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Virion infectivity factor

 K0H249_9HIV1            Unreviewed;       192 AA.
K0H249;
28-NOV-2012, integrated into UniProtKB/TrEMBL.
28-NOV-2012, sequence version 1.
18-JUL-2018, entry version 28.
RecName: Full=Virion infectivity factor {ECO:0000256|RuleBase:RU003341};
Name=vif {ECO:0000313|EMBL:AFU33767.1};
Human immunodeficiency virus 1.
Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
NCBI_TaxID=11676 {ECO:0000313|EMBL:AFU33767.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:AFU33767.1}
NUCLEOTIDE SEQUENCE.
STRAIN=AA122a01R {ECO:0000313|EMBL:AFU33792.1},
AA122a02R {ECO:0000313|EMBL:AFU33774.1},
AA122a04L {ECO:0000313|EMBL:AFU33759.1},
AA122a05L {ECO:0000313|EMBL:AFU33755.1},
AA122a06L {ECO:0000313|EMBL:AFU33767.1},
AA122a08R {ECO:0000313|EMBL:AFU33780.1}, and
AA122a09L {ECO:0000313|EMBL:AFU33751.1};
PubMed=22960785; DOI=10.1038/nature11519;
Rolland M., Edlefsen P.T., Larsen B.B., Tovanabutra S.,
Sanders-Buell E., Hertz T., de Camp A.C., Carrico C., Menis S.,
Magaret C.A., Ahmed H., Juraska M., Chen L., Konopa P., Nariya S.,
Stoddard J.N., Wong K., Zhao H., Deng W., Maust B.S., Bose M.,
Howell S., Bates A., Lazzaro M., O'Sullivan A., Lei E., Bradfield A.,
Ibitamuno G., Assawadarachai V., O'Connell R.J., de Souza M.S.,
Nitayaphan S., Rerks-Ngarm S., Robb M.L., McLellan J.S., Georgiev I.,
Kwong P.D., Carlson J.M., Michael N.L., Schief W.R., Gilbert P.B.,
Mullins J.I., Kim J.H.;
"Increased HIV-1 vaccine efficacy against viruses with genetic
signatures in Env V2.";
Nature 490:417-420(2012).
[2] {ECO:0000313|EMBL:AFU33767.1}
NUCLEOTIDE SEQUENCE.
STRAIN=AA122a01R {ECO:0000313|EMBL:AFU33792.1},
AA122a02R {ECO:0000313|EMBL:AFU33774.1},
AA122a04L {ECO:0000313|EMBL:AFU33759.1},
AA122a05L {ECO:0000313|EMBL:AFU33755.1},
AA122a06L {ECO:0000313|EMBL:AFU33767.1},
AA122a08R {ECO:0000313|EMBL:AFU33780.1}, and
AA122a09L {ECO:0000313|EMBL:AFU33751.1};
PubMed=25646817;
RV144 Sequencing Team;
Edlefsen P.T., Rolland M., Hertz T., Tovanabutra S., Gartland A.J.,
deCamp A.C., Magaret C.A., Ahmed H., Gottardo R., Juraska M.,
McCoy C., Larsen B.B., Sanders-Buell E., Carrico C., Menis S.,
Kijak G.H., Bose M., Arroyo M.A., O'Connell R.J., Nitayaphan S.,
Pitisuttithum P., Kaewkungwal J., Rerks-Ngarm S., Robb M.L., Kirys T.,
Georgiev I.S., Kwong P.D., Scheffler K., Pond S.L., Carlson J.M.,
Michael N.L., Schief W.R., Mullins J.I., Kim J.H., Gilbert P.B.;
"Comprehensive sieve analysis of breakthrough HIV-1 sequences in the
RV144 vaccine efficacy trial.";
PLoS Comput. Biol. 11:E1003973-E1003973(2015).
-!- SUBCELLULAR LOCATION: Host cell membrane
{ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059686};
Peripheral membrane protein {ECO:0000256|RuleBase:RU003341,
ECO:0000256|SAAS:SAAS01059686}; Cytoplasmic side
{ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059686}.
Host cytoplasm {ECO:0000256|RuleBase:RU003341}. Virion
{ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059682}.
Note=In the cytoplasm, seems to colocalize with intermediate
filament vimentin. A fraction is associated with the cytoplasmic
side of cellular membranes, presumably via the interaction with
Pr55Gag precursor. {ECO:0000256|RuleBase:RU003341}.
-!- SIMILARITY: Belongs to the primate lentivirus group Vif protein
family. {ECO:0000256|RuleBase:RU003341,
ECO:0000256|SAAS:SAAS01059764}.
-----------------------------------------------------------------------
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EMBL; JX448211; AFU33751.1; -; Genomic_RNA.
EMBL; JX448212; AFU33755.1; -; Genomic_RNA.
EMBL; JX448213; AFU33759.1; -; Genomic_RNA.
EMBL; JX448215; AFU33767.1; -; Genomic_RNA.
EMBL; JX448217; AFU33774.1; -; Genomic_RNA.
EMBL; JX448218; AFU33780.1; -; Genomic_RNA.
EMBL; JX448220; AFU33792.1; -; Genomic_RNA.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
GO; GO:0019058; P:viral life cycle; IEA:InterPro.
HAMAP; MF_04081; HIV_VIF; 1.
InterPro; IPR000475; Viral_infect.
Pfam; PF00559; Vif; 1.
PRINTS; PR00349; VIRIONINFFCT.
3: Inferred from homology;
Host cell membrane {ECO:0000256|SAAS:SAAS01059755};
Host cytoplasm {ECO:0000256|SAAS:SAAS01059745};
Host membrane {ECO:0000256|SAAS:SAAS01059755};
Host-virus interaction {ECO:0000256|SAAS:SAAS01059733};
Membrane {ECO:0000256|SAAS:SAAS01059755};
Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01059744};
Virion {ECO:0000256|SAAS:SAAS01059762}.
SEQUENCE 192 AA; 22716 MW; 64B6592EE0C72D52 CRC64;
MENKWQVMIV WQVDRMRIRT WNSIVKHHMY TSKKAKEWVY RHHYESQHPK VSSEVHIPLG
KAKLIIRTYW GLQTGEKDWH LGHGVSIEWR QRNYSTQIDP DLADKLIHLQ YFDCFSDSAI
RRAILGQVVR HRCEYPSGHN KVGSLQYLAL KALAAPKRIK PPLPSVKKLT EDRWNKPQKI
RGHKENPTMN GH


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