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Virion infectivity factor (Vif) (SOR protein) [Cleaved into: p17; p7]

 A0A1L7DWZ5_9HIV1        Unreviewed;       192 AA.
A0A1L7DWZ5;
15-MAR-2017, integrated into UniProtKB/TrEMBL.
15-MAR-2017, sequence version 1.
18-JUL-2018, entry version 11.
RecName: Full=Virion infectivity factor {ECO:0000256|RuleBase:RU003341};
Name=vif {ECO:0000313|EMBL:APU04807.1};
Human immunodeficiency virus 1.
Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
NCBI_TaxID=11676 {ECO:0000313|EMBL:APU04807.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:APU04807.1}
NUCLEOTIDE SEQUENCE.
STRAIN=CH427.PL.011608.A2.1 {ECO:0000313|EMBL:APU04152.1},
CH427.PL.011608.A2.10 {ECO:0000313|EMBL:APU04161.1},
CH427.PL.011608.A2.2 {ECO:0000313|EMBL:APU04170.1},
CH427.PL.011608.A2.3 {ECO:0000313|EMBL:APU04179.1},
CH427.PL.011608.A2.4 {ECO:0000313|EMBL:APU04188.1},
CH427.PL.011608.A2.5 {ECO:0000313|EMBL:APU04197.1},
CH427.PL.011608.A2.6 {ECO:0000313|EMBL:APU04206.1},
CH427.PL.011608.A2.7 {ECO:0000313|EMBL:APU04215.1},
CH427.PL.011608.A2.8 {ECO:0000313|EMBL:APU04224.1},
CH427.PL.011608.A2.9 {ECO:0000313|EMBL:APU04233.1},
CH427.PL.011608.BE.1 {ECO:0000313|EMBL:APU04242.1},
CH427.PL.011608.UT.1 {ECO:0000313|EMBL:APU04251.1},
CH427.PL.011608.UT.10 {ECO:0000313|EMBL:APU04260.1},
CH427.PL.011608.UT.2 {ECO:0000313|EMBL:APU04269.1},
CH427.PL.011608.UT.3 {ECO:0000313|EMBL:APU04278.1},
CH427.PL.011608.UT.4 {ECO:0000313|EMBL:APU04287.1},
CH427.PL.011608.UT.5 {ECO:0000313|EMBL:APU04296.1},
CH427.PL.011608.UT.6 {ECO:0000313|EMBL:APU04304.1},
CH427.PL.011608.UT.7 {ECO:0000313|EMBL:APU04313.1},
CH427.PL.011608.UT.8 {ECO:0000313|EMBL:APU04322.1},
CH427.PL.011608.UT.9 {ECO:0000313|EMBL:APU04331.1},
CH427_SGA.600.1 {ECO:0000313|EMBL:APU07260.1},
CH427_SGA.600.11 {ECO:0000313|EMBL:APU07275.1},
CH427_SGA.600.12 {ECO:0000313|EMBL:APU07283.1},
CH427_SGA.600.13 {ECO:0000313|EMBL:APU07290.1},
CH427_SGA.600.14 {ECO:0000313|EMBL:APU07298.1},
CH427_SGA.600.15 {ECO:0000313|EMBL:APU07306.1},
CH427_SGA.600.16 {ECO:0000313|EMBL:APU07314.1},
CH427_SGA.600.18 {ECO:0000313|EMBL:APU07322.1},
CH427_SGA.600.19 {ECO:0000313|EMBL:APU07330.1},
CH427_SGA.600.2 {ECO:0000313|EMBL:APU07338.1},
CH427_SGA.600.20 {ECO:0000313|EMBL:APU07346.1},
CH427_SGA.600.21 {ECO:0000313|EMBL:APU07354.1},
CH427_SGA.600.24 {ECO:0000313|EMBL:APU07369.1},
CH427_SGA.600.25 {ECO:0000313|EMBL:APU07377.1},
CH427_SGA.600.26 {ECO:0000313|EMBL:APU07385.1},
CH427_SGA.600.27 {ECO:0000313|EMBL:APU07393.1},
CH427_SGA.600.29 {ECO:0000313|EMBL:APU07401.1},
CH427_SGA.600.30 {ECO:0000313|EMBL:APU07416.1},
CH427_SGA.600.31 {ECO:0000313|EMBL:APU07424.1},
CH427_SGA.600.32 {ECO:0000313|EMBL:APU07432.1},
CH427_SGA.600.33 {ECO:0000313|EMBL:APU07440.1},
CH427_SGA.600.35 {ECO:0000313|EMBL:APU07448.1},
CH427_SGA.600.36 {ECO:0000313|EMBL:APU07456.1},
CH427_SGA.600.37 {ECO:0000313|EMBL:APU07464.1},
CH427_SGA.600.39 {ECO:0000313|EMBL:APU07472.1},
CH427_SGA.600.4 {ECO:0000313|EMBL:APU07479.1},
CH427_SGA.600.6 {ECO:0000313|EMBL:APU07487.1},
CH427_SGA.600.7 {ECO:0000313|EMBL:APU07495.1},
CH427_SGA.600.8 {ECO:0000313|EMBL:APU07503.1},
CH427_SGA.600.9 {ECO:0000313|EMBL:APU07511.1},
CH492.CV.020608.UT.10 {ECO:0000313|EMBL:APU04421.1},
CH492.CV.020608.UT.11 {ECO:0000313|EMBL:APU04430.1},
CH492.CV.020608.UT.16 {ECO:0000313|EMBL:APU04475.1},
CH492.CV.020608.UT.17 {ECO:0000313|EMBL:APU04484.1},
CH492.CV.020608.UT.3 {ECO:0000313|EMBL:APU04502.1},
CH492.CV.020608.UT.5 {ECO:0000313|EMBL:APU04520.1},
CH492.CV.020608.UT.6 {ECO:0000313|EMBL:APU04529.1},
CH492.CV.020608.UT.7 {ECO:0000313|EMBL:APU04538.1},
CH492.CV.020608.UT.9 {ECO:0000313|EMBL:APU04556.1},
CH492.PL.031108.A2.10 {ECO:0000313|EMBL:APU04574.1},
CH492.PL.031108.A2.11 {ECO:0000313|EMBL:APU04583.1},
CH492.PL.031108.A2.12 {ECO:0000313|EMBL:APU04592.1},
CH492.PL.031108.A2.13 {ECO:0000313|EMBL:APU04601.1},
CH492.PL.031108.A2.15 {ECO:0000313|EMBL:APU04619.1},
CH492.PL.031108.A2.16 {ECO:0000313|EMBL:APU04628.1},
CH492.PL.031108.A2.3 {ECO:0000313|EMBL:APU04673.1},
CH492.PL.031108.A2.4 {ECO:0000313|EMBL:APU04682.1},
CH492.PL.031108.A2.5 {ECO:0000313|EMBL:APU04691.1},
CH492.PL.031108.BE.11 {ECO:0000313|EMBL:APU04753.1},
CH492.PL.031108.BE.12 {ECO:0000313|EMBL:APU04762.1},
CH492.PL.031108.BE.14 {ECO:0000313|EMBL:APU04780.1},
CH492.PL.031108.BE.2 {ECO:0000313|EMBL:APU04789.1},
CH492.PL.031108.BE.4 {ECO:0000313|EMBL:APU04807.1},
CH492.PL.031108.BE.5 {ECO:0000313|EMBL:APU04816.1},
CH492.PL.031108.BE.7 {ECO:0000313|EMBL:APU04834.1},
CH492.PL.031108.BE.8 {ECO:0000313|EMBL:APU04843.1},
CH492.PL.031108.BE.9 {ECO:0000313|EMBL:APU04852.1},
CH492.PL.031108.UT.12 {ECO:0000313|EMBL:APU04888.1},
CH492.PL.031108.UT.13 {ECO:0000313|EMBL:APU04897.1},
CH492.PL.031108.UT.2 {ECO:0000313|EMBL:APU04906.1},
CH492.PL.031108.UT.3 {ECO:0000313|EMBL:APU04915.1},
CH492.PL.031108.UT.4 {ECO:0000313|EMBL:APU04924.1},
CH492.PL.031108.UT.6 {ECO:0000313|EMBL:APU04942.1},
CH492.PL.031108.UT.7 {ECO:0000313|EMBL:APU04951.1},
CH492.PL.031108.UT.9 {ECO:0000313|EMBL:APU04969.1},
CH492_SGA.1A5 {ECO:0000313|EMBL:APU07526.1},
CH492_SGA.1A7 {ECO:0000313|EMBL:APU07534.1},
CH492_SGA.1A8 {ECO:0000313|EMBL:APU07541.1},
CH492_SGA.1A9 {ECO:0000313|EMBL:APU07549.1},
CH492_SGA.1B11 {ECO:0000313|EMBL:APU07557.1},
CH492_SGA.1B5 {ECO:0000313|EMBL:APU07565.1},
CH492_SGA.1D12 {ECO:0000313|EMBL:APU07573.1},
CH492_SGA.1D3 {ECO:0000313|EMBL:APU07589.1},
CH492_SGA.1D4 {ECO:0000313|EMBL:APU07597.1},
CH492_SGA.1D6 {ECO:0000313|EMBL:APU07605.1},
CH492_SGA.1E1 {ECO:0000313|EMBL:APU07613.1},
CH492_SGA.1F11 {ECO:0000313|EMBL:APU07645.1},
CH492_SGA.1G3 {ECO:0000313|EMBL:APU07661.1},
CH492_SGA.1H1 {ECO:0000313|EMBL:APU07669.1},
CH492_SGA.1H11 {ECO:0000313|EMBL:APU07677.1},
CH492_SGA.1H8 {ECO:0000313|EMBL:APU07692.1},
CH492_SGA.2B7 {ECO:0000313|EMBL:APU07708.1},
CH492_SGA.2B8 {ECO:0000313|EMBL:APU07716.1},
CH492_SGA.2C12 {ECO:0000313|EMBL:APU07724.1},
CH492_SGA.2E7 {ECO:0000313|EMBL:APU07748.1},
CH492_SGA.2F5 {ECO:0000313|EMBL:APU07756.1},
CH492_SGA.2G12 {ECO:0000313|EMBL:APU07771.1},
CH492_SGA.2G4 {ECO:0000313|EMBL:APU07787.1},
CH492_SGA.2G6 {ECO:0000313|EMBL:APU07795.1},
CH492_SGA.2G8 {ECO:0000313|EMBL:APU07803.1}, and
CH492_SGA.2H8 {ECO:0000313|EMBL:APU07811.1};
PubMed=28069935;
Iyer S.S., Bibollet-Ruche F., Sherrill-Mix S., Learn G.H.,
Plenderleith L., Smith A.G., Barbian H.J., Russell R.M., Gondim M.V.,
Bahari C.Y., Shaw C.M., Li Y., Decker T., Haynes B.F., Shaw G.M.,
Sharp P.M., Borrow P., Hahn B.H.;
"Resistance to type 1 interferons is a major determinant of HIV-1
transmission fitness.";
Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2017).
-!- SUBCELLULAR LOCATION: Host cell membrane
{ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059686};
Peripheral membrane protein {ECO:0000256|RuleBase:RU003341,
ECO:0000256|SAAS:SAAS01059686}; Cytoplasmic side
{ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059686}.
Host cytoplasm {ECO:0000256|RuleBase:RU003341}. Virion
{ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059682}.
Note=In the cytoplasm, seems to colocalize with intermediate
filament vimentin. A fraction is associated with the cytoplasmic
side of cellular membranes, presumably via the interaction with
Pr55Gag precursor. {ECO:0000256|RuleBase:RU003341}.
-!- SIMILARITY: Belongs to the primate lentivirus group Vif protein
family. {ECO:0000256|RuleBase:RU003341,
ECO:0000256|SAAS:SAAS01059764}.
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EMBL; KY112197; APU04152.1; -; Genomic_RNA.
EMBL; KY112198; APU04161.1; -; Genomic_RNA.
EMBL; KY112199; APU04170.1; -; Genomic_RNA.
EMBL; KY112200; APU04179.1; -; Genomic_RNA.
EMBL; KY112201; APU04188.1; -; Genomic_RNA.
EMBL; KY112202; APU04197.1; -; Genomic_RNA.
EMBL; KY112203; APU04206.1; -; Genomic_RNA.
EMBL; KY112204; APU04215.1; -; Genomic_RNA.
EMBL; KY112205; APU04224.1; -; Genomic_RNA.
EMBL; KY112206; APU04233.1; -; Genomic_RNA.
EMBL; KY112207; APU04242.1; -; Genomic_RNA.
EMBL; KY112208; APU04251.1; -; Genomic_RNA.
EMBL; KY112209; APU04260.1; -; Genomic_RNA.
EMBL; KY112210; APU04269.1; -; Genomic_RNA.
EMBL; KY112211; APU04278.1; -; Genomic_RNA.
EMBL; KY112212; APU04287.1; -; Genomic_RNA.
EMBL; KY112213; APU04296.1; -; Genomic_RNA.
EMBL; KY112214; APU04304.1; -; Genomic_RNA.
EMBL; KY112215; APU04313.1; -; Genomic_RNA.
EMBL; KY112216; APU04322.1; -; Genomic_RNA.
EMBL; KY112217; APU04331.1; -; Genomic_RNA.
EMBL; KY112260; APU04421.1; -; Genomic_RNA.
EMBL; KY112261; APU04430.1; -; Genomic_RNA.
EMBL; KY112266; APU04475.1; -; Genomic_RNA.
EMBL; KY112267; APU04484.1; -; Genomic_RNA.
EMBL; KY112269; APU04502.1; -; Genomic_RNA.
EMBL; KY112271; APU04520.1; -; Genomic_RNA.
EMBL; KY112272; APU04529.1; -; Genomic_RNA.
EMBL; KY112273; APU04538.1; -; Genomic_RNA.
EMBL; KY112275; APU04556.1; -; Genomic_RNA.
EMBL; KY112277; APU04574.1; -; Genomic_RNA.
EMBL; KY112278; APU04583.1; -; Genomic_RNA.
EMBL; KY112279; APU04592.1; -; Genomic_RNA.
EMBL; KY112280; APU04601.1; -; Genomic_RNA.
EMBL; KY112282; APU04619.1; -; Genomic_RNA.
EMBL; KY112283; APU04628.1; -; Genomic_RNA.
EMBL; KY112288; APU04673.1; -; Genomic_RNA.
EMBL; KY112289; APU04682.1; -; Genomic_RNA.
EMBL; KY112290; APU04691.1; -; Genomic_RNA.
EMBL; KY112297; APU04753.1; -; Genomic_RNA.
EMBL; KY112298; APU04762.1; -; Genomic_RNA.
EMBL; KY112300; APU04780.1; -; Genomic_RNA.
EMBL; KY112301; APU04789.1; -; Genomic_RNA.
EMBL; KY112303; APU04807.1; -; Genomic_RNA.
EMBL; KY112304; APU04816.1; -; Genomic_RNA.
EMBL; KY112306; APU04834.1; -; Genomic_RNA.
EMBL; KY112307; APU04843.1; -; Genomic_RNA.
EMBL; KY112308; APU04852.1; -; Genomic_RNA.
EMBL; KY112312; APU04888.1; -; Genomic_RNA.
EMBL; KY112313; APU04897.1; -; Genomic_RNA.
EMBL; KY112314; APU04906.1; -; Genomic_RNA.
EMBL; KY112315; APU04915.1; -; Genomic_RNA.
EMBL; KY112316; APU04924.1; -; Genomic_RNA.
EMBL; KY112318; APU04942.1; -; Genomic_RNA.
EMBL; KY112319; APU04951.1; -; Genomic_RNA.
EMBL; KY112321; APU04969.1; -; Genomic_RNA.
EMBL; KY112218; APU07260.1; -; Genomic_RNA.
EMBL; KY112220; APU07275.1; -; Genomic_RNA.
EMBL; KY112221; APU07283.1; -; Genomic_RNA.
EMBL; KY112222; APU07290.1; -; Genomic_RNA.
EMBL; KY112223; APU07298.1; -; Genomic_RNA.
EMBL; KY112224; APU07306.1; -; Genomic_RNA.
EMBL; KY112225; APU07314.1; -; Genomic_RNA.
EMBL; KY112226; APU07322.1; -; Genomic_RNA.
EMBL; KY112227; APU07330.1; -; Genomic_RNA.
EMBL; KY112228; APU07338.1; -; Genomic_RNA.
EMBL; KY112229; APU07346.1; -; Genomic_RNA.
EMBL; KY112230; APU07354.1; -; Genomic_RNA.
EMBL; KY112232; APU07369.1; -; Genomic_RNA.
EMBL; KY112233; APU07377.1; -; Genomic_RNA.
EMBL; KY112234; APU07385.1; -; Genomic_RNA.
EMBL; KY112235; APU07393.1; -; Genomic_RNA.
EMBL; KY112236; APU07401.1; -; Genomic_RNA.
EMBL; KY112238; APU07416.1; -; Genomic_RNA.
EMBL; KY112239; APU07424.1; -; Genomic_RNA.
EMBL; KY112240; APU07432.1; -; Genomic_RNA.
EMBL; KY112241; APU07440.1; -; Genomic_RNA.
EMBL; KY112242; APU07448.1; -; Genomic_RNA.
EMBL; KY112243; APU07456.1; -; Genomic_RNA.
EMBL; KY112244; APU07464.1; -; Genomic_RNA.
EMBL; KY112245; APU07472.1; -; Genomic_RNA.
EMBL; KY112246; APU07479.1; -; Genomic_RNA.
EMBL; KY112247; APU07487.1; -; Genomic_RNA.
EMBL; KY112248; APU07495.1; -; Genomic_RNA.
EMBL; KY112249; APU07503.1; -; Genomic_RNA.
EMBL; KY112250; APU07511.1; -; Genomic_RNA.
EMBL; KY112323; APU07526.1; -; Genomic_RNA.
EMBL; KY112324; APU07534.1; -; Genomic_RNA.
EMBL; KY112325; APU07541.1; -; Genomic_RNA.
EMBL; KY112326; APU07549.1; -; Genomic_RNA.
EMBL; KY112327; APU07557.1; -; Genomic_RNA.
EMBL; KY112328; APU07565.1; -; Genomic_RNA.
EMBL; KY112329; APU07573.1; -; Genomic_RNA.
EMBL; KY112331; APU07589.1; -; Genomic_RNA.
EMBL; KY112332; APU07597.1; -; Genomic_RNA.
EMBL; KY112333; APU07605.1; -; Genomic_RNA.
EMBL; KY112334; APU07613.1; -; Genomic_RNA.
EMBL; KY112338; APU07645.1; -; Genomic_RNA.
EMBL; KY112340; APU07661.1; -; Genomic_RNA.
EMBL; KY112341; APU07669.1; -; Genomic_RNA.
EMBL; KY112342; APU07677.1; -; Genomic_RNA.
EMBL; KY112344; APU07692.1; -; Genomic_RNA.
EMBL; KY112346; APU07708.1; -; Genomic_RNA.
EMBL; KY112347; APU07716.1; -; Genomic_RNA.
EMBL; KY112348; APU07724.1; -; Genomic_RNA.
EMBL; KY112351; APU07748.1; -; Genomic_RNA.
EMBL; KY112352; APU07756.1; -; Genomic_RNA.
EMBL; KY112354; APU07771.1; -; Genomic_RNA.
EMBL; KY112356; APU07787.1; -; Genomic_RNA.
EMBL; KY112357; APU07795.1; -; Genomic_RNA.
EMBL; KY112358; APU07803.1; -; Genomic_RNA.
EMBL; KY112359; APU07811.1; -; Genomic_RNA.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
GO; GO:0019058; P:viral life cycle; IEA:InterPro.
HAMAP; MF_04081; HIV_VIF; 1.
InterPro; IPR000475; Viral_infect.
Pfam; PF00559; Vif; 1.
PRINTS; PR00349; VIRIONINFFCT.
3: Inferred from homology;
Host cell membrane {ECO:0000256|SAAS:SAAS01059755};
Host cytoplasm {ECO:0000256|SAAS:SAAS01059745};
Host membrane {ECO:0000256|SAAS:SAAS01059755};
Host-virus interaction {ECO:0000256|SAAS:SAAS01059733};
Membrane {ECO:0000256|SAAS:SAAS01059755};
Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01059744};
Virion {ECO:0000256|SAAS:SAAS01059762}.
SEQUENCE 192 AA; 22748 MW; 6FD173D1D4C07469 CRC64;
MENRWQVLIV WQVDRMRIRT WNSLVKHHMH ISKRANGWFY RHHYESRHPK VSSEVHIPLG
DARLIIRTYW GLHTGEREWH LGHGVSIEWR LRRYSTQVDP GLADQLIHMH YFDCFADSAI
RKAILGHIVI PRCDYQAGHN KVGSLQYLAL TALIKPKKIK PPLPSVRKLV EDRWNKPQKT
RGRRGNHTMN GH


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'L0126-1 Coagulation factor X (F10) (cleaved) antibody Ab host: Rabbit 50 Вµg
'L0203-2 Coagulation factor XII (F12) (cleaved) antibody Ab host: Rabbit 0.1 mg
'L0259-1 Coagulation factor VII (F7) (cleaved) antibody Ab host: Rabbit 50 Вµg
L0199-1 Coagulation factor X (F10) (cleaved) Rabbit antibody Ab Aff - Purified 50


 

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