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WASH complex subunit 1 (WAS protein family homolog 1)

 WASH1_DANRE             Reviewed;         481 AA.
A4IG59; A8DZA2;
19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
19-JAN-2010, sequence version 2.
12-SEP-2018, entry version 64.
RecName: Full=WASH complex subunit 1 {ECO:0000250|UniProtKB:A8K0Z3};
AltName: Full=WAS protein family homolog 1;
Name=washc1 {ECO:0000250|UniProtKB:A8K0Z3}; Synonyms=wash, Wash1;
ORFNames=si:ch211-11f8.1;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Acts as a nucleation-promoting factor at the surface of
endosomes, where it recruits and activates the Arp2/3 complex to
induce actin polymerization, playing a key role in the fission of
tubules that serve as transport intermediates during endosome
sorting. Its assembly in the WASH core complex seems to inhibit
its NPF activity and is required for its membrane targeting.
{ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}.
-!- SUBUNIT: Component of the WASH complex.
{ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}.
-!- SUBCELLULAR LOCATION: Early endosome membrane
{ECO:0000250|UniProtKB:A8K0Z3}. Recycling endosome membrane
{ECO:0000250|UniProtKB:Q8VDD8}.
-!- DOMAIN: The VCA (verprolin, cofilin, acidic) domain promotes actin
polymerization by the Arp2/3 complex in vitro.
{ECO:0000250|UniProtKB:C4AMC7}.
-!- SIMILARITY: Belongs to the WASH1 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAP09504.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AL928990; CAP09504.1; ALT_SEQ; Genomic_DNA.
EMBL; BC134941; AAI34942.1; -; mRNA.
RefSeq; NP_001103920.1; NM_001110450.1.
UniGene; Dr.91775; -.
SMR; A4IG59; -.
STRING; 7955.ENSDARP00000087184; -.
PaxDb; A4IG59; -.
PeptideAtlas; A4IG59; -.
PRIDE; A4IG59; -.
Ensembl; ENSDART00000092752; ENSDARP00000087184; ENSDARG00000063457.
GeneID; 555174; -.
KEGG; dre:555174; -.
CTD; 555174; -.
ZFIN; ZDB-GENE-050419-138; wash1.
eggNOG; ENOG410IFZ4; Eukaryota.
eggNOG; ENOG410YN2V; LUCA.
GeneTree; ENSGT00390000016717; -.
HOGENOM; HOG000007381; -.
HOVERGEN; HBG066686; -.
InParanoid; A4IG59; -.
KO; K18461; -.
OMA; NLRHEET; -.
OrthoDB; EOG091G0GKX; -.
PhylomeDB; A4IG59; -.
TreeFam; TF318222; -.
PRO; PR:A4IG59; -.
Proteomes; UP000000437; Chromosome 18.
Bgee; ENSDARG00000063457; Expressed in 17 organ(s), highest expression level in mature ovarian follicle.
ExpressionAtlas; A4IG59; baseline.
GO; GO:0005829; C:cytosol; IEA:GOC.
GO; GO:0005769; C:early endosome; ISS:UniProtKB.
GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0071203; C:WASH complex; ISS:UniProtKB.
GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO; GO:0043014; F:alpha-tubulin binding; ISS:UniProtKB.
GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; ISS:UniProtKB.
GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISS:UniProtKB.
InterPro; IPR028290; WASH1.
InterPro; IPR021854; WASH1_WAHD.
PANTHER; PTHR23331; PTHR23331; 1.
Pfam; PF11945; WASH_WAHD; 1.
2: Evidence at transcript level;
Actin-binding; Complete proteome; Endosome; Membrane;
Protein transport; Reference proteome; Transport.
CHAIN 1 481 WASH complex subunit 1.
/FTId=PRO_0000390966.
DOMAIN 371 393 WH2.
REGION 1 54 Required for WASH complex assembly.
{ECO:0000250|UniProtKB:C4AMC7}.
REGION 359 481 VCA. {ECO:0000250|UniProtKB:C4AMC7}.
COMPBIAS 305 354 Pro-rich.
CONFLICT 341 341 M -> I (in Ref. 2; AAI34942).
{ECO:0000305}.
CONFLICT 453 453 G -> S (in Ref. 2; AAI34942).
{ECO:0000305}.
SEQUENCE 481 AA; 52112 MW; 6A4C2029A8DC82CE CRC64;
MVRMTQKRYL EGQVYSVPLI QPDLRREEAV HQITDALQYL EMISTDIFTR VSESVEKNRA
HLQSVTDRIK LAQARVQKIK GSKKATKVFS SAKYPAPEKL QDYSSIFTGA VDPASQKRPR
IKVQSKLRPL DDKAQQEKLM YLPVCVNTKK RSEDETEEGL GSLPRNVNSV SSLLLFNTTE
NLYKKYVFLD PLAGAVTKTH TTLETEKEDK PFDAPLSITK REQLERQTAE NYFYVPDLGQ
VPEIDVPSYL PDLPGIADDL MYSADLGPGF APSVPASNSI PELPSFGTDH DESSGSDSQF
KLEAPPPPPP PPPPPPEPTH VPVPPPGTSA APPPPPPPPP MTADNTDASS PAPPTGTVKG
APSEVVQPSN GRASLLESIR NAGGIGKANL RNVKERKMEK KKQKEQEQVG ATVSGGDLMS
DLFNKLAMRR KGISGKGPAG QGDSSEAPAS SGGAFARMSD VIPPLPAPQQ SAADDEDDWE
A


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