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Vesicular integral-membrane protein VIP36 (Glycoprotein GP36b) (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36)

 LMAN2_HUMAN             Reviewed;         356 AA.
Q12907; Q53HH1;
27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
30-AUG-2017, entry version 149.
RecName: Full=Vesicular integral-membrane protein VIP36;
AltName: Full=Glycoprotein GP36b;
AltName: Full=Lectin mannose-binding 2;
AltName: Full=Vesicular integral-membrane protein 36;
Short=VIP36;
Flags: Precursor;
Name=LMAN2; Synonyms=C5orf8;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Hartmann E., Reimann B., Goerlich D., Rapoport T.A., Prehn S.;
"Human GP36b glycoprotein of the endoplasmic reticulum.";
Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Smooth muscle;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
SUBCELLULAR LOCATION.
PubMed=10444376;
Fullekrug J., Scheiffele P., Simons K.;
"VIP36 localisation to the early secretory pathway.";
J. Cell Sci. 112:2813-2821(1999).
[5]
GLYCOSYLATION AT ASN-183.
PubMed=12754519; DOI=10.1038/nbt827;
Zhang H., Li X.-J., Martin D.B., Aebersold R.;
"Identification and quantification of N-linked glycoproteins using
hydrazide chemistry, stable isotope labeling and mass spectrometry.";
Nat. Biotechnol. 21:660-666(2003).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[8]
CLEAVAGE OF SIGNAL PEPTIDE [LARGE SCALE ANALYSIS] AFTER ALA-44, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
-!- FUNCTION: Plays a role as an intracellular lectin in the early
secretory pathway. Interacts with N-acetyl-D-galactosamine and
high-mannose type glycans and may also bind to O-linked glycans.
Involved in the transport and sorting of glycoproteins carrying
high mannose-type glycans (By similarity). {ECO:0000250}.
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
Note=Binds 2 calcium ions per subunit. {ECO:0000250};
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
compartment membrane {ECO:0000269|PubMed:10444376}; Single-pass
type I membrane protein {ECO:0000269|PubMed:10444376}. Golgi
apparatus membrane {ECO:0000269|PubMed:10444376}; Single-pass
membrane protein {ECO:0000269|PubMed:10444376}. Endoplasmic
reticulum membrane {ECO:0000269|PubMed:10444376}; Single-pass type
I membrane protein {ECO:0000269|PubMed:10444376}.
-!- TISSUE SPECIFICITY: Ubiquitous.
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EMBL; U10362; AAA19572.1; -; mRNA.
EMBL; AK222609; BAD96329.1; -; mRNA.
EMBL; BC017263; AAH17263.1; -; mRNA.
CCDS; CCDS4417.1; -.
PIR; G01447; G01447.
RefSeq; NP_006807.1; NM_006816.2.
UniGene; Hs.75864; -.
ProteinModelPortal; Q12907; -.
SMR; Q12907; -.
BioGrid; 116159; 30.
IntAct; Q12907; 9.
MINT; MINT-4999928; -.
STRING; 9606.ENSP00000303366; -.
iPTMnet; Q12907; -.
PhosphoSitePlus; Q12907; -.
SwissPalm; Q12907; -.
BioMuta; LMAN2; -.
DMDM; 21264108; -.
EPD; Q12907; -.
MaxQB; Q12907; -.
PaxDb; Q12907; -.
PeptideAtlas; Q12907; -.
PRIDE; Q12907; -.
TopDownProteomics; Q12907; -.
Ensembl; ENST00000303127; ENSP00000303366; ENSG00000169223.
GeneID; 10960; -.
KEGG; hsa:10960; -.
UCSC; uc003mge.4; human.
CTD; 10960; -.
GeneCards; LMAN2; -.
HGNC; HGNC:16986; LMAN2.
HPA; HPA003927; -.
MIM; 609551; gene.
neXtProt; NX_Q12907; -.
OpenTargets; ENSG00000169223; -.
PharmGKB; PA25919; -.
eggNOG; KOG3839; Eukaryota.
eggNOG; ENOG410YH8V; LUCA.
GeneTree; ENSGT00530000062977; -.
HOGENOM; HOG000164540; -.
HOVERGEN; HBG052334; -.
InParanoid; Q12907; -.
KO; K10082; -.
OMA; DNFEGLG; -.
OrthoDB; EOG091G0AZ1; -.
PhylomeDB; Q12907; -.
TreeFam; TF313311; -.
Reactome; R-HSA-204005; COPII (Coat Protein 2) Mediated Vesicle Transport.
Reactome; R-HSA-5694530; Cargo concentration in the ER.
ChiTaRS; LMAN2; human.
GeneWiki; LMAN2; -.
GenomeRNAi; 10960; -.
PRO; PR:Q12907; -.
Proteomes; UP000005640; Chromosome 5.
Bgee; ENSG00000169223; -.
CleanEx; HS_LMAN2; -.
ExpressionAtlas; Q12907; baseline and differential.
Genevisible; Q12907; HS.
GO; GO:0009986; C:cell surface; IDA:UniProtKB.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO; GO:0030246; F:carbohydrate binding; IDA:UniProtKB.
GO; GO:0001948; F:glycoprotein binding; IPI:UniProtKB.
GO; GO:0031072; F:heat shock protein binding; IPI:UniProtKB.
GO; GO:0005537; F:mannose binding; IMP:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0050766; P:positive regulation of phagocytosis; IMP:UniProtKB.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IMP:UniProtKB.
CDD; cd06901; lectin_VIP36_VIPL; 1.
InterPro; IPR013320; ConA-like_dom.
InterPro; IPR005052; Lectin_leg.
InterPro; IPR035664; VIP36_lectin.
Pfam; PF03388; Lectin_leg-like; 1.
SUPFAM; SSF49899; SSF49899; 1.
PROSITE; PS51328; L_LECTIN_LIKE; 1.
1: Evidence at protein level;
Calcium; Complete proteome; Disulfide bond; Endoplasmic reticulum;
Glycoprotein; Golgi apparatus; Lectin; Membrane; Metal-binding;
Protein transport; Reference proteome; Signal; Transmembrane;
Transmembrane helix; Transport.
SIGNAL 1 44 {ECO:0000244|PubMed:25944712,
ECO:0000255}.
CHAIN 45 356 Vesicular integral-membrane protein
VIP36.
/FTId=PRO_0000017666.
TOPO_DOM 45 322 Lumenal. {ECO:0000255}.
TRANSMEM 323 345 Helical. {ECO:0000255}.
TOPO_DOM 346 356 Cytoplasmic. {ECO:0000255}.
DOMAIN 52 276 L-type lectin-like. {ECO:0000255|PROSITE-
ProRule:PRU00658}.
REGION 164 166 Carbohydrate binding.
{ECO:0000255|PROSITE-ProRule:PRU00658}.
REGION 260 262 Carbohydrate binding.
{ECO:0000255|PROSITE-ProRule:PRU00658}.
METAL 162 162 Calcium. {ECO:0000255|PROSITE-
ProRule:PRU00658}.
METAL 164 164 Calcium; via carbonyl oxygen.
{ECO:0000255|PROSITE-ProRule:PRU00658}.
METAL 166 166 Calcium. {ECO:0000255|PROSITE-
ProRule:PRU00658}.
METAL 193 193 Calcium. {ECO:0000255|PROSITE-
ProRule:PRU00658}.
BINDING 96 96 Carbohydrate. {ECO:0000255|PROSITE-
ProRule:PRU00658}.
BINDING 131 131 Carbohydrate. {ECO:0000255|PROSITE-
ProRule:PRU00658}.
BINDING 190 190 Carbohydrate. {ECO:0000255|PROSITE-
ProRule:PRU00658}.
CARBOHYD 183 183 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:12754519}.
DISULFID 202 239 {ECO:0000255|PROSITE-ProRule:PRU00658}.
CONFLICT 266 266 H -> R (in Ref. 2; BAD96329).
{ECO:0000305}.
SEQUENCE 356 AA; 40229 MW; 196193C8E655141C CRC64;
MAAEGWIWRW GWGRRCLGRP GLLGPGPGPT TPLFLLLLLG SVTADITDGN SEHLKREHSL
IKPYQGVGSS SMPLWDFQGS TMLTSQYVRL TPDERSKEGS IWNHQPCFLK DWEMHVHFKV
HGTGKKNLHG DGIALWYTRD RLVPGPVFGS KDNFHGLAIF LDTYPNDETT ERVFPYISVM
VNNGSLSYDH SKDGRWTELA GCTADFRNRD HDTFLAVRYS RGRLTVMTDL EDKNEWKNCI
DITGVRLPTG YYFGASAGTG DLSDNHDIIS MKLFQLMVEH TPDEESIDWT KIEPSVNFLK
SPKDNVDDPT GNFRSGPLTG WRVFLLLLCA LLGIVVCAVV GAVVFQKRQE RNKRFY


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