GENTAUR Molecular Products.

 A0A1L7DWZ5_9HIV1        Unreviewed;       192 AA.
 A0A1L7DWZ5;
 15-MAR-2017, integrated into UniProtKB/TrEMBL.
 15-MAR-2017, sequence version 1.
 28-MAR-2018, entry version 8.
 RecName: Full=Virion infectivity factor {ECO:0000256|HAMAP-Rule:MF_04081};
          Short=Vif {ECO:0000256|HAMAP-Rule:MF_04081};
 AltName: Full=SOR protein {ECO:0000256|HAMAP-Rule:MF_04081};
 Contains:
   RecName: Full=p17 {ECO:0000256|HAMAP-Rule:MF_04081};
 Contains:
   RecName: Full=p7 {ECO:0000256|HAMAP-Rule:MF_04081};
 Name=vif {ECO:0000256|HAMAP-Rule:MF_04081,
 ECO:0000313|EMBL:APU04807.1};
 Human immunodeficiency virus 1.
 Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
 Lentivirus; Primate lentivirus group.
 NCBI_TaxID=11676 {ECO:0000313|EMBL:APU04807.1};
 NCBI_TaxID=9606; Homo sapiens (Human).
 [1] {ECO:0000313|EMBL:APU04807.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=CH427.PL.011608.A2.1 {ECO:0000313|EMBL:APU04152.1},
 CH427.PL.011608.A2.10 {ECO:0000313|EMBL:APU04161.1},
 CH427.PL.011608.A2.2 {ECO:0000313|EMBL:APU04170.1},
 CH427.PL.011608.A2.3 {ECO:0000313|EMBL:APU04179.1},
 CH427.PL.011608.A2.4 {ECO:0000313|EMBL:APU04188.1},
 CH427.PL.011608.A2.5 {ECO:0000313|EMBL:APU04197.1},
 CH427.PL.011608.A2.6 {ECO:0000313|EMBL:APU04206.1},
 CH427.PL.011608.A2.7 {ECO:0000313|EMBL:APU04215.1},
 CH427.PL.011608.A2.8 {ECO:0000313|EMBL:APU04224.1},
 CH427.PL.011608.A2.9 {ECO:0000313|EMBL:APU04233.1},
 CH427.PL.011608.BE.1 {ECO:0000313|EMBL:APU04242.1},
 CH427.PL.011608.UT.1 {ECO:0000313|EMBL:APU04251.1},
 CH427.PL.011608.UT.10 {ECO:0000313|EMBL:APU04260.1},
 CH427.PL.011608.UT.2 {ECO:0000313|EMBL:APU04269.1},
 CH427.PL.011608.UT.3 {ECO:0000313|EMBL:APU04278.1},
 CH427.PL.011608.UT.4 {ECO:0000313|EMBL:APU04287.1},
 CH427.PL.011608.UT.5 {ECO:0000313|EMBL:APU04296.1},
 CH427.PL.011608.UT.6 {ECO:0000313|EMBL:APU04304.1},
 CH427.PL.011608.UT.7 {ECO:0000313|EMBL:APU04313.1},
 CH427.PL.011608.UT.8 {ECO:0000313|EMBL:APU04322.1},
 CH427.PL.011608.UT.9 {ECO:0000313|EMBL:APU04331.1},
 CH427_SGA.600.1 {ECO:0000313|EMBL:APU07260.1},
 CH427_SGA.600.11 {ECO:0000313|EMBL:APU07275.1},
 CH427_SGA.600.12 {ECO:0000313|EMBL:APU07283.1},
 CH427_SGA.600.13 {ECO:0000313|EMBL:APU07290.1},
 CH427_SGA.600.14 {ECO:0000313|EMBL:APU07298.1},
 CH427_SGA.600.15 {ECO:0000313|EMBL:APU07306.1},
 CH427_SGA.600.16 {ECO:0000313|EMBL:APU07314.1},
 CH427_SGA.600.18 {ECO:0000313|EMBL:APU07322.1},
 CH427_SGA.600.19 {ECO:0000313|EMBL:APU07330.1},
 CH427_SGA.600.2 {ECO:0000313|EMBL:APU07338.1},
 CH427_SGA.600.20 {ECO:0000313|EMBL:APU07346.1},
 CH427_SGA.600.21 {ECO:0000313|EMBL:APU07354.1},
 CH427_SGA.600.24 {ECO:0000313|EMBL:APU07369.1},
 CH427_SGA.600.25 {ECO:0000313|EMBL:APU07377.1},
 CH427_SGA.600.26 {ECO:0000313|EMBL:APU07385.1},
 CH427_SGA.600.27 {ECO:0000313|EMBL:APU07393.1},
 CH427_SGA.600.29 {ECO:0000313|EMBL:APU07401.1},
 CH427_SGA.600.30 {ECO:0000313|EMBL:APU07416.1},
 CH427_SGA.600.31 {ECO:0000313|EMBL:APU07424.1},
 CH427_SGA.600.32 {ECO:0000313|EMBL:APU07432.1},
 CH427_SGA.600.33 {ECO:0000313|EMBL:APU07440.1},
 CH427_SGA.600.35 {ECO:0000313|EMBL:APU07448.1},
 CH427_SGA.600.36 {ECO:0000313|EMBL:APU07456.1},
 CH427_SGA.600.37 {ECO:0000313|EMBL:APU07464.1},
 CH427_SGA.600.39 {ECO:0000313|EMBL:APU07472.1},
 CH427_SGA.600.4 {ECO:0000313|EMBL:APU07479.1},
 CH427_SGA.600.6 {ECO:0000313|EMBL:APU07487.1},
 CH427_SGA.600.7 {ECO:0000313|EMBL:APU07495.1},
 CH427_SGA.600.8 {ECO:0000313|EMBL:APU07503.1},
 CH427_SGA.600.9 {ECO:0000313|EMBL:APU07511.1},
 CH492.CV.020608.UT.10 {ECO:0000313|EMBL:APU04421.1},
 CH492.CV.020608.UT.11 {ECO:0000313|EMBL:APU04430.1},
 CH492.CV.020608.UT.16 {ECO:0000313|EMBL:APU04475.1},
 CH492.CV.020608.UT.17 {ECO:0000313|EMBL:APU04484.1},
 CH492.CV.020608.UT.3 {ECO:0000313|EMBL:APU04502.1},
 CH492.CV.020608.UT.5 {ECO:0000313|EMBL:APU04520.1},
 CH492.CV.020608.UT.6 {ECO:0000313|EMBL:APU04529.1},
 CH492.CV.020608.UT.7 {ECO:0000313|EMBL:APU04538.1},
 CH492.CV.020608.UT.9 {ECO:0000313|EMBL:APU04556.1},
 CH492.PL.031108.A2.10 {ECO:0000313|EMBL:APU04574.1},
 CH492.PL.031108.A2.11 {ECO:0000313|EMBL:APU04583.1},
 CH492.PL.031108.A2.12 {ECO:0000313|EMBL:APU04592.1},
 CH492.PL.031108.A2.13 {ECO:0000313|EMBL:APU04601.1},
 CH492.PL.031108.A2.15 {ECO:0000313|EMBL:APU04619.1},
 CH492.PL.031108.A2.16 {ECO:0000313|EMBL:APU04628.1},
 CH492.PL.031108.A2.3 {ECO:0000313|EMBL:APU04673.1},
 CH492.PL.031108.A2.4 {ECO:0000313|EMBL:APU04682.1},
 CH492.PL.031108.A2.5 {ECO:0000313|EMBL:APU04691.1},
 CH492.PL.031108.BE.11 {ECO:0000313|EMBL:APU04753.1},
 CH492.PL.031108.BE.12 {ECO:0000313|EMBL:APU04762.1},
 CH492.PL.031108.BE.14 {ECO:0000313|EMBL:APU04780.1},
 CH492.PL.031108.BE.2 {ECO:0000313|EMBL:APU04789.1},
 CH492.PL.031108.BE.4 {ECO:0000313|EMBL:APU04807.1},
 CH492.PL.031108.BE.5 {ECO:0000313|EMBL:APU04816.1},
 CH492.PL.031108.BE.7 {ECO:0000313|EMBL:APU04834.1},
 CH492.PL.031108.BE.8 {ECO:0000313|EMBL:APU04843.1},
 CH492.PL.031108.BE.9 {ECO:0000313|EMBL:APU04852.1},
 CH492.PL.031108.UT.12 {ECO:0000313|EMBL:APU04888.1},
 CH492.PL.031108.UT.13 {ECO:0000313|EMBL:APU04897.1},
 CH492.PL.031108.UT.2 {ECO:0000313|EMBL:APU04906.1},
 CH492.PL.031108.UT.3 {ECO:0000313|EMBL:APU04915.1},
 CH492.PL.031108.UT.4 {ECO:0000313|EMBL:APU04924.1},
 CH492.PL.031108.UT.6 {ECO:0000313|EMBL:APU04942.1},
 CH492.PL.031108.UT.7 {ECO:0000313|EMBL:APU04951.1},
 CH492.PL.031108.UT.9 {ECO:0000313|EMBL:APU04969.1},
 CH492_SGA.1A5 {ECO:0000313|EMBL:APU07526.1},
 CH492_SGA.1A7 {ECO:0000313|EMBL:APU07534.1},
 CH492_SGA.1A8 {ECO:0000313|EMBL:APU07541.1},
 CH492_SGA.1A9 {ECO:0000313|EMBL:APU07549.1},
 CH492_SGA.1B11 {ECO:0000313|EMBL:APU07557.1},
 CH492_SGA.1B5 {ECO:0000313|EMBL:APU07565.1},
 CH492_SGA.1D12 {ECO:0000313|EMBL:APU07573.1},
 CH492_SGA.1D3 {ECO:0000313|EMBL:APU07589.1},
 CH492_SGA.1D4 {ECO:0000313|EMBL:APU07597.1},
 CH492_SGA.1D6 {ECO:0000313|EMBL:APU07605.1},
 CH492_SGA.1E1 {ECO:0000313|EMBL:APU07613.1},
 CH492_SGA.1F11 {ECO:0000313|EMBL:APU07645.1},
 CH492_SGA.1G3 {ECO:0000313|EMBL:APU07661.1},
 CH492_SGA.1H1 {ECO:0000313|EMBL:APU07669.1},
 CH492_SGA.1H11 {ECO:0000313|EMBL:APU07677.1},
 CH492_SGA.1H8 {ECO:0000313|EMBL:APU07692.1},
 CH492_SGA.2B7 {ECO:0000313|EMBL:APU07708.1},
 CH492_SGA.2B8 {ECO:0000313|EMBL:APU07716.1},
 CH492_SGA.2C12 {ECO:0000313|EMBL:APU07724.1},
 CH492_SGA.2E7 {ECO:0000313|EMBL:APU07748.1},
 CH492_SGA.2F5 {ECO:0000313|EMBL:APU07756.1},
 CH492_SGA.2G12 {ECO:0000313|EMBL:APU07771.1},
 CH492_SGA.2G4 {ECO:0000313|EMBL:APU07787.1},
 CH492_SGA.2G6 {ECO:0000313|EMBL:APU07795.1},
 CH492_SGA.2G8 {ECO:0000313|EMBL:APU07803.1}, and
 CH492_SGA.2H8 {ECO:0000313|EMBL:APU07811.1};
 PubMed=28069935;
 Iyer S.S., Bibollet-Ruche F., Sherrill-Mix S., Learn G.H.,
 Plenderleith L., Smith A.G., Barbian H.J., Russell R.M., Gondim M.V.,
 Bahari C.Y., Shaw C.M., Li Y., Decker T., Haynes B.F., Shaw G.M.,
 Sharp P.M., Borrow P., Hahn B.H.;
 "Resistance to type 1 interferons is a major determinant of HIV-1
 transmission fitness.";
 Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2017).
 -!- FUNCTION: Counteracts the innate antiviral activity of host
     APOBEC3F and APOBEC3G. Forms a complex with host APOBEC3F and
     APOBEC3G thus preventing the entry of these lethally hypermutating
     enzymes into progeny virions. Recruits an active E3 ubiquitin
     ligase complex composed of elongin BC, CUL5, and RBX2 to induce
     polyubiquitination of APOBEC3G and APOBEC3F. In turn, they are
     directed to the 26S proteasome for degradation. Vif interaction
     with APOBEC3G also blocks its cytidine deaminase activity in a
     proteasome-independent manner, suggesting a dual inhibitory
     mechanism. May interact directly with APOBEC3G mRNA in order to
     inhibit its translation. Seems to play a role in viral morphology
     by affecting the stability of the viral nucleoprotein core.
     Finally, Vif also contributes to the G2 cell cycle arrest observed
     in HIV infected cells. {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- SUBUNIT: Homomultimer; in vitro and presumably in vivo. Interacts
     with viral RNA and Pr55Gag precursor; these interactions mediate
     Vif incorporation into the virion. Interacts with the viral
     reverse transcriptase. Interacts with human APOBEC3F and APOBEC3G.
     Interacts with host UBCE7IP1 isoform 3/ZIN and possibly with SAT.
     Interacts with host tyrosine kinases HCK and FYN; these
     interactions may decrease level of phosphorylated APOBEC3G
     incorporation into virions. Interacts with host ABCE1; this
     interaction may play a role in protecting viral RNA from damage
     during viral assembly. Forms an E3 ligase complex by interacting
     with host CUL5 and elongin BC complex (ELOB and ELOC). Interacts
     with host MDM2; this interaction targets Vif for degradation by
     the proteasome. {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000256|HAMAP-
     Rule:MF_04081, ECO:0000256|SAAS:SAAS00594051}; Peripheral membrane
     protein {ECO:0000256|HAMAP-Rule:MF_04081,
     ECO:0000256|SAAS:SAAS00594051}; Cytoplasmic side
     {ECO:0000256|HAMAP-Rule:MF_04081, ECO:0000256|SAAS:SAAS00594051}.
     Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04081}. Virion
     {ECO:0000256|HAMAP-Rule:MF_04081, ECO:0000256|SAAS:SAAS00594062}.
     Note=In the cytoplasm, seems to colocalize with intermediate
     filament vimentin. A fraction is associated with the cytoplasmic
     side of cellular membranes, presumably via the interaction with
     Pr55Gag precursor. Incorporated in virions at a ratio of
     approximately 7 to 20 molecules per virion. {ECO:0000256|HAMAP-
     Rule:MF_04081}.
 -!- INDUCTION: Expressed late during infection in a Rev-dependent
     manner. {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- DOMAIN: The BC-like-box motif mediates the interaction with
     elongin BC complex. {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- DOMAIN: The HCCH motif (H-x(5)-C-x(18)-C-x(5)-H) mediates the
     interaction with CUL5. {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- PTM: Highly phosphorylated on serine and threonine residues.
     {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- PTM: Polyubiquitinated and degraded by the proteasome in the
     presence of APOBEC3G. {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- PTM: Processed in virion by the viral protease.
     {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- MISCELLANEOUS: HIV-1 lineages are divided in three main groups, M
     (for Major), O (for Outlier), and N (for New, or Non-M, Non-O).
     The vast majority of strains found worldwide belong to the group
     M. Group O seems to be endemic to and largely confined to Cameroon
     and neighboring countries in West Central Africa, where these
     viruses represent a small minority of HIV-1 strains. The group N
     is represented by a limited number of isolates from Cameroonian
     persons. The group M is further subdivided in 9 clades or subtypes
     (A to D, F to H, J and K). {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- MISCELLANEOUS: Required for replication in 'nonpermissive' cells,
     including primary T-cells, macrophages and certain T-cell lines,
     but is dispensable for replication in 'permissive' cell lines,
     such as 293T cells. In nonpermissive cells, Vif-defective viruses
     can produce virions, but they fail to complete reverse
     transcription and cannot successfully infect new cells.
     {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- MISCELLANEOUS: Vif-defective viruses show catastrophic failure in
     reverse transcription due to APOBEC-induced mutations that
     initiate a DNA base repair pathway and compromise the structural
     integrity of the ssDNA. In the absence of Vif, the virion is
     morphologically abnormal. {ECO:0000256|HAMAP-Rule:MF_04081}.
 -!- SIMILARITY: Belongs to the primate lentivirus group Vif protein
     family. {ECO:0000256|HAMAP-Rule:MF_04081,
     ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS00594061}.
 -!- CAUTION: Lacks conserved residue(s) required for the propagation
     of feature annotation. {ECO:0000256|HAMAP-Rule:MF_04081}.
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 EMBL; KY112197; APU04152.1; -; Genomic_RNA.
 EMBL; KY112198; APU04161.1; -; Genomic_RNA.
 EMBL; KY112199; APU04170.1; -; Genomic_RNA.
 EMBL; KY112200; APU04179.1; -; Genomic_RNA.
 EMBL; KY112201; APU04188.1; -; Genomic_RNA.
 EMBL; KY112202; APU04197.1; -; Genomic_RNA.
 EMBL; KY112203; APU04206.1; -; Genomic_RNA.
 EMBL; KY112204; APU04215.1; -; Genomic_RNA.
 EMBL; KY112205; APU04224.1; -; Genomic_RNA.
 EMBL; KY112206; APU04233.1; -; Genomic_RNA.
 EMBL; KY112207; APU04242.1; -; Genomic_RNA.
 EMBL; KY112208; APU04251.1; -; Genomic_RNA.
 EMBL; KY112209; APU04260.1; -; Genomic_RNA.
 EMBL; KY112210; APU04269.1; -; Genomic_RNA.
 EMBL; KY112211; APU04278.1; -; Genomic_RNA.
 EMBL; KY112212; APU04287.1; -; Genomic_RNA.
 EMBL; KY112213; APU04296.1; -; Genomic_RNA.
 EMBL; KY112214; APU04304.1; -; Genomic_RNA.
 EMBL; KY112215; APU04313.1; -; Genomic_RNA.
 EMBL; KY112216; APU04322.1; -; Genomic_RNA.
 EMBL; KY112217; APU04331.1; -; Genomic_RNA.
 EMBL; KY112260; APU04421.1; -; Genomic_RNA.
 EMBL; KY112261; APU04430.1; -; Genomic_RNA.
 EMBL; KY112266; APU04475.1; -; Genomic_RNA.
 EMBL; KY112267; APU04484.1; -; Genomic_RNA.
 EMBL; KY112269; APU04502.1; -; Genomic_RNA.
 EMBL; KY112271; APU04520.1; -; Genomic_RNA.
 EMBL; KY112272; APU04529.1; -; Genomic_RNA.
 EMBL; KY112273; APU04538.1; -; Genomic_RNA.
 EMBL; KY112275; APU04556.1; -; Genomic_RNA.
 EMBL; KY112277; APU04574.1; -; Genomic_RNA.
 EMBL; KY112278; APU04583.1; -; Genomic_RNA.
 EMBL; KY112279; APU04592.1; -; Genomic_RNA.
 EMBL; KY112280; APU04601.1; -; Genomic_RNA.
 EMBL; KY112282; APU04619.1; -; Genomic_RNA.
 EMBL; KY112283; APU04628.1; -; Genomic_RNA.
 EMBL; KY112288; APU04673.1; -; Genomic_RNA.
 EMBL; KY112289; APU04682.1; -; Genomic_RNA.
 EMBL; KY112290; APU04691.1; -; Genomic_RNA.
 EMBL; KY112297; APU04753.1; -; Genomic_RNA.
 EMBL; KY112298; APU04762.1; -; Genomic_RNA.
 EMBL; KY112300; APU04780.1; -; Genomic_RNA.
 EMBL; KY112301; APU04789.1; -; Genomic_RNA.
 EMBL; KY112303; APU04807.1; -; Genomic_RNA.
 EMBL; KY112304; APU04816.1; -; Genomic_RNA.
 EMBL; KY112306; APU04834.1; -; Genomic_RNA.
 EMBL; KY112307; APU04843.1; -; Genomic_RNA.
 EMBL; KY112308; APU04852.1; -; Genomic_RNA.
 EMBL; KY112312; APU04888.1; -; Genomic_RNA.
 EMBL; KY112313; APU04897.1; -; Genomic_RNA.
 EMBL; KY112314; APU04906.1; -; Genomic_RNA.
 EMBL; KY112315; APU04915.1; -; Genomic_RNA.
 EMBL; KY112316; APU04924.1; -; Genomic_RNA.
 EMBL; KY112318; APU04942.1; -; Genomic_RNA.
 EMBL; KY112319; APU04951.1; -; Genomic_RNA.
 EMBL; KY112321; APU04969.1; -; Genomic_RNA.
 EMBL; KY112218; APU07260.1; -; Genomic_RNA.
 EMBL; KY112220; APU07275.1; -; Genomic_RNA.
 EMBL; KY112221; APU07283.1; -; Genomic_RNA.
 EMBL; KY112222; APU07290.1; -; Genomic_RNA.
 EMBL; KY112223; APU07298.1; -; Genomic_RNA.
 EMBL; KY112224; APU07306.1; -; Genomic_RNA.
 EMBL; KY112225; APU07314.1; -; Genomic_RNA.
 EMBL; KY112226; APU07322.1; -; Genomic_RNA.
 EMBL; KY112227; APU07330.1; -; Genomic_RNA.
 EMBL; KY112228; APU07338.1; -; Genomic_RNA.
 EMBL; KY112229; APU07346.1; -; Genomic_RNA.
 EMBL; KY112230; APU07354.1; -; Genomic_RNA.
 EMBL; KY112232; APU07369.1; -; Genomic_RNA.
 EMBL; KY112233; APU07377.1; -; Genomic_RNA.
 EMBL; KY112234; APU07385.1; -; Genomic_RNA.
 EMBL; KY112235; APU07393.1; -; Genomic_RNA.
 EMBL; KY112236; APU07401.1; -; Genomic_RNA.
 EMBL; KY112238; APU07416.1; -; Genomic_RNA.
 EMBL; KY112239; APU07424.1; -; Genomic_RNA.
 EMBL; KY112240; APU07432.1; -; Genomic_RNA.
 EMBL; KY112241; APU07440.1; -; Genomic_RNA.
 EMBL; KY112242; APU07448.1; -; Genomic_RNA.
 EMBL; KY112243; APU07456.1; -; Genomic_RNA.
 EMBL; KY112244; APU07464.1; -; Genomic_RNA.
 EMBL; KY112245; APU07472.1; -; Genomic_RNA.
 EMBL; KY112246; APU07479.1; -; Genomic_RNA.
 EMBL; KY112247; APU07487.1; -; Genomic_RNA.
 EMBL; KY112248; APU07495.1; -; Genomic_RNA.
 EMBL; KY112249; APU07503.1; -; Genomic_RNA.
 EMBL; KY112250; APU07511.1; -; Genomic_RNA.
 EMBL; KY112323; APU07526.1; -; Genomic_RNA.
 EMBL; KY112324; APU07534.1; -; Genomic_RNA.
 EMBL; KY112325; APU07541.1; -; Genomic_RNA.
 EMBL; KY112326; APU07549.1; -; Genomic_RNA.
 EMBL; KY112327; APU07557.1; -; Genomic_RNA.
 EMBL; KY112328; APU07565.1; -; Genomic_RNA.
 EMBL; KY112329; APU07573.1; -; Genomic_RNA.
 EMBL; KY112331; APU07589.1; -; Genomic_RNA.
 EMBL; KY112332; APU07597.1; -; Genomic_RNA.
 EMBL; KY112333; APU07605.1; -; Genomic_RNA.
 EMBL; KY112334; APU07613.1; -; Genomic_RNA.
 EMBL; KY112338; APU07645.1; -; Genomic_RNA.
 EMBL; KY112340; APU07661.1; -; Genomic_RNA.
 EMBL; KY112341; APU07669.1; -; Genomic_RNA.
 EMBL; KY112342; APU07677.1; -; Genomic_RNA.
 EMBL; KY112344; APU07692.1; -; Genomic_RNA.
 EMBL; KY112346; APU07708.1; -; Genomic_RNA.
 EMBL; KY112347; APU07716.1; -; Genomic_RNA.
 EMBL; KY112348; APU07724.1; -; Genomic_RNA.
 EMBL; KY112351; APU07748.1; -; Genomic_RNA.
 EMBL; KY112352; APU07756.1; -; Genomic_RNA.
 EMBL; KY112354; APU07771.1; -; Genomic_RNA.
 EMBL; KY112356; APU07787.1; -; Genomic_RNA.
 EMBL; KY112357; APU07795.1; -; Genomic_RNA.
 EMBL; KY112358; APU07803.1; -; Genomic_RNA.
 EMBL; KY112359; APU07811.1; -; Genomic_RNA.
 GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
 GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
 GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
 GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
 GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
 GO; GO:0019058; P:viral life cycle; IEA:InterPro.
 HAMAP; MF_04081; HIV_VIF; 1.
 InterPro; IPR000475; Viral_infect.
 Pfam; PF00559; Vif; 1.
 PRINTS; PR00349; VIRIONINFFCT.
 2: Evidence at transcript level;
 Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04081,
 ECO:0000256|SAAS:SAAS00135760};
 Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04081,
 ECO:0000256|SAAS:SAAS00487388};
 Host membrane {ECO:0000256|HAMAP-Rule:MF_04081,
 ECO:0000256|SAAS:SAAS00135760};
 Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04081,
 ECO:0000256|SAAS:SAAS00487339};
 Membrane {ECO:0000256|HAMAP-Rule:MF_04081,
 ECO:0000256|SAAS:SAAS00135760};
 Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_04081};
 RNA-binding {ECO:0000256|HAMAP-Rule:MF_04081};
 Ubl conjugation {ECO:0000256|HAMAP-Rule:MF_04081};
 Ubl conjugation pathway {ECO:0000256|HAMAP-Rule:MF_04081,
 ECO:0000256|SAAS:SAAS00487332};
 Virion {ECO:0000256|HAMAP-Rule:MF_04081,
 ECO:0000256|SAAS:SAAS00487311}.
 REGION       14     17       Interaction with host APOBEC3F; F1-box.
                              {ECO:0000256|HAMAP-Rule:MF_04081}.
 REGION       40     44       Interaction with host APOBEC3G; G-box.
                              {ECO:0000256|HAMAP-Rule:MF_04081}.
 REGION       54     72       Interaction with host APOBEC3F and
                              APOBEC3G; FG-box. {ECO:0000256|HAMAP-
                              Rule:MF_04081}.
 REGION       74     79       Interaction with host APOBEC3F; F2-box.
                              {ECO:0000256|HAMAP-Rule:MF_04081}.
 REGION       75    114       RNA-binding. {ECO:0000256|HAMAP-
                              Rule:MF_04081}.
 REGION      151    164       Multimerization. {ECO:0000256|HAMAP-
                              Rule:MF_04081}.
 REGION      171    172       Membrane association. {ECO:0000256|HAMAP-
                              Rule:MF_04081}.
 MOTIF       108    139       HCCH motif. {ECO:0000256|HAMAP-
                              Rule:MF_04081}.
 MOTIF       144    153       BC-box-like motif. {ECO:0000256|HAMAP-
                              Rule:MF_04081}.
 SITE        150    151       Cleavage in virion (by viral protease).
                              {ECO:0000256|HAMAP-Rule:MF_04081}.
 MOD_RES      96     96       Phosphothreonine; by host MAP4K1.
                              {ECO:0000256|HAMAP-Rule:MF_04081}.
 MOD_RES     144    144       Phosphoserine; by host.
                              {ECO:0000256|HAMAP-Rule:MF_04081}.
 MOD_RES     165    165       Phosphoserine; by host MAP4K1.
                              {ECO:0000256|HAMAP-Rule:MF_04081}.
 MOD_RES     188    188       Phosphothreonine; by host.
                              {ECO:0000256|HAMAP-Rule:MF_04081}.
 SEQUENCE   192 AA;  22748 MW;  6FD173D1D4C07469 CRC64;
 MENRWQVLIV WQVDRMRIRT WNSLVKHHMH ISKRANGWFY RHHYESRHPK VSSEVHIPLG
 DARLIIRTYW GLHTGEREWH LGHGVSIEWR LRRYSTQVDP GLADQLIHMH YFDCFADSAI
 RKAILGHIVI PRCDYQAGHN KVGSLQYLAL TALIKPKKIK PPLPSVRKLV EDRWNKPQKT
 RGRRGNHTMN GH

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