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Viral IRF4-like protein (vIRF-4)

 VIRF4_HHV8P             Reviewed;         911 AA.
Q2HR73; D0UZS2;
16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
21-MAR-2006, sequence version 1.
23-MAY-2018, entry version 58.
RecName: Full=Viral IRF4-like protein;
Short=vIRF-4;
Name=vIRF-4;
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
sarcoma-associated herpesvirus).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Gammaherpesvirinae; Rhadinovirus.
NCBI_TaxID=868565;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=10400794;
Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
"Identification of a spliced gene from Kaposi's sarcoma-associated
herpesvirus encoding a protein with similarities to latent membrane
proteins 1 and 2A of Epstein-Barr virus.";
J. Virol. 73:6953-6963(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16760382; DOI=10.1099/vir.0.81919-0;
Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
"Kaposi's sarcoma-associated herpesvirus immune modulation: an
overview.";
J. Gen. Virol. 87:1781-1804(2006).
[3]
FUNCTION, AND INTERACTION WITH HOST MDM2.
PubMed=19369353; DOI=10.1128/JVI.02353-08;
Lee H.R., Toth Z., Shin Y.C., Lee J.S., Chang H., Gu W., Oh T.K.,
Kim M.H., Jung J.U.;
"Kaposi's sarcoma-associated herpesvirus viral interferon regulatory
factor 4 targets MDM2 to deregulate the p53 tumor suppressor
pathway.";
J. Virol. 83:6739-6747(2009).
[4]
X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 202-216.
PubMed=22056774; DOI=10.1038/nsmb.2142;
Lee H.R., Choi W.C., Lee S., Hwang J., Hwang E., Guchhait K., Haas J.,
Toth Z., Jeon Y.H., Oh T.K., Kim M.H., Jung J.U.;
"Bilateral inhibition of HAUSP deubiquitinase by a viral interferon
regulatory factor protein.";
Nat. Struct. Mol. Biol. 18:1336-1344(2011).
-!- FUNCTION: Plays a role in host cell apoptosis modulation by
promoting TP53/p53 ubiquitination and subsequent degradation and
thus downregulating TP53/p53-mediated apoptosis.
{ECO:0000269|PubMed:19369353}.
-!- SUBUNIT: Interacts with host MDM2; this interaction facilitates
the proteasomal degradation of TP53/p53.
{ECO:0000269|PubMed:19369353}.
-!- INTERACTION:
Q00987:MDM2 (xeno); NbExp=2; IntAct=EBI-9001898, EBI-389668;
-!- SUBCELLULAR LOCATION: Host nucleus.
-!- SIMILARITY: Belongs to the IRF family. {ECO:0000255|PROSITE-
ProRule:PRU00840}.
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EMBL; AF148805; ABD28910.1; -; Genomic_DNA.
RefSeq; YP_001129412.1; NC_009333.1.
PDB; 2XXN; X-ray; 1.60 A; B=202-216.
PDBsum; 2XXN; -.
SMR; Q2HR73; -.
BioGrid; 1776998; 32.
IntAct; Q2HR73; 1.
PRIDE; Q2HR73; -.
GeneID; 4961495; -.
KEGG; vg:4961495; -.
KO; K21858; -.
Proteomes; UP000000942; Genome.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0044212; F:transcription regulatory region DNA binding; IEA:InterPro.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0016032; P:viral process; IEA:UniProtKB-KW.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
InterPro; IPR036388; WH-like_DNA-bd_sf.
PROSITE; PS51507; IRF_2; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; DNA-binding; Host nucleus;
Host-virus interaction; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 911 Viral IRF4-like protein.
/FTId=PRO_0000423775.
DNA_BIND 7 114 IRF tryptophan pentad repeat.
{ECO:0000255|PROSITE-ProRule:PRU00840}.
COMPBIAS 235 490 Pro-rich.
TURN 207 210 {ECO:0000244|PDB:2XXN}.
SEQUENCE 911 AA; 97956 MW; 0F82DA473774DC2D CRC64;
MPKAGGSEWA TLWIIDALEN NKFPYFSWFD RNNLLFAAPA PLPAGSDIPP GWYSVYHAFD
EECDRVYGPS PVVGQTVYGR FGRLLRGTRR AVVRNDLRYS DTFGGSYVVW QLVRTPFKNC
TYCYGAAYGP EKLQRFIQCL LSPPMQTTAT RRSDTREQSY EEAGAAAPAP PKAPSGLRGR
PRKSNRYYNV GDITTEQKAA CSVWIPVNEG ASTSGMGSSG TRQVTQASSF TWRVPGDPPA
PSTLTGPSDP HSSGAGLPGT APPKPQHETR LAGTVSGVSG VAQTPGDTGQ LAPPMRDGSR
LPSTSPWIPA CFPWGDLPVT GWWPQGASGL PEKVHPPTTG QFDPLSPRWT YTGIPSSQLN
PAAPSWIPPH AQAGTFVGEF SQGAPLAPQG LLPQSGQCAS AWLPRRETGA EGACGASTEG
RAPQGAASER VYPFEPQPPS APAPGYAKPS CYNWSPLAEP PATRPIRAPV WHPPVGHAVV
PEVRTPLWIP WSSGGAPNQG LSHTQGGASA TPSAGAPPTP EVAERQEPSS SGIPYVCQGD
NMATGYRRVT TSSGALEVEI IDLTGDSDTP STTVASTPLP VSGPRVFQPT VLYSAPEPAV
NPEVSHLPTE LERRECVCPG SGERPRVPLV STYAGDRYAV GGYGPEQSLV PPPLGLPLTL
SNLQGEDICT WEEGLGNILS ELQEEPSSST RQATDRRRPR SRSPHGRRTP VSHSGPEKPP
SKMFFDPPDS QRVSFVVEIF VYGNLRGTLR REGDAGEAML CSWPVGDTLG HLCQSFVPEL
LRIPRLTVPS PEQMEILNRV FEGLGHGFPI FCSMSGIYSR NATQVEGWWF GNPNSRYERI
LRSFSPRVPQ QLFNTARYLA TTAAIPQTPL SVNPVTCGTV FFGASPASTE NFQNVPLTVK
IFIGSIWDSL H


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