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Virion infectivity factor (Vif) (Q protein) (SOR protein)

 VIF_SIVTA               Reviewed;         238 AA.
P89905;
08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
15-MAR-2017, entry version 79.
RecName: Full=Virion infectivity factor;
Short=Vif;
AltName: Full=Q protein;
AltName: Full=SOR protein;
Name=vif;
Simian immunodeficiency virus AGM.tantalus (SIV-agm.tan) (Simian
immunodeficiency virus African green monkey tantalus).
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
Lentivirus; Primate lentivirus group.
NCBI_TaxID=349692;
NCBI_TaxID=60712; Chlorocebus tantalus (Tantalus monkey) (Cercopithecus tantalus).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=tantalus-1;
PubMed=9123848; DOI=10.1006/viro.1996.8387;
Soares M.A., Robertson D.L., Hui H., Allan J.S., Shaw G.M., Hahn B.H.;
"A full-length and replication-competent proviral clone of SIVAGM from
tantalus monkeys.";
Virology 228:394-399(1997).
[2]
INTERACTION WITH HUMAN CUL5, AND MUTAGENESIS OF HIS-111; CYS-117;
CYS-135 AND HIS-141.
PubMed=16076960; DOI=10.1073/pnas.0502440102;
Luo K., Xiao Z., Ehrlich E., Yu Y., Liu B., Zheng S., Yu X.-F.;
"Primate lentiviral virion infectivity factors are substrate receptors
that assemble with cullin 5-E3 ligase through a HCCH motif to suppress
APOBEC3G.";
Proc. Natl. Acad. Sci. U.S.A. 102:11444-11449(2005).
-!- FUNCTION: Counteracts the innate antiviral activity of APOBEC3G.
Forms a complex with host APOBEC3G thus preventing the entry of
this lethally hypermutating enzyme into progeny virions. Functions
as an adapter molecule, recruiting APOBEC3G to the ubiquitin-
proteasome machinery. Targets APOBEC3G for degradation through the
assembly with elongin BC complex, CUL5 and RBX1. Binds viral RNA
and affects the stability of viral nucleoprotein core. May play a
role in viral morphology (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homomultimer; in vitro and presumably in vivo. Interacts
with viral Pr55Gag precursor and host APOBEC3G. The interaction
between Vif and APOBEC3G is species-specific, which may play a
role in restricting the replication of SIV to their host. Forms an
E3 ligase complex by interacting with host CUL5 and elongin BC
complex (ELOB and ELOC) (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Host cell
membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
Cytoplasmic side {ECO:0000250}. Virion {ECO:0000250}. Note=Seems
to colocalize with intermediate filament vimentin. A fraction is
associated with the cytoplasmic side of cellular membranes,
presumably via the interaction with Pr55Gag precursor (By
similarity). {ECO:0000250}.
-!- INDUCTION: Expressed late during infection in a Rev-dependent
manner.
-!- DOMAIN: The BC-like-box motif mediates the interaction with
elongin BC complex. {ECO:0000250}.
-!- DOMAIN: The HCCH motif (H-x(5)-C-x(18)-C-x(5)-H) mediates the
interaction with CUL5. {ECO:0000250}.
-!- PTM: Processed in virion by the viral protease. {ECO:0000250}.
-!- PTM: Highly phosphorylated on serine and threonine residues.
{ECO:0000250}.
-!- PTM: Polyubiquitinated and degraded by the proteasome in the
presence of APOBEC3G. {ECO:0000250}.
-!- MISCELLANEOUS: Vif-defective viruses show catastrophic failure in
reverse transcription due to APOBEC-induced mutations that
initiate a DNA base repair pathway and compromise the structural
integrity of the ssDNA. In the absence of Vif, the virion is
morphologically abnormal.
-!- SIMILARITY: Belongs to the primate lentivirus group Vif protein
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; U58991; AAC57053.1; -; Genomic_DNA.
SMR; P89905; -.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
GO; GO:0019058; P:viral life cycle; IEA:InterPro.
InterPro; IPR000475; Viral_infect.
Pfam; PF00559; Vif; 1.
PRINTS; PR00349; VIRIONINFFCT.
1: Evidence at protein level;
Host cell membrane; Host cytoplasm; Host membrane;
Host-virus interaction; Membrane; Phosphoprotein; Ubl conjugation;
Ubl conjugation pathway; Virion.
CHAIN 1 238 Virion infectivity factor.
/FTId=PRO_0000085335.
REGION 159 175 Multimerization. {ECO:0000250}.
MOTIF 111 146 HCCH motif. {ECO:0000250}.
MOTIF 152 161 BC-box-like motif. {ECO:0000250}.
MOD_RES 99 99 Phosphothreonine; by host. {ECO:0000250}.
MOD_RES 152 152 Phosphoserine; by host. {ECO:0000250}.
MUTAGEN 111 111 H->L: Complete loss of interaction with
CUL5. {ECO:0000269|PubMed:16076960}.
MUTAGEN 117 117 C->S: Complete loss of interaction with
CUL5. {ECO:0000269|PubMed:16076960}.
MUTAGEN 135 135 C->S: Complete loss of interaction with
CUL5. {ECO:0000269|PubMed:16076960}.
MUTAGEN 141 141 H->L: Complete loss of interaction with
CUL5. {ECO:0000269|PubMed:16076960}.
SEQUENCE 238 AA; 28169 MW; 0E15A107E0627762 CRC64;
MEREKLWVTR LTWRVSGEHI DKWKGIVKYH MRNRLQDWTY LMHYQCGWAW YTCSRFLIPL
GGEGKIVVDC YWHLTPEQGW LSTYAVAISF ENWQNTYKTE VTPDVADHMI HCHYFPCFTD
RAIQQAIRGE SFLWCTYKEG HVAENHWGQV RSLQFLALTV YTDFLRNGRR KRFQGKKTRM
VRNLGSQQGA VGRMIKRHGS RTQSGSTTPF WERTPLPSME LLSGRRGKEW GTNDRKGL


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