI.
GO; GO:0008021; C:synaptic vesicle; ISO:MGI.
GO; GO:0015495; F:gamma-aminobutyric acid:proton symporter activity; IDA:MGI.
GO; GO:0015187; F:glycine transmembrane transporter activity; IDA:MGI.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0015816; P:glycine transport; IDA:MGI.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0098700; P:neurotransmitter loading into synaptic vesicle; IEA:Ensembl.
InterPro; IPR013057; AA_transpt_TM.
Pfam; PF01490; Aa_trans; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Cytoplasmic vesicle;
Glycoprotein; Membrane; Neurotransmitter transport; Nitration;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 525 Vesicular inhibitory amino acid
transporter.
/FTId=PRO_0000093822.
TOPO_DOM 1 133 Cytoplasmic. {ECO:0000255}.
TRANSMEM 134 154 Helical. {ECO:0000255}.
TOPO_DOM 155 204 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 205 225 Helical. {ECO:0000255}.
TOPO_DOM 226 242 Cytoplasmic. {ECO:0000255}.
TRANSMEM 243 263 Helical. {ECO:0000255}.
TOPO_DOM 264 265 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 266 286 Helical. {ECO:0000255}.
TOPO_DOM 287 305 Cytoplasmic. {ECO:0000255}.
TRANSMEM 306 326 Helical. {ECO:0000255}.
TOPO_DOM 327 341 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 342 362 Helical. {ECO:0000255}.
TOPO_DOM 363 384 Cytoplasmic. {ECO:0000255}.
TRANSMEM 385 405 Helical. {ECO:0000255}.
TOPO_DOM 406 438 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 439 459 Helical. {ECO:0000255}.
TOPO_DOM 460 461 Cytoplasmic. {ECO:0000255}.
TRANSMEM 462 482 Helical. {ECO:0000255}.
TOPO_DOM 483 489 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 490 510 Helical. {ECO:0000255}.
TOPO_DOM 511 525 Cytoplasmic. {ECO:0000255}.
MOD_RES 186 186 Nitrated tyrosine.
{ECO:0000244|PubMed:16800626}.
CARBOHYD 341 341 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 515 525 LIEAYRTNAED -> KFAGLET (in isoform 2).
{ECO:0000303|PubMed:9395291}.
/FTId=VSP_007063.
CONFLICT 432 432 G -> E (in Ref. 1; CAA04864).
{ECO:0000305}.
SEQUENCE 525 AA; 57381 MW; EBD63E01A4B54C07 CRC64;
MATLLRSKLT NVATSVSNKS QAKVSGMFAR MGFQAATDEE AVGFAHCDDL DFEHRQGLQM
DILKSEGEPC GDEGAEAPVE GDIHYQRGGA PLPPSGSKDQ AVGAGGEFGG HDKPKITAWE
AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF LIIFAAVVCC YTGKILIACL YEENEDGEVV
RVRDSYVAIA NACCAPRFPT LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ
KSWSIIATAV LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY
IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL KGLFALVAYL
TWADETKEVI TDNLPGSIRA VVNLFLVAKA LLSYPLPFFA AVEVLEKSLF QEGSRAFFPA
CYGGDGRLKS WGLTLRCALV VFTLLMAIYV PHFALLMGLT GSLTGAGLCF LLPSLFHLRL
LWRKLLWHQV FFDVAIFVIG GICSVSGFVH SLEGLIEAYR TNAED


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